GB1113473A – Water-soluble derivatives of antibiotics containing free amino-groups and method for preparing the same
– Google Patents
GB1113473A – Water-soluble derivatives of antibiotics containing free amino-groups and method for preparing the same
– Google Patents
Water-soluble derivatives of antibiotics containing free amino-groups and method for preparing the same
Info
Publication number
GB1113473A
GB1113473A
GB2174965A
GB2174965A
GB1113473A
GB 1113473 A
GB1113473 A
GB 1113473A
GB 2174965 A
GB2174965 A
GB 2174965A
GB 2174965 A
GB2174965 A
GB 2174965A
GB 1113473 A
GB1113473 A
GB 1113473A
Authority
GB
United Kingdom
Prior art keywords
colistin
glycosides
water
free amino
preparing
Prior art date
1965-05-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2174965A
Inventor
Gaetano Di Modica
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SEPREM ETS
Original Assignee
SEPREM ETS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1965-05-21
Filing date
1965-05-21
Publication date
1968-05-15
1965-05-21
Application filed by SEPREM ETS
filed
Critical
SEPREM ETS
1965-05-21
Priority to GB2174965A
priority
Critical
patent/GB1113473A/en
1966-05-17
Priority to CH712166A
priority
patent/CH449851A/en
1966-05-20
Priority to BE681323D
priority
patent/BE681323A/xx
1966-05-20
Priority to NL6607007A
priority
patent/NL6607007A/xx
1966-05-20
Priority to DE19661543545
priority
patent/DE1543545A1/en
1966-05-20
Priority to BR17970866A
priority
patent/BR6679708D0/en
1966-05-20
Priority to AT478466A
priority
patent/AT275030B/en
1966-05-21
Priority to ES0327030A
priority
patent/ES327030A1/en
1966-05-23
Priority to LU51165A
priority
patent/LU51165A1/xx
1968-05-15
Publication of GB1113473A
publication
Critical
patent/GB1113473A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
C07K7/50—Cyclic peptides containing at least one abnormal peptide link
C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
C07K7/62—Polymyxins; Related peptides
Abstract
The invention relates to water-soluble N-glycosides of the antibiotics cycloserine and the polymyxins, wherein one or more of the free amino groups of the antibiotic are condensed with the aldose radical of glucose, mannose, arabinose, xylose, ribose or maltose. The polymyxins are tyrothricin, colistin, or bacitracin, which may form any of mono-, di-, tri-, tetra-, or penta-N-glycosides, the particular colistin specified being Colistin A. The glycosides are prepared by warming an aqueous or methanolic solution of the antibiotic free base and the sugar, if required in the presence of a catalyst, and isolating the required product by evaporating the aqueous solution to dryness and recrystallizing the impure residue, or by addition of ether to the methanolic solution to precipitate the product. Examples are given for the preparation of a mixed colistin N-glucoside; colistin sulphate salt is used as a starting material, with preliminary conversion to the free base. The subject matters of Specifications 739,727 and 656,897 are specifically disclaimed.
GB2174965A
1965-05-21
1965-05-21
Water-soluble derivatives of antibiotics containing free amino-groups and method for preparing the same
Expired
GB1113473A
(en)
Priority Applications (9)
Application Number
Priority Date
Filing Date
Title
GB2174965A
GB1113473A
(en)
1965-05-21
1965-05-21
Water-soluble derivatives of antibiotics containing free amino-groups and method for preparing the same
CH712166A
CH449851A
(en)
1965-05-21
1966-05-17
Process for the preparation of a water-soluble derivative of an antibiotic substance having one or more free amino groups
BE681323D
BE681323A
(en)
1965-05-21
1966-05-20
NL6607007A
NL6607007A
(en)
1965-05-21
1966-05-20
DE19661543545
DE1543545A1
(en)
1965-05-21
1966-05-20
Method for preparing new water-soluble derivatives of amino groups containing antibiotics
BR17970866A
BR6679708D0
(en)
1965-05-21
1966-05-20
WATER-SOLUBLE DERIVATIVES OF FREE AMINATED GROUPS CONTAINING ANTIBIOTICS AND METHOD FOR PREPARING THEM
AT478466A
AT275030B
(en)
1965-05-21
1966-05-20
Process for the preparation of new water-soluble derivatives of antibiotics containing free amino groups
ES0327030A
ES327030A1
(en)
1965-05-21
1966-05-21
Method for preparing soluble derivatives in water of free amino groups containing antibiotics. (Machine-translation by Google Translate, not legally binding)
LU51165A
LU51165A1
(en)
1965-05-21
1966-05-23
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
GB2174965A
GB1113473A
(en)
1965-05-21
1965-05-21
Water-soluble derivatives of antibiotics containing free amino-groups and method for preparing the same
Publications (1)
Publication Number
Publication Date
GB1113473A
true
GB1113473A
(en)
1968-05-15
Family
ID=10168140
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB2174965A
Expired
GB1113473A
(en)
1965-05-21
1965-05-21
Water-soluble derivatives of antibiotics containing free amino-groups and method for preparing the same
Country Status (9)
Country
Link
AT
(1)
AT275030B
(en)
BE
(1)
BE681323A
(en)
BR
(1)
BR6679708D0
(en)
CH
(1)
CH449851A
(en)
DE
(1)
DE1543545A1
(en)
ES
(1)
ES327030A1
(en)
GB
(1)
GB1113473A
(en)
LU
(1)
LU51165A1
(en)
NL
(1)
NL6607007A
(en)
1965
1965-05-21
GB
GB2174965A
patent/GB1113473A/en
not_active
Expired
1966
1966-05-17
CH
CH712166A
patent/CH449851A/en
unknown
1966-05-20
DE
DE19661543545
patent/DE1543545A1/en
active
Pending
1966-05-20
AT
AT478466A
patent/AT275030B/en
active
1966-05-20
BR
BR17970866A
patent/BR6679708D0/en
unknown
1966-05-20
NL
NL6607007A
patent/NL6607007A/xx
unknown
1966-05-20
BE
BE681323D
patent/BE681323A/xx
unknown
1966-05-21
ES
ES0327030A
patent/ES327030A1/en
not_active
Expired
1966-05-23
LU
LU51165A
patent/LU51165A1/xx
unknown
Also Published As
Publication number
Publication date
AT275030B
(en)
1969-10-10
DE1543545A1
(en)
1970-01-02
BR6679708D0
(en)
1973-10-23
LU51165A1
(en)
1966-07-23
BE681323A
(en)
1966-10-31
NL6607007A
(en)
1966-11-22
ES327030A1
(en)
1967-03-16
CH449851A
(en)
1968-01-15
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