GB1064315A – Halogen-containing derivatives of 6-chromanol
– Google Patents
GB1064315A – Halogen-containing derivatives of 6-chromanol
– Google Patents
Halogen-containing derivatives of 6-chromanol
Info
Publication number
GB1064315A
GB1064315A
GB2506/64D
GB250664D
GB1064315A
GB 1064315 A
GB1064315 A
GB 1064315A
GB 2506/64 D
GB2506/64 D
GB 2506/64D
GB 250664 D
GB250664 D
GB 250664D
GB 1064315 A
GB1064315 A
GB 1064315A
Authority
GB
United Kingdom
Prior art keywords
acylates
chromanyl
derivatives
halomethyl
vitamin
Prior art date
1963-03-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2506/64D
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-03-19
Filing date
1964-03-16
Publication date
1967-04-05
1964-03-16
Application filed by Merck and Co Inc
filed
Critical
Merck and Co Inc
1967-04-05
Publication of GB1064315A
publication
Critical
patent/GB1064315A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
C07D311/78—Ring systems having three or more relevant rings
C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
C07F9/02—Phosphorus compounds
C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
C—CHEMISTRY; METALLURGY
C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
C11B5/00—Preserving by using additives, e.g. anti-oxidants
C11B5/0071—Preserving by using additives, e.g. anti-oxidants containing halogens, sulfur or phosphorus
Abstract
1,064,315. 5-Halomethyl derivatives of 6- chromanyl acylates; derivatives of Vitamins E and K1. MERCK & CO. Inc. March 16, 1964 [March 19, 1963], No. 2506/66. Divided out of 1,064,311. Headings C2C and C2V. Novel 5-halomethyl 6-chromanyl acylates (II) are obtained by reacting the appropriate γ-hydroxy derivative of 1 : 4-quinones (I) with an alkanoyl halide, e.g. acetyl chloride, propionyl bromide or propionyl chloride, according to the equation wherein X is chlorine or bromine, Y is C 1-5 alkyl, Z is -CH = CH-CH = CH- or two methoxy or methyl groups, and R is -CH 3 or where n is an integer from 1 to 9. The reaction may be carried out at room temperature and in the absence of a solvent. Specified 1 : 4- quinones used are derivatives of Vitamin K1 (III), a compound of the coenzyme Q series (IV) and a Vitamin E derivative V having the formulµ The 5-halomethyl 6-chromanyl acylates may be converted into the corresponding 5-acetoxymethyl-6-chromanyl acylates by reaction with silver acetate, optionally in the presence of acetic acid.
GB2506/64D
1963-03-19
1964-03-16
Halogen-containing derivatives of 6-chromanol
Expired
GB1064315A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US266201A
US3160638A
(en)
1963-03-19
1963-03-19
5-phosphomethyl derivatives of 6-chromanols and processes for preparing same
Publications (1)
Publication Number
Publication Date
GB1064315A
true
GB1064315A
(en)
1967-04-05
Family
ID=23013597
Family Applications (3)
Application Number
Title
Priority Date
Filing Date
GB2506/64D
Expired
GB1064315A
(en)
1963-03-19
1964-03-16
Halogen-containing derivatives of 6-chromanol
GB11038/64A
Expired
GB1064311A
(en)
1963-03-19
1964-03-16
Phosphorus-containing derivatives of 6-chromanol
GB2505/66A
Expired
GB1064314A
(en)
1963-03-19
1964-03-16
Phosphorus-containing derviatives of 6-chromanols
Family Applications After (2)
Application Number
Title
Priority Date
Filing Date
GB11038/64A
Expired
GB1064311A
(en)
1963-03-19
1964-03-16
Phosphorus-containing derivatives of 6-chromanol
GB2505/66A
Expired
GB1064314A
(en)
1963-03-19
1964-03-16
Phosphorus-containing derviatives of 6-chromanols
Country Status (5)
Country
Link
US
(1)
US3160638A
(en)
DE
(1)
DE1493981A1
(en)
FR
(1)
FR1397408A
(en)
GB
(3)
GB1064315A
(en)
NL
(1)
NL6402952A
(en)
Families Citing this family (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3453291A
(en)
*
1967-01-26
1969-07-01
Us Navy
Phosphate derivatives of 3-hydroxyflavone
US5627165A
(en)
*
1990-06-13
1997-05-06
Drug Innovation & Design, Inc.
Phosphorous prodrugs and therapeutic delivery systems using same
ITTO20030140U1
(en)
*
2003-09-16
2005-03-17
Interfila Srl
COSMETIC PENCIL
US20050065099A1
(en)
*
2003-09-19
2005-03-24
Gail Walkinshaw
Treatment of mitochondrial diseases
Family Cites Families (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US2486542A
(en)
*
1949-05-20
1949-11-01
Distillation Products Inc
Simultaneous haloalkylation and reduction of organic compounds
NL92451C
(en)
*
1955-08-19
US3026330A
(en)
*
1960-05-09
1962-03-20
Merck & Co Inc
Chroman compounds having antioxidant activity
1963
1963-03-19
US
US266201A
patent/US3160638A/en
not_active
Expired – Lifetime
1964
1964-03-16
GB
GB2506/64D
patent/GB1064315A/en
not_active
Expired
1964-03-16
GB
GB11038/64A
patent/GB1064311A/en
not_active
Expired
1964-03-16
GB
GB2505/66A
patent/GB1064314A/en
not_active
Expired
1964-03-18
FR
FR967828A
patent/FR1397408A/en
not_active
Expired
1964-03-18
DE
DE19641493981
patent/DE1493981A1/en
active
Pending
1964-03-19
NL
NL6402952A
patent/NL6402952A/xx
unknown
Also Published As
Publication number
Publication date
GB1064311A
(en)
1967-04-05
DE1493981A1
(en)
1969-08-07
FR1397408A
(en)
1965-04-30
NL6402952A
(en)
1964-09-21
GB1064314A
(en)
1967-04-05
US3160638A
(en)
1964-12-08
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