GB1294706A – Improvements in or relating to the preparation of the monohydrate of the sodium salt of 6-(3-phenyl-5-methylisoxazole-4-carbamido)-penicillanic acid
– Google Patents
GB1294706A – Improvements in or relating to the preparation of the monohydrate of the sodium salt of 6-(3-phenyl-5-methylisoxazole-4-carbamido)-penicillanic acid
– Google Patents
Improvements in or relating to the preparation of the monohydrate of the sodium salt of 6-(3-phenyl-5-methylisoxazole-4-carbamido)-penicillanic acid
Info
Publication number
GB1294706A
GB1294706A
GB4890670A
GB4890670A
GB1294706A
GB 1294706 A
GB1294706 A
GB 1294706A
GB 4890670 A
GB4890670 A
GB 4890670A
GB 4890670 A
GB4890670 A
GB 4890670A
GB 1294706 A
GB1294706 A
GB 1294706A
Authority
GB
United Kingdom
Prior art keywords
phenyl
carbamido
penicillanic acid
acid
methylisoxazole
Prior art date
1970-10-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4890670A
Inventor
Marina Alexeevna Panina
Gersh Izrailevich Kleiner
Ivan Timofeevich Strukov
Alexandra Fedorovna Zdobnova
Maria Kvzminichna Andreeva
Nonna Mikhailovna Ryabova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VNII ANTIBIOTIKOV
Original Assignee
VNII ANTIBIOTIKOV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1970-10-14
Filing date
1970-10-14
Publication date
1972-11-01
1970-10-14
Application filed by VNII ANTIBIOTIKOV
filed
Critical
VNII ANTIBIOTIKOV
1970-10-14
Priority to GB4890670A
priority
Critical
patent/GB1294706A/en
1972-11-01
Publication of GB1294706A
publication
Critical
patent/GB1294706A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Abstract
1294706 Preparation of substituted penicillanic acid salts VSESOJUZNY NAUCHNOISSLEDOVATELSKY INSTITUT ANTIBIOTIKOV 14 Oct 1970 48906/70 Heading C2A A method of preparing 6-(3-phenyl-5-methylisoxazole-4-carbamido)-penicillanic acid sodium salt monohydrate (oxacilline) comprises reacting sodium acetate, which may be anhydrous or a 30-35% aqueous solution, with 6-(3-phenyl-5-methyl-isoxazole- 4-carbamido)-penicillanic acid. The acid may be prepared by condensation of 6-aminopenicillanic acid with 3-phenyl-5-methylisoxazole-4-carboxylic. acid chloride in the presence of a binder for hydrogen chloride, e.g. sodium bicarbonate. The condensation may be carried out in an aqueous acetone medium and the reaction product may be extracted with an organic solvent. The organic extract is dried to a moisture content of 0À8 to 1.0% as determined by the Fisher method. Pharmaceutical compositions for peroral or parenteral administration may be prepared from 6-(3-phenyl-5- methylinoxazole-4-carbamido)-penicillanic acid sodium salt monohydrate as obtained by the method described above.
GB4890670A
1970-10-14
1970-10-14
Improvements in or relating to the preparation of the monohydrate of the sodium salt of 6-(3-phenyl-5-methylisoxazole-4-carbamido)-penicillanic acid
Expired
GB1294706A
(en)
Priority Applications (1)
Application Number
Priority Date
Filing Date
Title
GB4890670A
GB1294706A
(en)
1970-10-14
1970-10-14
Improvements in or relating to the preparation of the monohydrate of the sodium salt of 6-(3-phenyl-5-methylisoxazole-4-carbamido)-penicillanic acid
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
GB4890670A
GB1294706A
(en)
1970-10-14
1970-10-14
Improvements in or relating to the preparation of the monohydrate of the sodium salt of 6-(3-phenyl-5-methylisoxazole-4-carbamido)-penicillanic acid
Publications (1)
Publication Number
Publication Date
GB1294706A
true
GB1294706A
(en)
1972-11-01
Family
ID=10450394
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB4890670A
Expired
GB1294706A
(en)
1970-10-14
1970-10-14
Improvements in or relating to the preparation of the monohydrate of the sodium salt of 6-(3-phenyl-5-methylisoxazole-4-carbamido)-penicillanic acid
Country Status (1)
Country
Link
GB
(1)
GB1294706A
(en)
Cited By (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
CN102285998A
(en)
*
2011-06-17
2011-12-21
桂林理工大学
Preparation method of amorphous and three polymorphic substances of flucloxacillin sodium
CN103288852A
(en)
*
2011-06-17
2013-09-11
桂林理工大学
Preparation method of flucloxacillin sodium crystal form II
1970
1970-10-14
GB
GB4890670A
patent/GB1294706A/en
not_active
Expired
Cited By (6)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
CN102285998A
(en)
*
2011-06-17
2011-12-21
桂林理工大学
Preparation method of amorphous and three polymorphic substances of flucloxacillin sodium
CN103288852A
(en)
*
2011-06-17
2013-09-11
桂林理工大学
Preparation method of flucloxacillin sodium crystal form II
CN103288850A
(en)
*
2011-06-17
2013-09-11
桂林理工大学
Preparation method of flucloxacillin sodium amorphous crystal-form substance
CN102285998B
(en)
*
2011-06-17
2013-12-18
桂林理工大学
Preparation method of amorphous and three polymorphic substances of flucloxacillin sodium
CN103288852B
(en)
*
2011-06-17
2015-05-20
桂林理工大学
Preparation method of flucloxacillin sodium crystal form II
CN103288850B
(en)
*
2011-06-17
2015-09-23
桂林理工大学
The preparation method of the amorphous crystal formation thing of Sodium flucloxacillin
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Legal Events
Date
Code
Title
Description
1973-03-14
PS
Patent sealed
1975-05-14
PLNP
Patent lapsed through nonpayment of renewal fees
