GB1311117A – Basically substituted 2,4-1h,3h-quinazolinedione derivatives and processes for the production thereof
– Google Patents
GB1311117A – Basically substituted 2,4-1h,3h-quinazolinedione derivatives and processes for the production thereof
– Google Patents
Basically substituted 2,4-1h,3h-quinazolinedione derivatives and processes for the production thereof
Info
Publication number
GB1311117A
GB1311117A
GB3238370A
GB3238370A
GB1311117A
GB 1311117 A
GB1311117 A
GB 1311117A
GB 3238370 A
GB3238370 A
GB 3238370A
GB 3238370 A
GB3238370 A
GB 3238370A
GB 1311117 A
GB1311117 A
GB 1311117A
Authority
GB
United Kingdom
Prior art keywords
reaction
trimethoxy
prepared
hydroxypropyl
nitro
Prior art date
1969-07-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3238370A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cassella Farbwerke Mainkur AG
Original Assignee
Cassella Farbwerke Mainkur AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1969-07-04
Filing date
1970-07-03
Publication date
1973-03-21
1970-07-03
Application filed by Cassella Farbwerke Mainkur AG
filed
Critical
Cassella Farbwerke Mainkur AG
1973-03-21
Publication of GB1311117A
publication
Critical
patent/GB1311117A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
C07D239/72—Quinazolines; Hydrogenated quinazolines
C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
C07D239/96—Two oxygen atoms
A—HUMAN NECESSITIES
A63—SPORTS; GAMES; AMUSEMENTS
A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
A63B43/00—Balls with special arrangements
A63B43/02—Balls with special arrangements with a handle
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C265/00—Derivatives of isocyanic acid
C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
Abstract
1311117 Quinazoline derivatives CASSELLA FARBWERKE MAINKUR AG 3 July 1970 [4 July 1969] 32383/70 Heading C2C Novel compounds I: in which R is a secondary aliphatic, cycloaliphatic or araliphatic amine radical with 2-10 C or a 5-, 6- or 7-membered heterocyclic amine radical optionally having a further N atom or an O or S atom, said radicals being attached through the N atom; R, where it is a secondary aliphatic amine radical, being optionally substituted by a piperidino group; R 1 is alkoxy and n is 2 or 3, are prepared by (1) reaction of R-H with the ‘ appropriate 3-(γ-halo-#-hydroxypropyl)-quinazoline; (2) reaction of with the appropriate 3-unsubstituted quinazoline; (3) cyclization of a compound II: with COCl 2 , ClCOOC 2 H 5 or urea; (4) condensation of a compound III: with H 2 N-CH 2 -CH(OH)-CH 2 R and cyclization of the resultant intermediate; or (5) reaction of a compound with 4 2 N-CH 2 -CH(OH)-CH 2 R. Intermediates isolated are 6,7,8-trimethoxy- 2,4 – (1H,3H) – quinasoline dione, prepared from 3,4,5 – trimethoxy – anthranilamide and ethyl chloroformate; 3 – (γ – chloro – # – hydroxypropyl) – 6,7,8 – trimethoxy – 2,4 – (1H,3H) – quinazoline dione, prepared by reaction of the 3- unsubstituted derivative with epichlorohydrin, or by reaction of 2,3,4-trimethoxy-6-methoxycarbonyl-phenyl isocyanate with 3-chloro-1- amino-propan-2-ol hydrochloride; 2-nitro-3,4,5- trimethoxy – N – (γ – chloro – # – hydroxypropyl)- benzamide, prepared by reaction of 3-chloro-1- amino-propan-2-ol-HCl with 2-nitro-3,4,5-trimethoxybenzoyl chloride; 2-nitro-3,4,5-trimethoxy – N – (γ – morpholino – # – hydroxypropyl)- benzamide, prepared by reaction of morpholine with the previous intermediate; 2-amino-3,4,5- trimethoxy – N – (γ – morpholino – # – hydroxypropyl)-benzamide, prepared by reduction of the nitro derivative above or by reaction of 2-nitro- 3,4,5-trimethoxybenzoyl chloride with N-(γ- amino – # – hydroxypropyl) – morpholine and subsequent catalytic hydrogenation, or by reaction of 3,4,5-trimethoxy-isatoic anhydride with γ – morpholino – # – hydroxy – propylamine; 2,3,4 – trimethoxy – 6 – methoxy – carbonyl – phenyl isocyanate, prepared by reaction of methyl 3,4,5 – trimethoxy – anthranilate with phosgene; 3,4 – dimethoxy – 6 – methoxycarbonylphenyl-carbamoyl chloride, prepared from methyl 4,5 – dimethoxy – anthranilate and phosgene; and N – (3,4 – dimethoxy – 6 – methoxycarbonylphenyl) – N
GB3238370A
1969-07-04
1970-07-03
Basically substituted 2,4-1h,3h-quinazolinedione derivatives and processes for the production thereof
Expired
GB1311117A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
DE19691934037
DE1934037A1
(en)
1969-07-04
1969-07-04
Basically substituted derivatives of 2,4- (1H, 3H) -quinazolinedione
Publications (1)
Publication Number
Publication Date
GB1311117A
true
GB1311117A
(en)
1973-03-21
Family
ID=5738913
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB3238370A
Expired
GB1311117A
(en)
1969-07-04
1970-07-03
Basically substituted 2,4-1h,3h-quinazolinedione derivatives and processes for the production thereof
Country Status (9)
Country
Link
US
(1)
US3718648A
(en)
AT
(5)
AT297001B
(en)
BE
(1)
BE753010A
(en)
BR
(1)
BR6915193D0
(en)
CH
(5)
CH549026A
(en)
DE
(1)
DE1934037A1
(en)
FR
(1)
FR2059482B1
(en)
GB
(1)
GB1311117A
(en)
NL
(1)
NL7009212A
(en)
Families Citing this family (6)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
SE368009B
(en)
*
1971-09-16
1974-06-17
Kabi Ab
US3879393A
(en)
*
1973-06-18
1975-04-22
Miles Lab
Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
DE2833140A1
(en)
*
1978-07-28
1980-02-07
Boehringer Sohn Ingelheim
NEW N-SUBSTITUTED HETEROCYCLES
US4268511A
(en)
*
1980-03-11
1981-05-19
Berri-Balzac
3-Amino(1H,3H)quinazoline-2,4-dione derivatives and their therapeutic applications
JPS58159480A
(en)
*
1982-03-17
1983-09-21
Chugai Pharmaceut Co Ltd
Novel phenylpiperazine derivative
PL165856B1
(en)
*
1990-04-24
1995-02-28
Dresden Arzneimittel
Method of obtaining novel 3-/mercaptoalkyl/-quinazoline-/1h,3h/-diones-2,4
Family Cites Families (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3274194A
(en)
*
1963-03-29
1966-09-20
Miles Lab
Quinazolinedione derivatives
1969
1969-07-04
DE
DE19691934037
patent/DE1934037A1/en
active
Pending
1969-12-16
BR
BR215193/69A
patent/BR6915193D0/en
unknown
1970
1970-06-23
NL
NL7009212A
patent/NL7009212A/xx
unknown
1970-06-25
US
US00049932A
patent/US3718648A/en
not_active
Expired – Lifetime
1970-07-03
CH
CH1013470A
patent/CH549026A/en
not_active
IP Right Cessation
1970-07-03
CH
CH1013370A
patent/CH549025A/en
not_active
IP Right Cessation
1970-07-03
GB
GB3238370A
patent/GB1311117A/en
not_active
Expired
1970-07-03
FR
FR7024775A
patent/FR2059482B1/fr
not_active
Expired
1970-07-03
AT
AT603870A
patent/AT297001B/en
not_active
IP Right Cessation
1970-07-03
AT
AT604070A
patent/AT297003B/en
not_active
IP Right Cessation
1970-07-03
CH
CH1013670A
patent/CH550182A/en
not_active
IP Right Cessation
1970-07-03
AT
AT603770A
patent/AT297000B/en
not_active
IP Right Cessation
1970-07-03
CH
CH1013770A
patent/CH550183A/en
not_active
IP Right Cessation
1970-07-03
AT
AT604170A
patent/AT297004B/en
not_active
IP Right Cessation
1970-07-03
AT
AT603970A
patent/AT297002B/en
not_active
IP Right Cessation
1970-07-03
CH
CH1013570A
patent/CH549580A/en
not_active
IP Right Cessation
1970-07-03
BE
BE753010D
patent/BE753010A/en
unknown
Also Published As
Publication number
Publication date
US3718648A
(en)
1973-02-27
AT297001B
(en)
1972-03-10
DE1934037A1
(en)
1971-01-07
CH549025A
(en)
1974-05-15
BE753010A
(en)
1971-01-04
BR6915193D0
(en)
1973-01-11
CH549026A
(en)
1974-05-15
AT297000B
(en)
1972-03-10
FR2059482B1
(en)
1974-05-10
AT297003B
(en)
1972-03-10
AT297002B
(en)
1972-03-10
AT297004B
(en)
1972-03-10
FR2059482A1
(en)
1971-06-04
CH549580A
(en)
1974-05-31
CH550183A
(en)
1974-06-14
CH550182A
(en)
1974-06-14
NL7009212A
(en)
1971-01-06
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Legal Events
Date
Code
Title
Description
1973-08-01
PS
Patent sealed [section 19, patents act 1949]
1976-02-04
PLNP
Patent lapsed through nonpayment of renewal fees
