AU686365B2 – New peptide compounds derived from boronic acid, process for preparing them and pharmaceutical compositions containing them
– Google Patents
AU686365B2 – New peptide compounds derived from boronic acid, process for preparing them and pharmaceutical compositions containing them
– Google Patents
New peptide compounds derived from boronic acid, process for preparing them and pharmaceutical compositions containing them
Info
Publication number
AU686365B2
AU686365B2
AU21801/95A
AU2180195A
AU686365B2
AU 686365 B2
AU686365 B2
AU 686365B2
AU 21801/95 A
AU21801/95 A
AU 21801/95A
AU 2180195 A
AU2180195 A
AU 2180195A
AU 686365 B2
AU686365 B2
AU 686365B2
Authority
AU
Australia
Prior art keywords
boronic acid
preparing
pharmaceutical compositions
compositions containing
compounds derived
Prior art date
1994-06-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU21801/95A
Other versions
AU2180195A
(en
Inventor
Guillaume De Nanteuil
Philippe Gloanec
Michel Laubie
Christine Lila
Alain Rupin
Serge Simonet
Tony Verbeuren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1994-06-22
Filing date
1995-06-20
Publication date
1998-02-05
1995-06-20
Application filed by ADIR SARL
filed
Critical
ADIR SARL
1996-01-04
Publication of AU2180195A
publication
Critical
patent/AU2180195A/en
1998-02-05
Application granted
granted
Critical
1998-02-05
Publication of AU686365B2
publication
Critical
patent/AU686365B2/en
2015-06-20
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
C07K5/06—Dipeptides
C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P7/00—Drugs for disorders of the blood or the extracellular fluid
A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K38/00—Medicinal preparations containing peptides
Abstract
Boronic acid peptide derivs. of formula (I) R1NH-C(R2)(R2′)-CO-A-CO-NH-CH(R3)-B(OR4)(OR5) and their enantiomers, diastereomers and epimers and their addn. salts are new. In (I), R1 is e.g. H, 1-6C acyl, 2-7C alkoxycarbonyl, benzyloxycarbonyl, etc.; R2 is e.g. H, Ph, thienylmethyl, (pyridinyl) methyl, diphenylmethyl, fluoroenyl, naphthylmethyl etc.; R2′ is H or benzyl; or R2+R2′ is CHPh; R3 is e.g. (CH2)mSC(=NH)NHR, (CH2)mN(R)CH=NH or gp. of formula (a) etc.; m =1-6; R is H or 1-6C alkyl; X is S or amino; R4 and R5 are H or 1-6C alkyl; or B(OR4)(OR5) is pinanediol boronic ester; A is N(A2)(CH2)n; n = 1-2; A2 is e.g. Ph, indanyl, 3-7C cycloalkyl (opt. ring substd. by 1-6C alkyl), 3-7C cycloalkenyl, bicyclo(2.1.1)hexyl etc..
AU21801/95A
1994-06-22
1995-06-20
New peptide compounds derived from boronic acid, process for preparing them and pharmaceutical compositions containing them
Ceased
AU686365B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
FR9407589A
FR2721611B1
(en)
1994-06-22
1994-06-22
New peptide derivatives of boronic acid, their process of preparation and the pharmaceutical compositions which contain them.
FR9407589
1994-06-22
Publications (2)
Publication Number
Publication Date
AU2180195A
AU2180195A
(en)
1996-01-04
AU686365B2
true
AU686365B2
(en)
1998-02-05
Family
ID=9464456
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU21801/95A
Ceased
AU686365B2
(en)
1994-06-22
1995-06-20
New peptide compounds derived from boronic acid, process for preparing them and pharmaceutical compositions containing them
Country Status (13)
Country
Link
US
(1)
US5585360A
(en)
EP
(1)
EP0688788B1
(en)
JP
(1)
JP2862496B2
(en)
CN
(1)
CN1121077A
(en)
AT
(1)
ATE199910T1
(en)
AU
(1)
AU686365B2
(en)
CA
(1)
CA2152205A1
(en)
DE
(1)
DE69520389D1
(en)
FI
(1)
FI953089A
(en)
FR
(1)
FR2721611B1
(en)
NO
(1)
NO952482L
(en)
NZ
(1)
NZ272401A
(en)
ZA
(1)
ZA955176B
(en)
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* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US6825169B1
(en)
1991-10-22
2004-11-30
Trustees Of Tufts College
Inhibitors of dipeptidyl-aminopeptidase type IV
US5707966A
(en)
*
1994-03-04
1998-01-13
Eli Lilly And Company
Antithrombotic agents
US5885967A
(en)
*
1994-03-04
1999-03-23
Eli Lilly And Company
Antithrombotic agents
CA2143533A1
(en)
*
1994-03-04
1995-09-05
Kenneth D. Kurz
Antithrombotic agents
US5726159A
(en)
*
1994-03-04
1998-03-10
Eli Lilly And Company
Antithrombotic agents
ZA951618B
(en)
*
1994-03-04
1996-08-27
Lilly Co Eli
Antithrombotic agents
US5705487A
(en)
*
1994-03-04
1998-01-06
Eli Lilly And Company
Antithrombotic agents
US5602101A
(en)
*
1994-03-04
1997-02-11
Eli Lilly And Company
Antithrombotic agents
US5914319A
(en)
*
1995-02-27
1999-06-22
Eli Lilly And Company
Antithrombotic agents
US5710130A
(en)
*
1995-02-27
1998-01-20
Eli Lilly And Company
Antithrombotic agents
US5811402A
(en)
*
1996-03-22
1998-09-22
Eli Lilly And Company
Antithrombotic diamides
US5965532A
(en)
1996-06-28
1999-10-12
Trustees Of Tufts College
Multivalent compounds for crosslinking receptors and uses thereof
US6194435B1
(en)
1996-10-11
2001-02-27
Cor Therapeutics, Inc.
Lactams as selective factor Xa inhibitors
US6063794A
(en)
1996-10-11
2000-05-16
Cor Therapeutics Inc.
Selective factor Xa inhibitors
US6262047B1
(en)
1996-10-11
2001-07-17
Cor Therapeutics, Inc.
Selective factor Xa inhibitors
US6369080B2
(en)
1996-10-11
2002-04-09
Cor Therapeutics, Inc.
Selective factor Xa inhibitors
US6369063B1
(en)
1997-04-14
2002-04-09
Cor Therapeutics, Inc.
Selective factor Xa inhibitors
JP2001523226A
(en)
1997-04-14
2001-11-20
シーオーアール セラピューティクス インコーポレイテッド
Selective factor Xa inhibitor
CA2285705A1
(en)
*
1997-04-14
1998-10-22
Cor Therapeutics, Inc.
Selective factor xa inhibitors
US6100234A
(en)
1997-05-07
2000-08-08
Tufts University
Treatment of HIV
US6040145A
(en)
1997-05-07
2000-03-21
Tufts University
Potentiation of the immune response
US6218382B1
(en)
1997-08-11
2001-04-17
Cor Therapeutics, Inc
Selective factor Xa inhibitors
US6228854B1
(en)
1997-08-11
2001-05-08
Cor Therapeutics, Inc.
Selective factor Xa inhibitors
US6333321B1
(en)
1997-08-11
2001-12-25
Cor Therapeutics, Inc.
Selective factor Xa inhibitors
NZ503359A
(en)
1997-09-29
2002-02-01
Point Therapeutics Inc
Method for proliferating haematopoietic cells in vitro in the absence of exogenous cytokines
MY132924A
(en)
1998-05-04
2007-10-31
Point Therapeutics Inc
Hematopoietic stimulation
US6890904B1
(en)
1999-05-25
2005-05-10
Point Therapeutics, Inc.
Anti-tumor agents
CA2446282A1
(en)
*
2001-05-30
2002-12-05
Novartis Ag
2-{[n-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid derivatives
EP1466916B1
(en)
2002-09-09
2007-10-24
Trigen Limited
Peptide boronic acids useful in making salts thereof
US20050119226A1
(en)
*
2003-09-09
2005-06-02
Trigen Limited
Methods for synthesizing organoboronic compounds and products thereof
US20050176651A1
(en)
*
2002-09-09
2005-08-11
Trigen Limited
Peptide boronic acids useful in making salts thereof
US7112572B2
(en)
*
2002-09-09
2006-09-26
Trigen Limited
Multivalent metal salts of boronic acids
US20060084592A1
(en)
*
2002-09-09
2006-04-20
Trigen Limited
Peptide boronic acid inhibitors
US20050282757A1
(en)
*
2002-09-09
2005-12-22
Trigen Limited
Peptide boronic acid compounds useful in anticoagulation
GB0405272D0
(en)
*
2004-03-09
2004-04-21
Trigen Ltd
Compounds
GB0507577D0
(en)
2005-04-14
2005-05-18
Novartis Ag
Organic compounds
Citations (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0471651A2
(en)
*
1990-08-13
1992-02-19
Sandoz Ltd.
Peptide boronic acid derivatives having protease inhibiting activity
WO1992007869A1
(en)
*
1990-11-06
1992-05-14
Thrombosis Research Institute
Inhibitors and substrates of thrombin
AU5630294A
(en)
*
1993-02-24
1994-09-01
Les Laboratoires Servier
New peptide compounds derived from boronic acid, process for preparing them and pharmaceutical compositions containing them
Family Cites Families (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US5187157A
(en)
*
1987-06-05
1993-02-16
Du Pont Merck Pharmaceutical Company
Peptide boronic acid inhibitors of trypsin-like proteases
US5288707A
(en)
*
1990-08-13
1994-02-22
Sandoz Ltd.
Borolysine peptidomimetics
IL109319A0
(en)
*
1993-04-27
1994-07-31
Du Pont Merck Pharma
Amidino and guanidino substituted boronic acid compounds
IL111175A0
(en)
*
1993-10-07
1994-12-29
Du Pont Merck Pharma
Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them
1994
1994-06-22
FR
FR9407589A
patent/FR2721611B1/en
not_active
Expired – Lifetime
1995
1995-06-02
US
US08/458,504
patent/US5585360A/en
not_active
Expired – Fee Related
1995-06-20
CA
CA002152205A
patent/CA2152205A1/en
not_active
Abandoned
1995-06-20
AU
AU21801/95A
patent/AU686365B2/en
not_active
Ceased
1995-06-21
AT
AT95401462T
patent/ATE199910T1/en
not_active
IP Right Cessation
1995-06-21
JP
JP7154218A
patent/JP2862496B2/en
not_active
Expired – Lifetime
1995-06-21
CN
CN95106659A
patent/CN1121077A/en
active
Pending
1995-06-21
DE
DE69520389T
patent/DE69520389D1/en
not_active
Expired – Lifetime
1995-06-21
NO
NO952482A
patent/NO952482L/en
not_active
Application Discontinuation
1995-06-21
EP
EP95401462A
patent/EP0688788B1/en
not_active
Expired – Lifetime
1995-06-21
NZ
NZ272401A
patent/NZ272401A/en
unknown
1995-06-21
FI
FI953089A
patent/FI953089A/en
unknown
1995-06-22
ZA
ZA955176A
patent/ZA955176B/en
unknown
Patent Citations (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0471651A2
(en)
*
1990-08-13
1992-02-19
Sandoz Ltd.
Peptide boronic acid derivatives having protease inhibiting activity
WO1992007869A1
(en)
*
1990-11-06
1992-05-14
Thrombosis Research Institute
Inhibitors and substrates of thrombin
AU5630294A
(en)
*
1993-02-24
1994-09-01
Les Laboratoires Servier
New peptide compounds derived from boronic acid, process for preparing them and pharmaceutical compositions containing them
Also Published As
Publication number
Publication date
CA2152205A1
(en)
1995-12-23
US5585360A
(en)
1996-12-17
JPH083187A
(en)
1996-01-09
FR2721611B1
(en)
1996-09-27
AU2180195A
(en)
1996-01-04
EP0688788A1
(en)
1995-12-27
NO952482D0
(en)
1995-06-21
FI953089A
(en)
1995-12-23
JP2862496B2
(en)
1999-03-03
FR2721611A1
(en)
1995-12-29
NO952482L
(en)
1995-12-27
FI953089A0
(en)
1995-06-21
DE69520389D1
(en)
2001-04-26
ATE199910T1
(en)
2001-04-15
EP0688788B1
(en)
2001-03-21
NZ272401A
(en)
1996-05-28
ZA955176B
(en)
1996-02-08
CN1121077A
(en)
1996-04-24
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Legal Events
Date
Code
Title
Description
2002-01-24
MK14
Patent ceased section 143(a) (annual fees not paid) or expired
