GB1065188A

GB1065188A – An ethylamino thienyl cyclohexanone
– Google Patents

GB1065188A – An ethylamino thienyl cyclohexanone
– Google Patents
An ethylamino thienyl cyclohexanone

Info

Publication number
GB1065188A

GB1065188A
GB12161/66A
GB1216166A
GB1065188A
GB 1065188 A
GB1065188 A
GB 1065188A
GB 12161/66 A
GB12161/66 A
GB 12161/66A
GB 1216166 A
GB1216166 A
GB 1216166A
GB 1065188 A
GB1065188 A
GB 1065188A
Authority
GB
United Kingdom
Prior art keywords
thienyl
prepared
ether
action
formula
Prior art date
1965-03-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB12161/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Parke Davis and Co LLC

Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1965-03-19
Filing date
1966-03-18
Publication date
1967-04-12

1966-03-18
Application filed by Parke Davis and Co LLC
filed
Critical
Parke Davis and Co LLC

1967-04-12
Publication of GB1065188A
publication
Critical
patent/GB1065188A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom

C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom

C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms

C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Abstract

The novel compound of the formula and its acid addition salts are prepared either by thermal rearrangement of a compound of formula or by ethylation of the corresponding N-unsubstituted amine, optionally followed by salt formation. 2 – Amino – 2 – (2 – thienyl) – cyclohexanone, employed in the second process above, is prepared by thermal rearrangement of 1-hydroxycyclopentyl 2 – thienyl ketimine, which is prepared from its tetrahydropyranyl ether by action of HCl followed by basification, and this ether is prepared by reaction of 2-thienyl lithium with the tetrahydro-2-pyranyl ether of cyclopentanone cyanohydrin. 1 – Hydroxycyclopentyl 2 – thienyl N – ethylketimine used in the second process above is prepared either by reaction of ethylamide and 1 – hydroxy – cyclopentyl 2 – thienyl ketone, which is prepared by action of 2-thienylmagnesium bromide on the tetrahydro-2-pyranyl ether of cyclopentanone – cyanohydrin followed by hydrolysis, or by action of ethylamine on 1 – bromocyclopentyl – 2 – thienyl ketone which is prepared by bromination of cyclopentyl 2-thienyl ketone. 2 – Thienyl lithium is prepared from thiophene and butyl lithium. The compound of the first formula above and its acid addition salts may be administered orally or parenterally as anaesthetics or anti-convulsants.

GB12161/66A
1965-03-19
1966-03-18
An ethylamino thienyl cyclohexanone

Expired

GB1065188A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US44136865A

1965-03-19
1965-03-19

Publications (1)

Publication Number
Publication Date

GB1065188A
true

GB1065188A
(en)

1967-04-12

Family
ID=23752605
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB12161/66A
Expired

GB1065188A
(en)

1965-03-19
1966-03-18
An ethylamino thienyl cyclohexanone

Country Status (11)

Country
Link

BE
(1)

BE678092A
(en)

BR
(1)

BR6677981D0
(en)

CH
(2)

CH453384A
(en)

DE
(1)

DE1300953B
(en)

DK
(1)

DK112246B
(en)

ES
(1)

ES324380A1
(en)

FR
(2)

FR1471911A
(en)

GB
(1)

GB1065188A
(en)

IL
(1)

IL25416A
(en)

NL
(1)

NL145238B
(en)

SE
(2)

SE325584B
(en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

NL294634A
(en)

*

1963-06-28

1966

1966-03-18
SE
SE03596/66A
patent/SE325584B/xx
unknown

1966-03-18
FR
FR54138A
patent/FR1471911A/en
not_active
Expired

1966-03-18
BR
BR177981/66A
patent/BR6677981D0/en
unknown

1966-03-18
BE
BE678092D
patent/BE678092A/xx
not_active
IP Right Cessation

1966-03-18
DE
DEP39011A
patent/DE1300953B/en
active
Pending

1966-03-18
DK
DK143466AA
patent/DK112246B/en
unknown

1966-03-18
IL
IL25416A
patent/IL25416A/en
unknown

1966-03-18
GB
GB12161/66A
patent/GB1065188A/en
not_active
Expired

1966-03-18
ES
ES0324380A
patent/ES324380A1/en
not_active
Expired

1966-03-18
NL
NL666603587A
patent/NL145238B/en
not_active
IP Right Cessation

1966-03-18
CH
CH394366A
patent/CH453384A/en
unknown

1966-03-18
CH
CH252468A
patent/CH457500A/en
unknown

1966-06-14
FR
FR65371A
patent/FR5589M/fr
not_active
Expired

1968

1968-02-15
SE
SE01975/68A
patent/SE325585B/xx
unknown

Also Published As

Publication number
Publication date

BE678092A
(en)

1966-09-01

IL25416A
(en)

1969-09-25

SE325584B
(en)

1970-07-06

BR6677981D0
(en)

1973-09-11

FR5589M
(en)

1967-12-04

NL6603587A
(en)

1966-09-20

FR1471911A
(en)

1967-03-03

SE325585B
(en)

1970-07-06

CH453384A
(en)

1968-06-14

DE1300953B
(en)

1969-08-14

NL145238B
(en)

1975-03-17

DK112246B
(en)

1968-11-25

ES324380A1
(en)

1967-02-01

CH457500A
(en)

1968-06-15

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