AU616291B2 - Creación de Inventos y Patentes con Inteligencia Artificial

AU616291B2 – New 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as medicinal agents, pharmaceutical products and intermediates
– Google Patents
New 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as medicinal agents, pharmaceutical products and intermediates

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Publication number
AU616291B2

AU616291B2
AU39297/89A
AU3929789A
AU616291B2
AU 616291 B2
AU616291 B2
AU 616291B2
AU 39297/89 A
AU39297/89 A
AU 39297/89A
AU 3929789 A
AU3929789 A
AU 3929789A
AU 616291 B2
AU616291 B2
AU 616291B2
Authority
AU
Australia
Prior art keywords
formula
carbon atoms
alkyl
compounds
radical
Prior art date
1988-08-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Application number
AU39297/89A
Other versions

AU3929789A
(en

Inventor
Wilhelm Bartmann
Gerhard Beck
Ernold Granzer
Gunther Wess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1988-08-06
Filing date
1989-08-04
Publication date
1991-10-24

1989-08-04
Application filed by Hoechst AG
filed
Critical
Hoechst AG

1990-02-08
Publication of AU3929789A
publication
Critical
patent/AU3929789A/en

1991-10-24
Application granted
granted
Critical

1991-10-24
Publication of AU616291B2
publication
Critical
patent/AU616291B2/en

2009-08-04
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

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2

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4,6-bis(4-fluorophenyl)-2-propan-2-yl-2h-pyrimidine-1-carbaldehyde
Chemical compound

O=CN1C(C(C)C)N=C(C=2C=CC(F)=CC=2)C=C1C1=CC=C(F)C=C1
YLLITFMIRHJHBO-UHFFFAOYSA-N
0.000
description
2

OZJPLYNZGCXSJM-UHFFFAOYSA-N
5-valerolactone
Chemical compound

O=C1CCCCO1
OZJPLYNZGCXSJM-UHFFFAOYSA-N
0.000
description
2

HBAQYPYDRFILMT-UHFFFAOYSA-N
8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one
Chemical class

C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O
HBAQYPYDRFILMT-UHFFFAOYSA-N
0.000
description
2

IKHGUXGNUITLKF-UHFFFAOYSA-N
Acetaldehyde
Chemical compound

CC=O
IKHGUXGNUITLKF-UHFFFAOYSA-N
0.000
description
2

NLXLAEXVIDQMFP-UHFFFAOYSA-N
Ammonia chloride
Chemical class

[NH4+].[Cl-]
NLXLAEXVIDQMFP-UHFFFAOYSA-N
0.000
description
2

VEXZGXHMUGYJMC-UHFFFAOYSA-M
Chloride anion
Chemical compound

[Cl-]
VEXZGXHMUGYJMC-UHFFFAOYSA-M
0.000
description
2

XTHFKEDIFFGKHM-UHFFFAOYSA-N
Dimethoxyethane
Chemical compound

COCCOC
XTHFKEDIFFGKHM-UHFFFAOYSA-N
0.000
description
2

KFZMGEQAYNKOFK-UHFFFAOYSA-N
Isopropanol
Chemical compound

CC(C)O
KFZMGEQAYNKOFK-UHFFFAOYSA-N
0.000
description
2

238000005684
Liebig rearrangement reaction
Methods

0.000
description
2

FYYHWMGAXLPEAU-UHFFFAOYSA-N
Magnesium
Chemical compound

[Mg]
FYYHWMGAXLPEAU-UHFFFAOYSA-N
0.000
description
2

ABLZXFCXXLZCGV-UHFFFAOYSA-N
Phosphorous acid
Chemical class

OP(O)=O
ABLZXFCXXLZCGV-UHFFFAOYSA-N
0.000
description
2

241000700159
Rattus
Species

0.000
description
2

KEAYESYHFKHZAL-UHFFFAOYSA-N
Sodium
Chemical compound

[Na]
KEAYESYHFKHZAL-UHFFFAOYSA-N
0.000
description
2

FAPWRFPIFSIZLT-UHFFFAOYSA-M
Sodium chloride
Chemical class

[Na+].[Cl-]
FAPWRFPIFSIZLT-UHFFFAOYSA-M
0.000
description
2

YTPLMLYBLZKORZ-UHFFFAOYSA-N
Thiophene
Chemical compound

C=1C=CSC=1
YTPLMLYBLZKORZ-UHFFFAOYSA-N
0.000
description
2

CIUQDSCDWFSTQR-UHFFFAOYSA-N
[C]1=CC=CC=C1
Chemical compound

[C]1=CC=CC=C1
CIUQDSCDWFSTQR-UHFFFAOYSA-N
0.000
description
2

229960000583
acetic acid
Drugs

0.000
description
2

150000007513
acids
Chemical class

0.000
description
2

239000002585
base
Substances

0.000
description
2

239000003613
bile acid
Substances

0.000
description
2

244000309464
bull
Species

0.000
description
2

150000001733
carboxylic acid esters
Chemical class

0.000
description
2

238000004587
chromatography analysis
Methods

0.000
description
2

208000029078
coronary artery disease
Diseases

0.000
description
2

238000002425
crystallisation
Methods

0.000
description
2

230000008025
crystallization
Effects

0.000
description
2

125000004981
cycloalkylmethyl group
Chemical group

0.000
description
2

125000004210
cyclohexylmethyl group
Chemical group

[H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]

0.000
description
2

229940079919
digestives enzyme preparation
Drugs

0.000
description
2

229940043279
diisopropylamine
Drugs

0.000
description
2

201000010099
disease
Diseases

0.000
description
2

208000037265
diseases, disorders, signs and symptoms
Diseases

0.000
description
2

238000010828
elution
Methods

0.000
description
2

239000012362
glacial acetic acid
Substances

0.000
description
2

150000002632
lipids
Chemical class

0.000
description
2

NUJOXMJBOLGQSY-UHFFFAOYSA-N
manganese dioxide
Chemical compound

O=[Mn]=O
NUJOXMJBOLGQSY-UHFFFAOYSA-N
0.000
description
2

239000002609
medium
Substances

0.000
description
2

150000004702
methyl esters
Chemical class

0.000
description
2

CTSLXHKWHWQRSH-UHFFFAOYSA-N
oxalyl chloride
Chemical compound

ClC(=O)C(Cl)=O
CTSLXHKWHWQRSH-UHFFFAOYSA-N
0.000
description
2

239000007800
oxidant agent
Substances

0.000
description
2

230000003647
oxidation
Effects

0.000
description
2

238000007254
oxidation reaction
Methods

0.000
description
2

229910052763
palladium
Inorganic materials

0.000
description
2

239000002243
precursor
Substances

0.000
description
2

229910000033
sodium borohydride
Inorganic materials

0.000
description
2

239000012279
sodium borohydride
Substances

0.000
description
2

239000012312
sodium hydride
Substances

0.000
description
2

229910000104
sodium hydride
Inorganic materials

0.000
description
2

239000000758
substrate
Substances

0.000
description
2

239000000725
suspension
Substances

0.000
description
2

238000003786
synthesis reaction
Methods

0.000
description
2

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toluene-4-sulfonic acid
Chemical compound

CC1=CC=C(S(O)(=O)=O)C=C1
JOXIMZWYDAKGHI-UHFFFAOYSA-N
0.000
description
2

URAYPUMNDPQOKB-UHFFFAOYSA-N
triacetin
Chemical compound

CC(=O)OCC(OC(C)=O)COC(C)=O
URAYPUMNDPQOKB-UHFFFAOYSA-N
0.000
description
2

LALRXNPLTWZJIJ-UHFFFAOYSA-N
triethylborane
Chemical compound

CCB(CC)CC
LALRXNPLTWZJIJ-UHFFFAOYSA-N
0.000
description
2

RIOQSEWOXXDEQQ-UHFFFAOYSA-N
triphenylphosphine
Chemical compound

C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1
RIOQSEWOXXDEQQ-UHFFFAOYSA-N
0.000
description
2

OOKAZRDERJMRCJ-KOUAFAAESA-N
(3r)-7-[(1s,2s,4ar,6s,8s)-2,6-dimethyl-8-[(2s)-2-methylbutanoyl]oxy-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-3-hydroxy-5-oxoheptanoic acid
Chemical compound

C1=C[C@H](C)[C@H](CCC(=O)C[C@@H](O)CC(O)=O)C2[C@@H](OC(=O)[C@@H](C)CC)C[C@@H](C)C[C@@H]21
OOKAZRDERJMRCJ-KOUAFAAESA-N
0.000
description
1

MPDDTAJMJCESGV-CTUHWIOQSA-M
(3r,5r)-7-[2-(4-fluorophenyl)-5-[methyl-[(1r)-1-phenylethyl]carbamoyl]-4-propan-2-ylpyrazol-3-yl]-3,5-dihydroxyheptanoate
Chemical compound

C1([C@@H](C)N(C)C(=O)C2=NN(C(CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C2C(C)C)C=2C=CC(F)=CC=2)=CC=CC=C1
MPDDTAJMJCESGV-CTUHWIOQSA-M
0.000
description
1

AITNMTXHTIIIBB-UHFFFAOYSA-N
1-bromo-4-fluorobenzene
Chemical compound

FC1=CC=C(Br)C=C1
AITNMTXHTIIIBB-UHFFFAOYSA-N
0.000
description
1

KQYRZLXFPVKGJI-UHFFFAOYSA-N
2,4-bis(4-fluorophenyl)-6-propan-2-ylbenzaldehyde
Chemical compound

C(C)(C)C1=C(C=O)C(=CC(=C1)C1=CC=C(C=C1)F)C1=CC=C(C=C1)F
KQYRZLXFPVKGJI-UHFFFAOYSA-N
0.000
description
1

BJSKRAUSGPAOQG-UHFFFAOYSA-N
4,6-bis(4-fluorophenyl)-1-hydroxy-2-propan-2-yl-2h-pyrimidine
Chemical compound

ON1C(C(C)C)N=C(C=2C=CC(F)=CC=2)C=C1C1=CC=C(F)C=C1
BJSKRAUSGPAOQG-UHFFFAOYSA-N
0.000
description
1

WMHRYMDGHQIARA-UHFFFAOYSA-N
4-hydroxyoxan-2-one
Chemical compound

OC1CCOC(=O)C1
WMHRYMDGHQIARA-UHFFFAOYSA-N
0.000
description
1

XVMSFILGAMDHEY-UHFFFAOYSA-N
6-(4-aminophenyl)sulfonylpyridin-3-amine
Chemical compound

C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1
XVMSFILGAMDHEY-UHFFFAOYSA-N
0.000
description
1

KYARBIJYVGJZLB-UHFFFAOYSA-N
7-amino-4-hydroxy-2-naphthalenesulfonic acid
Chemical compound

OC1=CC(S(O)(=O)=O)=CC2=CC(N)=CC=C21
KYARBIJYVGJZLB-UHFFFAOYSA-N
0.000
description
1

ZCYVEMRRCGMTRW-UHFFFAOYSA-N
7553-56-2
Chemical compound

[I]
ZCYVEMRRCGMTRW-UHFFFAOYSA-N
0.000
description
1

QTBSBXVTEAMEQO-UHFFFAOYSA-M
Acetate
Chemical compound

CC([O-])=O
QTBSBXVTEAMEQO-UHFFFAOYSA-M
0.000
description
1

241000251468
Actinopterygii
Species

0.000
description
1

ZETHHMPKDUSZQQ-UHFFFAOYSA-N
Betulafolienepentol
Natural products

C1C=C(C)CCC(C(C)CCC=C(C)C)C2C(OC)OC(OC)C2=C1
ZETHHMPKDUSZQQ-UHFFFAOYSA-N
0.000
description
1

WKBOTKDWSSQWDR-UHFFFAOYSA-N
Bromine atom
Chemical compound

[Br]
WKBOTKDWSSQWDR-UHFFFAOYSA-N
0.000
description
1

206010057248
Cell death
Diseases

0.000
description
1

229920001268
Cholestyramine
Polymers

0.000
description
1

239000006144
Dulbecco’s modiﬁed Eagle’s medium
Substances

0.000
description
1

206010014476
Elevated cholesterol
Diseases

0.000
description
1

229940121710
HMGCoA reductase inhibitor
Drugs

0.000
description
1

229910010082
LiAlH
Inorganic materials

0.000
description
1

WHXSMMKQMYFTQS-UHFFFAOYSA-N
Lithium
Chemical compound

[Li]
WHXSMMKQMYFTQS-UHFFFAOYSA-N
0.000
description
1

LFTLOKWAGJYHHR-UHFFFAOYSA-N
N-methylmorpholine N-oxide
Chemical compound

CN1(=O)CCOCC1
LFTLOKWAGJYHHR-UHFFFAOYSA-N
0.000
description
1

101100030361
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene
Proteins

0.000
description
1

ZJPGOXWRFNKIQL-JYJNAYRXSA-N
Phe-Pro-Pro
Chemical compound

C([C@H](N)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(O)=O)C1=CC=CC=C1
ZJPGOXWRFNKIQL-JYJNAYRXSA-N
0.000
description
1

239000002202
Polyethylene glycol
Substances

0.000
description
1

ZLMJMSJWJFRBEC-UHFFFAOYSA-N
Potassium
Chemical compound

[K]
ZLMJMSJWJFRBEC-UHFFFAOYSA-N
0.000
description
1

UIIMBOGNXHQVGW-UHFFFAOYSA-M
Sodium bicarbonate
Chemical class

[Na+].OC([O-])=O
UIIMBOGNXHQVGW-UHFFFAOYSA-M
0.000
description
1

PCSMJKASWLYICJ-UHFFFAOYSA-N
Succinic aldehyde
Chemical compound

O=CCCC=O
PCSMJKASWLYICJ-UHFFFAOYSA-N
0.000
description
1

NINIDFKCEFEMDL-UHFFFAOYSA-N
Sulfur
Chemical compound

[S]
NINIDFKCEFEMDL-UHFFFAOYSA-N
0.000
description
1

235000019486
Sunflower oil
Nutrition

0.000
description
1

GYXYBRXSVLUGDB-UHFFFAOYSA-N
[Ru+].C1(=CC=CC=C1)P(C1=CC=CC=C1)C1=CC=CC=C1.C1(=CC=CC=C1)P(C1=CC=CC=C1)C1=CC=CC=C1.C1(=CC=CC=C1)P(C1=CC=CC=C1)C1=CC=CC=C1
Chemical compound

[Ru+].C1(=CC=CC=C1)P(C1=CC=CC=C1)C1=CC=CC=C1.C1(=CC=CC=C1)P(C1=CC=CC=C1)C1=CC=CC=C1.C1(=CC=CC=C1)P(C1=CC=CC=C1)C1=CC=CC=C1
GYXYBRXSVLUGDB-UHFFFAOYSA-N
0.000
description
1

XJLXINKUBYWONI-DQQFMEOOSA-N
[[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
Chemical compound

NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1
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0.000
description
1

239000013543
active substance
Substances

0.000
description
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238000005904
alkaline hydrolysis reaction
Methods

0.000
description
1

AZDRQVAHHNSJOQ-UHFFFAOYSA-N
alumane
Chemical class

[AlH3]
AZDRQVAHHNSJOQ-UHFFFAOYSA-N
0.000
description
1

150000001450
anions
Chemical class

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description
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238000013459
approach
Methods

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239000007864
aqueous solution
Substances

0.000
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150000003934
aromatic aldehydes
Chemical class

0.000
description
1

GDTBXPJZTBHREO-UHFFFAOYSA-N
bromine
Substances

BrBr
GDTBXPJZTBHREO-UHFFFAOYSA-N
0.000
description
1

229910052794
bromium
Inorganic materials

0.000
description
1

239000002775
capsule
Substances

0.000
description
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MMCOUVMKNAHQOY-UHFFFAOYSA-N
carbonoperoxoic acid
Chemical class

OOC(O)=O
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0.000
description
1

230000015556
catabolic process
Effects

0.000
description
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239000007795
chemical reaction product
Substances

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description
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238000004440
column chromatography
Methods

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229940125904
compound 1
Drugs

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230000009089
cytolysis
Effects

0.000
description
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HEOKFDGOFROELJ-UHFFFAOYSA-N
diacetal
Natural products

COc1ccc(C=C/c2cc(O)cc(OC3OC(COC(=O)c4cc(O)c(O)c(O)c4)C(O)C(O)C3O)c2)cc1O
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0.000
description
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SBZXBUIDTXKZTM-UHFFFAOYSA-N
diglyme
Chemical compound

COCCOCCOC
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0.000
description
1

238000004821
distillation
Methods

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description
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230000008030
elimination
Effects

0.000
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1

238000003379
elimination reaction
Methods

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125000004185
ester group
Chemical group

0.000
description
1

239000012259
ether extract
Substances

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150000002170
ethers
Chemical class

0.000
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230000029142
excretion
Effects

0.000
description
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238000000605
extraction
Methods

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239000000706
filtrate
Substances

0.000
description
1

238000001914
filtration
Methods

0.000
description
1

238000003818
flash chromatography
Methods

0.000
description
1

125000001153
fluoro group
Chemical group

0.000
description
1

239000000499
gel
Substances

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description
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239000001087
glyceryl triacetate
Substances

0.000
description
1

235000013773
glyceryl triacetate
Nutrition

0.000
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150000002391
heterocyclic compounds
Chemical class

0.000
description
1

238000004128
high performance liquid chromatography
Methods

0.000
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230000007062
hydrolysis
Effects

0.000
description
1

238000006460
hydrolysis reaction
Methods

0.000
description
1

CBOIHMRHGLHBPB-UHFFFAOYSA-N
hydroxymethyl
Chemical compound

O[CH2]
CBOIHMRHGLHBPB-UHFFFAOYSA-N
0.000
description
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239000002471
hydroxymethylglutaryl coenzyme A reductase inhibitor
Substances

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description
1

239000011630
iodine
Substances

0.000
description
1

238000002955
isolation
Methods

0.000
description
1

229910052744
lithium
Inorganic materials

0.000
description
1

NRUBUZBAZRTHHX-UHFFFAOYSA-N
lithium;propan-2-ylazanide
Chemical compound

[Li+].CC(C)[NH-]
NRUBUZBAZRTHHX-UHFFFAOYSA-N
0.000
description
1

210000004185
liver
Anatomy

0.000
description
1

210000001853
liver microsome
Anatomy

0.000
description
1

239000011777
magnesium
Substances

0.000
description
1

229910052749
magnesium
Inorganic materials

0.000
description
1

238000005259
measurement
Methods

0.000
description
1

IOMMMLWIABWRKL-WUTDNEBXSA-N
nazartinib
Chemical compound

C1N(C(=O)/C=C/CN(C)C)CCCC[C@H]1N1C2=C(Cl)C=CC=C2N=C1NC(=O)C1=CC=NC(C)=C1
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0.000
description
1

229930027945
nicotinamide-adenine dinucleotide
Natural products

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150000002825
nitriles
Chemical class

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description
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238000000655
nuclear magnetic resonance spectrum
Methods

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235000015097
nutrients
Nutrition

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1

230000003287
optical effect
Effects

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239000003960
organic solvent
Substances

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229910052698
phosphorus
Inorganic materials

0.000
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1

229940096701
plain lipid modifying drug hmg coa reductase inhibitors
Drugs

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229920000570
polyether
Polymers

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description
1

229920001223
polyethylene glycol
Polymers

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229920000036
polyvinylpyrrolidone
Polymers

0.000
description
1

239000001267
polyvinylpyrrolidone
Substances

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235000013855
polyvinylpyrrolidone
Nutrition

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description
1

229910052700
potassium
Inorganic materials

0.000
description
1

239000011591
potassium
Substances

0.000
description
1

235000015497
potassium bicarbonate
Nutrition

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229910000028
potassium bicarbonate
Inorganic materials

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description
1

239000011736
potassium bicarbonate
Substances

0.000
description
1

TYJJADVDDVDEDZ-UHFFFAOYSA-M
potassium hydrogencarbonate
Chemical compound

[K+].OC([O-])=O
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description
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238000012746
preparative thin layer chromatography
Methods

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description
1

239000011541
reaction mixture
Substances

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238000010992
reflux
Methods

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230000001172
regenerating effect
Effects

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229920005989
resin
Polymers

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239000011347
resin
Substances

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238000012552
review
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230000033764
rhythmic process
Effects

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238000000926
separation method
Methods

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229910000030
sodium bicarbonate
Inorganic materials

0.000
description
1

HPALAKNZSZLMCH-UHFFFAOYSA-M
sodium;chloride;hydrate
Chemical class

O.[Na+].[Cl-]
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description
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239000007787
solid
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239000008247
solid mixture
Substances

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150000005846
sugar alcohols
Polymers

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229910052717
sulfur
Inorganic materials

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239000011593
sulfur
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239000002600
sunflower oil
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230000001629
suppression
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t test
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238000004809
thin layer chromatography
Methods

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229930192474
thiophene
Natural products

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238000011282
treatment
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229960002622
triacetin
Drugs

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description
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239000003981
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Substances

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C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members

C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms

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C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts

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C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members

C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

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C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members

C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings

C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members

C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom

C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings

C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members

C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms

C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings

C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D309/30—Oxygen atoms, e.g. delta-lactones

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C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom

C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom

C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms

C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings

C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00

C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings

C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms

C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings

C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

6-Fluoro-3,5-dihydroxy carboxylic acid derivatives of the formula I and the corresponding lactones of the formula II in which R1 and R2 have the specified meanings, a process for the preparation of these compounds, the use thereof as medicinal agents and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.

Description

T I 7 6 A, COMMONWEALTH OF AUSTRA A 2 9 Form 1 PATENTS ACT 1952-69 COMPLETE SPECIFICATION
(ORIGINAL)
Class Int. Class Application Number: Lodged: Complete Specification Lodged: t, Accepted: Published: ,»Pri6rity: Related Art Related Art: Name of Applicant: t I Address of Applicant: Actual Inventor: Address for Service HOECHST AKTIENGESELLSCHAFT 50 Bruningstrasse, D6230 Frankfurt/Main Germany 80, Federal Republic of GERHARD BECK, WILHELM BARTMANN, GUNTHER WESS, ERNOLD GRANZER EDa5Kf XMaR &(S,Watermark Patent Trademark Attorneys QUEEN STREET, MELBOURNE, AUSTRALIA, 3000.
Complete Specification for the invention entitled: NEW 6-FLUORO-3,5-DIHYDROXY CARBOXYLIC ACIDS AND DERIVATIVES THEREOF, A PROCESS FOR THE PREPARATION THEREOF, THE USE THEREOF AS MEDICINAL AGENTS, PHARMACEUTICAL PRODUCTS AND INTERMEDIATES The following statement is a full description of this invention, including the best method of performing it known to US ~~rrr_~x YI- i HOECHST AKTIENGESELLSCHAFT Dr. D/gm HOE 88/F 198 Description New 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as medicinal agents, pharmaceutical products and intermediates 0 a o oo 0oo 0 0 The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) catalyzes the formation of mevalonic acid from 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). This reaction plays a central part in the biosynthesis of cholesterol. Derivatives of 3-hydroxy-3methylglutaric acid (HMG) and of mevalonic acid have been described as inhibitors of cholesterol biosynthesis (M.R.
Boots et al., J. Pharm. Sci. 69, 306 (1980), F.M. Singer et al., Proc. Soc. Exper. Biol. Med. 102, 270 (1959), H.
Feres, Tetrahedron Lett. 24, 3769 (1983)). 3-Hydroxy-3methylglutaric acid itself shows a significant cholesterol-lowering action in rats and in tests on humans (Z, Beg, Experientia 23, 380 (1967), ibid 24, 15 (1968), P.J.
Lupien et al., Lancet 1978, 2, 283).
It has now been found that the fluoro dihydroxy carboxylic acid6 of the general formula I, as well as the corresponding lactones of the formula II, are inhibitors of HMG-CoA reductase.
The invention therefore relates to 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof of the general formula I H OH OH I 2 2
F
and the corresponding lactones of the formula II L 2 HO 5 «YII Ho0 In the general formulae I and II, IR denotes A) the group of substituted 6-membered ring aromatics and heteroaromatics a, b, c S R R Rd Sb C hydrogen, a straight-chain or branched alkyl or S:atoms 5 in which 8:8″ Z denotes a radical of the formula -CH or a nitro- I gen atom, I R 3
R
4 and R 5 independently of one another denote hydrogen, a straight-chain or branched alkyl or 1 0 alkenyl radical, each of which has up to 6 carbon ,I .atoms and which can optionally be substituted on S, the terminal carbon by a cycloalkyl or cycloalkenyl radical, each of which has 3-6 carbon atoms, or denote a cyclic hydrocarbon radical which is saturated or up to doubly unsaturated and has 3-7 carbon atoms, or an aromatic radical selected from the group comprising phenyl, furyl, thienyl and pyridinyl, which can optionally carry in the nucleus 1-3 identical or different substituents from the following group: halogen, trifluoromethyl, alkyl or alkenyl, each of which has up to 6 carbon atoms, hydroxyl, alkoxy having 1-6 carbon atoms, carboxyl or carbalkoxy having i 3 1-6 carbon atoms in the alkoxy moiety, B) the group of substituted 5-membered ring heteroaromatics
^R
R R 9 in which G-E denotes the following atomic sequences a) N-C (1H-pyrrol-2yl) b) S-C (2-thienyl) Soo c) C-N (1H-pyrrol-3-yl) d) C-O (3-furyl) e) C-S (3-thienyl) S and
R
6 denotes H, straight-chain Cl-C-alkyl, C 3
-C
6 o 0 branched alkyl, trifluoromethyl, halogen or phenyl which is optionally substituted 1-2 times by fluorine, chlorine or methyl,
R
7 denotes H, straight-chain C 1 -C4-alkyl, branched
C
3 -C6-alkyl, trifluoromethyl, halogen or phenyl,
SR
8 denotes H, cycloalkyl having 5-8 ring carbon atoms, branched C 3
-C
6 -alkyl, or phenyl, which can in turn be substituted 1-2 times by straight-chain C,-C 3 -alkyl, halogen or trifluoromethyl, and R denotes H, straight-chain Ci-C 3 -alkyl, branched
C
3
-C
6 -alkyl, cycloalkyl having 5-8 ring carbon atoms, trifluoromethyl or phenyl which can in turn be substituted 1-2 times by straight-chain Cz-C 3 -alkyl, halogen or trifluoromethyl, and
R
7 and R 9 together also denote a conjugated unsaturated radical having 4 carbon atoms, so that
R
7 and R 9 form a fused-on aromatic moiety, and in which the substituents R 7 and R» are absent in those heteroaromatics which have oxygen and sulfur at the relevant positions, or C) the group of substituted olefins
-F
1 ~r~;nuu -L 4 I 10 i RI2 12 in which
R’
0 R» and R 12 independently of one another denote a straight-chain or branched alkyl or alkenyl radical, each of which has up to 6 carbon atoms and can optionally be substituted on the terminal carbon by a cycloalkyl or cycloalkenyl radical, each of which has 3-6 carbon atoms, or denote a ‘cyclic hydrocarbon radical which is saturated or up to doubly unsaturated and has 3-7 carbon atoms S*.0 or an aromatic radical selected from the group S comprising phenyl, furyl, thienyl or pyridinyl, which can optionally carry in the nucleus 1-3 i identical or different substituents from the following groups: halogen, trifluoromethyl, alkyl or alkenyl, each having up to 6 carbon atoms, hydroxyl, alkoxy having 1-6 carbon atoms, car- S’ boxyl or carbalkoxy having 1-6 carbon atoms in the alkoxy moiety, and
R
2 denotes hydrogen, a straight-chain or branched alkyl or alkenyl radical, each of which has up to 8 carbon atoms, a benzyl radical whose nucleus can be substituted 1-2 times by halogen or an alkyl radical having 1-4 carbon atoms, or denotes alkali metal or an ammonium ion NR 13
R
4 R’1R 16 where
R
1
R
1
R»
1 and R 16 are identical or different and denote hydrogen, alkyl having 1-4 carbon atoms or hydroxyalkyl having 1-4 carbon atoms.
The invention relates to the pure enantiomers having the absolute configuration 4R, 6S specified in the general formula I or the absolute configuration 3R, 5S depicted in formula II.
-1 iI
I
4 1 4 44 I r4 4 44 4 64 4 5 If R i denotes the group specified under A, the following applies: Preferred among the substituents R 3 and R 4 are a straightchain or branched alkyl radical having 1-4 carbon atoms, a cycloalkyl radical having 5-6 carbon atoms, a cycloalkylmethyl or cycloalkenylmethyl radical having a ring size of 5-6 carbon atoms, a phenyl radical which can optionally carry 1-3 identical or different substituents from the following group: halogen, trifluoromethyl, alkyl having 1-4 carbon atoms, hydroxyl, alkoxy having 1-4 carbon atoms or carbalkoxy having 1-4 carbon atoms in the alkoxy moiety.
Preferred among the meanings for R 5 are hydrogen, a straight-chain or branched alkyl or alkenyl radical, each of which has up to 6 carbon atoms, a cycloalkyl or cycloalkenyl radical, each of which has 5-6 carbon atoms, a phenyl or pyridinyl radical, it being possible for the aromatic radicals optionally to carry 1-3 identical or different substituents from the following groups: halogen, alkyl having 1-4 carbon atoms, hydroxyl, alkoxy having 1-4 carbon atoms or carbalkoxy having 1-4 carbon atoms in the alkoxy moiety.
SI
Particularly preferred among the substituents R 3 are: methyl, isopropyl, sec.-butyl, tert.-butyl, cyclohexyl, phenyl, 4-chlorophenyl, 4-fluorophenyl, 4-methoxyphenyl, 4-fluoro-3-methylphenyl, 3,5-dimethylphenyl, cyclohexylmethyl and 4-trifluoromethylphenyl.
Particularly preferred among the substituents R 4 are: methyl, isopropyl, sec.-butyl, tert.-butyl, cyclohexyl, phenyl, 4-chlorophenyl, 4-fluorophenyl, 4-methoxyphenyl, 4-fluoro-3-methylphenyl, 3,5-dimethylphenyl, cyclohexylmethyl and 4-trifluoromethylphenyl.
Particularly preferred among the substituents R 5 are: 1 i 6 hydrogen, methyl, isopropyl, tert.-butyl, cyclohexyl, phenyl, 4-fluorophenyl, 2,5-dimethylphenyl, phenyl and 4-trifluoromethylphenyl.
i If R1 denotes the group specified under B, the following applies: Preferred among the substituents R 6 are: H, methyl, ethyl, propyl, isopropyl, t-butyl and trifluoromethyl.
Preferred among the substituents R 7 are: straight-chain Cz-C 4 -alkyl, branched C 3
-C
6 -alkyl, trifluoromethyl and phenyl.
o 0 0 a.
Preferred among the substituents R 8 are: cycloalkyl having i 5 or 6 ring carbon atoms, or phenyl which can in turn be substituted 1 or 2 times by methyl, ethyl, chlorine, bromine, fluorine or trifluoromethyl.
Preferred among the substituents R 9 are: straight-chain Cz-C 3 -alkyl, branched C 3
-C
6 -alkyl, trifluoromethyl, or °phenyl which can in turn be substituted 1 or 2 times by methyl, ethyl, propyl, trifluoromethyl, chlorine or fluorine.
4 t Particularly preferred among the substituents R 6 are those mentioned hereinafter: methyl, isopropyl, tertiary-butyl s and trifluoromethyl.
Particularly preferred among the substituents R 7 are: methyl, isopropyl, tertiary-butyl, trifluoromethyl and phenyl.
If R 1 denotes the group specified under C, the following applies: Preferred among the substituents R 10 and R 11 are: a straight-chain or branched alkyl radical having 1-4 carbon atoms, a cycloalkyl radical having 5-6 carbon -7atoms, a cycloalkylmethyl or cycloalkenylmethyl radical having a ring size of 5-6 carbon atoms, a phenyl radical which can optionally carry 1-3 identical or different substituents from the following group: halogen, trifluoromethyl, alkyl having 1-4 carbon atoms, hydroxyl, i alkoxy having 1-4 carbon atoms or carbalkoxy having 1-4 I carbon atoms in the alkoxy moiety.
ij Preferred among the meanings for R 12 are a straight-chain V{ or branched alkyl or alkenyl radical each having up to 6 carbon atoms, a phenyl or pyridinyl radical, it being possible for the aromatic radicals optionally to carry 1tI 3 identical or different substituents from the following groups: halogen, alkyl having 1-4 carbon atoms, hydroxyl, S alkoxy having 1-4 carbon atoms or carbalkoxy having 1-4 ’15 carbon atoms in the alkoxy moiety.
Particularly preferred among the substituents R 10 are: methyl, isopropyl, sec.-butyl, tert.-butyl, cyclohexyl, phenyl, 4-chlorophenyl, 4-fluorophenyl, 4-methoxyphenyl, 4-fluoro-3-methylphenyl, 3,5-dimethylphenyl, cyclohexyl- 2 methyl or 4-trifluoromethylphenyl.
Particularly preferred among the substituents R» are: phenyl, 4-chlorophenyl, 4-fluorophenyl, 4-methoxyphenyl, j 4-fluoro-3-methylphenyl, 3,5-dimethylphenyl, cyclohexyli methyl and 4-trifluoromethylphenyl.
Particularly preferred among the substituents R 12 are phenyl, 4-fluorophenyl, 2,5-dimethylphenyl, 4-fluoro-3methylphenyl, 3,5-dimethylphenyl and 4-trifluoromethylphenyl.
The invention furthermore relates to a process for the preparation tf the compounds of the general formulae I and II, which comprises a) converting appropriately substituted aldehydes of the formula III i
L
8
III
SCHO
F
in which R 1 has the specified meaning, into the corresponding hydroxy esters of the general formula IV H OH 1 IV A CO 2 R 2 017
F
o: °5 in which R 1 has the specified meaning, and R 1 7 represents *o °g a suitable optically active acid protecting group which determines the stereochemistry at C-3, or an alkyl o0 radical having 1-8 carbon atoms 00 O 00 0.
0* b) converting the optically active compounds of the formula IV with achiral acetic ester enolates either directly or after previous conversion into the corresponj o ding alkyl esters, preferably methyl esters, into the optically active compounds of the formula V o °o H OH o 1
CO
2 8
V
R
1 I, 2
F
in which R 1 has the specified meaning, and R 16 is alkyl having 1-8 carbon atoms, c) converting the hydroxy keto esters of the formula V into the corresponding 6-fluoro-3,5-dihydroxy compounds of the formula I H OH OH 1 l CO 2
R
2 I 9 in which R 1 has the meaning specified for formula I, and
R
2 is alkyl having 1-8 carbon atoms, and, where appropriate, hydrolyzing a resulting compound to a compound of the formula I in which R 2 represents a metal cation, where appropriate liberating therefrom the free acid (R 2 hydrogen), and where appropriate converting the free acid into compounds of the formula I with R 2 alkyl or alkenyl, each having up to 8 carbon atoms, ammonium ion, benzyl or appropriately substituted benzyl, d) and converting a resulting compound of the formula I •where appropriate into a lactone of the formula II 0 II H 00 in which R 1 has the specified meaning.
St’ The conversion of compounds of the formula III via compounds of the formula IV into compounds of the formula V is carried out by different variants depending on the circumstances and requirements, such as, for example, 1. reaction of the enolates of achiral acetic esters such as, for example, ethyl or propyl esters, which are prepared with strong bases, preferably LDA, in THF, with aldehydes of the formula III in solvents such as, for example, THF, at temperatures between -78°C and 0°C, results in racemic compounds of the formula IV in which R 17 denotes an achiral acid protecting group such as, for example, the ethyl or propyl group. Reaction with another acetic ester enolate in solvents such as, for example, THF at -78°C to room temperature results in racemic compounds of the formula V.
2. Reaction of aldehydes of the formula III with lithium, sodium, potassium or magnesium enolates of Soptically active acetic esters in solvents such as i THF at -78°C to 0°C results in optically active compounds of the formula IV. R 17 in this case denotes i a suitable optically active acid protecting group which determines the stereochemistry at C-3. The group preferably used for this is i tjj li H i OH 1 which, according to M. Braun and R. Devant i o..,10 (Tetrahedron Lett. 25, 5031 (1984)) yields the 3R i configuration and is prepared from L-(+)-mandelic I acid. However, other chiral optically active groups are also suitable. The compounds of the formula IV, which are now optically active, are converted with achiral acetic ester enolates according to variant 1 either directly into the compounds of the formula V, which are now optically active, or after previous I conversion into the appropriate alkyl esters, preferably methyl esters.
S 20 The conversion of compounds of the formula V into compounds of the formula I is carried out, for example, in Sanalogy to a process known from the literature Narasaka and H.C. Pai, Chemistry Lett. 1980 1415).
Initial reaction is with a trialkylborane, preferably triethylborane, in THF at room temperature, followed by reduction at -78°C to 0°C with sodium borohydride, where appropriate with the addition of methanol. The stereochemical relationships specified in formula I (syn. dihydroxy) are obtained in this way.
The compounds of the formulae I and II obtained by variant 1 can, where appropriate, be separated into the i ~l-Fi- ?r 11 pure enantiomers by the known processes of racemate resolution. The salts and acids of the compounds of the general formula I are obtained by generally known methods.
The lactones of the formula II are likewise obtained by known processes, for example by elimination of water, from the open dihydroxy carboxylic acids of the formula I, R 2 H, in benzene, hexa.ne or toluene with addition of p-toluenesulfonic acid or trifluoroacetic acid at room temperature to the reflux temperature.
i The aldehydes of the formula III can be prepared from the compounds of the general formula VI o. 44 H o 0 o S: VI (X -COOR 1
-CN)
where X is a nitrile group or an ester group, in a variety of ways: S’ 15 a) reaction of the nitriles of the formula VI in which R 1 has the meaning specified for formula I with diisobutylaluminum hydride (DIBAH) in THF at -10*C to 500 results, after hydrolysis, immediately in the aldehydes of the formula III.
b) Reaction of the carboxylic esters of the formule, VI (X -COOR 19 in which R 1 has the meaning specified for formula I, and R 1 is alkyl having 1-8 carbon atoms, results, by reduction with DIBAH in THF at -10°C to 50°C, initially in the corresponding alcohols of the formula VII I I -12- H I CHO2H VII i 1 in which R 1 has the meaning specified for formula I. The alcohols VII can be converted into the aldehydes of the formula III by oxidation with customary oxidizing agents such as chromium(VI) oxide, Swern’s reagent (oxalyl chloride/DMSO/NEt 3 CrO 3 Pyr, manganese dioxide, or by the method of K.B. Sharpless et al., Tetrahedron Lett.
29, 2503 (1976) with N-methylmorpholine/(PPh 3 3 RuClz in customary solvents such as, for example, CH 2 Cl 2 or acetone at temperatures between -50°C and The compounds of the formula VI (X -COOR 19 are obtained from the aldehydes of the formula VIII SI R’-CH= VIII in which R 1 has the meaning specified for formula I, s .pecifically by reaction with the phosphonates of the general formula IX 0 F
R
20 j tP–CH-X 2’R 2 0 in which R 20 denotes an alkoxy group having 1-6 carbon atoms or a phenyl group which can be substituted 1 to 3 times by halogen or alkoxy having 1-5 carbon atoms, and X has the meaning specified for formula VI, by the Horner-Emmons-Wittig method (Horner et al. Chem. Ber. j1, 61 (1958)).
The reaction is preferably carried out in solvents such as dimethoxyethane or THF in the presence of a base such as, for example, sodium hydride or BuLi at temperatures between -20″C and room temperature. The predominant products are the E isomers which can be purified, where appropriate, by crystallization or chromatography.
The phosphonates of the formula IX are obtained by i 71 13 processes known from the literature, for example by the method of G. Etemad-Moghadam, J. Seyden-Penne, Bull. Soc.
France 3, 448 (1985) or EP-A 224,417, or H. Machleidt, R.
Wessendorf, Liebigs Ann. Chem. 674, 1 (1964).
The aldehydes of the formula VIII are obtained by oxidation with customary oxidizing agents such as, for example, chromium(VI) oxide, Swern’s reagent or CrO 3 Pyr in customary solvents such as, for example,
CH
2 C1 2 acetone etc. at temperatures between -50’C and +30*C from the alcohols of the general formula X R1-CH 2 OH
X
in which R 1 has the meaning specified for formula I. The alcohol of the general formula X is prepared by processes described in the literature, as is evident from the table which follows. The aldehydes VIII are obtained directly in accordance with citations and Preparation of the alcohols X
R
1
R’-CH
2 OH X I N
AK
3
R
4 N, Z R
R
4 NNR 5 3 4
R
R a R German Offenlegungsschrift 38 23 045 (corresponding to EP-A 0,307,342; US Patent Application Serial No.: 216 458) German Patent Application P 38 00 785.1 (corresponding to US Patent Application Serial No.: 294 096) Preparation of the aldehydes
R
I
-CH=0 VIII: G.E. Stokker et al. J. Med. Chem.
29, 173 (1986) (another method for the preparation of the aldehydes is described in Example 1 I_
I
14 a I6 R R I C C lii at t a at 1
I
j: d I 1
I
i! t .i:Ei ii B i
B
Preparation of the correspondingly substituted alcohols X by reduction of the appropriate carboxylic esters with LiAlH 4 DIBAH or AlH 3 is described: a) for example for G-E equal to S-C: J.M. Spragur et al., J. Am.
Chem. Soc. 56 (1934) 2665 Heterocyclic Compounds Vol. 44, Part 1, Thiophene and Derivatives, J. Wiley Sons, N.Y.
1985, especially page 197 b) for G-E equal to C-S: S.
Gronowitz et al., Acta pharm.
sued. 9 (1972) 301 c) for G-E equal to C-O: F. Boberg et al., Liebigs Ann. Chem. 1984, 233 (7) d) for G-E equal to C-N: European Patent Application A 0,221,025 (8) or by analogous methods. German Offenlegungsschrift 37 22 806 (9) (corresponding to EP-A 0,300,249; US Patent Application Serial No.: 216 423) and European Patent Application A 0,221,025 propose another process for the preparation of appropriately substituted aldehydes VIII.
German Offenlegungsschrift 37 22 807 (10) (corresponding to EP-A 0,306,649; US Patent Application Serial No.: 216 331).
‘t’ 1
V
t Intermediates are purified where necess crystallization, flas~h chromatography c iry by distillation, ~r HPLC.
Besides the compounds described in the examples, the following compounds can be prepared by the process according to the invention: Z-6(S)-2-[(6-(4-fluorophenyl)-4-isopropyl-3-phenyl-pyridazin-5-yl)]-(l-flucro-2-ethenyl)-4(R)-hydroxy-3,4,5,6tetrahydro-2H-pyran-2 -one 44.
94 4 44 4 4 4, 4.
44,.
4 e 9 44 4 4Q 44 4 4 4 4 4 t (4-(4-fluorophenyl)-3,6-bis-isopropyl-pyridazin- 5-yl) ]-(1-fluoro-2-ethenyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2 -one Z-6(S)-2-[(6-tert.-butyl-4-(4-fluorophenyl)-3-phenylpyridazin-5-yl) ]-(1-fluoro-2-ethenyl)-4(R)-hydroxy-3,4,5,6tetrahydro- 2H-pyran- 2-one 1Z, 3E, 6(S)-[l-fluoro-3-iopropyl-4-(4-fluoro-3-methylphenyl)-4- 5-dimethyl-2-methoxyphenyl)butadienyl]-4(r hydroxy-3 6-tetrahydro-2H-pyran-2-one 1Z, 3E, 6 [1-f luoro-3-isobutyl-4, 4-di- (4-f luorophenyl) 4- -hydroxy-3, 4,5, 6-tetrahydro-2H-pyran-2-one Z-6(S)-2-[2-iBopropyl-4-phenyl-6-(4-fluorophenyl)-phenyl]- (1-f luoro-2-ethenyl -hydroxy-3, 4,5, 6-tetrahydro-2Hpyran- 2-one Z-6(S)-2-[1-cyclohexyl-2-isopropyl-4-(4-fluorophenyl)-Hpyrl3y](-loo2ehnl-()hdoy3456 tetrahydro-2H-pyran-2-one Z-6 (S 6-bis- (4-f luorophenyl) 1-methylethyl) pyii–l–lootey)4()hdoy3456 tetrahydro-2H-pyran-2 -one Z -6(S)-(l-fluoro-2-(4-(4-fluorophenyl)-2-(l-methylethyl)- 6-phenylpyridin-3-yl)-ethenyl)-4-(R)-hydroxy-3,4,5,6tetrahydro-2H-pyran-2 -one t-butyl 6Z-3(R), 5(S)-dihydroxy-7-[2-isopropyl-4-phenyl-6- (4-f luorophenyl) -phenyl luoro-heptanoate t-butyl 6Z-3(R), 5(S)-dihydroxy-7-[1-cyclohexyl-2-iso- Ii propyl-4-(4-fluorophenyl) -1H-pyrrol-3-yl]-6-fluoro-hept-6enoate t-butyl 6Z-7-(4,6-bis-(4-fluorophenyl)-2-(1-methylethyl)pyridin-3-yl)-3R, 5S-dihydroxy-6-fluorohept-6-enoate t-butyl 6Z-3(R), 5(S)-dihydroxy-6-fluoro-7-(4-(4-fluorophenyl)-2-( 1-methylethyl)-6-phenylpyridin-3-yl)-hept-6enoate tert.-butyl 6Z-3(R), 5(S)-dihydroxy-6-fluoro-7-[6-(4fluorophenyl) -4-isopropyl-3-phenyl-pyridazin-5-yl] -hept-6- I ene-carboxylate tert.-butyl 6Z-3(R), 5(S)-dihydroxy-6-fluoro-7-[4-(4fluorophenyl 6-biB-isopropyl-pyridazin-5-yl ]-hept-6-enecarboxylate tert.-butyl 6Z-3(R), 5(S)-dihydroxy-6-fluoro-7-[6-tert.butyl-4-(4-fluorophenyl)-3-phenyl-pyridazin-5-yl-hept-6ene-carboxylate t-butyl 6Z, BE, 5(S)-dihydroxy-9-(3,5-dimethyl-2methoxyphenyl) (4-f luoro-3-methylphenyl) -6-f luoro-8isopropyl-6, 8-nonadienoate t-butyl 6Z, 5(S)-dihydroxy-9,9-di-(4-fluorophenyl)- 6-f luoro-8-isobutyl-6, 8-nonadienoate LlgIPIII~L– iji I-U Ily- 17 Biological test systems: 1. HMG-CoA reductase activity in enzyme preparations The HMG-CoA reductase activity was measured on solubilized enzyme preparations from liver microsomes from rats which, after a changeover in the day/night rhythm, had been induced with cholestyramine («Cuemid).
The substrate used was 4 C-HMG-CoA, and the concentration of NADPH was maintained constant during the incubation by a regenerating system. «C-Mevalonate was S 10 separated from the substrate and other products
«C-
HMG) by column elution, with the elution profile of each .E individual sample being determined.
Permanent inclusion of H-mevalonate was dispensed with S. because the determination was for relative data on the inhibitory effect. In each test series the enzyme-free control, the enzyme-containing normal mixture 100 and those with added product, final concentration 10 to M, were treated together. Each individual value was Sformed as the mean of 3 parallel samples. The significance of the differences between means for product-free and product-containing samples was assessed using the t test.
The method described above was used to measure, for example, the following figures for the inhibition of HMG- CoA reductase by the compounds according to the invention
[IC,
5 /mol/liter means the molar concentration of the compound per liter necessary for 50 inhibition]: Table 1 Compound of ICs 5 /mol/liter Example a 2.9 x b 9.0 x 100 g 1.8 x 10- 9 I 18 18 2. Suppression or inhibition of HMG-CoA reductase in cell cultures of HEP-G2 cells Monolayers of HEP-G2 cells in the lipoprotein-free nutrient medium were preincubated with appropriate concentrations of the test substances for a defined time (for example 1 hour) and, after addition of the labeled precursor, for example sodium 14 C-acetate, the incubation was continued (for example for 3 hours). An internal standard 3 H-cholesterol) was added and then a portion of the cells underwent alkaline hydrolysis. The lipids from the hydrolyzed cells were extracted with chloroform/methanol. After addition of carrier cholesterol to this lipid l’ mixture it was subjected to preparative thin-layer chromatography, the cholesterol band was visualized with iodine vapor and then isolated, and the amount of «Ccholesterol formed from the «C-precursor was determined by scintigraphy. Cell protein was determined in an aliquot of the cells so that it is possible to calculate the amount of 14C-cholesterol formed per unit time and per mg of cell protein. The inhibitory effect of the particular test product on the cholesterol biosynthesis by jHEP-G2 cell cultures was obtained by comparing this Sfigure with the amount of «C-cholesterol formed per mg of cell protein and unit time in a culture treated in the same way but free of test substance.
4- 19- Examination of substances for inhibition of cholesterol V biosynthesis in confluent cell cultures (monolayers) of HEP-G2 cells 1. Lipoprotein-free medium (DMEM) 24 h 2. Incubation with test products 1 h 3. Incubation with 14C-acetate 3 h 4. Cytolysis V 5. TLC separation of the reaction product 14C-cholesterol *e t S. 6. Isolation of the 14 C-cholesterol S* 7. Scintillation measurement 15 r 8. Result j in nmol of «14C-cholesterol/mg of cell protein by comparison with the solvent control I The method described above was used to measure, for example, the following figures for the inhibition of cholesterol biosynthesis (in HEP-G2 cells) by the compounds according to the invention (the IC 50 /mol/liter is that concentration of the compound which brings about 50 inhibition of cholesterol biosynthesis) (Tab. 2).
Table 2 Compound of IC 50 /mol/liter Example a 1.9 x 10- 8 11 a 1.8 x 10-8 10 g 2.5 x 10- 9 b 4.6 x 10 11 b 2.0 x 10-8 20 The compounds of the general formula I and II are distinguished by strongly inhibiting HMG-CoA reductase, the rate-determining enzyme of cholesterol biosynthesis.
The extent of the inhibition by compounds of the general formula I and II, which is characterized by IC 5 s values in the range 10 7 to 10 9 mol per liter, is distinctly higher than for completely synthetic HMG-CoA reductase inhibitors known from the literature, such as, for example, those described by G.E. Stokker et al., J. Med. Chem. 29, 170 (1986).
The enzyme HMG-CoA reductase is widespread in nature. It i* s catalyzes the formation of mevalonic acid from HMG-CoA.
This reaction is a central step in cholesterol biosynthesis (cf. J.R. Sabine in CRC Series in Enzyme Biology: 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase, CRC Press Inc. Boca Raten, Florida 1983 (ISBN 0-8493-6551- SHigh cholesterol levels are thought to be associated with i a number of diseases such as, for example, coronary heart diseases or arteriosclerosis. This is why lowering elevated cholesterol levels is an aim of therapy for preventing and treating such diseases.
One approach to this comprises inhibiting or reducing endogenous cholesterol biosynthesis. Inhibitors of HMG- CoA reductase block cholesterol biosynthesis at an early stage.
The compounds of the general formula I and II are therefore suitable as hypolipidemics and for the treatment and prophylaxis of arteriosclerotic changes.
The invention therefore also relates to pharmaceutical products based on these compounds, and to the use thereof as medicinal agents, especially as hypolipidemics and for the prophylaxis of arteriosclerotic changes.
21 The compounds of the formula I and II are used as hypolipidemics or anti-arteriosclerotics in oral doses of 3 to 2500 mg per day, but preferably in the dose range 500 mg. These daily doses can also, if required, be divided into two to four individual doses or administered in depot form. The dosage regimen may depend on the type, age, weight, sex and medical condition of the patient.
An additional cholesterol-lowering effect can be achieved by concurrent administration of the compounds according to the invention with substances which bind bile acids, such as, for example, anion exchanger resins. Excretion of bile acids results in increased de novo synthesis and thus in increased breakdown of cholesterol (cf. M.S.
j’ 1. Brown, P.T. Koranen and J.C. Goldstein, Science 212, 628 15 (1981); M.S. Brown, J.C. Goldstein, Spektrum der Wissenschaft 1985, 1, 96).
The compounds of the formula I according to the invention can be used in the form of the esters, as free acids or in the form of the physiologically acceptable inorganic S 20 or organic salts thereof. The compounds of the formula I and II can be used in the form of the aqueous solutions Si or suspensions thereof, o’r else dissolved or suspended in pharmacologically acceptable organic solvents such as monohydric or polyhydric alcohols such as, for example, ethanol, ethylene glycol or glycerol, in triacetin, in alcohol/acetaldehyde diacetal mixtures, oils such as, for /j example, sunflower oil or fish liver oil, ethers such as, for example, diethylene glycol dimethyl ether, or else polyethers such as, for example, polyethylene glycol, or else in the presence of other pharmacologically acceptable polymeric vehicles such as, for example, polyvinylpyrrolidone, or in solid compositions.
Preferred for the compound of the formula I or II are solid presentations which can be administered orally and which can contain the customary auxiliaries. They are prepared by customary methods.
22- Particularly suitable as composition for oral use are tablets, coated tablets or capsules. One dosage unit preferably contains 10 to 500 mg of active substance.
The compounds of the formula III, IV, V, VI and VII are new and represent valuable intermediates for the preparation of compounds of the formula I. The invention therefore also relates to these compounds and to processes for the preparation thereof.
Preliminary note: Unless indicated otherwise, NMR spectra were recorded in CDC 3 with TMS as internal standard. The following abbreviations are used to classify NMR signals: s singlet, brs broad singlet, d doublet, t *triplet, q quartet, h heptet, mc centered multiplet, m multiplet.
Melting points are uncorrected.
The following abbreviations are used for substituents: Si iso, t tertiary, c cyclo.
Example 1 General procedure for the preparation of compounds of the general formula VIII I Example la S4,6-Bis(4-fluorophenyl)-2-(1-methylethyl)-pyrimidine-3aldehyde I 12 g (0.12 mole) of Cr0 3 are suspended in 400 ml of abs.
CH
2
C
2 by stirring under argon. After 15 min, the mixture is cooled to 0°C and a solution of 19.4 ml (0.24 mol) of pyridine in 100 ml of abs. CH 2 C1 2 is added dropwise. The mixture is then allowed to warm to room temperature while stirring, and 8 g (24 mmol) of 3-hydroxy-4,6-bis(4fluorophenyl)-2-(1-methylethyl)-pyrimidine (formula X, prepared as described in German Patent Application P 38 23 045.3) are added dropwise. The mixture is stirred 23 at room temperature for 2 h. After the reaction is complete, the methylene chloride phase is decanted off and concentrated in vacuo, and the residue is purified by flash chromatography (CHzCl,) on silica gel.
Yield: 7.2 g (89 of theory) of pale crystals melting point 119-122″C of VIIIa Rf 0.84 (cyclohexane/ethyl acetate 2 1).
1 H NIR: 6 values in ppm 1.4 6H, CH 3 4.0 1H, CH), 7.0-7.9 6H, aromat. prot.), 8.5-8.9 2H, aromat. prot.), 10.1 1H, CH=O) MS: m/e 338 Cz 0
H
16
F
2
N
2 0 Example lb 11 S, The compounds VIII b-VIII 1 were prepared in a manner analogous to that described in Example la (cf. Tab. 1).
The aromatic aldehydes VIII f and VIII 1 can also be S»prepared as described in Example if.
Example If 2-Isopropyl-4,6-bis-(4-fluorophenyl)-benzaldehyde VIII f 4.17 g (9 mmol) of the palladium complex
N-CH
Pd OAc F 2 (prepared in analogy to the description in the review by R.F. Heck, Palladium Reagents in Organic Synthesis, Academic Press 1985, page 290-94) in 100 ml of abs.
toluene are mixed with 18.9 g (72 mmol) of triphenylphosphine at room temperature, and the mixture is stirred for 30 min. A Grignard solution prepared from
A
24- 0.875 g (36 mmol) of magnesium turnings, 60 ml of abs.
diethyl ether and 7.0 g (40 mmol) of 4-bromofluorobenzene is added dropwise at 20°C within 2 min. The mixture is then stirred at room temperature for 15 min and neutralized with 50 concentrated hydrochloric acid. The org.
phase is separated off. dried and concentrated in vacuo.
The residue is filtered through silica gel by cyclohexane/toluene 10 1. The aldehyde VIII f is obtained.
Yield: 2.31 g (80.6 of theory) melting point 110-112°C R 0.4 (cyclohexane/toluene 1 1) 1H NMR: 6 values in ppm. 1.4 6H, CH 3 4.0 1H, CH), 7.0-7.9 8H, aromat. prot.), 10.0 1H, CH=O).
MS: m/e 336 C 22
H
1 8
F
2 0 s w_ 25 Table 1 Vill
II
Example Compound R Yield% 1 VIIfa I 1 N a 89
F
m.p. 0
C
1 H NXR 6/ppm MS m/e cf descriptiom nxiple la
I
I IIII t Vli 82.5 Mp. 1040 C21 H 1 FNO (319 i i n-;
IIE
i :f
-I
I~
.Bl~b d c VIIIc d VilId OCHb
F
F
N
F
79.4 Mp.72-730 C H F 0 20 zo20 (314) 81.2 Mp. 1360 C 20
H
16
F
2
N
2 0 (338) VIIe
N-
78.8 Mp. 1220 C 20 jN0 (307) 00.6 ef. ription Example if i Vilf ‘2 26 Table 1 H O Ii
VII
Example Compound Yield% Rf m p0.
1H NMR 6/ppm MS Wie VIIg IN rN N 73 inp. 616C 17
H
17
FN
2 0 (284) :i
:I
tt h NIIh I Villi 69 pale oil C 2 1
H
1 7
F
2
NO
69.2 mp. 87-C C sHF 2 0 72 pale oil C 1 6
H
21
FN
2 0 62 uip. L19L2DOC C 1 7
H
2 0FNO (337) t286) (300) (273) t t Vill;
II
N N% k VI 1k
N
94 yellow oil c 1 9
H
2 1 FO (284) I VII I 27- Example 2 General procedure for the preparation of compounds of the general formula VI (X CO 2
R
9 Example 2a Ethyl 2Z-2-fluoro-3-[4,6-bis-(4-fluorophenyl)-2-(1-methylethyl)-pyrimidin-3-yl]-acrylate 8.06 g (0.022 mole) of ethyl phosphinoxy-fluoroacetate (formula IX, R 2 0
C
6 HS, X C02Et; prepared as described by G. Etemad-Moghadam and J. Seyden-Penne in Bull. Soc.
Chim. France 3, 448-454 (1985)) are dissolved in 180 ml of abs. THF under argon. 15 ml (24 mmol) of a solution of butyllithium in hexane are added dropwise to this solution while stirring at O’C. After stirring for S’ min, 7.6 g (22.4 mmol) of 4,6-bis-(4-fluorophenyl)-2-(1methylethyl)-pyrimidine-3-aldehyde (from Example la) dissolved in 10 ml of abs. THF are added dropwise at room temperature. The reaction is complete after about 3 h.
200 ml of diethyl ether are added, and the mixture is extracted 2 x with saturated sodium chloride solution.
The org. phase is separated off, dried with MgSO 4 filtered and concentrated in vacuo.
Yield: 7.8 g (75 of theory) of pale crystals ;i melting point 85-89°C of VIa R 0.52 (cyclohexane/ethyl acetate 10 1).
1H NMR: 6 values in ppm 1.35 3H, CH 3 1.40 6H,
CH
3 3.2 1H, CH), 4.4 2H, OCH 2
CH
3 7.12 J 33Hz, 1H, CH 7.1-7.2 4H, aromat prot.), 7.7 and 8.6 2+2H, aromat prot.) I MS m/e 426 C24H2IF3N202 28- Example 2a-21 The compounds VI b-VI 1 were prepared in a manner analogous to that described in Example 2a (cf. Tab. 2) Example 3 General procedure for the preparation of compounds of the general formula VI (X CN) Example 3a 2-Fluoro-3-[4,6-bis-(4-fluorophenyl)-2-(1-methylethyl)pyrimidin-3-yl]-acrylonitrile 0.28 g (6 mmol) of sodium hydride 55 suspension in oil is suspended in 20 ml of abs. DME. While stirring, 1.17 g (0.95 ml, 6 mmol) of 2-(O,O-diethylphosphono)-2-fluoro- :.acetonitrile (formula IX, R 20
OC
2
H
5 X C N; prepared as described in EP-A 224,417) are added dropwise, and the mixture is stirred for 15 min. Then 1.6 g (5 mmol) of 4,6-bis-(4-fluorophenyl)-2-(1-methylethyl)-pyrimidine-3aldehyde from Example la are added dropwise. After 1 h Sthe reaction mixture is adjusted to pH 7 with 2 N hydrochloric acid and concentrated in vacuo. The residue is mixed with 200 ml of EA/H 2 0 in the ratio 1 1, and the j ethyl acetate phase is separated off, washed 2 x with I saturated sodium chloride solution, dried, filtered and concentrated in vacuo, and the residue is purified on a Ssilica gel column (cyclohexane/ethyl acetate 10 1) Yield: 1.6 g (72 of theory) of yellow crystals melting point 112’C VIa’, X=CN R, 0.49 (Z isomer) cyclohexane/ethyl acetate 10 1 1 H NMR: 6 values in ppm 1.4 6H, CH 3 3.18 1H, CH), 6.78 1H, J 32 Hz, CH CF), 7.2-8.5 8H, aromat. Prot.) -29 MS: me 361C 22
H
17
F
2
N
3 Example 3b-31 The compounds VI b’-VI 1′ (X =CN) can be prepared in a manner analogous to that described in Example 3a.
30 Table 2 x itl (X z 00.,Et) Example Compound Yield% Rf (Z) m p. 0 C 1 H NMR 6/ppm MS:mWe-= 2 a Vla I 0. 75 M-P. 89′ cf. dscriptici ExaWle 2a b t, *v t 2 c VIC 2 d VId 63% 74% 84 Rf E0.55 C 2 5H 2 3 02 (407) Rf =0.59 C4H FP2O (U2) Rf 0.46 C 2 4 2 1
FPP
2 2 (42b) Rf 0.49 C 2 4H 23
NF
2 (395)
F
F
F
N_
2 W~e 2 f V-r f 2 73 S Rf 0.51 C 26
H
2
.F
2 0 2 (424) 31 Table 2 x H1
F
v I (X ODIEt) Yield% Rf (Z) Example Compound 1 H NMR 6/ppm MS Wie 2;q W Vg N~z N 71 Xf 0. 57 c21 H22 N2 F2 02 (372) ht 69 R 0.55 C 25H2 F 3NO2 54 R f 0.48 C 22H 21F 302 (425) 2± 1 vii
F
(374) 2 j VIj 57 R f 0.52 c22 H26 F2 N2 02 (388) 2 k \7Th
F
0i,
N-
F
‘0 63 R f 0.51 C 2 H 25NF 02 71 R f .9C3H2 0 2 (361) (372) -32- Example 4 General procedure for the preparation of compounds of the general formula VII Example 4a 2Z-1-Hydroxy-3-fluoro-3-[4,6-bis-(4-fluorophenyl)-2-(1methylethyl)-pyrimidin-3-yl]-2-propene 12.1 g (28.6 mmol) of ethyl 2Z-2-fluoro-3-[4,6-bis-(4fluorophenyl)-2-(1-methylethyl)-pyrimidin-3-yl]-acrylate (Example 2a) are dissolved in 200 ml of abs. CHzCl 2 and, at O’C, 52.4 ml (62.4 mmol) of diisobutylaluminum hydride are added dropwise under argon. The mixture is stirred at room temperature for 2 h. After the reaction is complete, the excess reagent is decomposed with 10 ml of isopropanol, and then 30 ml of water are added, and the mixture is stirred for about 1/2 hour and filtered through a clarifying layer to remove precipitated aluminum salts.
The filtrate is dried with MgSO 4 filtered and concentrated. Column chromatography on silica gel (cyclohexane/ethyl acetate 4 1) yields the title compound.
Yield: 9.8 g of white crystals (90 of theory) of VIIa melting point 112-114″C R 0.2 (cyclohexane/ethyl acetate 2 1) 1H NMR: 6 values in ppm. 1.38 6H, CH), 1.5 1H, OH), 3.28 1H, CH), 4.2 (dd, 2H J 12 Hz, CH 2
OH),
z 5.92 1H J 36 Hz, CH=CF), 7.1-7.2 4H, aromat.
prot.), 8.55-8.65 2H, aromat. prot.) E isomer: 3.7 (dd, 2H, J 20 Hz, CH2OH), 6.35 1H J
E
16 Hz, CH=CF) MS: m/e 384
C
22
H
1
,ON
2
F
3 33 Example 4b-41 The compounds VIIb-VII I were prepared in a manner analogous to that described in Example 4a (cf. Tab. 3) ~t L ‘we, I t >i
I
ci sIt, Rf (Z) m p. C (Z) 1 H N1MR 6/ppm= MS :mWe-= cf. descriptioni E5Lmple 4 a Ii 4 4/ 87 R f u0.25 C 23H 21F2NO 63 R f.a0.42 C 22H 23FO2 62 B f.a0.21 C 22H 1 83 R f a0.27 C 22H 21NTO (365) (360) (38,d) (353) 4 8. Vild N
F
N-
4 f Vilf 78 Rfa 0.31 C 2 4 H 2 1
F
3 0 (8 (382 35 Table 3 Example Compound R
F
4 9 VIIgI 0
F
*1 0* 4~#d V:Ih F VII Yield% Rf 1 H NMR 6/ppm
M.P.
0 C(Z) MS W/e 62 w0.32 C 19H 20N F20 (330) 74 R a0.26 C 23H 20F3NO (383) 4± 1 viii
F
4j VIIj
NN)
82 R f a0.40 C 20H 1 9
F
3 0 67 R f.a0.29 C 20H 24F2NO2 A9 R f.a0.32 C 19H 23 FO2 81 R 0.35 C 21
H
24 F 20 (332) (246) (319) (330) ti (C
CC
F
VI~k 0
N-
VII I
F
‘0 -36- Example General procedure for the preparation of compounds of the general formula III Example 5a (variant A) h 2Z-2-Fluoro-3-[4,6-bis-(4-fluorophenyl)-2-(l-methylethyl) -pyrimid.in-3-yl ]-propene-2-aldehyde 11.3 g (97 inmol) of N-methyl-morpholine N-oxide 97 %pure (Fluka) are dissolved in 150 ml of abs. acetone. 0.9 g (0.97 mnol) of tris-(triphenylphosphine) -ruthenium(I) V chloride (Fluka) is added while stirring at 20*C. Subsequently, 9.3 g (24.2 mnol) of 2Z-1-hydroxy-2-fluoro-3- Ii [4,6-bis-(4-fluorophenyl)-2-(l-methylethyl)-pyrinidin-3yl]-2-propene (Example 4a) in 150 ml of abs. acetone are added dropwise. The mixture is stirred at room temperature for 20 h. The solvent is removed in vacuo, and the residue is filtered through silica gel (diethyl ether containing 1 NEt 3 Yield: 6.4 g (67.5 %of theory) of white crystals lIla Melting point 159-1620C Rf= 0.89 (cyclohexane/ethyl acetate =1 :1) 2 H NMIR: 6 values in ppm: 1.38 6H, CH!) .5 h H 6.9 1H, J 34 Hz, CH!CF), 7.1-7.25 (in, 8H, aromat. prot.), 7.6-7,7 (mn, 2H, aroinat. prot.), 8.55-8.65 (in, 2H, aromat. prot.), 9.4 1H J 16 Hz, CH=O).
MS: W/e 382 C 22
H
1 7
N
2
F
3 0 Example 5b-51 The compounds III b-Ill 1 were prepared in a manner analogous to that described in Example 5a (cf. Tab. 4) -37- The compounds III a-III 1 can also be obtained by variant B, as described in Example 5a which follows.
Example 5a’ (variant B) 2Z-2-Fluoro-3-[4,6-bis-(4-fluorophenyl-2-(1-methylethyl)pyrimidin-3-yl]-propene-2-aldehyde 7.2 g (20 mmol) of 2-fluoro-3-[4,6-bis-(4-fluorophenyl)- 2-(l-methylethyl)-pyrimidin-3-yl]-acrylonitrile (Example 3a) are dissolved in 150 ml of abs. THF. At -100C 35 ml mmol) of diisobutylaluminum hydride (1.2 molar solution in toluene) are added dropwise, and the mixture is stirred for a further 2 h in the cold. The pH is then adjusted to 5-6 with 1 N hydrochloric acid, and the ,o mixture is extracted with ethyl acetate. The combined EA phases are washed free of acid with NaHC03, dried with I MgSO,, filtered and concentrated in vacuo. The residue is Schromatographed on silica gel (cyclohexane/ethyl .acetate 10 1) Yield: fraction 16-60 3.1 g of IIIa (E isomer) R 0.45 fraction 61-120 3.1 g of IIIa (Z isomer) R, 0.27 Melting point 159-162°C 1 H NMR: Z isomer, identical to Example 5a (variant A) 6 6.92 ppm, J 34 Hz, CH=CF 1 H NMR: E isomer S6 7.31 ppm, J 16 Hz, CH=CF -38 Table 4 CH U 0 ml Example Compound Yield% Rf ‘H NMR 6/ppm
M.P.
0 C(Z) MS m/e Ila 67.5 cf. description Examle 41 t k.1 111b 62.4 R f.a0. 82 C 23H 19F2NO (363) Ili11C 82 R f.a0.92 C 11H 21F (358) 1116 I~J
F
71 R f 6 C2H17 F3 N2 (382) 0 Mle
F
‘0 89 a0.80 C 22 11 19
NT
87 R.a0.78 C 24
H
19 F 3 0 (357) (380) 39 Table 4 0 It Example Compound Yield% Rf (Z) 1NMR 6/p~mn m.p.OC(Z) MS m/e Ilug
F
83 R fa 0.90 c19 H18 2 F20 (32B) I It I II I C I I I ~I Ilh 95 91 R fu 0.82 C 23H 18F 3NO R 0.95 C 20H 17F 30 (381) (330) 1 11i II11j k 111k N N
F
,0 78 81 R faO.70 C 2 H 22F2N 2 Rt 0.85 C 19H 21NF 0 (344) (317)
F
64 6 %Rf. a 0.9 C 2 1
H
2 2
F
2 0 38 (328) Example 6 General procedure for the preparation of compounds of the general formula IV with R’ 7 OH N Example 6a 4Z-3(S)-Hydroxy-4-fluoro-5-[4,6-bis-(4-fluorophenyl)-2-(1methylethyl )-pyrimidin-3-yl ]-pent-4-ene.-carboxylic acid 2 -hytra ester (hytra 2 -hydroxy- 1, 2, 2-triphenylacetate) 9.3 ml of butyllithium, (13.5 mmol) are added dropwise to g (2.1 ml, 13.5 mmol) of abs. diisopropylamine in 33 ml of abs. THF while stirring at O*C. The mixture is then stirred at 0*C for 20 min. Then 2.21 g (6.6 mmol) of -2-hydroxy-l, 2, 2-triphenylacetate (Merck-Schuchardt) suspended in 50 ml of abs. THF are added dzopwise at to the lithium isopropylamide solution. The mixture is 0 stirred further at 0*C until a clear orange-red solu-tion has resulted. At -65*C 2.4 g (6.4 mmol) of 2Z-2-fluoro-3- 6-bis- (4-f luorophenyl -methylethyl) -pyrimidin-3yl]-propene-2-aldehyde (Example 5a) in 20 ml of abs. THF are added dropwise, and the mixture is stirred further for 1 h. Subsequently 20 ml of 50 saturated ammonium chloride solution are added dropwise, the mixture is extracted with 2 x 50 ml of methylene chloride, and the org. extracts are washed 2 x with water, dried with MgSO 4 filtered and concentrated.
Yield: 5.2 g of white crystals (87 of theory) Melting point 193-195*C Rf= 0.29 (cyclohexane/sethyl acetate 4 1) -41- 1H1 NMR 6 values in ppm: 1.30 (dd, 6H, CH 3 1.55 2H, OH) 2.45 and 2.82 2H, CH 2 3. 2 1H, CH), 4.3z 4.45 (mn, 1H1, CHOH), 5.95 1H J 38 Hz, CH=CF), 6.74, 1H, CH-CAH), 7.0-7.8 (mn, 21H, aroinat. prot.), (mn, 2H, aromat. prot.) MS: Wne 714 C44H 37
N
2
F
3
O
4 Example 6b-61 The compounds VI b-VI 1 were prepared in a manner analogous to that described in Example 6a (cf. Tab. a e.g ego 0 0 4* 0 0O 0 C C *4 a a S a, a *4 *g a, c.
a a
I
1 -r n -IILlilll~.l- Table 5 42 K- 17 I II p C. I cv- CW& TyC/-t~
F
Ri Yield% 1% ‘H NMR 6/ppm MS m/e= Example Compound 6 a Iva
F
Ii
N.
87 -cf. description Ekmple 6a 4 1 (414 4 r 1 414 46 b 4 14r 91 R a0.31 C H FNO (695) C 45 39 2 d.
6 c Nc 6 IVd 78 R f .46 C4H 4F30 4 (690) ra
F
0
N_
C
65 R fa0.27 C 4 3 N20 (714) 73% P .0.36 C H NF0O (683) f 44 39 2 4 6 a JS f 1v 92 R f a0.33 C 4 6
H
3 9 3 (712 (712) Table Example Compound 69 IVg II h -43 Yield% Rf (Z) m p. 0
C(Z)
2Hl NMR 6/ppm= MS Wie I O
F
N
69 R f.a0.39 C 4 H 38N 2 F 204A (660) 77 R fa0.31 C 45
H
38 F 3NO 4 (713) 6j lvi ji IVj k M 61 IV 1 K1 r)-J N i
F
‘0 92 w0.42 C 42H 37F3O .(662) 59 R f0.31 C 42H 42F2N 20 (676) 81 R 0.38 C 41H 41NF 0 4 (649) 89 *f 0.40 C 4 3
H
4 2
F
2 0 4 (660) 44 Example 7 General procedure for the preparation of compounds of the general formula IV with R 17
CH
3 Example 7a Methyl 4Z-3(S)-hydroxy-4-fluoro-5-[4,6-bis-(4-fluorophenyl)-2-(1-methylethyl)-pyrimidin-3-yl]-pent-4-enecarboxylate 5.2 g (7.3 mmol) of 4Z-3-(S)-hydroxy-4-fluoro-5-[4,6-bis- (4-fluorophenyl)-2-(l-methylethyl)-pyrimidin-3-yl]-pent- 4-ene-carboxylic acid 2(S)-hytra ester (from Example 6a) in 50 ml of abs. methanol are added dropwise to a solution of 184 mg (8 mmol) of sodium in 50 ml of methanol.
The mixture is stirred at room temperature for 16 h.
After the reaction is complete, 0.5 ml of glacial acetic acid is added, then 30 ml of toluene are added and the mixture is concentrated in vacuo. The residue is dissolved in ether, and the ether phase is washed 2 x with water, dried with MgSO 4 filtered and concentrated.
Filtration through silica gel with cyclohexane/ethyl acetate 4 1 yields IYield: 3.25 g (97.6 of pale oil Rf 0.25 (cyclohexane/ethyl acetate 4 1) 1 H NMR 6 values in ppm: 1.38 CH 3 6H), 2.05 1H, OH), 2.4-2.7 2H, CHz), 3.25 1H, CH), 3.75 3H,
OCH
3 4.5-4.6 1H, CHOH), 6.1 1H J 38 Hz,
Z
CH=CF), 7.05-7.2 4H, aromat. prot.), 7.65-7.75 (m, 2H, aromat. prot.), 8.55-8.65 2H, aromat. prot.) MS: m/e 456 C2H23NF303 45 Example 7b-71 The compounds IVm-IVx were prepared in a manner analogous to that described in Example 7a (cf. Tab. 6)
‘I
ft..
I I I II I I, *4
I,
46 Table 6
U
CW- a V i.
I F 7 It Example Compound Yield% Rf (Z) m .p 0 C( Z) ‘NMR 6/ppm MS W/e 7a IV M 7 IV 0 7 d IV P j~rF 0
N
F
N-
F
CF
97.6 cf. description~ Example 7a 82 R f.a0.27 C 26H 25F2NO 3 (437) 71 R fv0. 41 C 2 5
H
27 F 3 0 3 (432) 87 PR f 0.31 C 25
H
23
F
3 N 2 0 3 IV q 57 P f.w0.32 C 2 5
H
2 5 NF 2 0 3 (425) 7 f IV r 68 3f 0.28 C 27 H 2 5
F
3 0 3 KTable 6 VExample compound -47 C/ CW-:»OO3 I R17 CH 3 Yield% Rf (Z) in. p.
0 C Z) 1 H NMR 6/ppm MS
F
7; IV s N~z N 1– 69 R f =0.2 9 C 22H 24N 2O 3 (402) S I S S. I 4 7 b t I I
I,
IV t 92 R f. a 0.27 C 26
H
23 F 30 3 (455) 71 IV U 7 j IVyv 0
F
N~ 72 R f a0.38 C 2 3
H
2 3
F
3 0 3 .(404) 65 R f 0.’37 C 23H 28F N 203(48
F
IV w0 81 P a0.39 C 22
H
27 NF 2 0 3 (391)
F
‘0 IV X Iv x 72 Rtu 0.30 C 2 4
H
28
F
2 0 3 (42 (402) -48- 1K. Example 8 General procedure f or the preparation of compounds of the general formula V Example 8a Tert. butyl6Z-3-oxo-5(S).-hydroxy-6-fluoro-7-[4,6-bis-(4fluorophenyl) -methylethyl)-pyrimidin-3-yl]-hept-6ene-carboxylate 12.5 ml (29 mmol) of butyllithium (15 strength solution in hexane) are added dzopwise at -70*C to 2.02 g (2.8 ml, mniol) of diisopropylamine in 12.5 ml of abs. THF. The mixture is stirred at 0OC for 30 min. It is then cooled to -700C, and 2.33 g (20 mmol, 2.7 ml) of tert.-butyl K ~cetate are added dropwise, and stirring at -700C is continued for 30 min, then 2.3 g (5 mmol) of methyl 4Z- 3(S)-hydroxy-4-fluoro-5-[4,6-bis-(4-fluorophenyl)-2-(lmethylethyl) -pyrimidin-3-yl ]-pent-4-ene-carboxylate (from Example 7a) in 25 ml of abs. THF are added dropwise at The mixture is subsequently allowed to warm to R.T. and 60 ml of 50 saturated ammonium chloride solution are added. Extraction with 3 x 100 ml of methylene chloride is carried out. The CH 2 ,Cl 2 extracts are washed with water, dried with MgSO 4 filtered and concentrated in vacuo.
Yield: 3.1 g of pale oil (82 of theory) Rf= 0.54 (cyclohexane/ethyl acetate 2 :1) ‘R NMR 6 values in ppm: 1.38 6H, CH 3 1.45 9H,
CH
3 y, 1.6 (1H, S, OH), 2.5-2.9 (in, 2H, CHO), 3.2-3.4 (mn, 2H, CH 2 4.6-4.7 (mn, 1H, CHOH), 6.1 1H, J =38 Hz, z CH=CF), 7.1-7.2 (mn, 4H, aromat. prot.), 7.65-7.75 (in, 2H, aromat. prot.), 8.55-8.65 (in, 2H, aroinat. prot.) MS: mWe 540 CO~~FO C30H3jN2F304 49 Example 8b-81 The compounds Vb-Vl were prepared in a manner analogous to that described in Example 8a (cf. Tab. 7).
i i Table 7 Example Compound 50 040 It0 Yield% Rf ‘H NMR 6/ppm MS W/e= 8 a va 82 cf. description Fkcaple 8a
LI
I
II t t ii 8 b a C VC C H 0
C
3
F
F
69 81 72 R 0.56 C 31
H
43
F
2
NOA
R f 0.70 C 30H 35F 304 R f 0.82. C 30H 31F 3N 204 (521) (540) ad Vd Ve 59 R f. 0 0.59 C 3 0 11 33
NF
2 0 2 (509) R. f 0.58 C 3 2
H
3 3
F
3 0 4 (538) 51 ii
V
A Table 7 R1Yield% Rf 1 H NMR 6/ppm= rn.p.
0 C(Z) MS m/e Example Compound 8; Vg
F
N
66 R f 0.62 C 27H 32N 2F 2 04 *1 I, t
C
4 8 h 4 r ~t 77 R f w0. 57 C 31H 32F3NO (486) (539) (488) (502) (475) 8± vj i Vj
F
N-
86 69 62 R f 0.68 C 28H 31F 304 R 0.65 C 28143 F 2N 204 R 0.58 C 27
H
35 NF 2 0 4 8 k Vk, 81 V1 8 Vi76 RP. a 0.52 C 2 9
H
3 6 7 2 0 4 (86 (486) 52- Example 9 SGeneral procedure for the preparation of compounds of the general formula I (R 2 t-C 4
H
g Example 9a tert. Butyl 6Z-3(R),5(S)-dihydroxy-6-fluoro-7-[4,6-bis- (4-fluorophenyl)-2-(l-methylethyl)-pyrimidin-3-yl]-hept- 6-ene-carboxylate ml of methanol in 40 ml of abs. THF are added dropwise to a solution of 5.5 ml (5.5 mmol) of triethylborane (1 I mole/liter) in abs. THF, and the mixture is stirred at R.T. for 1 h. At -70’C 2.5 g (5 mmol) of tert. butyl 62- 3-oxo-5(S)-hydroxy-6-fluoro-7-[4,6-bis-(4-fluorophenyl)- 2-(1-methylethyl)-pyrimidin-3-yl]-hept-6-enecarboxylate (from Example 8a) in 20 ml of abs. THF are added dropwise, and the mixture is stirred for 30 min. Then 210 mg mmol) of sodium borohydride are added and the mixture is stirred at -70°C. After the reaction is complete, 0.5 ml of glacial acetic acid in 3 ml of toluene is added in the cold, and stirring is continued for 5 min. Subsequently 50 ml of 50 saturated sodium bicarbonate solution are added at and the mixture is extracted with methylene chloride. The org. extracts are dried with MgSO 4 filtered, concentrated in vacuo and filtered through silica gel (cyclohexane/ethyl acetate 2 1) Yield: 3.0 g of pale crystals (92.3 of theory), melting point 148″C R, 0.325 (cyclohexane/ethyl acetate 2 1) ‘H NMR 6 values in ppm: 1.35 6H, CHa), 1.5 9H,
CH
3 1.42-1.6 2H, CH 2 2.4(d, 2H, CHCO 2 -tert.but), 3.3 IH, CH), 3.9 1H, OH), 4.1 1H, OH), 4.12- 4.28 1H, CHOH), 4.35-4.45 1H, CHOH), 6.08 1H, K -53z J =38 Hz, CH=CF), 7.05-7.15 (in, 1H, aroinat. prot.), 7.7- 7.8 (in, 1H, aromat. prot.), 8.55-8.65 (mn, 2H, aromat.
prot.) MS: W/e =540 C30H3IN 2 F304 Example 9b-91 The compounds I b-I 1 are prepared in a manner analogous to that described in Example 9a (cf. Tab. 8) 54
I
Table 8 Example Compound C4″i C’j CI CY- 4t~ CIO e4 k
NIF
Yield% R, ‘H NNR 6/ppm m.p.
0 C(Z) MS m/e 9 a Ia
F
II
f 92.3 cf. description Ebample 9a I t aa g tr 78 9 C Ic N Ii
NF
9d Ctri 69 73 82 69 R u 0.33 C 31H 4F NO R f 0.39 C 30H 37F 0 R f 0.37 C 30H F N 20 tfa0.42 C 3H3F2NO SM 0.28
C
3 2H 35
F
3 0 4 (523) (518) (542) (511) (540)
F
le C 0
-PO
N-
9f If
F
I
2 55 Table 8 cont’d/….
Example Compound Yield: Rf «H NMR 6/ppm m. p.
0 C(Z) MS mie 99 Ig
N
88 R f 0.36 C 2H 34N 2F 204 (488) c t 9 h t c 86 78 82 Rfa 032C 31
H
34
F
3 N0 R a 0.41 C 28H 33F 304 R fw 039C 2 8
H
3 8 2 2 0 4 R w0.44 C2I3NF204 (541) (490) (504) (477) rIi
F
Ik ‘0F 9 1 1 1 59 91~R ai5 0.30 C 2 9
H
3 8 F 2 0 4 (48
(ASS)
4 -56- Exaimple General procedure for the preparation of compounds of the general formula II Example Z-6(S)-2-[(4,6-bis-(4-f.luorophenyl)-2-(-methylethyl..
pyrimidin-3-yl) ]-(1-fluoro-2–ethenyl)-4(R)-hydroxy- 3,4,5, 6-tetrahydro-2H-pyran-2-one 2.7 g (5 nimol) of tert. butyl 6Z-3(R), 5(S)-dihydroxy-6- 1j C fluoro-7-[4,6-bis-(4-fluorophenyl)-2-(-methylethyl).
pyriinidin- 3-ylJ]-hept- 6-enecarboxyl ate (Example 9a) are dissolved in 50 ml of mnethylene chloride, and 3.99 g (2.7 ml, 35 mmcl) of tri-Fluoroacetic acid are added. The mixture is stirred at R.T. for 6 h and then neutralized with potassium bicarbonate solution and extracted 2 x with diethyl ether. The ether extracts are dried with MgSO 4 filtered, concentrated and filtered through silica gel,, Yield: 1.39 g (70 of theory) white crystals of melting point 1980C Optical rotation: (J5=-13.20 (CH 3 OH, C 1) 11 0.13 (cyclohexane/ethyl acetate =2 :1) 1H1 NMR 6 values in ppm: 1.38 6H, CH 3 1.55 11H, OH), 1.8-2.0 (in, 2H, CH 2 2.6-2.8 (mn, 2H, CH 2 CO), 3.25 1H, CH), 4.35-4.45 (mn, 1H, CHOH), 5.15-5.35 (mi, 111,
Z
CHOCO), 6.1 111, J 35 Hz, CH=CF), 7.1-7.2 (in, 4H, aroinat. prot.), 7.6-7.75 (mn, 2H, aromat. prot.), 8.5-8.6 (mn, 211, aroxnat. prot.) MS: m/e 468
C
26
H
2 3
N
2
F
3 0 3 57 Example lOb-l0l The compounds II b-II 1 were prepared in a manner analogous to that described in Example 10a (cf. Tab. 9).
Table 9 58 ill Example Compound Yield% Rf (Z) H NMR 6/ppm m.p.
0 C(Z) MS m/e r t C t ftr b C C C Ila hIb 70 cf. description Example 72 81 1 tR f 0.15 C27H25F2 3 (499) 1.35(d, 6H), 1.2-1.95(H, 28), 2.55-2.80(m, 2H), 3.35(h,1H), 4.35-4.45(m,lH), 5.15-5.25(m,1H) 6.10 1H, J 36Hz) 7.1-72(r,2H), 8.5-8.6(nH), 7.45-7.55 (m,3H) Fp. ‘i165-167 0 C 7.65-7.75 (m,2H) r ~j :6 i .i b si i t
E
O C Ilc
CH
2 4 0
F
C-
R f0.22 C 26 H27F3 (444) NMR: 1.08(d, 6H), 1.85-1.75 und 1.60-1.52 (each m, total 3H) 2.25 und 2.20 each s, each 3H) ,2.56 (dd, J 18Hz,
J
2 4Hz, 1H), 2.7(dd, J 1 =188z, J 2 w4HZ, 1H) 2.87(h, 18), 4.22(m, 18), 5.05(m, 1H) fH) ~C k 10 8 68 r a0? C 26
H
23
F
3 2 NMR: 1.44(dd, J.7Hz, 68), 1.52-1.93(m, 2.84 2H), 3.45(h, 1H), 5.2(m, 6.12(d, 1H, 3.37Hz), 7.00-7.41(m, 72% R f a0.16
C
26
H
2 5NFO 3 (468) 3H); 2.61- 1H) 8H) 0
F
N-
(437) NMR: 1.3(dd, 68), 1.5-1.7(m, 28), 2.0-2.3Cm, 2H), 2.6-2.9(broad s, 17) 3.1(h, 1H), 4.2-4.25(m, 1 5.1-5.2 1H), 6.12(d, 1H, J.36Hz), 6.5(3, 1H) 6.9-7.5(m, 9H) 86 R f 0.15 C 28
H
25
F
3 0 3 (466) NMR: 1.3(dd, 68), 1.6(s, 18), 1.7-2.0Cm, 2H) 2.55-2.80(m, 2H), 3.45(h, 18), 5.23Cm, 1H), 4.2-4 2H), 6.10(d, 18, J-36Hz), 7.1-7.6(m, 1o Ihf r I cruiui~-~ f 59 Table 9 cont’d/….
Example Compound Yield% Rf (Z) 1H NMR 6/ppm m.p.
0 C(Z) MS m/e 9 hIg
F
NN
72 R fw0.22 C23 24N2F203 (414) mp. 138 0
C
1.25(d,6H), 1.3(d6H), 1.75-2.0(m,21i, 1.1(broad s, 2.6-2.8(m,2H), 3.1-3.3(n, 2H), 4.32-4.40(m,lH), 5.15-5.3(m,1H), 6.02 (d,J=36Hz,1H), 7.05-7.15(m,2H), 7.5-7.65(m,2H) zf t tr~ It t C 78 R f 0.16 C 27H 24NF 0 (467) NMR:(analogus to c.10 b, 7.1-8.2(m, 8H) 1 1 j Ii ‘Ii
F
I’
N9N~ 63 Rf a 0.25 C H423F303 (416) NMR: 1.1(d, 6H), 1.55-1.68 und 1.73-1.90 (each m, total 3H) 2.57(dd, T 1 7Hz, J 2 =4Hz, 1H), 2.70 (d,
J
1 17H, J 2 =4Hz, 1H) 2.87(h, 1H), 4.25(m, 1H), 5.05(m, 1H), 6.4-7.1(m 9H) 72 R f a0.20 C 242N F 2NO (430) M: (analogus Eb. 10 d, 7.00 7.41 4H) 1.1 9H k 1
F
0 If i 81 f 0.24 C 23
H
2 7
NF
2 0 3 (403) NMR: 1.35 und 1.45 (each 6H, d) 2H) 2.55-2.75(m, 2N), 2.6(broad S, 1H) 3.3 1H) 4.25-4.35(m, 1H), 5.2-5.3(m, 1H), 4.4(h, 1H) 6.05(d, 1H, J w 36Hz), 6.5-7.35(arcmt. protons) 68 R a 0.26
C
2
SH
2 8 F03 (414) NMR: 1.3(dd, 6M), 1.65(s, 1N), i.7-2.0(m, 2H) 2.55-2.75(m, 2H), 2.9 and 3.4 (each 1H, h) 4 3-4.A(m, 1H), 5.20-5.28(m, 6.08 1H, 3. 36Hz) 6.95-7.55(m, 6H) 60 Example 10 m The compound of the formula II in which R 1 represents a pyrimidine radical of the formula
IF
t is obtained in a manner analogous to that described in the previous examples. It has a melting point of 195-197″C.
General procedure for the preparation of compounds of the general formula I
R
2
H
Example 11a 6Z-3(R), 5(S)-Dihydroxy-6-fluoro-7-[4,6-bis-(4-fluorophenyl)-2-(1-methylethyl)-pyrimidin-3-yl]-hept-6-enecarboxylic acid 1 eq. of 10 strength aqueous sodium hydroxide solution is added to a solution of 0.5 g of tert. butyl 6Z-3(R), 5(S)-dihydroxy-6-fluoro-7-[4,6-bis-(4-fluorophenyl)-2-(lmethylethyl)-pyrimidin-3-yl]-hept-6-ene-carboxylate (Example 9a) in 5 ml of ethanol, and the mixture is stirred at room temperature for 3 h. The pH is then adjusted to 3- 4 with 0.5 N hydrochloric acid in the cold, saturated brine is added, and the mixture is extracted 3 x with ethyl acetate. The org. extracts are dried with MgSO 4 filtered and concentrated in vacuo.
61 Yield: 0.42 g (92 of theory) of pale oil.
R, 0.13 (cyclohexane/ethyl acetate 2 1) 1H NMR 6 values in ppm: (in DMSO) 1.3 6H, CH 3 1.65 2H, CH 2 1.75 1H, OH), 2.0-2.3 2H, CH 2 3.3 1H, CH), 3.7-3.9 1H, CHOH), 4.15-4.3 1H,
Z
CHOH), 6.15 1H J 36 Hz, CH=CF), 7.25-7.4 4H, aromat. prot.), 7.8-7.9 2H, aromat. prot.), 8.45-8.55 2H, aromat. prot.), 5.5-5.9 (broad s, 1H, COOH) MS: m/e C St Example 11 b-11 1 The compounds of the formula I with R 2 H corresponding to Example 11 b-11 1 are prepared in a manner analogous to that described in Example lla.
It is also possible under the same reaction conditions as in Example lla to hydrolyze the lactones of the general i formula II (Example 10a) to the free carboxylic acids or Sthe salts thereof.

Claims (8)

1-6 carbon atoms, carboxyl or carbalkoxy having 1-6 carbon atoms in the alkoxy moiety, B) the group of substituted 5-membered ring hetero- aromatics S ‘R L in which G-E denotes the following atomic sequences S-a) N-C (1H-pyrrol-2yl) b) S-C (2-thienyl) c) C-N (1H-pyrrol-3-yl) d) C-O (3-furyl) e) C-S (3-thienyl) Sand R 6 denotes H, straight-chain Ci-C4-alkyl, C 3 -Ce- branched alkyl, trifluoromethyl, halogen or phenyl which is optionally substituted 1-2 times by fluorine, chlorine or methyl, R denotes H, straight-chain Ci-C4-alkyl, branched C 3 -C 6 -alkyl, trifluoromethyl, halogen or phenyl, R 8 denotes H, cycloalkyl having 5-8 ring carbon i atoms, branched C 3 -C-alkyl, or phenyl, which can in turn be substituted 1-2 times by straight- chain Ci-C 3 -alkyl, halogen or trifluoromethyl, and R 9 denotes H, straight-chain Ci-C 3 -alkyl, branched C 3 -C-alkyl, cycloalkyl having 5-8 ring carbon atoms, trifluoromethyl or phenyl which can in turn be substituted 1-2 times by straight-chain Ci-C 3 -alkyl, halogen or trifluoromethyl, and R 7 and R 9 together also denote a conjugated unsaturated radical having 4 carbon atoms, so t] a ii s C) t 64 hat R 7 and R 9 form a fused-on aromatic moiety, nd in which the substituents R 7 and R 8 are absent n those heteroaromatics which have oxygen and ulfur at the relevant positions, or he group of substituted olefins atr I I a a a ar Cs C in which R 1 i R n and R 12 independently of one another denote a straight-chain or branched alkyl or alkenyl radical, each of whicL has up to 6 carbon atoms and can optionally be substituted on the terminal carbon by a cycloalkyl or cycloalkenyl radical, each of which has 3-6 carbon atoms, or denote a cyclic hydrocarbon radical which is saturated or up to doubly unsaturated and has 3-7 carbon atoms or an aromatic radical selected from the group comprising phenyl, furyl, thienyl or pyridinyl, which can optionally carry in the nucleus 1-3 identical or different substituents from the following groups: halogen, trifluoromethyl, alkyl or alkenyl, each having up to 6 carbon atoms, hydroxyl, alkoxy having 1-6 carbon atoms, car- boxyl or carbalkoxy having 1-6 carbon atoms in the alkoxy moiety, and R 2 denotes hydrogen, a straight-chain or branched alkyl or alkenyl radical, each of which has up to 8 carbon atoms, a benzyl radical whose nucleus can be substituted 1-2 times by halogen or an alkyl radical having 1-4 carbon atoms, or denotes alkali metal or an ammonium ion Ni 13 R»R SR 1 6 where R 13 R 14 R 15 and R 16 are identical or different and denote hydrogen, alkyl having 1-4 carbon atoms or hydroxyalkyl having 1-4 carbon atoms. r 65

2. A process for the preparation of the compounds of the general formulae I and II, which comprises a) converting appropriately substituted aldehydes of the formula III H R ICHO II in which RI. the a-~ifie~–mean°’ into the corres- ponding hydroxy esters of the general formula IV H OH I 1 IV 1 C02R17 R 2 F in which R 1 has the specified meaning, and R 17 represents a suitable optically active acid protecting group which determines the stereochemistry at C-3, or an alkyl radical having 1-8 carbon atoms b) converting the optically active compounds of the formula IV with achiral acetic ester enolates, either directly or after previous conversion into the corres- ponding alkyl esters, into the optically active compounds of the formula V H OH R 0SCO V 13 V in which R 1 has the specified meaning, and R 18 is alkyl having 1-8 carbon atoms, c) converting the hydroxy keto esters of the formula V into the corresponding 6-fluoro-3,5-dihydroxy compounds of the formula I in which R1 ha i Sis alkyl havin hydrolyzing a i formula I in w appropriate li hydrogen), and into compounds each having up appropriately Sd) and convert where appropri in which R 1 ha

3. A phai as clz pharma

4. A meth arteri compri such t claime A comE 66 H OH I CO.R 2 s the meaning specified for formula I, and R2 g 1-8 carbon atoms, and, where appropriate, resulting compound to a compound of the hich R 2 represents a metal cation, where berating therefrom the free acid (R where appropriate converting the free acid of the formula I with R 2 alkyl or alkenyl, to 8 carbon atoms, ammonium ion, benzyl or substituted benzyl, ing a resulting compound of the formula I ate into a Jactone of the formula II 0 «0 s the specified meaning. rmaceutical product which contains a compound limed in claim 1 in adjunct with iceutically acceptable carriers or excipients. od of prophylaxis and therapy of osclerosis and hypercholesterolemia sing administering to a patient requiring reatment an effective amount of a compound as d in claim 1. )ound of the formula III C R 1 C-tC-CHO III in which R 1 has the meaning specified for formula I in claim 1. -67-

6. A compound of the formula IV H OH 11 F IV in which R1 has the meaning specified for formula I in claim 1, and R 7 is alkyl having 1-8 carbon atoms.

7. A compound of the formula V H OH 0 4 0 R V 9 2 it in which R1 has the meaning specified for formula I in claim 1, and R 18 is alkyl having 1-8 carbon atoms.

8. A compound of the formula VI H R VI in which R 1 has the meaning specified for formula I, and X is a nitrile group or an ester gronp COOR 19 where R1 9 is alkyl having 1-8 carbon atoms.

9. A compound of the formula VII H R CH 2 0i VI2 F in which R1 has the meaning specified for formula I in claim 1. DATED this 3rd day of August 1989. HOECHST AKTIENGESELLSCHAFT WATERMARK PATENT TRADEMARK ATTORNEYS MELBOURNE. VIC. 3000.

AU39297/89A
1988-08-06
1989-08-04
New 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as medicinal agents, pharmaceutical products and intermediates

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SUBSTITUTED 7- (PYRIDAZIN-5-YL) -3,5-DIHYDROXYHEPTANE (EN) – ACID, YOUR CORRESPONDING (DELTA) -LACTONE OR. DERIVATIVES, PROCESS FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS, PHARMACEUTICAL PREPARATIONS AND INTERMEDIATE PRODUCTS

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Process for stereoselective preparation of 5-substituted delta-lactones and their use

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