AU7575987A – N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
– Google Patents
AU7575987A – N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
– Google Patents
N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
Info
Publication number
AU7575987A
AU7575987A
AU75759/87A
AU7575987A
AU7575987A
AU 7575987 A
AU7575987 A
AU 7575987A
AU 75759/87 A
AU75759/87 A
AU 75759/87A
AU 7575987 A
AU7575987 A
AU 7575987A
AU 7575987 A
AU7575987 A
AU 7575987A
Authority
AU
Australia
Prior art keywords
phosphonylmethoxyalkyl
purines
pyrimidines
therapeutic application
derivatives
Prior art date
1986-07-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU75759/87A
Other versions
AU600002B2
(en
Inventor
Erik De Clercq
Antonin Holy
Ivan Rosenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stichting Rega VZW
Institute of Organic Chemistry and Biochemistry CAS
Original Assignee
Stichting Rega VZW
Institute of Organic Chemistry and Biochemistry CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1986-07-18
Filing date
1987-07-17
Publication date
1988-01-21
1987-07-17
Application filed by Stichting Rega VZW, Institute of Organic Chemistry and Biochemistry CAS
filed
Critical
Stichting Rega VZW
1988-01-21
Publication of AU7575987A
publication
Critical
patent/AU7575987A/en
1990-08-02
Application granted
granted
Critical
1990-08-02
Publication of AU600002B2
publication
Critical
patent/AU600002B2/en
1997-04-17
Assigned to STICHTING REGA VZW, INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
reassignment
STICHTING REGA VZW
Alteration of Name(s) in Register under S187
Assignors: CESKOSLOVENSKA AKADEMIE VED, STICHTING REGA VZW
2012-07-17
Adjusted expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
C07F9/02—Phosphorus compounds
C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
C07F9/02—Phosphorus compounds
C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P31/12—Antivirals
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
C07F9/02—Phosphorus compounds
C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
C07F9/6509—Six-membered rings
C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Abstract
This invention relates to new nucleotide analogues exhibiting antiviral activity which represent N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases and to methods for their preparation and to their use in pharmaceutical compositions. These compounds are easily accessible from heterocyclic bases and their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds according to this invention exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.
AU75759/87A
1986-07-18
1987-07-17
N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
Expired
AU600002B2
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
CS865469A
CS264222B1
(en)
1986-07-18
1986-07-18
N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
Publications (2)
Publication Number
Publication Date
AU7575987A
true
AU7575987A
(en)
1988-01-21
AU600002B2
AU600002B2
(en)
1990-08-02
Family
ID=5399635
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU75759/87A
Expired
AU600002B2
(en)
1986-07-18
1987-07-17
N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
Country Status (21)
Country
Link
US
(3)
US5142051A
(en)
EP
(1)
EP0253412B1
(en)
JP
(1)
JPH0822866B2
(en)
KR
(1)
KR950004179B1
(en)
AT
(1)
ATE57932T1
(en)
AU
(1)
AU600002B2
(en)
CA
(1)
CA1340856C
(en)
CS
(1)
CS264222B1
(en)
DE
(2)
DE19775085I2
(en)
DK
(1)
DK170646B1
(en)
EG
(1)
EG18273A
(en)
ES
(1)
ES2036194T3
(en)
FI
(1)
FI86856C
(en)
GR
(1)
GR3002534T3
(en)
IE
(1)
IE60117B1
(en)
IL
(1)
IL83235A
(en)
LU
(1)
LU90155I2
(en)
NL
(1)
NL970036I2
(en)
NZ
(1)
NZ221100A
(en)
PT
(1)
PT85354B
(en)
ZA
(1)
ZA875283B
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU613592B2
(en)
*
1986-11-18
1991-08-08
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
Families Citing this family (81)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
CS264222B1
(en)
*
1986-07-18
1989-06-13
Holy Antonin
N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
US5650510A
(en)
*
1986-11-18
1997-07-22
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
JPH0217199A
(en)
*
1988-07-05
1990-01-22
Japan Tobacco Inc
Production of 2′-deoxy-beta-adenosine
US5688778A
(en)
*
1989-05-15
1997-11-18
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Nucleoside analogs
US5302585A
(en)
*
1990-04-20
1994-04-12
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
DE69110528T2
(en)
*
1990-04-20
1996-03-14
Acad Of Science Czech Republic
Chiral 2- (phosphonomethoxy) propyl guanine as an antiviral agent.
CZ285420B6
(en)
*
1990-04-24
1999-08-11
Ústav Organické Chemie A Biochemie Avčr
N-(3-fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases, processes of their preparation and use
CS387190A3
(en)
*
1990-08-06
1992-03-18
Ustav Organicke Chemie A Bioch
(2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof
WO1992002511A1
(en)
*
1990-08-10
1992-02-20
Bristol-Myers Squibb Company
Novel process for the preparation of nucleotides
ATE167679T1
(en)
*
1990-09-14
1998-07-15
Acad Of Science Czech Republic
PHOSPHONATE PRECURSORS
US5208221A
(en)
*
1990-11-29
1993-05-04
Bristol-Myers Squibb Company
Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
KR0184530B1
(en)
*
1991-10-11
1999-05-15
카렐 마르티넥
Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives
US6057305A
(en)
1992-08-05
2000-05-02
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Antiretroviral enantiomeric nucleotide analogs
US5817647A
(en)
*
1993-04-01
1998-10-06
Merrell Pharmaceuticals Inc.
Unsaturated acetylene phosphonate derivatives of purines
US5514798A
(en)
*
1993-06-02
1996-05-07
Gilead Sciences, Inc.
Method and cyclic carbonates for nucleotide analogues
US5798340A
(en)
*
1993-09-17
1998-08-25
Gilead Sciences, Inc.
Nucleotide analogs
WO1995007919A1
(en)
*
1993-09-17
1995-03-23
Gilead Sciences, Inc.
Method for dosing therapeutic compounds
US5656745A
(en)
*
1993-09-17
1997-08-12
Gilead Sciences, Inc.
Nucleotide analogs
US5502177A
(en)
*
1993-09-17
1996-03-26
Gilead Sciences, Inc.
Pyrimidine derivatives for labeled binding partners
US5468752A
(en)
*
1994-04-04
1995-11-21
Freeman; William R.
Treatment of conditions of abnormally increased intraocular pressure by administration of HPMPC and related phosphonylmethoxyalkylcytosines
JPH09511507A
(en)
*
1994-04-04
1997-11-18
フリーマン，ウイリアム・アール
Use of phosphonyl methoxyalkyl nucleosides to treat elevated intraocular pressure
US5977061A
(en)
*
1995-04-21
1999-11-02
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
N6 – substituted nucleotide analagues and their use
US5717095A
(en)
*
1995-12-29
1998-02-10
Gilead Sciences, Inc.
Nucleotide analogs
US6093816A
(en)
1996-06-27
2000-07-25
Isis Pharmaceuticals, Inc.
Cationic lipids
US5922695A
(en)
*
1996-07-26
1999-07-13
Gilead Sciences, Inc.
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
EP1256585B1
(en)
*
1997-07-25
2004-09-29
Gilead Sciences, Inc.
Process for preparing 9-(2-(diethylphosphonomethoxy)ethyl)-adenine
DE69923338T2
(en)
*
1998-11-02
2006-04-06
Gilead Sciences, Inc., Foster City
COMBINATION THERAPY FOR THE TREATMENT OF HEPATITIS B INFECTIONS
US6407077B1
(en)
1998-11-05
2002-06-18
Emory University
β-L nucleosides for the treatment of HIV infection
US7205404B1
(en)
*
1999-03-05
2007-04-17
Metabasis Therapeutics, Inc.
Phosphorus-containing prodrugs
EP1244668B1
(en)
*
2000-01-07
2006-04-05
Universitaire Instelling Antwerpen
Purine derivatives, process for their preparation and use thereof
AUPQ806700A0
(en)
*
2000-06-08
2000-07-06
Commonwealth Scientific And Industrial Research Organisation
Antiviral agents
UA75889C2
(en)
2000-07-21
2006-06-15
Гіліад Сайєнсіз, Інк.
Phosphonatnucleotide analogs prodrugs, a method for selection and preparation thereof
DE60207850T2
(en)
2001-03-01
2006-08-10
Abbott Laboratories, Abbott Park
POLYMORPH AND OTHER CRYSTALLINE FORMS OF CIS-FTC
CN1329404C
(en)
2001-06-29
2007-08-01
捷克科学院有机化学和生物化学研究所
6-2′-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral acticity
US7247621B2
(en)
*
2002-04-30
2007-07-24
Valeant Research & Development
Antiviral phosphonate compounds and methods therefor
CA2485597C
(en)
*
2002-05-13
2013-07-02
Metabasis Therapeutics, Inc.
Process for preparation of cyclic prodrugs of pmea and pmpa
NZ536328A
(en)
2002-05-13
2007-11-30
Metabasis Therapeutics Inc
Novel phosphonic acid based prodrugs of PMEA and its analogues
EP1923063A3
(en)
*
2003-01-14
2009-04-08
Gilead Sciences, Inc.
Compositions and methods for combination antiviral therapy
ATE496056T1
(en)
*
2003-06-16
2011-02-15
Acad Of Science Czech Republic
PYRIMIDINE COMPOUNDS WITH PHOSPHONATE GROUPS AS ANTIVIRAL NUCLEOTIDE ANALOGS
US20050080053A1
(en)
*
2003-08-29
2005-04-14
Biocryst Pharmaceuticals, Inc.
Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
EP1686949A2
(en)
*
2003-11-24
2006-08-09
Viropharma Incorporated
Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
WO2005090370A1
(en)
*
2004-02-05
2005-09-29
The Regents Of The University Of California
Pharmacologically active agents containing esterified phosphonates and methods for use thereof
KR20070011451A
(en)
2004-05-05
2007-01-24
예일 유니버시티
Novel antiviral helioxanthin analogs
CN1964967B
(en)
*
2004-06-08
2014-04-16
症变治疗公司
Lewis acid mediated synthesis of cyclic esters
WO2006066074A2
(en)
2004-12-16
2006-06-22
The Regents Of The University Of California
Lung-targeted drugs
WO2006130217A2
(en)
*
2005-04-01
2006-12-07
The Regents Of The University Of California
Substituted phosphate esters of nucleoside phosphonates
EP1868628B1
(en)
2005-04-08
2014-06-11
Chimerix, Inc.
Compounds, compositions and methods for the treatment of poxvirus infections
WO2006110656A2
(en)
*
2005-04-08
2006-10-19
Chimerix, Inc.
Compounds, compositions and methods for the treatment of viral infections and other medical disorders
TWI471145B
(en)
2005-06-13
2015-02-01
Bristol Myers Squibb & Gilead Sciences Llc
Unitary pharmaceutical dosage form
TWI375560B
(en)
2005-06-13
2012-11-01
Gilead Sciences Inc
Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
CN100526315C
(en)
2005-06-16
2009-08-12
浙江医药股份有限公司新昌制药厂
N2-quinoline or isoquinoline substituted purine derivative and its preparation method and uses
SG166791A1
(en)
2005-07-25
2010-12-29
Intermune Inc
Novel macrocyclic inhibitors of hepatitis c virus replication
DE602006019323D1
(en)
*
2005-10-11
2011-02-10
Intermune Inc
COMPOUNDS AND METHOD FOR INHIBITING THE REPLICATION OF THE HEPATITIS C VIRUS
US8076303B2
(en)
2005-12-13
2011-12-13
Spring Bank Pharmaceuticals, Inc.
Nucleotide and oligonucleotide prodrugs
FR2908133B1
(en)
2006-11-08
2012-12-14
Centre Nat Rech Scient
NOVEL NUCLEOTIDE ANALOGUES AS ANTIVIRAL PRECURSOR MOLECULES
GB0709408D0
(en)
*
2007-05-16
2007-06-27
Katholleke Universiteit Leuven
Anti-col herpes virus compounds
US20090181931A1
(en)
*
2008-01-16
2009-07-16
Oncolys Biopharma, Inc.
Antiviral activity of cidofovir against oncolytic viruses
JP5562255B2
(en)
2008-01-25
2014-07-30
キメリクス，インコーポレイテッド
How to treat viral infections
TWI444384B
(en)
2008-02-20
2014-07-11
Gilead Sciences Inc
Nucleotide analogues and their use in the treatment of malignancies
US20110059921A1
(en)
*
2008-03-27
2011-03-10
Ektar Therapeutics
Oligomer-Nitrogenous Base Conjugates
AP2010005416A0
(en)
*
2008-04-15
2010-10-31
Intermune Inc
Novel macrocyclic inhibitors of hepatitis c virus replication.
AU2009303483A1
(en)
*
2008-10-15
2010-04-22
Intermune, Inc.
Therapeutic antiviral peptides
US8614200B2
(en)
2009-07-21
2013-12-24
Chimerix, Inc.
Compounds, compositions and methods for treating ocular conditions
EP2462152A4
(en)
2009-08-03
2013-02-13
Chimerix Inc
Composition and methods of treating viral infections and viral induced tumors
TW201116540A
(en)
*
2009-10-01
2011-05-16
Intermune Inc
Therapeutic antiviral peptides
ES2629165T3
(en)
2010-02-12
2017-08-07
Chimerix, Inc.
Methods of treating a viral infection
EP2371369A1
(en)
2010-04-01
2011-10-05
Institut Gustave Roussy (IGR)
EGFR inhibitor and antiviral agent for simultaneous, separate or sequential use in the treatment and/or prevention and/or palliation of cancer
EP2563367A4
(en)
2010-04-26
2013-12-04
Chimerix Inc
Methods of treating retroviral infections and related dosage regimes
EP2648701B1
(en)
2010-12-10
2023-05-24
Sigmapharm Laboratories, LLC
Highly stable compositions of adefovir dipivoxil
CA2825825A1
(en)
*
2011-01-27
2012-08-02
The Trustees Of Princeton University
Inhibitors of mtor kinase as anti-viral agents
WO2012138954A1
(en)
2011-04-07
2012-10-11
Johnson Matthey Public Limited Company
Forms of cidofovir
WO2013095684A1
(en)
2011-12-22
2013-06-27
Geron Corporation
Guanine analogs as telomerase substrates and telomere length affectors
WO2013167743A1
(en)
2012-05-11
2013-11-14
Akron Molecules Gmbh
Use of compounds for the treatment of pain
CA2889903C
(en)
2012-10-29
2021-03-09
Manjinder Singh Phull
Antiviral phosphonate analogues and process for preparation thereof
AU2014228321C1
(en)
2013-03-15
2019-07-11
The Regents Of The University Of California
Acyclic nucleoside phosphonate diesters
CN106061984A
(en)
2014-02-13
2016-10-26
配体药物公司
Prodrug compounds and their uses
WO2016003812A1
(en)
2014-07-02
2016-01-07
Ligand Pharmaceuticals, Inc.
Prodrug compounds and uses therof
AU2015317972B2
(en)
2014-09-15
2019-10-17
The Regents Of The University Of California
Nucleotide analogs
WO2017048956A1
(en)
2015-09-15
2017-03-23
The Regents Of The University Of California
Nucleotide analogs
TWI740910B
(en)
*
2016-03-09
2021-10-01
美商艾洛斯生物製藥公司
Acyclic antivirals
US20230218644A1
(en)
2020-04-16
2023-07-13
Som Innovation Biotech, S.A.
Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
Family Cites Families (15)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4287188A
(en)
*
1977-02-24
1981-09-01
Burroughs Wellcome Co.
Purine derivatives
AU521577B2
(en)
*
1977-02-24
1982-04-22
Wellcome Foundation Limited, The
9-hydroxyethoxymethyl guanine phosphates
DE2909709A1
(en)
*
1979-03-12
1980-09-25
Kailash Kumar Dr Gauri
Nucleotide derivs. of purine, pyrimidine or (dihydro)pyridone base – having antiviral activity against resistant herpes virus strains
FI833504A
(en)
*
1982-09-30
1984-03-31
Syntex Inc
1-MONOPHOSPHATESTRAR, 1,3-BISPHOSPHATESTRAR OCH CYCLIC PHOSPHATESTRAR AV 9- (1,3-DIHYDROXI-2-PROPOXIMETHYL) -GUAN SAOSOM ANTIVIRALA AEMNEN
CS233665B1
(en)
*
1983-01-06
1985-03-14
Antonin Holy
Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
US5047533A
(en)
*
1983-05-24
1991-09-10
Sri International
Acyclic purine phosphonate nucleotide analogs
IL72173A0
(en)
*
1983-06-24
1984-10-31
Merck & Co Inc
Guanine derivatives,their preparation and pharmaceutical compositions containing them
US4670424A
(en)
*
1983-09-19
1987-06-02
Merck & Co., Inc.
Cyclic pyrophosphates of purine and pyrimidine acyclonucleosides
US4590269A
(en)
*
1984-03-29
1986-05-20
Syntex (U.S.A.) Inc.
Process for preparing the cyclic phosphate ester of substituted 9-(1,3-dihydroxy-2-propoxymethyl)purines
US4579849A
(en)
*
1984-04-06
1986-04-01
Merck & Co., Inc.
N-alkylguanine acyclonucleosides as antiviral agents
CS263951B1
(en)
*
1985-04-25
1989-05-12
Antonin Holy
9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1
(en)
*
1985-04-25
1989-05-12
Holy Antonin
Remedy with antiviral effect
CS264222B1
(en)
*
1986-07-18
1989-06-13
Holy Antonin
N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
NZ222553A
(en)
*
1986-11-18
1991-07-26
Bristol Myers Co
Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
CA1330794C
(en)
*
1987-03-27
1994-07-19
Phillip Frost
Anti-viral compounds, dosage forms and methods
1986
1986-07-18
CS
CS865469A
patent/CS264222B1/en
not_active
IP Right Cessation
1987
1987-07-16
NZ
NZ221100A
patent/NZ221100A/en
unknown
1987-07-17
DE
DE1997175085
patent/DE19775085I2/en
active
Active
1987-07-17
ES
ES198787110399T
patent/ES2036194T3/en
not_active
Expired – Lifetime
1987-07-17
FI
FI873165A
patent/FI86856C/en
not_active
IP Right Cessation
1987-07-17
IL
IL83235A
patent/IL83235A/en
not_active
IP Right Cessation
1987-07-17
US
US07/074,900
patent/US5142051A/en
not_active
Expired – Lifetime
1987-07-17
ZA
ZA875283A
patent/ZA875283B/en
unknown
1987-07-17
IE
IE194487A
patent/IE60117B1/en
not_active
IP Right Cessation
1987-07-17
AU
AU75759/87A
patent/AU600002B2/en
not_active
Expired
1987-07-17
CA
CA000542404A
patent/CA1340856C/en
not_active
Expired – Lifetime
1987-07-17
EP
EP87110399A
patent/EP0253412B1/en
not_active
Expired – Lifetime
1987-07-17
DE
DE8787110399T
patent/DE3765864D1/en
not_active
Expired – Lifetime
1987-07-17
DK
DK373487A
patent/DK170646B1/en
not_active
IP Right Cessation
1987-07-17
AT
AT87110399T
patent/ATE57932T1/en
active
1987-07-18
JP
JP62179877A
patent/JPH0822866B2/en
not_active
Expired – Lifetime
1987-07-18
KR
KR87007844A
patent/KR950004179B1/en
not_active
IP Right Cessation
1987-07-19
EG
EG42/87A
patent/EG18273A/en
active
1987-07-20
PT
PT85354A
patent/PT85354B/en
unknown
1990
1990-11-19
GR
GR90400937T
patent/GR3002534T3/en
unknown
1994
1994-10-11
US
US08/320,591
patent/US5641763A/en
not_active
Expired – Lifetime
1995
1995-03-28
US
US08/412,398
patent/US5869467A/en
not_active
Expired – Lifetime
1997
1997-10-01
NL
NL970036C
patent/NL970036I2/en
unknown
1997-10-21
LU
LU90155C
patent/LU90155I2/en
unknown
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU613592B2
(en)
*
1986-11-18
1991-08-08
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
Also Published As
Publication number
Publication date
KR950004179B1
(en)
1995-04-27
NL970036I1
(en)
1997-12-01
ZA875283B
(en)
1988-03-30
DK373487A
(en)
1988-01-19
FI86856C
(en)
1992-10-26
LU90155I2
(en)
1997-12-22
EP0253412A3
(en)
1989-04-26
US5142051A
(en)
1992-08-25
FI873165A
(en)
1988-01-19
EP0253412A2
(en)
1988-01-20
DK170646B1
(en)
1995-11-20
EG18273A
(en)
1992-12-30
DE19775085I2
(en)
2004-01-15
AU600002B2
(en)
1990-08-02
KR880001688A
(en)
1988-04-26
JPH0822866B2
(en)
1996-03-06
US5641763A
(en)
1997-06-24
FI873165A0
(en)
1987-07-17
PT85354B
(en)
1990-04-30
IL83235A
(en)
1992-11-15
DK373487D0
(en)
1987-07-17
NL970036I2
(en)
1998-03-02
IE60117B1
(en)
1994-06-01
JPS6345289A
(en)
1988-02-26
DE3765864D1
(en)
1990-12-06
EP0253412B1
(en)
1990-10-31
GR3002534T3
(en)
1993-01-25
ES2036194T3
(en)
1993-05-16
CS546986A1
(en)
1988-08-16
IL83235A0
(en)
1987-12-31
PT85354A
(en)
1987-08-01
US5869467A
(en)
1999-02-09
NZ221100A
(en)
1991-09-25
IE871944L
(en)
1988-01-18
CS264222B1
(en)
1989-06-13
FI86856B
(en)
1992-07-15
CA1340856C
(en)
1999-12-21
ATE57932T1
(en)
1990-11-15
Similar Documents
Publication
Publication Date
Title
EG18273A
(en)
1992-12-30
N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
HUT70505A
(en)
1995-10-30
Pyrrolo[2,3-d]pyrimidine derivatives, pharmaceutical compositions containing them and process for preparing them
HU9401445D0
(en)
1994-08-29
Nor-bile-acid derivatives, process for producing them and pharmaceutical compositions containing them
HU896762D0
(en)
1990-03-28
Process for preparation of pyrimidine-derivatives and for manufacturing of pharmaceutical compositions containing these compounds
IL88755A
(en)
1993-01-31
(1:, 2, 3:)-3-substituted-2- hydroxycyclo- butanemethanol derivatives and pharmaceutical and veterinary compositions containing the same
IL81002A
(en)
1991-07-18
3,4-diphenyl-pyrazoline-1-carboxamide derivatives,processes for the preparation thereof and insecticidal and acaricidal compositions containing the same
PT85128A
(en)
1987-07-01
Process for the preparation of pharmaceutical compounds containing as active ingredient 4-(1-methyl-4-piperydilidene)-4h-benzo-(4,5)-cyclohepta(1,2-b)thiophene-10(9h)-one
EP0321968A3
(en)
1990-10-31
Compounds active on the cardiovascular system
CA2046755A1
(en)
1992-02-07
/2r/-2-[di/2-propyl/phosphonylmethoxy]-3-p-toluenesulfonyloxy-1-trimethylacetoxypropane, its preparation and use
ES2013379A6
(en)
1990-05-01
Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
EP0333000A3
(en)
1990-11-28
Peptides with inhibitory activity of enzymatic systems, process for their preparation and pharmaceutical compositions containing them
PT85866A
(en)
1987-11-01
Process for the preparation of therapeutic agents for the treatment of peptic ulcers containing 1,2,3,6-tetrahydro-3-methyl-1-(5-oxohexyl)-7-propyl-purine,6-dione and their derivatives
IT1223395B
(en)
1990-09-19
CARDIOVASCULAR ACTIVITY COMPOUNDS
EP0332999A3
(en)
1990-11-28
Peptides with inhibitory activity of enzymatic systems, process for their preparation and pharmaceutical compositions containing them
IT8125874D0
(en)
1981-12-29
THERAPEUTIC COMPOSITIONS COLERETIC ADAPTIVITY CONTAINING AS AN ACTIVE PRINCIPLE DERIVED FROM COLANIC ACID.
EP0321967A3
(en)
1990-10-24
Compounds active on the cardiovascular system
TW360630B
(en)
1999-06-11
A secoaporphine compounds on arrhythmia
Legal Events
Date
Code
Title
Description
2000-02-03
NDB
Extension of term for standard patent granted (sect.76)
