GB1022010A

GB1022010A – Process for the production of new substituted malonic acid monohydrazides
– Google Patents

GB1022010A – Process for the production of new substituted malonic acid monohydrazides
– Google Patents
Process for the production of new substituted malonic acid monohydrazides

Info

Publication number
GB1022010A

GB1022010A
GB23327/64A
GB2332764A
GB1022010A
GB 1022010 A
GB1022010 A
GB 1022010A
GB 23327/64 A
GB23327/64 A
GB 23327/64A
GB 2332764 A
GB2332764 A
GB 2332764A
GB 1022010 A
GB1022010 A
GB 1022010A
Authority
GB
United Kingdom
Prior art keywords
compound
aqueous
general formula
malonic acid
acid
Prior art date
1963-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB23327/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-06-07
Filing date
1964-06-05
Publication date
1966-03-09

1964-06-05
Application filed by JR Geigy AG
filed
Critical
JR Geigy AG

1966-03-09
Publication of GB1022010A
publication
Critical
patent/GB1022010A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes

Abstract

The invention comprises compounds of the general formula wherein R1 is a hydrocarbon radical of up to 8C and R2 is H or halogen, their salts with organic or inorganic bases and the preparation thereof (a) by heating in an aqueous or aqueous-organic medium a compound of the general formula with an inorganic base, forming the acid and optionally preparing the base from the acid; (b) by hydrolysing or hydrogenolysing an alkyl or benzyl ester of compounds I; and (c) reacting an alkali metal salt of compound II with an aqueous hypohalogenite solution and reducing the compound formed of the general formula until the halogen atom in the alpha-position has been removed or hydrogenating the compound IV in the presence of an acid binding substance. n-Butyl malonic acid ethyl ester-N,N-diphenyl-hydrazide is prepared by reacting n-butyl malonic acid monoethyl ester and hydrazobenzene in the presence of dicyclohexylcarbodiimide. Pharmaceutical compositions comprise compounds I and a pharmaceutical carrier. The compositions, which show antipyretic and antiphlogistic acticity, may be formulated as tablets, capsules, suppositories or solutions for injection.

GB23327/64A
1963-06-07
1964-06-05
Process for the production of new substituted malonic acid monohydrazides

Expired

GB1022010A
(en)

Applications Claiming Priority (3)

Application Number
Priority Date
Filing Date
Title

CH716763A

CH421989A
(en)

1963-06-07
1963-06-07

Process for the preparation of new substituted malonic acid monohydrazides

CH716863A

CH421990A
(en)

1963-06-07
1963-06-07

Process for the preparation of new substituted malonic acid monohydrazides

CH716963A

CH421991A
(en)

1963-06-07
1963-06-07

Process for the preparation of new substituted malonic acid monohydrazides

Publications (1)

Publication Number
Publication Date

GB1022010A
true

GB1022010A
(en)

1966-03-09

Family
ID=27175718
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB23327/64A
Expired

GB1022010A
(en)

1963-06-07
1964-06-05
Process for the production of new substituted malonic acid monohydrazides

Country Status (10)

Country
Link

US
(1)

US3455999A
(en)

BE
(1)

BE648912A
(en)

CH
(3)

CH421989A
(en)

DE
(3)

DE1792714A1
(en)

DK
(4)

DK109928C
(en)

ES
(4)

ES300710A1
(en)

FI
(1)

FI42089B
(en)

FR
(2)

FR1410244A
(en)

GB
(1)

GB1022010A
(en)

NL
(1)

NL127616C
(en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE2915949A1
(en)

*

1979-04-20
1980-11-06
Angeli Inst Spa

NEW N, N’-DIPHENYLHYDRAZINE DERIVATIVE AND METHOD FOR THE PRODUCTION THEREOF

1963

1963-06-07
CH
CH716763A
patent/CH421989A/en
unknown

1963-06-07
CH
CH716963A
patent/CH421991A/en
unknown

1963-06-07
CH
CH716863A
patent/CH421990A/en
unknown

1964

1964-06-02
US
US372104A
patent/US3455999A/en
not_active
Expired – Lifetime

1964-06-04
FI
FI1204/64A
patent/FI42089B/fi
active

1964-06-05
NL
NL6406412A
patent/NL127616C/nl
active

1964-06-05
DE
DE19641792714
patent/DE1792714A1/en
active
Granted

1964-06-05
GB
GB23327/64A
patent/GB1022010A/en
not_active
Expired

1964-06-05
DE
DE19641543633
patent/DE1543633B1/en
active
Pending

1964-06-05
BE
BE648912D
patent/BE648912A/xx
unknown

1964-06-05
DE
DEG40774A
patent/DE1235936B/en
active
Pending

1964-06-06
DK
DK443465AA
patent/DK109928C/en
active

1964-06-06
DK
DK443365AA
patent/DK109927C/en
active

1964-06-06
ES
ES0300710A
patent/ES300710A1/en
not_active
Expired

1964-06-06
DK
DK282964AA
patent/DK112737B/en
unknown

1964-06-06
ES
ES300709A
patent/ES300709A1/en
not_active
Expired

1964-06-06
ES
ES300707A
patent/ES300707A1/en
not_active
Expired

1964-06-06
FR
FR977360A
patent/FR1410244A/en
not_active
Expired

1964-06-06
ES
ES300708A
patent/ES300708A1/en
not_active
Expired

1964-09-05
FR
FR987243A
patent/FR3853M/fr
not_active
Expired

1965

1965-08-30
DK
DK443565AA
patent/DK111490B/en
unknown

Also Published As

Publication number
Publication date

NL6406412A
(en)

1964-12-08

NL127616C
(en)

1969-11-17

BE648912A
(en)

1964-12-07

DE1235936B
(en)

1967-03-09

DK109928C
(en)

1968-08-05

ES300710A1
(en)

1965-05-16

CH421990A
(en)

1966-10-15

US3455999A
(en)

1969-07-15

DK112737B
(en)

1969-01-13

DE1793629A1
(en)

1972-03-09

DK111490B
(en)

1968-09-02

FI42089B
(en)

1970-02-02

CH421991A
(en)

1966-10-15

DK109927C
(en)

1968-08-05

CH421989A
(en)

1966-10-15

ES300709A1
(en)

1964-11-16

DE1543633B1
(en)

1971-08-12

FR3853M
(en)

1966-01-17

FR1410244A
(en)

1965-09-10

DE1792714A1
(en)

1972-01-05

ES300708A1
(en)

1964-11-16

DE1793629B2
(en)

1977-03-31

ES300707A1
(en)

1964-11-16

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