GB1104655A

GB1104655A – Tetracycline derivatives and process for their preparation
– Google Patents

GB1104655A – Tetracycline derivatives and process for their preparation
– Google Patents
Tetracycline derivatives and process for their preparation

Info

Publication number
GB1104655A

GB1104655A
GB3266165A
GB3266165A
GB1104655A
GB 1104655 A
GB1104655 A
GB 1104655A
GB 3266165 A
GB3266165 A
GB 3266165A
GB 3266165 A
GB3266165 A
GB 3266165A
GB 1104655 A
GB1104655 A
GB 1104655A
Authority
GB
United Kingdom
Prior art keywords
tetracycline
derivatives
antibiotic
sulphonic acid
inorganic
Prior art date
1965-07-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB3266165A
Inventor
Victor Armand
Philippe Rohrbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

LAB BOTTU SOC D EXPL DES

Original Assignee
LAB BOTTU SOC D EXPL DES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1965-07-30
Filing date
1965-07-30
Publication date
1968-02-28

1965-07-30
Application filed by LAB BOTTU SOC D EXPL DES
filed
Critical
LAB BOTTU SOC D EXPL DES

1965-07-30
Priority to GB3266165A
priority
Critical
patent/GB1104655A/en

1966-07-21
Priority to FR70362A
priority
patent/FR1489927A/en

1966-07-28
Priority to CH1094566A
priority
patent/CH458335A/en

1966-07-29
Priority to DE19661593403
priority
patent/DE1593403A1/en

1966-07-29
Priority to BR18167466A
priority
patent/BR6681674D0/en

1966-07-29
Priority to BE684849D
priority
patent/BE684849A/xx

1966-10-19
Priority to FR80562A
priority
patent/FR5755M/fr

1968-02-28
Publication of GB1104655A
publication
Critical
patent/GB1104655A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms

C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom

C07D327/04—Five-membered rings

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C233/00—Carboxylic acid amides

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms

C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom

C07D327/06—Six-membered rings

Abstract

The invention relates to derivatives of a tetracycline antibiotic, probably of formula wherein n is 3 or 4 and T is a decarbamoylated radical of a tetracycline antibiotic (especially tetracycline, oxytetracycline, chlortetracycline or demethylchlortetracycline), which derivatives are produced by reacting an internal ester of a hydroxyalkyl sulphonic acid of formula wherein n is 3 or 4, with a tetracycline antibiotic. In the case of chloropropane sulphonic acid and chlorobutane sulphonic acid salts, the hydrochloride of the antibiotic is reacted with two moles of the appropriate internal ester. In general, salts are formed with inorganic and organic acids (e.g. aryl or alkyl sulphonic acids) and with inorganic and organic bases (e.g. triethylamine and D(-)a -aminobenzyl penicillin). The compounds are stable and have antibacterial and antibacteriostatic properties. Pharmaceutical compositions for oral, parenteral or topical administration to humans or animals comprise one or more of the above tetracycline derivatives.

GB3266165A
1965-07-30
1965-07-30
Tetracycline derivatives and process for their preparation

Expired

GB1104655A
(en)

Priority Applications (7)

Application Number
Priority Date
Filing Date
Title

GB3266165A

GB1104655A
(en)

1965-07-30
1965-07-30
Tetracycline derivatives and process for their preparation

FR70362A

FR1489927A
(en)

1965-07-30
1966-07-21

Process for the preparation of new derivatives of the tetracycline series

CH1094566A

CH458335A
(en)

1965-07-30
1966-07-28

Process for the preparation of novel tetracycline derivatives

DE19661593403

DE1593403A1
(en)

1965-07-30
1966-07-29

Process for the preparation of sulfonic acid derivatives of the tetracyclines

BR18167466A

BR6681674D0
(en)

1965-07-30
1966-07-29

NEW DERIVATIVES FROM THE TETRACYCLINE SERIES AND PREPARATION PROCESS

BE684849D

BE684849A
(en)

1965-07-30
1966-07-29

FR80562A

FR5755M
(en)

1965-07-30
1966-10-19

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

GB3266165A

GB1104655A
(en)

1965-07-30
1965-07-30
Tetracycline derivatives and process for their preparation

Publications (1)

Publication Number
Publication Date

GB1104655A
true

GB1104655A
(en)

1968-02-28

Family
ID=10342095
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB3266165A
Expired

GB1104655A
(en)

1965-07-30
1965-07-30
Tetracycline derivatives and process for their preparation

Country Status (6)

Country
Link

BE
(1)

BE684849A
(en)

BR
(1)

BR6681674D0
(en)

CH
(1)

CH458335A
(en)

DE
(1)

DE1593403A1
(en)

FR
(1)

FR5755M
(en)

GB
(1)

GB1104655A
(en)

1965

1965-07-30
GB
GB3266165A
patent/GB1104655A/en
not_active
Expired

1966

1966-07-28
CH
CH1094566A
patent/CH458335A/en
unknown

1966-07-29
BR
BR18167466A
patent/BR6681674D0/en
unknown

1966-07-29
BE
BE684849D
patent/BE684849A/xx
unknown

1966-07-29
DE
DE19661593403
patent/DE1593403A1/en
active
Pending

1966-10-19
FR
FR80562A
patent/FR5755M/fr
not_active
Expired

Also Published As

Publication number
Publication date

FR5755M
(en)

1968-01-29

BR6681674D0
(en)

1973-10-25

CH458335A
(en)

1968-06-30

BE684849A
(en)

1967-01-03

DE1593403A1
(en)

1970-07-16

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