AU561149B2

AU561149B2 – Cardiotonic 4-semicarbazide quindyolines
– Google Patents

AU561149B2 – Cardiotonic 4-semicarbazide quindyolines
– Google Patents
Cardiotonic 4-semicarbazide quindyolines

Info

Publication number
AU561149B2

AU561149B2
AU20920/83A
AU2092083A
AU561149B2
AU 561149 B2
AU561149 B2
AU 561149B2
AU 20920/83 A
AU20920/83 A
AU 20920/83A
AU 2092083 A
AU2092083 A
AU 2092083A
AU 561149 B2
AU561149 B2
AU 561149B2
Authority
AU
Australia
Prior art keywords
carbon atoms
alkyl
phenyl
hydrogen
quindyolines
Prior art date
1982-11-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Application number
AU20920/83A
Other versions

AU2092083A
(en

Inventor
Anton Mentrup
Richard Reichl
Ernst Otto Renth
Kurt Schromm
Werner Traunecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim International GmbH

Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1982-11-02
Filing date
1983-11-02
Publication date
1987-04-30

1983-11-02
Application filed by Boehringer Ingelheim International GmbH
filed
Critical
Boehringer Ingelheim International GmbH

1984-05-10
Publication of AU2092083A
publication
Critical
patent/AU2092083A/en

1987-04-30
Application granted
granted
Critical

1987-04-30
Publication of AU561149B2
publication
Critical
patent/AU561149B2/en

2003-11-02
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

C07D239/72—Quinazolines; Hydrogenated quinazolines

C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4

C07D239/94—Nitrogen atoms

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/08—Vasodilators for multiple indications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/12—Antihypertensives

Abstract

Compounds of the formula wherein R1 is hydrogen, alkyl of 1 to 4 carbon atoms or trifluoromethyl; R2, R3 and R4 are each independently hydrogen, methyl or ethyl; R5 is hydrogen, alkyl of 1 to 8 carbon atoms, phenyl-(alkyl of 1 to 8 carbon atoms), cycloalkyl of 3 to 7 carbon atoms, (alkoxy of 1 to 4 carbon atoms) carbonyl-methyl, phenyl, substituted phenyl, naphthyl or substituted naphthyl; or R4 and R5, together with each other, are alkylene of 4 to 5 carbon atoms, optionally interrupted by -O- or -NR6-, where R6 is alkyl of 1 to 4 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics.

AU20920/83A
1982-11-02
1983-11-02
Cardiotonic 4-semicarbazide quindyolines

Ceased

AU561149B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE3240456

1982-11-02

DE19823240456

DE3240456A1
(en)

1982-11-02
1982-11-02

NEW SEMICARBAZIDES, THEIR PRODUCTION AND USE

Publications (2)

Publication Number
Publication Date

AU2092083A

AU2092083A
(en)

1984-05-10

AU561149B2
true

AU561149B2
(en)

1987-04-30

Family
ID=6177119
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU20920/83A
Ceased

AU561149B2
(en)

1982-11-02
1983-11-02
Cardiotonic 4-semicarbazide quindyolines

Country Status (27)

Country
Link

US
(1)

US4546102A
(en)

EP
(1)

EP0108981B1
(en)

JP
(1)

JPH0625165B2
(en)

KR
(1)

KR910003117B1
(en)

AT
(1)

ATE18042T1
(en)

AU
(1)

AU561149B2
(en)

CA
(1)

CA1210001A
(en)

CS
(1)

CS235987B2
(en)

DD
(1)

DD212512A5
(en)

DE
(2)

DE3240456A1
(en)

DK
(1)

DK157863C
(en)

ES
(5)

ES8501625A1
(en)

FI
(1)

FI77237C
(en)

GR
(1)

GR78947B
(en)

HK
(1)

HK58389A
(en)

HU
(1)

HU191889B
(en)

IE
(1)

IE56183B1
(en)

IL
(1)

IL70103A
(en)

NO
(1)

NO167201C
(en)

NZ
(1)

NZ206120A
(en)

PH
(1)

PH20225A
(en)

PL
(1)

PL141232B1
(en)

PT
(1)

PT77572B
(en)

SG
(1)

SG10889G
(en)

SU
(1)

SU1179926A3
(en)

YU
(1)

YU216483A
(en)

ZA
(1)

ZA838139B
(en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

BE792856A
(en)

*

1971-12-17
1973-06-15
Sandoz Sa

NEW DERIVATIVES OF TRIAZOLO-QUINAZOLINE, THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THESE

JPS55151570A
(en)

*

1979-05-15
1980-11-26
Takeda Chem Ind Ltd
Pyrimidine derivatives, their preparation and antimicrobial for agriculture

1982

1982-11-02
DE
DE19823240456
patent/DE3240456A1/en
not_active
Withdrawn

1983

1983-10-27
PT
PT77572A
patent/PT77572B/en
unknown

1983-10-28
PL
PL1983244355A
patent/PL141232B1/en
unknown

1983-10-28
DE
DE8383110812T
patent/DE3362201D1/en
not_active
Expired

1983-10-28
AT
AT83110812T
patent/ATE18042T1/en
not_active
IP Right Cessation

1983-10-28
YU
YU02164/83A
patent/YU216483A/en
unknown

1983-10-28
EP
EP83110812A
patent/EP0108981B1/en
not_active
Expired

1983-10-31
FI
FI833971A
patent/FI77237C/en
not_active
IP Right Cessation

1983-10-31
ES
ES526919A
patent/ES8501625A1/en
not_active
Expired

1983-10-31
US
US06/546,864
patent/US4546102A/en
not_active
Expired – Fee Related

1983-11-01
NO
NO833978A
patent/NO167201C/en
unknown

1983-11-01
CA
CA000440166A
patent/CA1210001A/en
not_active
Expired

1983-11-01
JP
JP58205715A
patent/JPH0625165B2/en
not_active
Expired – Lifetime

1983-11-01
SU
SU833659009A
patent/SU1179926A3/en
active

1983-11-01
IL
IL70103A
patent/IL70103A/en
not_active
IP Right Cessation

1983-11-01
GR
GR72840A
patent/GR78947B/el
unknown

1983-11-01
NZ
NZ206120A
patent/NZ206120A/en
unknown

1983-11-01
DD
DD83256216A
patent/DD212512A5/en
not_active
IP Right Cessation

1983-11-01
DK
DK501083A
patent/DK157863C/en
not_active
IP Right Cessation

1983-11-01
HU
HU833775A
patent/HU191889B/en
not_active
IP Right Cessation

1983-11-01
IE
IE2550/83A
patent/IE56183B1/en
not_active
IP Right Cessation

1983-11-01
KR
KR1019830005191A
patent/KR910003117B1/en
not_active
IP Right Cessation

1983-11-01
ZA
ZA838139A
patent/ZA838139B/en
unknown

1983-11-02
CS
CS838065A
patent/CS235987B2/en
unknown

1983-11-02
AU
AU20920/83A
patent/AU561149B2/en
not_active
Ceased

1983-11-02
PH
PH29792A
patent/PH20225A/en
unknown

1984

1984-05-04
ES
ES532179A
patent/ES8502427A1/en
not_active
Expired

1984-05-04
ES
ES532180A
patent/ES532180A0/en
active
Granted

1984-05-04
ES
ES532177A
patent/ES532177A0/en
active
Granted

1984-05-04
ES
ES532178A
patent/ES8502426A1/en
not_active
Expired

1989

1989-02-15
SG
SG108/89A
patent/SG10889G/en
unknown

1989-07-20
HK
HK583/89A
patent/HK58389A/en
unknown

Also Published As

Publication number
Publication date

HK58389A
(en)

1989-07-28

ES532179A0
(en)

1985-01-01

NZ206120A
(en)

1986-05-09

ES8502428A1
(en)

1985-01-01

HU191889B
(en)

1987-04-28

EP0108981B1
(en)

1986-02-19

PT77572B
(en)

1986-05-27

EP0108981A1
(en)

1984-05-23

ES8502427A1
(en)

1985-01-01

DE3362201D1
(en)

1986-03-27

DK157863C
(en)

1990-08-06

ES532180A0
(en)

1985-01-01

CA1210001A
(en)

1986-08-19

ES532178A0
(en)

1985-01-01

ES8502098A1
(en)

1984-12-16

FI77237B
(en)

1988-10-31

KR910003117B1
(en)

1991-05-18

DK501083A
(en)

1984-05-03

ES532177A0
(en)

1984-12-16

FI833971A0
(en)

1983-10-31

FI833971A
(en)

1984-05-03

DK501083D0
(en)

1983-11-01

SU1179926A3
(en)

1985-09-15

JPS5998070A
(en)

1984-06-06

ES526919A0
(en)

1984-12-01

ES8502426A1
(en)

1985-01-01

SG10889G
(en)

1989-09-29

DK157863B
(en)

1990-02-26

US4546102A
(en)

1985-10-08

FI77237C
(en)

1989-02-10

JPH0625165B2
(en)

1994-04-06

ES8501625A1
(en)

1984-12-01

PL244355A1
(en)

1985-02-13

NO167201C
(en)

1991-10-23

KR840006632A
(en)

1984-12-01

NO167201B
(en)

1991-07-08

AU2092083A
(en)

1984-05-10

IE832550L
(en)

1984-05-02

ZA838139B
(en)

1985-07-31

CS235987B2
(en)

1985-05-15

DD212512A5
(en)

1984-08-15

PH20225A
(en)

1986-10-23

PT77572A
(en)

1983-11-01

NO833978L
(en)

1984-05-03

IE56183B1
(en)

1991-05-08

IL70103A0
(en)

1984-02-29

ATE18042T1
(en)

1986-03-15

PL141232B1
(en)

1987-07-31

IL70103A
(en)

1987-01-30

YU216483A
(en)

1986-04-30

DE3240456A1
(en)

1984-05-03

GR78947B
(en)

1984-10-02

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Cardiotonic 4-semicarbazide quindyolines

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