AU637649B2 – Inhalation device and protective casing therefor
– Google Patents
AU637649B2 – Inhalation device and protective casing therefor
– Google Patents
Inhalation device and protective casing therefor
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Info
Publication number
AU637649B2
AU637649B2
AU66649/90A
AU6664990A
AU637649B2
AU 637649 B2
AU637649 B2
AU 637649B2
AU 66649/90 A
AU66649/90 A
AU 66649/90A
AU 6664990 A
AU6664990 A
AU 6664990A
AU 637649 B2
AU637649 B2
AU 637649B2
Authority
AU
Australia
Prior art keywords
inhaler
cover
inhalation device
cocking
protective casing
Prior art date
1989-11-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU66649/90A
Other versions
AU6664990A
(en
Inventor
Anthony Charles Lammond Wass
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1989-11-14
Filing date
1990-11-14
Publication date
1993-06-03
1990-11-14
Application filed by Riker Laboratories Inc
filed
Critical
Riker Laboratories Inc
1991-05-23
Publication of AU6664990A
publication
Critical
patent/AU6664990A/en
1993-06-03
Application granted
granted
Critical
1993-06-03
Publication of AU637649B2
publication
Critical
patent/AU637649B2/en
2010-11-14
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
A61M15/00—Inhalators
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
A61M15/00—Inhalators
A61M15/0091—Inhalators mechanically breath-triggered
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
A61M15/00—Inhalators
A61M15/0001—Details of inhalators; Constructional features thereof
A61M15/0021—Mouthpieces therefor
A61M15/0025—Mouthpieces therefor with caps
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
A61M15/00—Inhalators
A61M15/0091—Inhalators mechanically breath-triggered
A61M15/0096—Hindering inhalation before activation of the dispenser
Description
AUSTRALIA
Patents Act 6,37649 COMPLETE SPECIFICATION
(ORIGINAL)
Class Int. Class Application Number: Lodged: Complete Specification Lodged: Accepted: Published: Priority Related Art:
S.
*o a
*S
S
SO
S
Applicant(s): Riker Laboratories, Inc.
3M Center, Saint Paul, Minnesota, UNITED STATES OF AMERICA
S.
S
5000 S S 9 9 5 Address for Service is: PHILLIPS ORMONDE FITZPATRICK Patent and Trade Mark Attorneys 367 Collins Street Melbourne 3000 AUSTRALIA Complete Specification for the invention entitled: ftwim T Y V CA ‘A Cnz C C- t r C! N r Ir Our Ref 197724 POF Code: 1433/57875 The following statement is a full description of this invention, including the best method of performing it known to applicant(s): 1 INHALATION DEVICE AND PROTECTIVE CASING THEREFOR This invention relates to medical inhalers, and in particular to an improvement to the protective casing surrounding A metered dose inhaler, the casing comprising a body portion and a movable cover which, when displaced to allow the .patient accegs to the device, acts as a cocking lever for the priming of the inhaler.
Medical inhalers comprising an aerosol vial containing propellant and medicament and equlipped with a dispensing valve, a metered dose valve communicating with a mouthpiece, are known. Such inhalers may be incorporated in a housing including a breath actuated mechanism to synchronise dispensing of the medicament with inspiration by the patient. An example of such a device is commercially available from Minnesota Mining-and Manufacturing Company, -under the trade mark %UTOHALER and is disclosed, for examuple, in European Pa’zent No. 147028.
Co-pending European Patent Application No.
90309239.3 discloses an inhalation device comprising: a breath-actuated inhaler comprising a medicament reservoir mounted within a ‘housing which comprises a maouthpiece and breath -actuat ion Yneans which prevents dispensing from the teservoir until a patient inhales through the mouthpiect.., and, (ii) a protective casing 8urrounding the breath actuated inhaler, the casing comprising a body portion a movable cover which may be displaced to allow a patient. access to the mouthpiece to use the breath- 30 actuated inhaler whilst it is within the casing, the breath-actuated inhaler being removable from the protective casing and operable outside the casing.
la ZX1 It is an object of the present invention to provide a cover arrangement which primes the inhaler for use upon opening the cover.
According to this invention there is provided an inhalation device comprising: an inhaler comprising a housing which comprises a mouthpiece and actuation means having an inactive position in which dispensing from the inhaler is prevented and a cocked position in which dispensing from the inhaler is allowed, and (ii) a protective casing surrounding the inhaler, the casing comprising a biasing means for cocking the inhaler, a body portion, and a cover movable between open and closed positions which cover in the open position allows access to the mouthpiece, wherein movement to the open position causes relative movement of the inhaler and the biasing means thereby cocking the inhaler, characterized in that the cover is pivotally attached to said body portion and a cocking link is pivotally mounted at one end to the cover and has a portion in engagement with the inhaler or the biasing means, wherein pivotal movement of the cover from the closed position to the open position moves the inhaler relative to the biasing means via the cocking link and places the inhaler in the cocked position, and (ii) moves the pivot points between the cover and the cocking link and between the cover and the body portion through a straight line position to an overcenter 30 position.
This invention also extends to a protective casing for an inhaler having an active position and an inactive i position, which casing comprises: a body portion defining a chamber adapted to house 5 an inhaler therein, the chamber including biasing means for cocking said inhaler, and a cover movable between open and closed positions, which in the open position allows access to said ASP-A inhaler, characterised in that the movable cover is 2 r 4.
pivotally attached to the body portion, and a cocking link is pivotally mounted at one end to the cover and has a portion adapted to provide engagement with said inhaler or said biasing means, wherein pivotal movement of the cover from the closed position to the open position moves the inhaler relative to the biasing means via the cocking link and places the inhaler in the cocked position and (ii) moves the pivot points between the cover and the cocking link and between the cover and the body portion through a straight line position to an overcenter position.
The cocking link provides a simple, robust and effective method of priming an inhaler for use, by co-ordinating the act of opening the casing cover with cocking of the inhaler mechanism.
Preferably the cocking mechanism includes guide means to define the movement of the portion of the cocking link engaging the inhaler or biasing means. Generally, the cocking link includes at least one guide arm, typically two, engaging a suitable slot or recess in the body portion of the casing. Thus, the direction and extent of movement of the cocking link portion (and 7: therefore the inhaler or biasing means) is partly defined by both the direction and length of the recesses. In a preferred embodiment the cocking link o :i e 2acomprises a wishbone bracket having two arms, each arm engaging a corresponding guide recess in the body portion of the protective casing. The cocking link preferably acts directly on the inhaler.
The cover arrangement of the invention may be used with known metered dose or breath actuated pressurised inhalers. For a conventional pressurised inhaler comprising a cylindrical aerosol vial containing propellant and medicament and equipped with a dispensing~ valve, the inhaler is intended to be used in a substantially vertical position, in which the valve is lowermost relative to the vial. The cover may either be pivoted about a point lower than the inhaler, or about a point above the inhaler. Movement of the inhaler is generally completed in a substantially vertical OGG: direction, along the axis of the inhaler. The cover arrangement may also be used with dry powder devices OGG::. which require priming prior to use by the patient.
20 The cover arrangement of the invention is found to possess a number of advan’4ages, access to the aerosol dispenser and removal of the same, for cleaning purposes, freeing stem obstructions etc., is readily and simply effected without *seeC .0e:0. 25 disassem~bly of the device; the cover when fully closed provides an effectii a seal restricting the ingress of contaminants, mm: dirt or moisture; the cover is stable in the fully open position 30 avoiding any tendency to close during use;
OGG*
te when fully open, the cover is far removed from *:Noe theproximity of the users facial extremities, and is resistant to breakage at the mounting point resulting from accident or clumsy handling, and, movement of the inhaler within the casing is completed in a straight; line substantially free of obstructions and with reduced likelihood of jamming.
The invention will now be illustrated with reference to the accompanying drawings irt which: Figures 1. to 5 represent an inhalation device comprising a medical inhaler having a protective outer casing incorporating a cocking mechanism in accordance with the present invention; Figures I. and 4 illustrate sections through the device with the movable cover in the closed position and the inhaler uncocked; Figures 2 and 3 illustrate sections through the device with the movable cover fully open and the inhaler cooked for use, Figure 5 illustrates a front view of the device in 0 1 15 the cocked position of Figures 2 and 3, and Figures 6 and 7 represent partial sections through foe: the protective casing of a device in accordance with the invention which is adapted to accommodate aerosol :’bdispensers of different size.
The aerosol dispenser is omitted in Figures I to 3 to more fully illustrate the cocking mechanism.
Referring to Figures 1 to 3 an inhalation device comprises a protective casing adapted to receive a breath actuated aerosol dispenser, which casing comprises a body portion and movable cover Casing (1) defines a chamber in which the aerosol dispenser (omitted for purposes of clarity) is located. Cover (3) is pivotally mounted about allowing the patient to convert the device from an inactive closed format, in which the cover is in a home position (as depicted in Figures 1 and 4) to an open format in which the cover is fully displaced (as depicted in Figures 2, 3 and The act of opening cover provides the cocking force for the aerosol dispenser and allows the patient access to a suitable portal, such as a. mouth or nasal adapter, through which medicament may be inhaled. The inhaler is maintained in the closed format while not in use providing a compact, convenient shape minimizing contamination from dirt and moisture ingress etc. dver is advantageously provided with a snap fit to positively retain the cover in its closed position.
The cooking mechanism comprises a wishbone bracket wihich pivots about on cover such that opening of cover drives bracket from a home position (depicted in Figure 1) to a fully displaced position (depicted in Figures 2 and The direction and extent of bracket displ~acement is defined by the engagement of bracket arms and (10) with housing recesses (11) and (12) respectively. Recesses (11) and (12) are oriented such that displacement of cover (3) drives the bracket in a direction along the longitudinal axis of both casing and inhaler (represented by arrow 15000 i Referring to Figurez 4 and 5, the aerosol dispenser (13) is located within chamber by the provision of a groove (14) on the surface of dispenser (13) which pivotally engages the upper surfaces (17,16) of wishbone Gas*S bracket arms and (10) respectively, such that the aerosol container abuts against cocking spring thereby stably seating the dispenser.
In use, the device is held in the hand such that the longitudinal axis of the body portion approximates to the vertical. Full displacement of cover displaces bracket to lift the dispenser in a straight vertical path, without any rubbing contact with the internal surface of the body portion, thereby compressing cocking spring Subsequent relaxation of spring (15) upon device actuation, i.e. patient inspiration, provides the necessary force. for displacing the aerosol vial relative to the outlet valve member. In an alternative embodiment, cocking spring (15) may be replaced by a deform 1 able elastic member.
Body portion and groove (14) are confilured such that~ unwanted movement of the dispenser is prevented during device inversion. For example, body portiL:n (1) may be provided with one or more longitudinal spacer ribs (not shown) which project from the inner body surfaces to restrict lateral movement of the dispenser during day to day transport or accidental dropping by the user.
The dispenser may be removed for cleaning, freeing stem obstructions or replacement of a new aerosol vial upon exhaustion of the old, by the user simply lifting the dispenser against spring sufficient to disengage groove (14) from bracket arms and (10) and withdrawing the dispenser through the cover opening.
The extent of bracket displacement and hence lift imparted to the dispenser is proportional to the extent of the initial opening of the cover. Maximum dispenser lift and therefore spring compression is completed by displacing the cover through about 150′, whereas fully opening the cover requires a displacement of about 165′.
The user thus senses a stepped movement when displacing so. 15 the cover. During the first 150′ of displacement the in:. *cover works to compress the spring which reaches a maximum when pivot point passes through a straight ~Oline position defined by the upper surface (17) of bracket arm and pivot point (illustrated by 20 dotted line Bt Figure to an overcentre position at which the device is cocked.
The device may then be converted between two stable formats,# fully closed and fully open. Any intermediary position for cover opening is inherently 25 unstable, such that the casing will tend top~ards either of the stable formats, depending on which side of the 1501 step the cover presently lies. This prevents the cover from inadvertently snapping shut on the user’s facial extremities once fully opened and allows the cover to be far removed from obstructing the patient’s chin.
ease*: Additionally, the device is configured such that cover abuts a stop (16) to provide greater resistance to breakage at the pivot of c~over and housing as a result of mishandling or accidental dropping of the device.
The relative positions of the pivot points and allows the cover to be shaped tuch that, when the. cover is closed, the protective casing fully envelopes the inhaler restricting the ingress of contaminants.
Figures 6a and 7 of the accompanying drawings illustrate a breath-actuated inhaler in accordance with the invention in which the protective casing (34) may be modified to accommodate aerosol vials of different length. The body portion (SS) of the casing has an aperture (80) through which a shroud (82) extends which accommodates the aerosol vial (not shown). A series of shrouds (82) may be fabricated having different lengths in order to accommodate various sizes of aerosol vial.
Whilst a cooking spring may be positioned within the top of the shroud (82) (in a similar mianner to the cocking spring (15) shown in Figure to absorb and retain the cocking force applied when the cover is opened, a cocking spring external of the shroud (82) may 15 be employed. The shroud (82) is provided with a flange (84) and cocking spring (86) is positioned around the shroud (82) extending between the flange (84) and a stop or the top of the protective casing When the cover A is opened, the breath-actuated inhaler, together with 20 the shroud (82) is lifted (Figure 7) compressing cocking spring When the patient breathes through the mouthpiece, the breath-actuated mechanism is triggered moving the shroud (82) and aerosol vial downwards to fire AOOOthe aerosol valve.
25 In a further embodimnent of the invention (not illustrated in the drawings) the shroud (82) shown in Figures 8 and 10 may be dispensed with and replaced by a circumferential flange extending around the aerosol vial, equivalent to flange against which cocking spring 30 (86) will act. The circumferential flange may be fabricated as a snap-on component around the aerosol vial in the region of the neck of the vial. Thij; arrangement will obviate the need for fabricating a series of shrouds to accommodate the different sizes of aerosol vial, since the aerosol vial will simply extend through the, top of the protective casing.
Claims (19)
1. An inhalation device comprising: an inhaler comprising a housing which comprises a mouthpiece and actuation means having an inactive position in which dispensing from the inhaler is prevented and a cocked position in which dispensing from the inhaler is allowed, and (ii) a protective casing surrounding the inhaler, the casing comprising a biasing means for cocking the inhaler, a body portion, and a cover movable between open and closed positions which cover in the open position allows access to the mouthpiece, wherein movement to the open position causes relative movement of the inhaler and the biasing means thereby cocking the inhaler, characterized in that the cover is pivotally attached to said body portion and a cocking link is pivotally mounted at one end to the cover and has a portion in engagement with the inhaler or the biasing means, wherein pivotal movement of the cover from the closed position to the open position moves the inhaler relative to the biasing means via the cocking link and places the inhaler in the cocked position, and (ii) moves the pivot points between the cover and the cocking link and between the cover and the body portion through a straight line position to an overcenter position.
S2. An inhalation device as claimed in claim 1 in *which the cocking link portion is in pivotal engagement with the inhaler.
3. An inhalation device as claimed in claim 1 or claim 2 in which the inhaler comprises an aerosol vial containing propellant and medicament and equipped with a :dispensing valve.
4. An inhalation device as claimed in claim 1 or claim 2 in which the inhaler comprises a dry powder inhaler.
An inhalation device as claimed in any 39 o preceding claim in which the device includes guide means VF». F -8 to define the direction of movement of the portion of the cocking link engaging the inhaler.
6. An inhalation device as claimed in claim 5 in which the cocking link includes at least one guide arm engaging a slot or recess in the protective casing to define the direction of movement of the portion of the cocking link engaging the inhaler.
7. An inhalation device as claimed in any preceding claim in which the cocking link comprises a wishbone bracket having two arms, each arm engaging a guide recess in the body portion of the protective casing.
8. An inhalation device as claimed in any preceding claim in which the movement of the inhaler is in the axial direction of the inhaler.
9. An inhalation device as claimed in any preceding claim in which the movable cover pivots through at least 1500 to the fully opev position.
An inhalation device as claimed in any preceding claim in which the inhaler comprises a cylindrical vial and dispensing valve intended to be used i’,i a substantially vertical position with the valve lowermost.
11. An inhalation device as claimed in any preceding claim in which the protective casing completely envelops the inhaler when the cover is in the closed position.
12. An inhalation device as claimed in any preceding claim in which the inhaler is breath actuated.
13. An inhalation device as claimed in any preceding claim in which the biasing means is selec’ced from a compression spring or a deformable elastic member.
14. An inhalation device as claimed in any preceding cl~am in which the inhaler comprises an aerosol vial and the protective casing comprises a shroud surrounding the aerosol vial. An inhalation device as claimed in claim 14 in which the shroud is movable within the remainder of the protective casing and spring biased to urge the aerosol 39 vial towards a firing position.
SF 9 ,T
16. A protective casing for an inhaler having an active position and an inactive position, which casing comprises: a body portion defining a chamber adapted to house an inhaler therein, the chamber including biasing means for cocking said inhaler, and a cover movable between open and closed positions, which in the open position allows access to said inhaler, characterised in that the movable cover is pivotally attached to the body portion, and a cocking link is pivotally mounted at one end to the cover and has a portion adapted to provide engagement with said inhaler or said biasing means, wherein pivotal movement of the cover from the closed position to the open position moves the inhaler relative to the biasing means via the cocking link and places the inhaler in the cocked position and (ii) moves the pivot points between the cover and the cocking link and between the cover and the body portion through a straight line position to an overcenter position.
17. A protective casing as claimed in claim 16 having the features claimed in any one of claims 2 to
18. An inhalation device substantially as herein e 15 described with reference to any one of the accompanying drawings.
19. A protective casing for an inhaler substantially as herein described with reference to any one of the accompanying drawings. DATED: 23 March 1993 PHILLIPS ORMONDE FITZPATRICK Attorneys for: Qc efa ^fe^AL t^. RIKER LABORATORIES, INC. 9 s. 39 3197b 10
AU66649/90A
1989-11-14
1990-11-14
Inhalation device and protective casing therefor
Ceased
AU637649B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
GB8925707
1989-11-14
GB898925707A
GB8925707D0
(en)
1989-11-14
1989-11-14
Device
Publications (2)
Publication Number
Publication Date
AU6664990A
AU6664990A
(en)
1991-05-23
AU637649B2
true
AU637649B2
(en)
1993-06-03
Family
ID=10666271
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU66649/90A
Ceased
AU637649B2
(en)
1989-11-14
1990-11-14
Inhalation device and protective casing therefor
Country Status (9)
Country
Link
EP
(1)
EP0428380B1
(en)
JP
(1)
JPH03207375A
(en)
KR
(1)
KR910009293A
(en)
AU
(1)
AU637649B2
(en)
CA
(1)
CA2029736A1
(en)
DE
(1)
DE69003923T2
(en)
DK
(1)
DK0428380T3
(en)
ES
(1)
ES2044453T3
(en)
GB
(1)
GB8925707D0
(en)
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(en)
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1992-11-06
1996-10-09
Paul Richard Yerbury
Dust proof inhaler
WO1994020164A1
(en)
*
1993-03-03
1994-09-15
Glaxo Wellcome Inc.
Dry powder inhalator medicament carrier
US5388572A
(en)
*
1993-10-26
1995-02-14
Tenax Corporation (A Connecticut Corp.)
Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A
(en)
*
1993-12-02
1995-02-14
Tenax Corporation
Dry powder inhalator medicament carrier
KR100515795B1
(en)
*
1998-09-23
2005-11-25
도레이새한 주식회사
Biaxially Oriented Polyester Laminated Film
US6119853A
(en)
1998-12-18
2000-09-19
Glaxo Wellcome Inc.
Method and package for storing a pressurized container containing a drug
US6390291B1
(en)
1998-12-18
2002-05-21
Smithkline Beecham Corporation
Method and package for storing a pressurized container containing a drug
US6352152B1
(en)
1998-12-18
2002-03-05
Smithkline Beecham Corporation
Method and package for storing a pressurized container containing a drug
US6315112B1
(en)
1998-12-18
2001-11-13
Smithkline Beecham Corporation
Method and package for storing a pressurized container containing a drug
GB0015043D0
(en)
2000-06-21
2000-08-09
Glaxo Group Ltd
Medicament dispenser
GB0015034D0
(en)
*
2000-06-21
2000-08-09
Glaxo Group Ltd
Inhalation device
GB0015801D0
(en)
2000-06-28
2000-08-16
Innovata Biomed Ltd
Cover
AU2002251610A1
(en)
*
2001-12-25
2003-07-15
Evgeny Viktorovich Babarskov
Device for inhaling powder-like medicinal agents
US7814900B2
(en)
2002-03-22
2010-10-19
Clinical Designs Limited
Can fixture
GB0226022D0
(en)
*
2002-11-07
2002-12-18
Corporate Intellectual Propert
Device
GB0226021D0
(en)
*
2002-11-07
2002-12-18
Corporate Intellectual Propert
A container
GB0304000D0
(en)
2003-02-21
2003-03-26
Clinical Designs Ltd
Dispenser
GB0327112D0
(en)
2003-11-21
2003-12-24
Clincial Designs Ltd
Dispenser and reservoir
GB0328859D0
(en)
2003-12-12
2004-01-14
Clinical Designs Ltd
Dispenser and counter
ES2936138T3
(en)
2004-03-10
2023-03-14
Glaxo Group Ltd
A dispensing device
GB0425518D0
(en)
2004-11-19
2004-12-22
Clinical Designs Ltd
Substance source
GB0428204D0
(en)
2004-12-23
2005-01-26
Clinical Designs Ltd
Medicament container
GB0518355D0
(en)
2005-09-08
2005-10-19
Glaxo Group Ltd
An inhaler
GB0518400D0
(en)
2005-09-09
2005-10-19
Clinical Designs Ltd
Dispenser
WO2007109606A2
(en)
*
2006-03-17
2007-09-27
Csp Technologies, Inc.
Moisture-tight primary packaging for a dry powder inhaler
GB0904059D0
(en)
2009-03-10
2009-04-22
Euro Celtique Sa
Counter
GB0904040D0
(en)
2009-03-10
2009-04-22
Euro Celtique Sa
Counter
GB201615186D0
(en)
*
2016-09-07
2016-10-19
3M Innovative Properties Co
Energy storage mechanism for an inhaler
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Title
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Dart Ind Inc
Inhalation-responsive aerosol dispenser
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Rexall Drug Chemical
Dispensing device for flowing media, especially for inhalation devices
1989
1989-11-14
GB
GB898925707A
patent/GB8925707D0/en
active
Pending
1990
1990-11-13
EP
EP90312376A
patent/EP0428380B1/en
not_active
Expired – Lifetime
1990-11-13
ES
ES90312376T
patent/ES2044453T3/en
not_active
Expired – Lifetime
1990-11-13
DK
DK90312376.8T
patent/DK0428380T3/en
active
1990-11-13
KR
KR1019900018315A
patent/KR910009293A/en
not_active
Application Discontinuation
1990-11-13
CA
CA002029736A
patent/CA2029736A1/en
not_active
Abandoned
1990-11-13
DE
DE90312376T
patent/DE69003923T2/en
not_active
Expired – Fee Related
1990-11-14
JP
JP2308411A
patent/JPH03207375A/en
active
Pending
1990-11-14
AU
AU66649/90A
patent/AU637649B2/en
not_active
Ceased
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Assignee
Title
US3598294A
(en)
*
1969-11-13
1971-08-10
Dart Ind Inc
Inhalation-responsive aerosol dispenser
US4678106A
(en)
*
1984-07-31
1987-07-07
Glaxo Group Limited
Dispensing device
Also Published As
Publication number
Publication date
DE69003923T2
(en)
1994-05-05
ES2044453T3
(en)
1994-01-01
AU6664990A
(en)
1991-05-23
DK0428380T3
(en)
1993-12-13
JPH03207375A
(en)
1991-09-10
DE69003923D1
(en)
1993-11-18
EP0428380A1
(en)
1991-05-22
GB8925707D0
(en)
1990-01-04
CA2029736A1
(en)
1991-05-15
EP0428380B1
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1993-10-13
KR910009293A
(en)
1991-06-28
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