GB1063894A – Quinazolinedione derivatives
– Google Patents
GB1063894A – Quinazolinedione derivatives
– Google Patents
Quinazolinedione derivatives
Info
Publication number
GB1063894A
GB1063894A
GB11938/64A
GB1193864A
GB1063894A
GB 1063894 A
GB1063894 A
GB 1063894A
GB 11938/64 A
GB11938/64 A
GB 11938/64A
GB 1193864 A
GB1193864 A
GB 1193864A
GB 1063894 A
GB1063894 A
GB 1063894A
Authority
GB
United Kingdom
Prior art keywords
substituted
prepared
formula
unsubstituted
reacting
Prior art date
1963-03-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11938/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-03-29
Filing date
1964-03-20
Publication date
1967-04-05
1963-03-29
Priority to US269168A
priority
Critical
patent/US3274194A/en
1964-03-20
Application filed by Miles Laboratories Inc
filed
Critical
Miles Laboratories Inc
1964-03-20
Priority to GB11938/64A
priority
patent/GB1063894A/en
1966-06-27
Priority to FR67057A
priority
patent/FR1485847A/en
1966-06-29
Priority to BE683352D
priority
patent/BE683352A/xx
1967-04-05
Publication of GB1063894A
publication
Critical
patent/GB1063894A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Abstract
Novel compounds of the Formula I, wherein R1 represents a halogen atom or a nitro, amino or acylamino group; n represents a number from 0-6 inclusive; m represents a number from 0 to 4 inclusive, so that the radicals R1 are the same or different; and R2 represents a di-C1- 4 alkylamino, unsubstituted, phenyl substituted, substituted phenyl substituted or phenalkyl substituted piperazinyl, pyridyl, unsubstituted or phenyl substituted piperidyl, unsubstituted, phenyl substituted, or substituted phenyl substituted piperazinium, morpholinyl or unsubstituted or substituted benzodiazepinyl and pharmacologically acceptable salts thereof, are prepared by reacting an o-aminobenzamide of the Formula II with phosgene, or with ethyl chloroformate to give the corresponding ethoxy-carbamoyl derivative of the Formula III which is cyclized by heating preferably to a temperature above its melting point, or, where R1 represents a nitro group in the 6-position, by dehydrating an urea of the Formula IV and, if desired, converting a resulting piperazinyl compound into a piperazinium compound and, if desired, converting a free base into an acid addition salt thereof.
GB11938/64A
1963-03-29
1964-03-20
Quinazolinedione derivatives
Expired
GB1063894A
(en)
Priority Applications (4)
Application Number
Priority Date
Filing Date
Title
US269168A
US3274194A
(en)
1963-03-29
1963-03-29
Quinazolinedione derivatives
GB11938/64A
GB1063894A
(en)
1963-03-29
1964-03-20
Quinazolinedione derivatives
FR67057A
FR1485847A
(en)
1963-03-29
1966-06-27
Manufacturing process of new quinazolinediones
BE683352D
BE683352A
(en)
1963-03-29
1966-06-29
Applications Claiming Priority (4)
Application Number
Priority Date
Filing Date
Title
US269168A
US3274194A
(en)
1963-03-29
1963-03-29
Quinazolinedione derivatives
CA897976
1964-03-16
GB11938/64A
GB1063894A
(en)
1963-03-29
1964-03-20
Quinazolinedione derivatives
FR67057A
FR1485847A
(en)
1963-03-29
1966-06-27
Manufacturing process of new quinazolinediones
Publications (1)
Publication Number
Publication Date
GB1063894A
true
GB1063894A
(en)
1967-04-05
Family
ID=27426755
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB11938/64A
Expired
GB1063894A
(en)
1963-03-29
1964-03-20
Quinazolinedione derivatives
Country Status (4)
Country
Link
US
(1)
US3274194A
(en)
BE
(1)
BE683352A
(en)
FR
(1)
FR1485847A
(en)
GB
(1)
GB1063894A
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0454060A1
(en)
*
1990-04-24
1991-10-30
ARZNEIMITTELWERK DRESDEN GmbH
3-(Mercaptoalkyl)-quinazoline-2,4(1H,3H)-diones, processes for their preparation, and pharmaceutical compositions
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Priority date
Publication date
Assignee
Title
GB1062357A
(en)
*
1965-03-23
1967-03-22
Pfizer & Co C
Quinazolone derivatives
FR6720M
(en)
*
1967-06-13
1969-02-17
US3846430A
(en)
*
1968-01-12
1974-11-05
Bruneau & Cie Lab
1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine
DE1934037A1
(en)
*
1969-07-04
1971-01-07
Cassella Farbwerke Mainkur Ag
Basically substituted derivatives of 2,4- (1H, 3H) -quinazolinedione
DE1934036A1
(en)
*
1969-07-04
1971-01-07
Cassella Farbwerke Mainkur Ag
Basically substituted derivatives of 2,4- (1H, 3H) -quinazolinedione
US3962244A
(en)
*
1971-01-23
1976-06-08
Hoechst Aktiengesellschaft
Benzene sulfonyl ureas
US3919425A
(en)
*
1971-04-09
1975-11-11
Miles Lab
Method of producing vasodilation using certain 3-substituted-quinazoline derivatives
SE368009B
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*
1971-09-16
1974-06-17
Kabi Ab
US3819630A
(en)
*
1972-08-21
1974-06-25
R Parcell
3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
US3879393A
(en)
*
1973-06-18
1975-04-22
Miles Lab
Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
FR2429216A1
(en)
*
1978-06-20
1980-01-18
Synthelabo
CNS-active substd. alkyl-meta:tri:fluoro:methyl:thio:phenyl-piperazine – with psychotropic properties, useful in treatment of anxiety and depression
DE2833140A1
(en)
*
1978-07-28
1980-02-07
Boehringer Sohn Ingelheim
NEW N-SUBSTITUTED HETEROCYCLES
US4268511A
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*
1980-03-11
1981-05-19
Berri-Balzac
3-Amino(1H,3H)quinazoline-2,4-dione derivatives and their therapeutic applications
JPS58159480A
(en)
*
1982-03-17
1983-09-21
Chugai Pharmaceut Co Ltd
Novel phenylpiperazine derivative
JPS608274A
(en)
*
1983-06-27
1985-01-17
Fujisawa Pharmaceut Co Ltd
Novel quinazolinone derivative, its preparation and antiallergic agent
EP0293500A1
(en)
*
1987-06-01
1988-12-07
American Cyanamid Company
3-heteroalkyl-2,4.quinzaoline-diones
US4684654A
(en)
*
1985-08-14
1987-08-04
American Cyanamid Company
3-heteroalkyl-2,4-quinzaolinediones
US4753944A
(en)
*
1985-11-04
1988-06-28
American Cyanamid Company
Pharmaceutical methods of using 3-heteroarylalkyl-4-quinazolinones
US4710502A
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*
1985-11-04
1987-12-01
American Cyanamid Company
3-heteroarylalkyl-4-quinazolinones
US5296487A
(en)
*
1990-01-02
1994-03-22
Fujisawa Pharmaceutical Co., Ltd.
Quinazoline derivatives and their preparation
ATE126796T1
(en)
*
1990-01-02
1995-09-15
Fujisawa Pharmaceutical Co
QUINAZOLINE DERIVATIVES AND THEIR PRODUCTION.
IE913473A1
(en)
*
1990-10-15
1992-04-22
Fujisawa Pharmaceutical Co
Quinazoline derivatives and their preparation
IT1264124B1
(en)
*
1993-04-16
1996-09-10
Alfa Wassermann Spa
COMPOUNDS WITH A BENZAMIDE STRUCTURE ACTIVE IN GASTRO-INTESTINAL DISORDERS.
EP0789020B1
(en)
*
1996-02-01
2000-04-12
Sumitomo Chemical Company, Limited
Process for producing dioxoquinazolines
AU9002598A
(en)
1997-09-16
1999-04-05
Takeda Chemical Industries Ltd.
Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs
US6458783B1
(en)
*
1997-09-29
2002-10-01
Bristol-Myers Squibb Company
Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase
US6521630B1
(en)
1999-08-31
2003-02-18
Pfizer Inc.
Tetrahydroquinazoline-2,4-diones and therapeutic uses thereof
BRPI0416817A
(en)
*
2003-11-20
2007-03-06
Janssen Pharmaceutica Nv
Substituted 2-quinolinones and 7-phenylalkyl-2-quinoxalinones as poly (adp-ribose) polymerase inhibitors
AU2004295058B9
(en)
2003-11-20
2011-06-30
Janssen Pharmaceutica N.V.
6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
SG151249A1
(en)
*
2003-12-05
2009-04-30
Janssen Pharmaceutica Nv
6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
MXPA06014543A
(en)
2004-06-30
2007-03-23
Janssen Pharmaceutica Nv
Quinazolinone derivatives as parp inhibitors.
JP4852540B2
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*
2004-06-30
2012-01-11
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ
Phthalazine derivatives as PARP inhibitors
EP1763523B1
(en)
*
2004-06-30
2013-03-20
Janssen Pharmaceutica NV
Quinazolinedione derivatives as parp inhibitors
DK2134691T3
(en)
2007-03-08
2012-05-07
Janssen Pharmaceutica Nv
QUINOLINONDERIVATIVES AS PARP AND TANK INHIBITORS
EP2215075B1
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2007-10-26
2013-12-11
Janssen Pharmaceutica, N.V.
Quinolinone derivatives as parp inhibitors
ES2367760T3
(en)
*
2008-03-27
2011-11-08
Janssen Pharmaceutica, N.V.
DERIVATIVES OF QUINAZOLINONA AS INHIBITORS OF THE POLYMERIZATION OF THE TUBULIN.
CA2716726C
(en)
2008-03-27
2017-01-24
Janssen Pharmaceutica Nv
Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors
BRPI1009757B1
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2009-02-26
2020-01-14
Reviva Pharmaceuticals Inc
compound derived from arylpiperazine useful in the treatment of psychosis, schizophrenia, acute mania, bipolar disorder, autistic disorder or depression, pharmaceutical composition, and use thereof
BRPI1003506B1
(en)
2010-09-24
2019-12-03
Ache Int Bvi Ltd
alkyl-piperazine-phenyl-4 (3h) quinazolinone compound and use of the alkyl-piperazine-phenyl-4 (3h) quinazolinone compound associated with 5-ht1a and 5-ht2a serotonergic receptors
JP2017523245A
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2017-08-17
オレゴン ヘルス アンド サイエンス ユニヴァーシティＯｒｅｇｏｎ Ｈｅａｌｔｈ ＆ Ｓｃｉｅｎｃｅ Ｕｎｉｖｅｒｓｉｔｙ
VMAT inhibitor compounds
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1954-08-31
American Cyanamid Co
Preparation of dihydrouracils
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1963
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US
US269168A
patent/US3274194A/en
not_active
Expired – Lifetime
1964
1964-03-20
GB
GB11938/64A
patent/GB1063894A/en
not_active
Expired
1966
1966-06-27
FR
FR67057A
patent/FR1485847A/en
not_active
Expired
1966-06-29
BE
BE683352D
patent/BE683352A/xx
unknown
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0454060A1
(en)
*
1990-04-24
1991-10-30
ARZNEIMITTELWERK DRESDEN GmbH
3-(Mercaptoalkyl)-quinazoline-2,4(1H,3H)-diones, processes for their preparation, and pharmaceutical compositions
Also Published As
Publication number
Publication date
BE683352A
(en)
1966-12-29
FR1485847A
(en)
1967-06-23
US3274194A
(en)
1966-09-20
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None