AU538883B2 – 17alpha-acyloxy-5beta and 5alpha corticoids
– Google Patents
AU538883B2 – 17alpha-acyloxy-5beta and 5alpha corticoids
– Google Patents
17alpha-acyloxy-5beta and 5alpha corticoids
Info
Publication number
AU538883B2
AU538883B2
AU66513/81A
AU6651381A
AU538883B2
AU 538883 B2
AU538883 B2
AU 538883B2
AU 66513/81 A
AU66513/81 A
AU 66513/81A
AU 6651381 A
AU6651381 A
AU 6651381A
AU 538883 B2
AU538883 B2
AU 538883B2
Authority
AU
Australia
Prior art keywords
5beta
5alpha
17alpha
corticoids
acyloxy
Prior art date
1980-01-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU66513/81A
Other versions
AU6651381A
(en
Inventor
Donald Emory Ayer
Carl Alvin Schlagel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1980-01-31
Filing date
1981-01-21
Publication date
1984-08-30
1981-01-21
Application filed by Upjohn Co
filed
Critical
Upjohn Co
1981-08-06
Publication of AU6651381A
publication
Critical
patent/AU6651381A/en
1984-08-30
Application granted
granted
Critical
1984-08-30
Publication of AU538883B2
publication
Critical
patent/AU538883B2/en
2001-01-21
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 – C07J43/00
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
C07J71/0005—Oxygen-containing hetero ring
C07J71/001—Oxiranes
C07J71/0015—Oxiranes at position 9(11)
AU66513/81A
1980-01-31
1981-01-21
17alpha-acyloxy-5beta and 5alpha corticoids
Ceased
AU538883B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US06/117,401
US4318853A
(en)
1980-01-31
1980-01-31
9β,11β-Epoxy-5β-corticoids
US117401
1980-01-31
Publications (2)
Publication Number
Publication Date
AU6651381A
AU6651381A
(en)
1981-08-06
AU538883B2
true
AU538883B2
(en)
1984-08-30
Family
ID=22372732
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU66513/81A
Ceased
AU538883B2
(en)
1980-01-31
1981-01-21
17alpha-acyloxy-5beta and 5alpha corticoids
Country Status (18)
Country
Link
US
(1)
US4318853A
(en)
JP
(1)
JPS56122398A
(en)
KR
(1)
KR850001208B1
(en)
AU
(1)
AU538883B2
(en)
BE
(1)
BE887323A
(en)
CA
(1)
CA1155108A
(en)
CH
(1)
CH644614A5
(en)
DE
(1)
DE3102397A1
(en)
DK
(1)
DK39281A
(en)
ES
(1)
ES8300342A1
(en)
FR
(1)
FR2475048A1
(en)
GB
(1)
GB2070016B
(en)
GR
(1)
GR73511B
(en)
IT
(1)
IT1193576B
(en)
NL
(1)
NL8100467A
(en)
PH
(2)
PH16525A
(en)
SE
(1)
SE8100563L
(en)
ZA
(1)
ZA8118B
(en)
Families Citing this family (11)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE3243482A1
(en)
*
1982-11-22
1984-05-24
Schering AG, 1000 Berlin und 4709 Bergkamen
NEW 6 (ALPHA) METHYL CORTICOIDS, THEIR PRODUCTION AND USE
JP2545522B2
(en)
*
1985-10-23
1996-10-23
アルコン・ラボラトーリーズ，インコーポレイテッド
Tetrahydro angiogenesis inhibitor steroids
NL8900507A
(en)
*
1989-03-02
1990-10-01
Philips Nv
AMPLIFIER CIRCUIT WITH SATURATION DETECTION.
CA2139549A1
(en)
*
1994-01-28
1995-07-29
Kazumi Ogata
Corticoid derivatives and pharmaceutical and cosmetic compositions
GB2302807A
(en)
*
1995-07-04
1997-02-05
Surtech Int Ltd
Method and composition for treating atopic eczema
DE19737348C2
(en)
*
1997-08-27
2002-07-25
Dan-Gabriel Vulpescu
Pharmaceutical composition containing clindamycin and clotrimazole
HUE027715T2
(en)
2008-05-28
2016-10-28
Reveragen Biopharma Inc
Non-hormonal steroid modulators of nf-kb for treatment of disease
US9198921B2
(en)
2010-04-05
2015-12-01
Reveragen Biopharma, Inc.
Non-hormonal steroid modulators of NF-κB for treatment of disease
CN102225959B
(en)
*
2011-04-29
2012-11-07
中国科学院上海有机化学研究所
16beta-methyl-17alpha-hydroxypreg-3, 20- diketone compound and synthesis thereof
WO2017004205A1
(en)
2015-06-29
2017-01-05
Reveragen Biopharma, Inc.
NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
US11382922B2
(en)
2019-03-07
2022-07-12
Reveragen Biopharma, Inc.
Aqueous oral pharmaceutical suspension compositions
Family Cites Families (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US2831874A
(en)
*
1954-04-20
1958-04-22
Gnrd Patent Holdings Ltd
Improvements in the preparation of 17:21-diacyloxy-2:4-dibromo-3:11:20-triketoallopregnanes
US2854465A
(en)
*
1955-02-18
1958-09-30
Ciba Pharm Prod Inc
Process for the manufacture of halogen-pregnanes and dehalogenation products thereof
CH429716A
(en)
*
1961-06-24
1967-02-15
Vismara Francesco Spa
Process for the preparation of 17a-acyloxy-21-hydroxy steroids
US3681410A
(en)
*
1970-08-07
1972-08-01
Syntex Corp
Process for preparing 17{60 -hydroxy-20-keto and 17{60 ,21-dihydroxy-20-keto pregnanes and derivatives and intermediates thereof
1980
1980-01-31
US
US06/117,401
patent/US4318853A/en
not_active
Expired – Lifetime
1981
1981-01-02
ZA
ZA00810018A
patent/ZA8118B/en
unknown
1981-01-16
CA
CA000368713A
patent/CA1155108A/en
not_active
Expired
1981-01-16
GB
GB8101407A
patent/GB2070016B/en
not_active
Expired
1981-01-21
AU
AU66513/81A
patent/AU538883B2/en
not_active
Ceased
1981-01-24
PH
PH25134A
patent/PH16525A/en
unknown
1981-01-26
GR
GR63960A
patent/GR73511B/el
unknown
1981-01-26
DE
DE3102397A
patent/DE3102397A1/en
not_active
Withdrawn
1981-01-27
IT
IT19360/81A
patent/IT1193576B/en
active
1981-01-28
SE
SE8100563A
patent/SE8100563L/en
not_active
Application Discontinuation
1981-01-29
DK
DK39281A
patent/DK39281A/en
not_active
Application Discontinuation
1981-01-29
ES
ES498938A
patent/ES8300342A1/en
not_active
Expired
1981-01-30
FR
FR8101828A
patent/FR2475048A1/en
active
Granted
1981-01-30
NL
NL8100467A
patent/NL8100467A/en
not_active
Application Discontinuation
1981-01-30
BE
BE0/203661A
patent/BE887323A/en
not_active
IP Right Cessation
1981-01-30
CH
CH62681A
patent/CH644614A5/en
not_active
IP Right Cessation
1981-01-30
KR
KR1019810000285A
patent/KR850001208B1/en
active
IP Right Grant
1981-01-30
JP
JP1178381A
patent/JPS56122398A/en
active
Pending
1983
1983-06-21
PH
PH29092A
patent/PH19579A/en
unknown
Also Published As
Publication number
Publication date
KR850001208B1
(en)
1985-08-20
FR2475048B1
(en)
1984-11-16
DE3102397A1
(en)
1981-12-24
DK39281A
(en)
1981-08-01
ES498938A0
(en)
1982-11-01
ES8300342A1
(en)
1982-11-01
KR830005263A
(en)
1983-08-03
BE887323A
(en)
1981-07-30
ZA8118B
(en)
1982-01-27
CH644614A5
(en)
1984-08-15
US4318853A
(en)
1982-03-09
PH19579A
(en)
1986-05-26
IT8119360D0
(en)
1981-01-27
PH16525A
(en)
1983-11-10
GB2070016A
(en)
1981-09-03
SE8100563L
(en)
1981-08-01
FR2475048A1
(en)
1981-08-07
CA1155108A
(en)
1983-10-11
NL8100467A
(en)
1981-09-01
JPS56122398A
(en)
1981-09-25
GR73511B
(en)
1984-03-07
AU6651381A
(en)
1981-08-06
GB2070016B
(en)
1983-09-14
IT1193576B
(en)
1988-07-08
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Chair
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