AU621749B2 – Process for synthesizing beta-lactam compounds
– Google Patents
AU621749B2 – Process for synthesizing beta-lactam compounds
– Google Patents
Process for synthesizing beta-lactam compounds
Info
Publication number
AU621749B2
AU621749B2
AU55093/90A
AU5509390A
AU621749B2
AU 621749 B2
AU621749 B2
AU 621749B2
AU 55093/90 A
AU55093/90 A
AU 55093/90A
AU 5509390 A
AU5509390 A
AU 5509390A
AU 621749 B2
AU621749 B2
AU 621749B2
Authority
AU
Australia
Prior art keywords
azetidinone
enyl
alk
lactam compounds
synthesizing beta
Prior art date
1987-09-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU55093/90A
Other versions
AU5509390A
(en
Inventor
Shoichiro Uyeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1987-09-22
Filing date
1990-05-16
Publication date
1992-03-19
1990-05-16
Application filed by Shionogi and Co Ltd
filed
Critical
Shionogi and Co Ltd
1990-10-04
Publication of AU5509390A
publication
Critical
patent/AU5509390A/en
1992-03-19
Application granted
granted
Critical
1992-03-19
Publication of AU621749B2
publication
Critical
patent/AU621749B2/en
2008-09-21
Anticipated expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
230000002194
synthesizing effect
Effects
0.000
title
abstract
2
-1
beta-lactam compounds
Chemical class
0.000
title
1
239000002253
acid
Substances
0.000
abstract
1
229940041011
carbapenems
Drugs
0.000
abstract
1
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
C07F7/02—Silicon compounds
C07F7/08—Compounds having one or more C—Si linkages
C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
C07F7/02—Silicon compounds
C07F7/08—Compounds having one or more C—Si linkages
C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
C07F7/1804—Compounds having Si-O-C linkages
Abstract
An intermediate for synthesizing carbapenems is produced through 1) a reaction of 4-(leaving group substituted)-2-azetidinone ( I ) with (alk-2-enyl)halosilane ( II ) to afford 4-(leaving group substituted)-1-(alk-2-enyl)silyl-2-azetidinone ( III ) and then 2) a reaction of the product 4-(leaving group substituted)-1-(alk-2-enyl)silyl-2-azetidinone ( III ) with acid to give the corresponding 4-(alk-2-enyl)-2-azetidinone ( IV ).
AU55093/90A
1987-09-22
1990-05-16
Process for synthesizing beta-lactam compounds
Expired
AU621749B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
JP23806687
1987-09-22
JP62-238066
1987-09-22
Related Parent Applications (1)
Application Number
Title
Priority Date
Filing Date
AU22466/88A
Division
AU600169B2
(en)
1987-09-22
1988-09-21
Alkenylsilylazetidinone intermediates for carbapenems
Publications (2)
Publication Number
Publication Date
AU5509390A
AU5509390A
(en)
1990-10-04
AU621749B2
true
AU621749B2
(en)
1992-03-19
Family
ID=17024647
Family Applications (2)
Application Number
Title
Priority Date
Filing Date
AU22466/88A
Expired
AU600169B2
(en)
1987-09-22
1988-09-21
Alkenylsilylazetidinone intermediates for carbapenems
AU55093/90A
Expired
AU621749B2
(en)
1987-09-22
1990-05-16
Process for synthesizing beta-lactam compounds
Family Applications Before (1)
Application Number
Title
Priority Date
Filing Date
AU22466/88A
Expired
AU600169B2
(en)
1987-09-22
1988-09-21
Alkenylsilylazetidinone intermediates for carbapenems
Country Status (9)
Country
Link
US
(1)
US4960880A
(en)
EP
(1)
EP0308867B1
(en)
KR
(1)
KR960006800B1
(en)
AT
(1)
ATE125543T1
(en)
AU
(2)
AU600169B2
(en)
CA
(1)
CA1327808C
(en)
DE
(1)
DE3854215T2
(en)
ES
(1)
ES2054604T3
(en)
GR
(2)
GR910300002T1
(en)
Families Citing this family (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR2653429B1
(en)
*
1989-10-25
1991-12-20
Adir
NOVEL DERIVATIVES OF AZETIDIN-2-ONE, 1,3,4-TRISUBSTITUES, INTERMEDIATES USEFUL FOR THE SYNTHESIS OF BETA-LACTAMS, AND THEIR ASYMMETRIC SYNTHESIS PROCESS.
GB9015485D0
(en)
*
1990-07-13
1990-08-29
Glaxo Spa
Heterocyclic derivatives
UA50705C2
(en)
*
1992-09-18
2002-11-15
Мерк Енд Ко, Інк
Method for production of beta-methyl carbapenem intermediate compounds, intermediate compounds
US7285674B2
(en)
*
2004-05-06
2007-10-23
Interuniversitair Microelektronica Centrum (Imec)
Silane molecules with pre-activated and protein-resistant functionalities and silane films comprising such molecules
Citations (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU613724B2
(en)
*
1988-03-23
1991-08-08
Shionogi & Co., Ltd.
A new process for carbapenem intermediates
Family Cites Families (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
JPS6253994A
(en)
*
1985-05-09
1987-03-09
Yamanouchi Pharmaceut Co Ltd
1-substituted silyl-4-oxo-2-azetidinecarboxylic acid lower alkyl ester
1988
1988-09-20
EP
EP88115397A
patent/EP0308867B1/en
not_active
Expired – Lifetime
1988-09-20
ES
ES88115397T
patent/ES2054604T3/en
not_active
Expired – Lifetime
1988-09-20
AT
AT88115397T
patent/ATE125543T1/en
not_active
IP Right Cessation
1988-09-20
DE
DE3854215T
patent/DE3854215T2/en
not_active
Expired – Lifetime
1988-09-21
AU
AU22466/88A
patent/AU600169B2/en
not_active
Expired
1988-09-21
US
US07/247,264
patent/US4960880A/en
not_active
Expired – Lifetime
1988-09-22
CA
CA000578191A
patent/CA1327808C/en
not_active
Expired – Lifetime
1988-09-22
KR
KR1019880012268A
patent/KR960006800B1/en
not_active
IP Right Cessation
1990
1990-05-16
AU
AU55093/90A
patent/AU621749B2/en
not_active
Expired
1991
1991-11-15
GR
GR91300002T
patent/GR910300002T1/en
unknown
1995
1995-09-06
GR
GR950402453T
patent/GR3017323T3/en
unknown
Patent Citations (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU613724B2
(en)
*
1988-03-23
1991-08-08
Shionogi & Co., Ltd.
A new process for carbapenem intermediates
Also Published As
Publication number
Publication date
EP0308867B1
(en)
1995-07-26
ATE125543T1
(en)
1995-08-15
AU5509390A
(en)
1990-10-04
CA1327808C
(en)
1994-03-15
EP0308867A2
(en)
1989-03-29
DE3854215T2
(en)
1995-12-21
ES2054604T3
(en)
1995-12-01
KR960006800B1
(en)
1996-05-23
EP0308867A3
(en)
1990-08-16
ES2054604T1
(en)
1994-08-16
GR3017323T3
(en)
1995-12-31
AU2246688A
(en)
1989-03-23
KR890005049A
(en)
1989-05-11
AU600169B2
(en)
1990-08-02
US4960880A
(en)
1990-10-02
GR910300002T1
(en)
1991-11-15
DE3854215D1
(en)
1995-08-31
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