GB1197089A

GB1197089A – New Aminopyrimides and process for their preparation
– Google Patents

GB1197089A – New Aminopyrimides and process for their preparation
– Google Patents
New Aminopyrimides and process for their preparation

Info

Publication number
GB1197089A

GB1197089A
GB33852/67A
GB3385267A
GB1197089A
GB 1197089 A
GB1197089 A
GB 1197089A
GB 33852/67 A
GB33852/67 A
GB 33852/67A
GB 3385267 A
GB3385267 A
GB 3385267A
GB 1197089 A
GB1197089 A
GB 1197089A
Authority
GB
United Kingdom
Prior art keywords
group
alk
free
aliphatic
amino
Prior art date
1966-07-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB33852/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

BASF Schweiz AG

Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1966-07-28
Filing date
1967-07-24
Publication date
1970-07-01

1967-07-24
Application filed by Ciba AG
filed
Critical
Ciba AG

1970-07-01
Publication of GB1197089A
publication
Critical
patent/GB1197089A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00

C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC

Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S426/00—Food or edible material: processes, compositions, and products

Y10S426/807—Poultry or ruminant feed

Abstract

1,197,089. N,N1 – Di – [(pyrimidyl – 2 – amino) alkyl]-piperazines. CIBA Ltd. 24 July, 1967 [28 July, 1966; 13 June, 1967], No. 33852/67. Heading C2C. Novel N,N1 – di – [(pyrimidyl – 2 – amino) alkyl]-piperazines of the general formula wherein Alk, Alk1, Alk 1 and Alk 2 are each an alkylene radical which separates the nitrogen atoms connected by it by at least 2 carbon atoms, Alk and Alk1 having from 2 to 6 carbon atoms, R 1 and R1 1 are each a free amino group or an amino group mono- or di-substituted by 1 or 2 C 1-7 hydrocarbon radicals of aliphatic character, whose carbon chain may be interrupted once by an oxygen atom, a sulphur atom or an imino group and/or may be substituted by a free hydroxyl or free amino group; R 2 and R1 2 are each a hydrogen atom, a hydrocarbon radical of aliphatic or araliphatic character which may be interrupted once in the aliphatic carbon chain by an oxygen atom, an imino group or a sulphur atom, or a free or etherified hydroxyl or mercapto group; R 3 and R1 3 are each a hydrogen atom, a free amino group or an amino group mono- or di-substituted by 1 or 2 C 1-7 hydrocarbon radicals of aliphatic character, whose carbon chain may be interrupted once by an oxygen atom, a sulphur atom or an imino group and/or may be substituted by a free hydroxyl or free amino group, a hydrocarbon radical of aromatic, aliphatic or araliphatic character, in which the aliphatic carbon chain may be interrupted once by an oxygen atom, an imino group or a sulphur atom, or a free or eitherified hydroxyl or mercapto group; or in which R 2 and R 3 together and/or R1 2 and R1 3 together may each represent an alkylene group; and R and R1 are each a hydrogen atom or a C 1-7 alkyl or aryl-C 1-7 alkyl group; and N-oxides and acid addition salts thereof are prepared by reaction of a 2-methylthio-pyrimidine derivative with an N,N1-di-(aminoalkyl) piperazine, followed by optional conversion of the product to an N-oxide or acid addition salt thereof. 2 – Methylthio – 4 – amino – pyrimidines are prepared by reaction of a 2-methylthio-4- chloropyrimidine with ammonia or a suitable amine. Pharmaceutical compositions having antibacterial and anti-inflammatory activity comprise, as active ingredient, an N,N1-di-[(pyrimidyl-2-amino)-alkyl]-piperazine of the above general formula or an N-oxide or physiologically tolerable acid addition salt thereof, in admixture or conjunction with a pharmaceutically suitable carrier.

GB33852/67A
1966-07-28
1967-07-24
New Aminopyrimides and process for their preparation

Expired

GB1197089A
(en)

Applications Claiming Priority (4)

Application Number
Priority Date
Filing Date
Title

CH1583868A

CH485754A
(en)

1966-07-28
1966-07-28

Process for the preparation of new aminopyrimidines

CH1583668A

CH485753A
(en)

1966-07-28
1966-07-28

Process for the preparation of new aminopyrimidines

CH1096766A

CH486471A
(en)

1966-07-28
1966-07-28

Process for the preparation of new aminopyrimidines

CH837067

1967-06-13

Publications (1)

Publication Number
Publication Date

GB1197089A
true

GB1197089A
(en)

1970-07-01

Family
ID=27429142
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB33852/67A
Expired

GB1197089A
(en)

1966-07-28
1967-07-24
New Aminopyrimides and process for their preparation

Country Status (7)

Country
Link

US
(1)

US3503977A
(en)

BE
(1)

BE701938A
(en)

CH
(3)

CH485753A
(en)

DE
(1)

DE1670449A1
(en)

FR
(2)

FR1549237A
(en)

GB
(1)

GB1197089A
(en)

NL
(1)

NL6710407A
(en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

CH478816A
(en)

*

1965-10-22
1969-09-30
Ciba Geigy

Process for the preparation of new N, N’-di- (pyrimidyl- (4) -aminoalkyl) -diazacycloalkanes

1966

1966-07-28
CH
CH1583668A
patent/CH485753A/en
not_active
IP Right Cessation

1966-07-28
CH
CH1096766A
patent/CH486471A/en
not_active
IP Right Cessation

1966-07-28
CH
CH1583868A
patent/CH485754A/en
not_active
IP Right Cessation

1967

1967-07-12
US
US652679A
patent/US3503977A/en
not_active
Expired – Lifetime

1967-07-19
DE
DE19671670449
patent/DE1670449A1/en
active
Pending

1967-07-24
GB
GB33852/67A
patent/GB1197089A/en
not_active
Expired

1967-07-25
FR
FR1549237D
patent/FR1549237A/fr
not_active
Expired

1967-07-27
NL
NL6710407A
patent/NL6710407A/xx
unknown

1967-07-27
BE
BE701938D
patent/BE701938A/xx
unknown

1967-10-18
FR
FR7245D
patent/FR7245M/fr
not_active
Expired

Also Published As

Publication number
Publication date

CH485754A
(en)

1970-02-15

CH485753A
(en)

1970-02-15

US3503977A
(en)

1970-03-31

FR7245M
(en)

1969-09-08

NL6710407A
(en)

1968-01-29

DE1670449A1
(en)

1971-02-11

FR1549237A
(en)

1968-12-13

CH486471A
(en)

1970-02-28

BE701938A
(en)

1968-01-29

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Legal Events

Date
Code
Title
Description

1970-11-11
PS
Patent sealed [section 19, patents act 1949]

1975-02-19
PLNP
Patent lapsed through nonpayment of renewal fees

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