GB1046226A

GB1046226A – Substituted tetrahydroquinolines
– Google Patents

GB1046226A – Substituted tetrahydroquinolines
– Google Patents
Substituted tetrahydroquinolines

Info

Publication number
GB1046226A

GB1046226A
GB29972/63A
GB2997263A
GB1046226A
GB 1046226 A
GB1046226 A
GB 1046226A
GB 29972/63 A
GB29972/63 A
GB 29972/63A
GB 2997263 A
GB2997263 A
GB 2997263A
GB 1046226 A
GB1046226 A
GB 1046226A
Authority
GB
United Kingdom
Prior art keywords
alkyl
tetrahydroquinolines
antipyretic
sedative
oxo
Prior art date
1962-07-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB29972/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1962-07-27
Filing date
1963-07-29
Publication date
1966-10-19

1963-07-29
Application filed by Dr Karl Thomae GmbH
filed
Critical
Dr Karl Thomae GmbH

1966-10-19
Publication of GB1046226A
publication
Critical
patent/GB1046226A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems

C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom

C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D215/20—Oxygen atoms

C07D215/24—Oxygen atoms attached in position 8

C07D215/26—Alcohols; Ethers thereof

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems

C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom

C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D215/20—Oxygen atoms

C07D215/22—Oxygen atoms attached in position 2 or 4

C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Abstract

The invention comprises substituted 2-oxo-tetrahydroquinolines of general formulae wherein R1 is hydrogen or C1-C3 alkyl, R2 is halogen and R3 is C1-C3 alkyl, and the preparation thereof either by halogenation of a compound of formulae or (for compounds in which R1 is a straight-chained alkyl group) by cyclization of a compound of general formula wherein n is 1 or 2, X is a reactive substituent, R4 is H or a C1 or C2 alkyl radical if n is 2 an is H or a straight-chained C1-C3 alkyl radical if n is 1, by heating at between 80 DEG and 200 DEG C. with aluminium chloride, preferably in an inert solvent or in the presence of an alkali metal halide.ALSO:Pharmaceutical compositions having sedative, antipyretic and analgesic properties, for oral administration, comprise 2-oxo-tetrahydroquinolines of the general formulae wherein R1 is hydrogen or C1-C3 alkyl, R2 is halogen and R3 is C1-C3 alkyl, in association with a pharmaceutical carrier or excipient, and optionally contain another active substance having sedative, antipyretic and/or analgesic properties e.g. aminophenazone, acetylsalicylic acid, 1-phenyl-2, 3-dimethyl-5-pyrazalone or phenacetin.

GB29972/63A
1962-07-27
1963-07-29
Substituted tetrahydroquinolines

Expired

GB1046226A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

DET22518A

DE1232586B
(en)

1962-07-27
1962-07-27

Process for the preparation of substituted 2-oxo-1, 2, 3, 4-tetrahydroquinolines with sedative and antipyretic effects

Publications (1)

Publication Number
Publication Date

GB1046226A
true

GB1046226A
(en)

1966-10-19

Family
ID=7550576
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB29972/63A
Expired

GB1046226A
(en)

1962-07-27
1963-07-29
Substituted tetrahydroquinolines

Country Status (4)

Country
Link

CH
(1)

CH475985A
(en)

DE
(1)

DE1232586B
(en)

FR
(1)

FR3088M
(en)

GB
(1)

GB1046226A
(en)

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE102008022221A1
(en)

2008-05-06
2009-11-12
Universität des Saarlandes

Inhibitors of human aldosterone synthase CYP11B2

US8541404B2
(en)

2009-11-09
2013-09-24
Elexopharm Gmbh
Inhibitors of the human aldosterone synthase CYP11B2

1962

1962-07-27
DE
DET22518A
patent/DE1232586B/en
active
Pending

1963

1963-07-08
CH
CH847863A
patent/CH475985A/en
not_active
IP Right Cessation

1963-07-29
GB
GB29972/63A
patent/GB1046226A/en
not_active
Expired

1963-10-25
FR
FR942866A
patent/FR3088M/en
active
Active

Cited By (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE102008022221A1
(en)

2008-05-06
2009-11-12
Universität des Saarlandes

Inhibitors of human aldosterone synthase CYP11B2

US8685960B2
(en)

2008-05-06
2014-04-01
Elexopharm Gmbh
6-pyridin-3-yl-3,4-dihydro-1h-quinolin-2-one derivatives and related compounds as inhibitors of the human aldosterone synthase CYP11B2

US8541404B2
(en)

2009-11-09
2013-09-24
Elexopharm Gmbh
Inhibitors of the human aldosterone synthase CYP11B2

Also Published As

Publication number
Publication date

CH475985A
(en)

1969-07-31

DE1232586B
(en)

1967-01-19

FR3088M
(en)

1965-01-25

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