GB1132676A – Anti-tumour preparation and process for preparing the same
– Google Patents
GB1132676A – Anti-tumour preparation and process for preparing the same
– Google Patents
Anti-tumour preparation and process for preparing the same
Info
Publication number
GB1132676A
GB1132676A
GB10290/67A
GB1029067A
GB1132676A
GB 1132676 A
GB1132676 A
GB 1132676A
GB 10290/67 A
GB10290/67 A
GB 10290/67A
GB 1029067 A
GB1029067 A
GB 1029067A
GB 1132676 A
GB1132676 A
GB 1132676A
Authority
GB
United Kingdom
Prior art keywords
penicillin
cells
medium
streptococcus hemolyticus
suspension
Prior art date
1966-03-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10290/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
KH Neochem Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1966-03-08
Filing date
1967-03-03
Publication date
1968-11-06
1967-03-03
Application filed by Chugai Pharmaceutical Co Ltd, Kyowa Hakko Kogyo Co Ltd
filed
Critical
Chugai Pharmaceutical Co Ltd
1968-11-06
Publication of GB1132676A
publication
Critical
patent/GB1132676A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 – C12P39/00, by using microorganisms or enzymes
C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 – C12P39/00, by using microorganisms or enzymes by using bacteria
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
A61K35/66—Microorganisms or materials therefrom
A61K35/74—Bacteria
A61K35/741—Probiotics
A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
C12N1/20—Bacteria; Culture media therefor
C12N1/205—Bacterial isolates
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C – C12Q, RELATING TO MICROORGANISMS
C12R2001/00—Microorganisms ; Processes using microorganisms
C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S435/00—Chemistry: molecular biology and microbiology
Y10S435/8215—Microorganisms
Y10S435/822—Microorganisms using bacteria or actinomycetales
Y10S435/885—Streptococcus
Abstract
1,132,676. Anti-tumour preparation. CHUGAI SEIYAKU K.K. and KYOWA HAKKO KOGYO CO. Ltd. 3 March, 1967 [8 March, 1966], No. 10290/67. Heading A5B. An anti-tumour preparation containing the cells of Streptococcus hemolyticus having no virulence and no hemolytic activity but having anti-tumour activity is prepared by mixing penicillin and living cells of Streptococcus hemolyticus having anti-tumour activity in a suspension medium comprising an aqueous solution of salts, the amount of penicillin being such that the concentration of penicillin in the suspension medium exceeds 25,000 units per ml. of the total liquid in said mixture, and incubating the resulting mixture firstly at a temperature in the range of 30‹C to 38‹C and then at a temperature in the range of 38‹C to 50‹C so as to obtain the desired antitumour preparation in which the majority of the Streptococcus hemolyticus cells are dead. The first stage of incubation may be effected for 10 to 30 minutes and the second for 20 to 60 minutes. The concentration of penicillin in the suspension medium may be from 27,000 to 60,000 units/ml of the total liquid in the mixture. The suspension medium may be phosphate buffered saline or Bernheimer’s basul medium composed of maltose, KH 2 PO 4 , MgSO 4 .7H 2 O, distilled water and having a pH of from 6.8 to 7.0. The cells of Streptococcus hemolyticus may be obtained by cultivating Streptococcus hemolyticus in a cultivating medium in which the main carbon source is one other than glucose e.g. meat infusion broth or a medium containing ribonucleic acid and/or ribonuclease core each present in an amount of from 0.5 to 1.0% w/v. Penicillin may be added to the suspension medium prior to or after suspension of Streptococcus hemolyticus cells therein. The resulting suspension of cocci may be aseptically diluted with a salt solution, preferably containing penicillin to obtain a form suitable for therapeutic administration e.g. injection.
GB10290/67A
1966-03-08
1967-03-03
Anti-tumour preparation and process for preparing the same
Expired
GB1132676A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
JP1378466
1966-03-08
Publications (1)
Publication Number
Publication Date
GB1132676A
true
GB1132676A
(en)
1968-11-06
Family
ID=11842860
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB10290/67A
Expired
GB1132676A
(en)
1966-03-08
1967-03-03
Anti-tumour preparation and process for preparing the same
Country Status (15)
Country
Link
US
(1)
US3477914A
(en)
BE
(1)
BE695122A
(en)
CA
(1)
CA950847A
(en)
CH
(1)
CH526959A
(en)
CS
(1)
CS150186B2
(en)
DE
(1)
DE1617397C3
(en)
DK
(1)
DK115652B
(en)
ES
(1)
ES337684A1
(en)
FR
(1)
FR6516M
(en)
GB
(1)
GB1132676A
(en)
NL
(1)
NL6703623A
(en)
NO
(1)
NO121972B
(en)
SE
(1)
SE348943B
(en)
SU
(1)
SU520055A3
(en)
YU
(1)
YU33209B
(en)
Families Citing this family (9)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3627644A
(en)
*
1968-03-01
1971-12-14
Hajime Okamoto
Process for the cultivation of hemolytic streptococci
JPS496096B1
(en)
*
1970-09-30
1974-02-12
JPS54157815A
(en)
*
1978-05-29
1979-12-13
Chugai Pharmaceut Co Ltd
Anti-tumor substance and its preparation
JPS557014A
(en)
*
1978-06-29
1980-01-18
Chugai Pharmaceut Co Ltd
Antitumor agent and its preparation
JPS5679622A
(en)
*
1979-12-04
1981-06-30
Kanebo Ltd
Antitumor pharmaceutical
GB2079785B
(en)
*
1980-04-14
1984-10-03
Kanebo Ltd
Process for cultivation of hemolytic streptococcus pyogenes
FR2481314A1
(en)
*
1980-04-25
1981-10-30
Kanebo Ltd
Culturing Streptococcus pyogenes – to yield antitumour agent streptolysin S, using sugar as carbon source and controlled pH
US4401653A
(en)
*
1981-03-09
1983-08-30
Ayerst, Mckenna & Harrison Inc.
Combination of rapamycin and picibanil for the treatment of tumors
AU5359186A
(en)
*
1985-01-25
1986-08-13
Population Council, Inc., The
Method & product for enhancing circulating antibody response
1967
1967-03-03
GB
GB10290/67A
patent/GB1132676A/en
not_active
Expired
1967-03-06
US
US620661A
patent/US3477914A/en
not_active
Expired – Lifetime
1967-03-06
DE
DE1617397A
patent/DE1617397C3/en
not_active
Expired
1967-03-07
DK
DK117967AA
patent/DK115652B/en
not_active
IP Right Cessation
1967-03-07
SU
SU1139070A
patent/SU520055A3/en
active
1967-03-07
BE
BE695122D
patent/BE695122A/xx
not_active
IP Right Cessation
1967-03-07
ES
ES337684A
patent/ES337684A1/en
not_active
Expired
1967-03-07
NO
NO167165A
patent/NO121972B/no
unknown
1967-03-07
CH
CH331067A
patent/CH526959A/en
not_active
IP Right Cessation
1967-03-07
FR
FR97672A
patent/FR6516M/fr
not_active
Expired
1967-03-08
YU
YU0452/67A
patent/YU33209B/en
unknown
1967-03-08
SE
SE03170/67A
patent/SE348943B/xx
unknown
1967-03-08
CA
CA984,715,A
patent/CA950847A/en
not_active
Expired
1967-03-08
NL
NL6703623A
patent/NL6703623A/xx
unknown
1967-03-08
CS
CS1700A
patent/CS150186B2/cs
unknown
Also Published As
Publication number
Publication date
US3477914A
(en)
1969-11-11
YU45267A
(en)
1975-12-31
SU520055A3
(en)
1976-06-30
CH526959A
(en)
1972-08-31
NO121972B
(en)
1971-05-03
FR6516M
(en)
1968-12-09
DE1617397B2
(en)
1979-05-03
CS150186B2
(en)
1973-09-04
SE348943B
(en)
1972-09-18
DK115652B
(en)
1969-10-27
NL6703623A
(en)
1967-09-11
YU33209B
(en)
1976-06-30
DE1617397C3
(en)
1980-01-03
DE1617397A1
(en)
1971-03-18
BE695122A
(en)
1967-08-14
ES337684A1
(en)
1968-03-01
CA950847A
(en)
1974-07-09
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