AU6560686A – Improved process for preparing 5-(2,5-dimethylphenoxy)- 2,2-dimethylpentanoic acid
– Google Patents
AU6560686A – Improved process for preparing 5-(2,5-dimethylphenoxy)- 2,2-dimethylpentanoic acid
– Google Patents
Improved process for preparing 5-(2,5-dimethylphenoxy)- 2,2-dimethylpentanoic acid
Info
Publication number
AU6560686A
AU6560686A
AU65606/86A
AU6560686A
AU6560686A
AU 6560686 A
AU6560686 A
AU 6560686A
AU 65606/86 A
AU65606/86 A
AU 65606/86A
AU 6560686 A
AU6560686 A
AU 6560686A
AU 6560686 A
AU6560686 A
AU 6560686A
Authority
AU
Australia
Prior art keywords
dimethylphenoxy
preparing
dimethylpentanoic acid
improved process
alkali metal
Prior art date
1985-12-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU65606/86A
Other versions
AU590358B2
(en
Inventor
Francis R. Kearney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1985-12-09
Filing date
1986-11-24
Publication date
1987-06-11
1986-11-24
Application filed by Warner Lambert Co LLC
filed
Critical
Warner Lambert Co LLC
1987-06-11
Publication of AU6560686A
publication
Critical
patent/AU6560686A/en
1989-11-02
Application granted
granted
Critical
1989-11-02
Publication of AU590358B2
publication
Critical
patent/AU590358B2/en
2006-11-24
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
Abstract
An improved two-step process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid (gemfibrozil) which regularly affords gembibrozil in overall yields in excess of 80% comprises reacting an alkali metal salt of a lower alkyl ester of 2-methylpropanoic acid with 1,3-dibromopropane or 1-bromo-3-chloropropane in a polar aprotic solvent such as tetrahydrofuran, and then reacting the intermediate thus formed with an alkali metal salt of 2,5-dimethylphenol in a mixed toluene/dimethylsulfoxide solvent system.
AU65606/86A
1985-12-09
1986-11-24
Improved process for preparing 5-(2,5-dimethylphenoxy)- 2,2-dimethylpentanoic acid
Ceased
AU590358B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US806312
1985-12-09
US06/806,312
US4665226A
(en)
1985-12-09
1985-12-09
Process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
Publications (2)
Publication Number
Publication Date
AU6560686A
true
AU6560686A
(en)
1987-06-11
AU590358B2
AU590358B2
(en)
1989-11-02
Family
ID=25193782
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU65606/86A
Ceased
AU590358B2
(en)
1985-12-09
1986-11-24
Improved process for preparing 5-(2,5-dimethylphenoxy)- 2,2-dimethylpentanoic acid
Country Status (22)
Country
Link
US
(1)
US4665226A
(en)
EP
(1)
EP0226161B1
(en)
JP
(1)
JP2506094B2
(en)
KR
(2)
KR870005954A
(en)
CN
(1)
CN1012896B
(en)
AT
(1)
ATE47832T1
(en)
AU
(1)
AU590358B2
(en)
CA
(1)
CA1267155A
(en)
DE
(1)
DE3666805D1
(en)
DK
(1)
DK174496B1
(en)
ES
(1)
ES2011245B3
(en)
FI
(1)
FI85974C
(en)
GR
(1)
GR3000216T3
(en)
HK
(1)
HK112193A
(en)
HU
(1)
HU195635B
(en)
IE
(1)
IE59499B1
(en)
IL
(1)
IL80885A
(en)
IN
(1)
IN166169B
(en)
NO
(1)
NO164293C
(en)
PH
(1)
PH24273A
(en)
PT
(1)
PT83888B
(en)
ZA
(1)
ZA868893B
(en)
Families Citing this family (10)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
HU210180B
(en)
*
1990-05-11
1995-02-28
Egyt Gyogyszervegyeszeti Gyar
Process for preparing halogeneted polybasic esters
US5235097A
(en)
*
1990-05-11
1993-08-10
Egis Gyogyszergyar
Process for the preparation of 2,2-dimethyl-5-(2,5-dimethyl-phenoxy)-pentanoic acid, intermediates for preparing this compound and process for preparing the intermediates
US5041640A
(en)
*
1990-09-20
1991-08-20
Warner-Lambert Company
Process for mono-, di-, trisubstituted acetic acids
BE1007058A3
(en)
*
1992-06-16
1995-03-07
Omnichem Sa
A NEW METHOD FOR THE PREPARATION OF ACID 5- (2,5-dimethylphenoxy) -2,2-DIMETHYL pentanoic.
IT1265087B1
(en)
*
1993-05-20
1996-10-30
Recordati Chem Pharm
GEMFIBROZIL PREPARATION PROCESS
US5530145A
(en)
*
1994-06-14
1996-06-25
Syn-Tech Chem & Pharm Co., Ltd.
Anticholesteremic compounds
US5412112A
(en)
*
1994-06-14
1995-05-02
Industrial Technology Research Institute
Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids
US20050261493A1
(en)
*
2002-08-08
2005-11-24
Mark Fulston
Methods for the isolation and purification of ansamitocins
CN101440032B
(en)
*
2008-11-13
2012-05-23
浙江大学
Gemfibrozil polycrystalline type and preparation thereof
WO2020212955A1
(en)
*
2019-04-18
2020-10-22
Hikal Limited
Process for the preparation of a key intermediate of gemfibrozil
Family Cites Families (6)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3674836A
(en)
*
1968-05-21
1972-07-04
Parke Davis & Co
2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
US3759986A
(en)
*
1970-03-30
1973-09-18
Parke Davis & Co
Esters of 2,2-dimethyl-5-(aryloxy)-1-pentanols
US3707566A
(en)
*
1970-03-30
1972-12-26
Parke Davis & Co
Aryloxypentane compounds
GB1422679A
(en)
*
1972-11-16
1976-01-28
Funai Pharmaceutical Ind Ltd
Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same
GB2025942A
(en)
*
1978-05-31
1980-01-30
Sori Soc Rech Ind
Phenoxyalkylcarboxylic acids
DK305884A
(en)
*
1983-06-24
1984-12-25
Yamanouchi Pharma Co Ltd
PHENOXYDER DERIVATIVE, PROCEDURE FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION CONTAINING SUCH DERIVATIVE
1985
1985-12-09
US
US06/806,312
patent/US4665226A/en
not_active
Expired – Lifetime
1986
1986-11-18
IN
IN1005/DEL/86A
patent/IN166169B/en
unknown
1986-11-19
IE
IE306086A
patent/IE59499B1/en
not_active
IP Right Cessation
1986-11-24
ZA
ZA868893A
patent/ZA868893B/en
unknown
1986-11-24
AU
AU65606/86A
patent/AU590358B2/en
not_active
Ceased
1986-11-25
CA
CA000523753A
patent/CA1267155A/en
not_active
Expired – Fee Related
1986-12-01
FI
FI864900A
patent/FI85974C/en
not_active
IP Right Cessation
1986-12-03
KR
KR860010302A
patent/KR870005954A/en
not_active
IP Right Cessation
1986-12-05
PH
PH34561A
patent/PH24273A/en
unknown
1986-12-05
IL
IL80885A
patent/IL80885A/en
unknown
1986-12-08
EP
EP86117076A
patent/EP0226161B1/en
not_active
Expired
1986-12-08
JP
JP61290642A
patent/JP2506094B2/en
not_active
Expired – Fee Related
1986-12-08
DK
DK198605882A
patent/DK174496B1/en
not_active
IP Right Cessation
1986-12-08
HU
HU865104A
patent/HU195635B/en
not_active
IP Right Cessation
1986-12-08
AT
AT86117076T
patent/ATE47832T1/en
not_active
IP Right Cessation
1986-12-08
DE
DE8686117076T
patent/DE3666805D1/en
not_active
Expired
1986-12-08
ES
ES86117076T
patent/ES2011245B3/en
not_active
Expired – Lifetime
1986-12-08
NO
NO864933A
patent/NO164293C/en
unknown
1986-12-09
PT
PT83888A
patent/PT83888B/en
not_active
IP Right Cessation
1986-12-09
CN
CN86108472A
patent/CN1012896B/en
not_active
Expired
1987
1987-12-03
KR
KR1019860010302Q
patent/KR950003120B1/en
active
1989
1989-11-15
GR
GR89400242T
patent/GR3000216T3/en
unknown
1993
1993-10-21
HK
HK1121/93A
patent/HK112193A/en
not_active
IP Right Cessation
Also Published As
Publication number
Publication date
FI85974C
(en)
1992-06-25
PT83888A
(en)
1987-01-01
JP2506094B2
(en)
1996-06-12
FI864900A
(en)
1987-06-10
GR3000216T3
(en)
1990-12-31
FI85974B
(en)
1992-03-13
CN86108472A
(en)
1987-07-22
DK588286A
(en)
1987-06-10
ATE47832T1
(en)
1989-11-15
FI864900A0
(en)
1986-12-01
IL80885A0
(en)
1987-03-31
EP0226161A1
(en)
1987-06-24
NO864933L
(en)
1987-06-10
AU590358B2
(en)
1989-11-02
HUT43024A
(en)
1987-09-28
DE3666805D1
(en)
1989-12-14
HU195635B
(en)
1988-06-28
US4665226A
(en)
1987-05-12
EP0226161B1
(en)
1989-11-08
PT83888B
(en)
1989-05-12
NO164293B
(en)
1990-06-11
NO164293C
(en)
1990-09-19
IN166169B
(en)
1990-03-24
IE59499B1
(en)
1994-03-09
DK174496B1
(en)
2003-04-22
KR950003120B1
(en)
1995-04-01
PH24273A
(en)
1990-05-29
CA1267155A
(en)
1990-03-27
HK112193A
(en)
1993-10-29
NO864933D0
(en)
1986-12-08
CN1012896B
(en)
1991-06-19
ZA868893B
(en)
1988-07-27
KR870005954A
(en)
1987-07-08
IE863060L
(en)
1987-06-09
DK588286D0
(en)
1986-12-08
ES2011245B3
(en)
1990-01-01
JPS62138447A
(en)
1987-06-22
IL80885A
(en)
1991-04-15
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A PROCEDURE FOR PREPARING P-CHLOROPHENOXYACETIL-PIPERONYL PIPERACINE.
JPS5325560A
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Preparation of 1-alkyl-2-aminoalkylpyrrolidine
JPS57120574A
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Method for increase of the silkworm productivity
Legal Events
Date
Code
Title
Description
2004-06-24
MK14
Patent ceased section 143(a) (annual fees not paid) or expired
