GB1112096A

GB1112096A – Process for the production of basically substituted arylalkyl ketones
– Google Patents

GB1112096A – Process for the production of basically substituted arylalkyl ketones
– Google Patents
Process for the production of basically substituted arylalkyl ketones

Info

Publication number
GB1112096A

GB1112096A
GB3331266A
GB3331266A
GB1112096A
GB 1112096 A
GB1112096 A
GB 1112096A
GB 3331266 A
GB3331266 A
GB 3331266A
GB 3331266 A
GB3331266 A
GB 3331266A
GB 1112096 A
GB1112096 A
GB 1112096A
Authority
GB
United Kingdom
Prior art keywords
general formula
azaspiro
carbon atoms
ketone
radical
Prior art date
1965-07-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB3331266A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1965-07-26
Filing date
1966-07-25
Publication date
1968-05-01

1965-07-26
Priority claimed from CH1044465A
external-priority
patent/CH458347A/en

1966-07-25
Application filed by JR Geigy AG
filed
Critical
JR Geigy AG

1968-05-01
Publication of GB1112096A
publication
Critical
patent/GB1112096A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 – C07D459/00, C07D463/00, C07D477/00 or C07D489/00

C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 – C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings

C07D491/10—Spiro-condensed systems

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom

C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members

C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D207/12—Oxygen or sulfur atoms

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members

C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D211/40—Oxygen atoms

C07D211/44—Oxygen atoms attached in position 4

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member

C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms

C07D211/74—Oxygen atoms

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms

C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

C07D495/10—Spiro-condensed systems

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms

C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

C07D497/10—Spiro-condensed systems

Abstract

Novel basically substituted arylalkyl ketones of the general formula wherein X and Y independently of each other represent oxygen or sulphur; R1 represents a divalent hydrocarbon radical having 2 to 11 carbon atoms, which links X and Y by way of 2 to 4 carbon atoms and has no unsaturated bonds at the two terminal carbon atoms; R2, R3 and R4 independently of each other represent hydrogen, low alkyl or alkoxy radicals or chlorine atoms, and when R4 is hydrogen, R2 and R3 also represent the methylenedioxy radical; and A represents a straight or branched chain alkylidene or alkylene radical having at most 4 carbon atoms, and acid addition salts thereof may be prepared by reacting an azaspiro compound of the general formula with a reactive ester of an arylalkyl hydroxy ketone of the general formula by the Mannich reaction of formaldehyde, a mineral acid salt of a compound of the second general formula and an arylalkyl ketone of the formula wherein R5 represents hydrogen, the methyl or ethyl radical; or by reaction of an azaspiro compound of the second general formula with an unsaturated ketone of the formula wherein R6, R7 and R8 represent hydrogen o alkyl radicals, followed in each method by optional conversion to a corresponding acid addition salt. Pharmaceutical preparations comprising as active ingredient at least one basically substituted arylalkyl ketone of the first general formula or a pharmaceutically acceptable acid addition salt thereof, together with at least one pharmaceutical carrier, have useful sedative, muscle relaxing, analgesic and appetite inhibitory action. Azaspiro compounds of the second general formula, such as 1,4-dioxa-8-azaspiro[4,5]decane and 1,5-dioxa-9-azaspiro[5,5]undecane may be prepared from 4,4-dihydroxypiperidine hydrochloride and the required dihydroxy-, hydroxy-, dimercapto- or mercapto-compounds.

GB3331266A
1965-07-26
1966-07-25
Process for the production of basically substituted arylalkyl ketones

Expired

GB1112096A
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

CH1044465A

CH458347A
(en)

1965-07-26
1965-07-26

Process for the preparation of new, basic substituted aryl-alkyl-ketones

CH867066

1966-06-15

Publications (1)

Publication Number
Publication Date

GB1112096A
true

GB1112096A
(en)

1968-05-01

Family
ID=25703605
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB3331266A
Expired

GB1112096A
(en)

1965-07-26
1966-07-25
Process for the production of basically substituted arylalkyl ketones

Country Status (5)

Country
Link

BE
(1)

BE684556A
(en)

ES
(3)

ES329444A1
(en)

GB
(1)

GB1112096A
(en)

IL
(1)

IL26208A
(en)

SE
(1)

SE306742B
(en)

1966

1966-07-23
ES
ES0329444A
patent/ES329444A1/en
not_active
Expired

1966-07-23
ES
ES0329446A
patent/ES329446A1/en
not_active
Expired

1966-07-23
ES
ES0329445A
patent/ES329445A1/en
not_active
Expired

1966-07-25
IL
IL2620866A
patent/IL26208A/en
unknown

1966-07-25
BE
BE684556D
patent/BE684556A/xx
unknown

1966-07-25
SE
SE1012466A
patent/SE306742B/xx
unknown

1966-07-25
GB
GB3331266A
patent/GB1112096A/en
not_active
Expired

Also Published As

Publication number
Publication date

ES329444A1
(en)

1967-05-16

IL26208A
(en)

1970-08-19

SE306742B
(en)

1968-12-09

ES329445A1
(en)

1967-11-16

ES329446A1
(en)

1967-05-16

BE684556A
(en)

1967-01-25

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