AU572888B2 – 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-i-yl-n- phenyl-acetamide derivatives
– Google Patents
AU572888B2 – 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-i-yl-n- phenyl-acetamide derivatives
– Google Patents
4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-i-yl-n- phenyl-acetamide derivatives
Info
Publication number
AU572888B2
AU572888B2
AU32861/84A
AU3286184A
AU572888B2
AU 572888 B2
AU572888 B2
AU 572888B2
AU 32861/84 A
AU32861/84 A
AU 32861/84A
AU 3286184 A
AU3286184 A
AU 3286184A
AU 572888 B2
AU572888 B2
AU 572888B2
Authority
AU
Australia
Prior art keywords
atoms
phenyl
branched
alkyl radical
alkynyloxy
Prior art date
1983-09-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU32861/84A
Other versions
AU3286184A
(en
Inventor
Michel Combourieu
Jean-Claude Laigle
Marie-Paule Landes
Jean-Francois Reyjal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riom Laboratoires Cerm «rl-Cerm» Sa
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1983-09-15
Filing date
1984-09-10
Publication date
1988-05-19
1984-09-10
Application filed by Centre Europeen de Recherches Mauvernay CERM
filed
Critical
Centre Europeen de Recherches Mauvernay CERM
1985-03-21
Publication of AU3286184A
publication
Critical
patent/AU3286184A/en
1988-05-19
Application granted
granted
Critical
1988-05-19
Publication of AU572888B2
publication
Critical
patent/AU572888B2/en
2004-09-10
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/08—Vasodilators for multiple indications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
1. Compounds of the formula : see diagramm : EP0143016,P9,F1 wherein R1 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R2 and R3 represent separately a phenyl radical, an alkyl radical linear or branched having 1-6 C atoms, or together with the carbon atom to which they are bounded a cycloalkyl radical of 5 to 7 C atoms ; R4 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R5 represents an alkyl radical linear or branched having 1-6 C atoms or phenyl radical optionally substituted by a halogen atom ; X represents hydrogen or halogen atom, and pharmaceutically acceptable addition salts thereof.
AU32861/84A
1983-09-15
1984-09-10
4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-i-yl-n- phenyl-acetamide derivatives
Ceased
AU572888B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
FR8314720A
FR2552083B1
(en)
1983-09-15
1983-09-15
(ALKYNYLOXY-3 HYDROXY-2-PROPYL) -4 PIPERAZINYL-1 N-PHENYL ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR8314720
1983-09-15
Publications (2)
Publication Number
Publication Date
AU3286184A
AU3286184A
(en)
1985-03-21
AU572888B2
true
AU572888B2
(en)
1988-05-19
Family
ID=9292262
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU32861/84A
Ceased
AU572888B2
(en)
1983-09-15
1984-09-10
4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-i-yl-n- phenyl-acetamide derivatives
Country Status (14)
Country
Link
EP
(1)
EP0143016B1
(en)
JP
(1)
JPS60142972A
(en)
KR
(1)
KR850002477A
(en)
AT
(1)
ATE28639T1
(en)
AU
(1)
AU572888B2
(en)
DE
(1)
DE3465085D1
(en)
DK
(1)
DK439384A
(en)
ES
(2)
ES8602724A1
(en)
FI
(1)
FI77243C
(en)
FR
(1)
FR2552083B1
(en)
GR
(1)
GR80359B
(en)
HU
(1)
HU192994B
(en)
PT
(1)
PT79214B
(en)
ZA
(1)
ZA846937B
(en)
Families Citing this family (7)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
MXPA02008213A
(en)
*
2000-02-22
2004-04-05
Cv Therapeutics Inc
Substituted piperazine compounds.
US6552023B2
(en)
2000-02-22
2003-04-22
Cv Therapeutics, Inc.
Aralkyl substituted piperazine compounds
US6677336B2
(en)
2000-02-22
2004-01-13
Cv Therapeutics, Inc.
Substituted piperazine compounds
US6451798B2
(en)
2000-02-22
2002-09-17
Cv Therapeutics, Inc.
Substituted alkyl piperazine derivatives
US6693099B2
(en)
*
2000-10-17
2004-02-17
The Procter & Gamble Company
Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
EP2142506B1
(en)
*
2007-03-30
2013-10-16
Council of Scientific & Industrial Research
Novel benzophenone hybrids as potential anticancer agents and a process for the preparation thereof
JP6077344B2
(en)
*
2013-03-12
2017-02-08
花王株式会社
Bleach composition comprising a piperazine derivative
Citations (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3951979A
(en)
*
1972-04-13
1976-04-20
Roland Yves Mauvernary
New amino propanediol derivatives
Family Cites Families (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR2173869B1
(en)
*
1972-04-13
1975-12-26
Cerm Cent Europ Rech Mauvernay
FR2403330A1
(en)
*
1977-06-16
1979-04-13
Fabre Sa Pierre
NEW DERIVATIVES OF BENZOYL-2-CHLORO-4-GLYCINANILIDES SUBSTITUTES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
1983
1983-09-15
FR
FR8314720A
patent/FR2552083B1/en
not_active
Expired
1984
1984-09-04
ZA
ZA846937A
patent/ZA846937B/en
unknown
1984-09-10
AU
AU32861/84A
patent/AU572888B2/en
not_active
Ceased
1984-09-13
ES
ES535899A
patent/ES8602724A1/en
not_active
Expired
1984-09-13
GR
GR80359A
patent/GR80359B/en
unknown
1984-09-13
JP
JP59192411A
patent/JPS60142972A/en
active
Pending
1984-09-14
EP
EP84401824A
patent/EP0143016B1/en
not_active
Expired
1984-09-14
KR
KR1019840005613A
patent/KR850002477A/en
not_active
Application Discontinuation
1984-09-14
FI
FI843617A
patent/FI77243C/en
not_active
IP Right Cessation
1984-09-14
DK
DK439384A
patent/DK439384A/en
not_active
Application Discontinuation
1984-09-14
PT
PT79214A
patent/PT79214B/en
unknown
1984-09-14
AT
AT84401824T
patent/ATE28639T1/en
not_active
IP Right Cessation
1984-09-14
HU
HU843473A
patent/HU192994B/en
not_active
IP Right Cessation
1984-09-14
DE
DE8484401824T
patent/DE3465085D1/en
not_active
Expired
1985
1985-07-05
ES
ES544919A
patent/ES8607265A1/en
not_active
Expired
Patent Citations (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3951979A
(en)
*
1972-04-13
1976-04-20
Roland Yves Mauvernary
New amino propanediol derivatives
Also Published As
Publication number
Publication date
ES8607265A1
(en)
1986-05-16
ES544919A0
(en)
1986-05-16
PT79214B
(en)
1986-08-22
FI77243B
(en)
1988-10-31
ZA846937B
(en)
1985-04-24
PT79214A
(en)
1984-10-01
FI843617L
(en)
1985-03-16
DK439384D0
(en)
1984-09-14
HUT35253A
(en)
1985-06-28
AU3286184A
(en)
1985-03-21
ATE28639T1
(en)
1987-08-15
GR80359B
(en)
1985-01-11
EP0143016B1
(en)
1987-07-29
FR2552083B1
(en)
1986-05-09
FI843617A0
(en)
1984-09-14
JPS60142972A
(en)
1985-07-29
DK439384A
(en)
1985-03-16
FI77243C
(en)
1989-02-10
ES535899A0
(en)
1985-12-01
EP0143016A1
(en)
1985-05-29
HU192994B
(en)
1987-08-28
KR850002477A
(en)
1985-05-13
DE3465085D1
(en)
1987-09-03
ES8602724A1
(en)
1985-12-01
FR2552083A1
(en)
1985-03-22
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