GB1341401A – Methylenedioxy quinazoline derivatives
– Google Patents
GB1341401A – Methylenedioxy quinazoline derivatives
– Google Patents
Methylenedioxy quinazoline derivatives
Info
Publication number
GB1341401A
GB1341401A
GB5637070A
GB5637070A
GB1341401A
GB 1341401 A
GB1341401 A
GB 1341401A
GB 5637070 A
GB5637070 A
GB 5637070A
GB 5637070 A
GB5637070 A
GB 5637070A
GB 1341401 A
GB1341401 A
GB 1341401A
Authority
GB
United Kingdom
Prior art keywords
group
methylenedioxy
general formula
chr
formula
Prior art date
1969-12-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5637070A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1969-12-01
Filing date
1970-11-27
Publication date
1973-12-19
1970-11-27
Application filed by Sandoz AG
filed
Critical
Sandoz AG
1973-12-19
Publication of GB1341401A
publication
Critical
patent/GB1341401A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 – C07D459/00, C07D463/00, C07D477/00 or C07D489/00
C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 – C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
C07D491/04—Ortho-condensed systems
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
C07D317/66—Nitrogen atoms not forming part of a nitro radical
Abstract
1341401 6,7-Methylenedioxy-2(IH)-quinazolinones SANDOZ Ltd 27 Nov 1970 [1 Dec 1969 5 May 1970] 56370/70 Heading C2C 6,7-Methylenedioxy-2(IH)-quinazolinones of the general formula wherein R is a C 1-5 alkyl group and #xy is a -C(R 1 )=N- or -CHR 1 -NH- group in which either R 1 is a radical of formula in which each of Y and Y 1 is a hydrogen, fluorine or chlorine atom or a C 1-3 alkyl, C 1-3 alkoxy, nitro or trifluoromethyl group, provided that no more than one of Y and Y 1 is a trifluoromethyl or nitro group, or Y and Y 1 are on adjacent carbon atoms and together form a methylenedioxy group, or R 1 is a radical of formula in which Y 2 is a hydrogen, fluorine or chlorine atom or a C 1-3 alkyl group, are prepared (a) when #xy is a -C(R 1 ) = N- group, by oxidation of the corresponding compound in which #xy is a -CHR 1 -NH- group in an inert organic solvent, and (b) when #xy is a -CHR 1 -NH- group, by reaction of a 3,4-methylenedioxyphenylurea of the general formula with an aldehyde of the general formula R 1 CHO at an elevated temperature, under substantially anhydrous conditions and in the presence of an acid. The products are novel, but 1-isopropyl-4- (p-fluorophenyl)-6,7-methylenedioxy-2(IH)-quinazolinone forms the subject of Specification 1,341,402. Pharmaceutical compositions having anti-inflammatory activity comprise, as active ingredient, a 6,7-methylenedioxy-2(IH)-quinazolinone of the first general formula above other than that in which R is an isopropyl group, #xy is a -C(R 1 )=N- group and R 1 is a p-fluorophenyl group, in association with a pharmaceutically acceptable carrier, and may be administered orally or parenterally.
GB5637070A
1969-12-01
1970-11-27
Methylenedioxy quinazoline derivatives
Expired
GB1341401A
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US88132569A
1969-12-01
1969-12-01
US3490270A
1970-05-05
1970-05-05
Publications (1)
Publication Number
Publication Date
GB1341401A
true
GB1341401A
(en)
1973-12-19
Family
ID=26711546
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB5637070A
Expired
GB1341401A
(en)
1969-12-01
1970-11-27
Methylenedioxy quinazoline derivatives
Country Status (8)
Country
Link
JP
(2)
JPS4946320B1
(en)
BE
(1)
BE759671A
(en)
CA
(1)
CA962679A
(en)
CH
(1)
CH539072A
(en)
ES
(1)
ES386022A1
(en)
FR
(1)
FR2081322B1
(en)
GB
(1)
GB1341401A
(en)
SE
(1)
SE364276B
(en)
Cited By (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0488144A1
(en)
*
1990-11-26
1992-06-03
Tsumura & Co.
Benzodioxole derivatives and hepatopathy improvers comprising the same
US6465472B1
(en)
1998-03-02
2002-10-15
Euro-Celtique S.A.
Substituted quinazolines and analogs and use thereof
Families Citing this family (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
JPS543264U
(en)
*
1977-06-07
1979-01-10
Family Cites Families (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
CH515911A
(en)
*
1968-07-01
1971-11-30
Sandoz Ag
Process for the preparation of 3,4-dihydro-4-phenyl-2 (1H) -quinazolinones
FR2012061A1
(en)
*
1969-06-30
1970-03-13
Sandoz Sa
Quinazolinone derivs – with antiphlogistic props
0
BE
BE759671D
patent/BE759671A/en
unknown
1970
1970-11-18
CH
CH1703570A
patent/CH539072A/en
not_active
IP Right Cessation
1970-11-27
GB
GB5637070A
patent/GB1341401A/en
not_active
Expired
1970-11-30
CA
CA099,406A
patent/CA962679A/en
not_active
Expired
1970-11-30
JP
JP10494470A
patent/JPS4946320B1/ja
active
Pending
1970-11-30
ES
ES386022A
patent/ES386022A1/en
not_active
Expired
1970-11-30
SE
SE1617470A
patent/SE364276B/xx
unknown
1970-12-01
FR
FR7043168A
patent/FR2081322B1/fr
not_active
Expired
1973
1973-04-17
JP
JP4274473A
patent/JPS4947759B1/ja
active
Pending
Cited By (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0488144A1
(en)
*
1990-11-26
1992-06-03
Tsumura & Co.
Benzodioxole derivatives and hepatopathy improvers comprising the same
US5227398A
(en)
*
1990-11-26
1993-07-13
Tsumura & Co.
Benzodioxole derivatives and hepatopathy improvers comprising the same
US6465472B1
(en)
1998-03-02
2002-10-15
Euro-Celtique S.A.
Substituted quinazolines and analogs and use thereof
US6765006B2
(en)
1998-03-02
2004-07-20
Euro-Celtique S.A.
Substituted quinazolines and analogs and the use thereof
US7652006B2
(en)
1998-03-02
2010-01-26
Euro-Celtique S.A.
Substituted 1(2H)-phthalazinones and pharmaceutical compositions thereof
Also Published As
Publication number
Publication date
ES386022A1
(en)
1973-12-16
CA962679A
(en)
1975-02-11
SE364276B
(en)
1974-02-18
BE759671A
(en)
1971-06-01
FR2081322B1
(en)
1974-10-11
JPS4946320B1
(en)
1974-12-09
CH539072A
(en)
1973-07-15
FR2081322A1
(en)
1971-12-03
JPS4947759B1
(en)
1974-12-17
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Legal Events
Date
Code
Title
Description
1974-05-01
PS
Patent sealed
1982-06-30
PCNP
Patent ceased through non-payment of renewal fee
