GB1292010A

GB1292010A – A new antibiotic, its production and its use
– Google Patents

GB1292010A – A new antibiotic, its production and its use
– Google Patents
A new antibiotic, its production and its use

Info

Publication number
GB1292010A

GB1292010A
GB26602/71A
GB2660271A
GB1292010A
GB 1292010 A
GB1292010 A
GB 1292010A
GB 26602/71 A
GB26602/71 A
GB 26602/71A
GB 2660271 A
GB2660271 A
GB 2660271A
GB 1292010 A
GB1292010 A
GB 1292010A
Authority
GB
United Kingdom
Prior art keywords
antibiotic
chloroform
rhodomycin
butanol
extract
Prior art date
1970-03-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB26602/71A
Inventor
Hans Brockmann
Martin Scheer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1970-03-18
Filing date
1971-04-19
Publication date
1972-10-11

1971-04-19
Application filed by Bayer AG
filed
Critical
Bayer AG

1972-10-11
Publication of GB1292010A
publication
Critical
patent/GB1292010A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS

C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals

C07H15/20—Carbocyclic rings

C07H15/24—Condensed ring systems having three or more rings

C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC

Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S435/00—Chemistry: molecular biology and microbiology

Y10S435/8215—Microorganisms

Y10S435/822—Microorganisms using bacteria or actinomycetales

Y10S435/886—Streptomyces

Abstract

1292010 The antibiotic #-rhodomycin V FARBENFABRIKEN BAYER AG 19 April 1971 [18 March 1970] 26602/71 Heading C2A The new antibiotic #-rhodomycin V having the Formula I wherein R is a tetraglycoside radical consisting of 1 mol. 2-desoxy-fucose, 1 mol. rhodosamine and 2 mols. rhodinose, is prepared by aerobically cultivating a #-rhodomycin V-producing strain of Streptomyces purpurascens (e.g CBS. 296.71) and isolating the #-rhodomycin V from the fermented culture by extracting with at least one solvent at a pH of 6À5 to 7À5. The antibiotic is a red crystalline solid melting with decomposition at 173-175 C., soluble in methanol, butanol, acetone, chloroform and aqueous acids, sparingly soluble in water and benzene and insoluble in cyclohexane, and having an optical rotation [α]20 313nm = -40 2 degrees (C=0À2 in CHCl 3 ). The fermented culture medium is treated with kieselguhr, filtered and the filter cake is extracted with acetone, the solution evaporated to low volume and back-extracted with butanol, which extract is in turn evaporated and the residue is taken up in chloroform. The culture filtrate also is extracted, preferably with butanol, the extract evaporated and the residue is taken up in chloroform. The antibiotic is obtained by chromatographing the combined chloroform solutions on carboxymethylcellulose with 10% aqueous potassium hydrogen phosphate, making the eluate slightly alkaline (pH 8À0) with ammonia and extracting with chloroform, and precipitating from this extract by adding petroleum ether. It may be purified by chromatography on cellulose with butanol-phosphate buffer 1 : 1, pH 5À8, extracting the alkalized extract with chloroform and precipitating with cyclohexane at boiling temperature. Pharmaceutical compositions having antibiotic activity against Gram-positive and Gramnegative bacteria and mycoplasma organisms (PPLO) comprise the antibiotic #-rhodomycin V of Formula (I) together with a pharmaceutically acceptable carrier, or in unit dosage form optionally without a carrier. The antibiotic may be admixed with an animal feedstuff to provide a veterinary composition.

GB26602/71A
1970-03-18
1971-04-19
A new antibiotic, its production and its use

Expired

GB1292010A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

DE19702012808

DE2012808A1
(en)

1970-03-18
1970-03-18

Publications (1)

Publication Number
Publication Date

GB1292010A
true

GB1292010A
(en)

1972-10-11

Family
ID=5765429
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB26602/71A
Expired

GB1292010A
(en)

1970-03-18
1971-04-19
A new antibiotic, its production and its use

Country Status (7)

Country
Link

US
(1)

US3723411A
(en)

BE
(1)

BE764472A
(en)

DE
(1)

DE2012808A1
(en)

FR
(1)

FR2085720B1
(en)

GB
(1)

GB1292010A
(en)

IL
(1)

IL36356A0
(en)

NL
(1)

NL7103590A
(en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4204038A
(en)

*

1976-04-07
1980-05-20
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
Process for preparing antibiotics MA 144-M1 and MA 144-M2

US4192915A
(en)

*

1976-08-16
1980-03-11
Bristol-Myers Company
Anthracycline glycosides from streptomyces

US4209588A
(en)

*

1976-10-05
1980-06-24
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
Process for producing new antitumor anthracycline antibiotics

US4385122A
(en)

*

1980-07-24
1983-05-24
Smithkline Beckman Corporation
Anthracycline antibiotics produced by streptosporangium fragile

US4293546A
(en)

*

1980-07-24
1981-10-06
Smithkline Corporation
Anthracycline antibiotics produced by Streptosporangium fragilis Shearer sp. nov. ATCC 31519

1970

1970-03-18
DE
DE19702012808
patent/DE2012808A1/de
active
Pending

1971

1971-03-05
IL
IL36356A
patent/IL36356A0/en
unknown

1971-03-12
US
US00123882A
patent/US3723411A/en
not_active
Expired – Lifetime

1971-03-17
NL
NL7103590A
patent/NL7103590A/xx
unknown

1971-03-18
BE
BE764472A
patent/BE764472A/en
unknown

1971-03-18
FR
FR7109601A
patent/FR2085720B1/fr
not_active
Expired

1971-04-19
GB
GB26602/71A
patent/GB1292010A/en
not_active
Expired

Also Published As

Publication number
Publication date

NL7103590A
(en)

1971-09-21

FR2085720A1
(en)

1971-12-31

DE2012808A1
(en)

1971-11-25

FR2085720B1
(en)

1974-08-30

BE764472A
(en)

1971-09-20

IL36356A0
(en)

1971-05-26

US3723411A
(en)

1973-03-27

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Legal Events

Date
Code
Title
Description

1973-02-21
PS
Patent sealed [section 19, patents act 1949]

1975-11-19
PLNP
Patent lapsed through nonpayment of renewal fees

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