GB1231567A – – Google Patents
GB1231567A – – Google Patents
Info
Publication number
GB1231567A
GB1231567A
GB1231567DA
GB1231567A
GB 1231567 A
GB1231567 A
GB 1231567A
GB 1231567D A
GB1231567D A
GB 1231567DA
GB 1231567 A
GB1231567 A
GB 1231567A
Authority
GB
United Kingdom
Prior art keywords
nitro
prepared
reacting
oxide
acridine
Prior art date
1968-08-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1968-08-31
Filing date
1969-08-20
Publication date
1971-05-12
1968-08-31
Priority claimed from PL128855A
external-priority
patent/PL66626B1/pl
1969-08-20
Application filed
filed
Critical
1971-05-12
Publication of GB1231567A
publication
Critical
patent/GB1231567A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
C07D219/08—Nitrogen atoms
C07D219/10—Nitrogen atoms attached in position 9
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
C07D219/08—Nitrogen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
C07D219/08—Nitrogen atoms
C07D219/10—Nitrogen atoms attached in position 9
C07D219/12—Amino-alkylamino radicals attached in position 9
Abstract
1,231,567. N – oxides of 1 – nitro – 9 – (dialkylaminoalkylamino) – acridines. STAROGARDZKIE ZAKLADY FARMACEUTYCZNE POLFA STAROGARD GDANSKI. 20 Aug., 1969 [31 Aug., 1968], No. 41462/69. Heading C2C. The invention comprises compounds of Formulµ (I), (II) and (III) (in which R is alkylene and R 2 is alkyl). Compounds (I) are prepared by reacting a 1 – nitro – 9 – (dialkylaminoalkylamino) – acridine with an oxidizing agent, e.g. perbenzoic or perphthalic acid, at a temperature of 5‹ to 35‹ C. Compounds (II) are prepared by reacting a 1 – nitro – 9 – (chloro, phenoxy or alkoxy)-acridine-10-oxide or the pyridine complex of a 1-nitro-9-haloacridine-10-oxide with a dialkylaminoalkylamine at a temperature of 80‹ to 120‹ C. Compounds (III) are prepared by reacting a compound (II) with an oxidizing agent at a temperature not greater than 5‹ C. 1 – Nitro – 9 – (chloro, phenoxy or alkoxy)- acridine-10-oxides are prepared by reacting a 1-nitro-9-(chloro, phenoxy or alkoxy)-acridine with an oxidizing agent. 1-Nitro-9-phenoxyacridine-10-oxide may also be prepared by reacting 1 – nitro – 9 – chloroacridine – 10 – oxide with phenol or sodium phenoxide. Pyridine complexes of 1-nitro-9-haloacridine- 10-oxides are prepared by heating a 1-nitro-9- haloacridine-10-oxide with pyridine at a temperature up to the boiling-point of pyridine.
GB1231567D
1968-08-31
1969-08-20
Expired
GB1231567A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
PL128855A
PL66626B1
(en)
1968-08-31
Publications (1)
Publication Number
Publication Date
GB1231567A
true
GB1231567A
(en)
1971-05-12
Family
ID=19950137
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB1231567D
Expired
GB1231567A
(en)
1968-08-31
1969-08-20
Country Status (6)
Country
Link
US
(1)
US3694448A
(en)
CH
(1)
CH517096A
(en)
DE
(1)
DE1942185C3
(en)
FR
(1)
FR2022144B1
(en)
GB
(1)
GB1231567A
(en)
SU
(1)
SU700518A1
(en)
Families Citing this family (6)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
PL106752B1
(en)
*
1976-02-25
1980-01-31
Politechnika Gdanska
HOW TO RECEIVE NEW 1-NITRO-9-ALKYL-ALKYL-ALKYL-ACID AND OR THEIR SALT
PL101032B1
(en)
*
1976-04-06
1978-11-30
METHOD OF OBTAINING 1-NITRO-9-DUALKYL-AMINOIZOALKYLAMIROACRIDINES OR THEIR SALTS
US4258191A
(en)
*
1979-03-29
1981-03-24
The United States Of America As Represented By The Secretary Of Health, Education And Welfare
Multi-step process for the production of methanesulfon-m-anisidide, 4′-(9-acridinylamino)-
GB9107843D0
(en)
*
1991-04-12
1991-05-29
Patterson Laurence H
Anti-cancer compounds
GB9107852D0
(en)
*
1991-04-12
1991-05-29
Patterson Laurence H
Anti-cancer compounds
DK1140184T3
(en)
1998-12-23
2003-09-29
Searle Llc
Combinations of cholesterol ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
Family Cites Families (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US2880210A
(en)
*
1959-03-31
Acridine n-oxides
US2500131A
(en)
*
1945-06-27
1950-03-07
Ralph L Evans
Di-nu-oxides of amino-substituted acridines and quinolines
US2762809A
(en)
*
1953-10-27
1956-09-11
Sterling Drug Inc
2, 3-alkylenedioxy-6-nitro-9-(hydroxy-alkylaminoalkylamino) acridines and their preparation
GB799361A
(en)
*
1956-02-15
1958-08-06
Parke Davis & Co
Acridine compounds and the preparation thereof
DE1620473C3
(en)
*
1964-05-25
1980-03-20
Starogardzkie Zaklady Farmaceutyczne Polfa Przedsiebiorstwo Panstwowe, Starogard Gdanski (Polen)
Process for the preparation of 1-nitro-9- (3′-dimethylaminopropylamino) acridine dihydrochloride
1969
1969-08-12
CH
CH1220469A
patent/CH517096A/en
not_active
IP Right Cessation
1969-08-19
DE
DE1942185A
patent/DE1942185C3/en
not_active
Expired
1969-08-20
GB
GB1231567D
patent/GB1231567A/en
not_active
Expired
1969-08-22
FR
FR696928866A
patent/FR2022144B1/fr
not_active
Expired
1969-08-28
SU
SU691364473A
patent/SU700518A1/en
active
1969-09-02
US
US854608A
patent/US3694448A/en
not_active
Expired – Lifetime
Also Published As
Publication number
Publication date
SU700518A1
(en)
1979-11-30
DE1942185A1
(en)
1970-03-05
DE1942185B2
(en)
1977-08-25
FR2022144A1
(en)
1970-07-31
CH517096A
(en)
1971-12-31
US3694448A
(en)
1972-09-26
FR2022144B1
(en)
1973-08-10
DE1942185C3
(en)
1978-04-20
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Legal Events
Date
Code
Title
Description
1971-09-22
PS
Patent sealed [section 19, patents act 1949]
1980-04-02
PCNP
Patent ceased through non-payment of renewal fee
