GB1262078A

GB1262078A – Preparation of phenoxy fumaric acid compounds and chromone-2-carboxylic acid compounds therefrom
– Google Patents

GB1262078A – Preparation of phenoxy fumaric acid compounds and chromone-2-carboxylic acid compounds therefrom
– Google Patents
Preparation of phenoxy fumaric acid compounds and chromone-2-carboxylic acid compounds therefrom

Info

Publication number
GB1262078A

GB1262078A
GB2485768A
GB2485768A
GB1262078A
GB 1262078 A
GB1262078 A
GB 1262078A
GB 2485768 A
GB2485768 A
GB 2485768A
GB 2485768 A
GB2485768 A
GB 2485768A
GB 1262078 A
GB1262078 A
GB 1262078A
Authority
GB
United Kingdom
Prior art keywords
formula
acid compounds
atoms
groups
group
Prior art date
1968-05-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB2485768A
Inventor
Colin Fitzmaurice
Hugh Cairns
Richard Hazard
John King
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fisons Pharmaceuticals Ltd

Original Assignee
Fisons Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1968-05-24
Filing date
1968-05-24
Publication date
1972-02-02

1968-05-24
Application filed by Fisons Pharmaceuticals Ltd
filed
Critical
Fisons Pharmaceuticals Ltd

1968-05-24
Priority to GB2485768A
priority
Critical
patent/GB1262078A/en

1972-02-02
Publication of GB1262078A
publication
Critical
patent/GB1262078A/en

Status
Expired
legal-status
Critical
Current

Links

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Global Dossier

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Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings

C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems

C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring

C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups

C07C59/40—Unsaturated compounds

C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups

C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings

C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Abstract

1,262,078. Aryloxyfumaric acids; chromone- 2-carboxylic acids. FISONS PHARMACEUTICALS Ltd. 9 May, 1969 [24 May, 1968], No. 24857/68. Heading C2C. Compounds of the formula wherein R6 is H or an R group, R is an alkyl group carrying one or more OH groups or a COOH group as substituents, an alkyl or aralkyl group interrupted by one or more O atoms which may, if desired, carry as substituents one or more OH groups, or is a heterocyclic ring containing C and O atoms which may be substituted by one or more OH groups or by one or more alkyl groups; R1, R2 and R3 are the same or different and each is H, halogen, lower alkyl or a group OR; or R1 and R2 together with the adjacent C atoms form a saturated or unsaturated heterocyclic ring containing only C and O atoms; are obtained by reacting a compound of the formula where M is H or an alkali metal cation with an acid of the formula or an ester thereof, where R12 is halogen and R13 is H, or R12 and R13 together form a C-C bond when R10 and R11 together form a C-C bond; or two of R10, R11, R12 and R13 are halogen, and the other two are H; under alkaline conditions, followed by hydrolysis of the product. Examples are given. Also, compounds of the formula or functional derivatives thereof; are obtained by cyclizing compounds of Formula I. Examples are given. 5 – (2 – Ethoxyethoxy) – 2 – ethyl phenol is obtained by reduction of 4-(2-ethoxyethoxy)-2- hydroxy-acetophenone with a Zn amalgam.

GB2485768A
1968-05-24
1968-05-24
Preparation of phenoxy fumaric acid compounds and chromone-2-carboxylic acid compounds therefrom

Expired

GB1262078A
(en)

Priority Applications (1)

Application Number
Priority Date
Filing Date
Title

GB2485768A

GB1262078A
(en)

1968-05-24
1968-05-24
Preparation of phenoxy fumaric acid compounds and chromone-2-carboxylic acid compounds therefrom

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

GB2485768A

GB1262078A
(en)

1968-05-24
1968-05-24
Preparation of phenoxy fumaric acid compounds and chromone-2-carboxylic acid compounds therefrom

Publications (1)

Publication Number
Publication Date

GB1262078A
true

GB1262078A
(en)

1972-02-02

Family
ID=10218344
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB2485768A
Expired

GB1262078A
(en)

1968-05-24
1968-05-24
Preparation of phenoxy fumaric acid compounds and chromone-2-carboxylic acid compounds therefrom

Country Status (1)

Country
Link

GB
(1)

GB1262078A
(en)

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0068250A1
(en)

*

1981-06-26
1983-01-05
Bayer Ag
Dioxybenzene ether derivatives, pharmaceutical compositions containing them, process for the preparation thereof and their use

US7365095B2
(en)

2005-04-22
2008-04-29
Wyeth
Chromane and chromene derivatives and uses thereof

1968

1968-05-24
GB
GB2485768A
patent/GB1262078A/en
not_active
Expired

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0068250A1
(en)

*

1981-06-26
1983-01-05
Bayer Ag
Dioxybenzene ether derivatives, pharmaceutical compositions containing them, process for the preparation thereof and their use

US7365095B2
(en)

2005-04-22
2008-04-29
Wyeth
Chromane and chromene derivatives and uses thereof

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