GB1105237A – Conessine derivatives
– Google Patents
GB1105237A – Conessine derivatives
– Google Patents
Conessine derivatives
Info
Publication number
GB1105237A
GB1105237A
GB32946/66A
GB3294666A
GB1105237A
GB 1105237 A
GB1105237 A
GB 1105237A
GB 32946/66 A
GB32946/66 A
GB 32946/66A
GB 3294666 A
GB3294666 A
GB 3294666A
GB 1105237 A
GB1105237 A
GB 1105237A
Authority
GB
United Kingdom
Prior art keywords
conessine
hydroxy
prepared
dimethylaminoconanine
dimethylamino
Prior art date
1965-07-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32946/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Delft BV
Original Assignee
Koninklijke Nederlandsche Gist en Spiritusfabriek BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1965-07-30
Filing date
1966-07-22
Publication date
1968-03-06
1966-07-22
Application filed by Koninklijke Nederlandsche Gist en Spiritusfabriek BV
filed
Critical
Koninklijke Nederlandsche Gist en Spiritusfabriek BV
1968-03-06
Publication of GB1105237A
publication
Critical
patent/GB1105237A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
C12P33/00—Preparation of steroids
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
C07J71/0036—Nitrogen-containing hetero ring
C07J71/0042—Nitrogen only
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S435/00—Chemistry: molecular biology and microbiology
Y10S435/8215—Microorganisms
Y10S435/911—Microorganisms using fungi
Abstract
The novel steroids 9a -hydroxyconessine and 12a -hydroxyconnesine are prepared by microbiological hydroxylation of conessine with enzymes of Botryodiplodia theobromae Pat. They may be converted to acid-addition salts and quaternary ammonium compounds, and they may be separated via the hemi-succinate of the 12a -ol which is formed at pH 9.5, unlike the 9a -ol which does not form such a salt. The 12a -ol may be oxidized to the 12-ketoconessine and acetylated to the 12a -acetoxy-conessine. The 9a -ol may be dehydrated to D 9(11)-conessine, which is also prepared by dehydration of 11a -hydroxy-conessine. The 9a -ol may be hydrogenated to 9a – hydroxy – 3b – dimethylaminoconanine which is also prepared by hydrogenating 11a – hydroxy – conessine to 11a – hydroxy – 3b -dimethylaminoconanine, dehydrating this to 3b – dimethylamino – D 9(11) – conenine, oxidizing this to 3b -dimethylamino-9a ,11a -epoxy-conanine 3-N-oxide and reducing this. Quaternary ammonium derivatives of the steroids of the invention, which are stated to be useful as muscular relaxing agents, may be made up into pharmaceutical compositions with suitable carriers. Suitable quaternizing agents are the esters of aliphatic and araliphatic alcohols with strong acids.
GB32946/66A
1965-07-30
1966-07-22
Conessine derivatives
Expired
GB1105237A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
NL6509936A
NL6509936A
(en)
1965-07-30
1965-07-30
Publications (1)
Publication Number
Publication Date
GB1105237A
true
GB1105237A
(en)
1968-03-06
Family
ID=19793779
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB32946/66A
Expired
GB1105237A
(en)
1965-07-30
1966-07-22
Conessine derivatives
Country Status (7)
Country
Link
US
(2)
US3466279A
(en)
BE
(1)
BE684672A
(en)
CH
(1)
CH492693A
(en)
DE
(1)
DE1568920A1
(en)
FR
(1)
FR1499235A
(en)
GB
(1)
GB1105237A
(en)
NL
(1)
NL6509936A
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US5364453A
(en)
*
1992-09-22
1994-11-15
Geobiotics, Inc.
Method for recovering gold and other precious metals from carbonaceous ores
Families Citing this family (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4301246A
(en)
*
1979-04-12
1981-11-17
Hoffmann-La Roche Inc.
Process for chenodeoxycholic acid production
US20100040568A1
(en)
*
2008-04-30
2010-02-18
Skinmedica, Inc.
Steroidal compounds as melanogenesis modifiers and uses thereof
JP5808797B2
(en)
2010-05-20
2015-11-10
ユニバーシティ オブ アイオワ リサーチ ファウンデーション
Methods for inhibiting muscle atrophy
US11090313B2
(en)
2010-05-20
2021-08-17
University Of Iowa Research Foundation
Methods for inhibiting muscle atrophy
JP6001060B2
(en)
2011-06-06
2016-10-05
ユニバーシティ オブ アイオワ リサーチ ファウンデーション
Methods for inhibiting muscle atrophy
Family Cites Families (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US2814629A
(en)
*
1956-07-30
1957-11-26
Olin Mathieson
12-oxygenated-4, 9(11)-pregnadiene-3, 20-dione
US2914543A
(en)
*
1957-03-01
1959-11-24
Olin Mathieson
Synthesis of steroids
US3067196A
(en)
*
1959-06-18
1962-12-04
Roussel Uclaf
Process for the preparation of steroids substituted in the 12-position and products resulting therefrom
US3047470A
(en)
*
1959-11-30
1962-07-31
American Cyanamid Co
Microbiological 11alpha-hydroxylation of 16alpha, 17alpha-epoxy pregnenes
NL126232C
(en)
*
1964-03-03
1969-04-15
1965
1965-07-30
NL
NL6509936A
patent/NL6509936A/xx
unknown
1966
1966-07-21
DE
DE19661568920
patent/DE1568920A1/en
active
Pending
1966-07-22
GB
GB32946/66A
patent/GB1105237A/en
not_active
Expired
1966-07-27
BE
BE684672D
patent/BE684672A/xx
unknown
1966-07-29
US
US568896A
patent/US3466279A/en
not_active
Expired – Lifetime
1966-07-29
FR
FR71536A
patent/FR1499235A/en
not_active
Expired
1966-07-29
CH
CH1100166A
patent/CH492693A/en
unknown
1969
1969-04-17
US
US817161A
patent/US3539449A/en
not_active
Expired – Lifetime
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US5364453A
(en)
*
1992-09-22
1994-11-15
Geobiotics, Inc.
Method for recovering gold and other precious metals from carbonaceous ores
Also Published As
Publication number
Publication date
DE1568920A1
(en)
1971-03-25
NL6509936A
(en)
1967-01-31
CH492693A
(en)
1970-06-30
US3539449A
(en)
1970-11-10
BE684672A
(en)
1967-01-27
FR1499235A
(en)
1967-10-27
US3466279A
(en)
1969-09-09
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