GB1342753A – Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof
– Google Patents
GB1342753A – Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof
– Google Patents
Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof
Info
Publication number
GB1342753A
GB1342753A
GB3175471A
GB3175471A
GB1342753A
GB 1342753 A
GB1342753 A
GB 1342753A
GB 3175471 A
GB3175471 A
GB 3175471A
GB 3175471 A
GB3175471 A
GB 3175471A
GB 1342753 A
GB1342753 A
GB 1342753A
Authority
GB
United Kingdom
Prior art keywords
alkyl
group
alkoxycarbonyl
carboxy
phenyl
Prior art date
1970-07-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3175471A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Merrell SpA
Original Assignee
Richardson Merrell SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1970-07-20
Filing date
1971-07-06
Publication date
1974-01-03
1971-07-06
Application filed by Richardson Merrell SpA
filed
Critical
Richardson Merrell SpA
1974-01-03
Publication of GB1342753A
publication
Critical
patent/GB1342753A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
C07D295/182—Radicals derived from carboxylic acids
C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
C07D295/205—Radicals derived from carbonic acid
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
Abstract
1342753 Diazacyclic compounds RICHARDSON-MERRELL SpA 6 July 1971 [20 July 1970] 31754/71 Heading C2C Novel diazacyclic compounds of the general formula wherein each of R and R 1 is a hydrogen or halogen atom or a trifluoromethyl, C 1-6 alkyl, phenyl, pyridyl, C 1-6 alkoxy, hydroxy, nitro, amino, mono- or di-C 1-6 alkylamino, C 2-7 alkanoylamino, C 2-7 alkoxycarbonyl, carboxy, carbamoyl, sulphamoyl or nitrile group or R and R 1 , when at adjacent positions, may together form a methylenedioxy group, R 2 is a hydrogen atom or a C 1-6 alkyl, phenyl, pyridyl, C 2-7 alkoxycarbonyl, carboxy, carbamoyl or sulphamoyl group, R 3 is a hydrogen atom or a C 1-6 alkyl, phenyl (optionally substituted by halogen atoms or C 1-6 alkyl or C 1-6 alkoxy groups), picolyl, benzyl (optionally substituted by halogen atoms or C 1-6 alkyl or C 1-6 alkoxy groups), alkanoyl, aroyl, cyanoethyl, C 2-7 alkoxycarbonyl, formyl, carboxy, carbethoxyethyl, N – monoalkyl-, N,N – dialkyl. or N- aryl – carbamoylmethyl, N – monoalkyl or N,N – dialkyl – carbamoylethyl, C 3-6 cycloalkyl or methyl-C 3-6 cycloalkyl group, n is 1, 2 or 3, each of A and B is a -Cmq-, -Cmq-Cwx- or -Cmq-Cwx-Cyzgroup, in which each of m, q, w, x, y and z is a hydrogen or halogen atom or a trifluoromethyl, C 1-6 alkyl, C 1-6 alkoxycarbonyl, carboxy, carbamoyl, sulphamoyl, phenyl, pyridyl, benzyl or picolyl group, or m and q, w and x or y and z together form an oxygen atom, and j and k are each 0 or 1, and pharmaceutically acceptable, non-toxic acid-addition salts thereof are prepared (a) by reaction of a ketone and a heterocyclic compound of the respective general formulµ and (b) when R 3 is an alkyl or acyl group, by alkylation or acylation of the corresponding compound in which R 3 is a hydrogen atom; followed optionally by salifaction of the product. Pharmaceutical compositions having analgesic, anti-inflammatory, antipyretic, sedative, myorelaxant, anti-hypertensive, diuretic and chloretic activity comprise, as active ingredient, a diazacyclic compound of the first general formula above or a pharmaceutically acceptable, acid-addition salt thereof, together with a carrier.
GB3175471A
1970-07-20
1971-07-06
Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof
Expired
GB1342753A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US5671270A
1970-07-20
1970-07-20
Publications (1)
Publication Number
Publication Date
GB1342753A
true
GB1342753A
(en)
1974-01-03
Family
ID=22006149
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB3175471A
Expired
GB1342753A
(en)
1970-07-20
1971-07-06
Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof
Country Status (10)
Country
Link
AU
(1)
AU459326B2
(en)
CA
(1)
CA969955A
(en)
CH
(1)
CH527198A
(en)
DE
(1)
DE2135458A1
(en)
ES
(1)
ES393429A1
(en)
FR
(1)
FR2100935B1
(en)
GB
(1)
GB1342753A
(en)
IL
(1)
IL37258A
(en)
PH
(1)
PH10173A
(en)
ZA
(1)
ZA714377B
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0000758A1
(en)
*
1977-08-02
1979-02-21
Takeda Chemical Industries, Ltd.
Dihydronaphthalene derivatives, their preparation and pharmaceutical compositions
Families Citing this family (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4130646A
(en)
1975-07-25
1978-12-19
E. R. Squibb & Sons, Inc.
1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof
FI68821C
(en)
*
1977-07-18
1985-11-11
Sandoz Ag
ANALOG FOUNDATION FOR FRAMSTAELLNING AV NYA TETRALINDERIVAT VILKA SAENKER BLODTRYCK OCH OEKAR BLODETSGENOMSTROEMNING
FR2633617B1
(en)
*
1988-07-04
1991-02-08
Adir
NOVEL BENZOCYCLOHEPTENE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
1971
1971-06-22
CA
CA116,294A
patent/CA969955A/en
not_active
Expired
1971-07-05
ZA
ZA714377A
patent/ZA714377B/en
unknown
1971-07-06
GB
GB3175471A
patent/GB1342753A/en
not_active
Expired
1971-07-07
IL
IL37258A
patent/IL37258A/en
unknown
1971-07-13
PH
PH12628A
patent/PH10173A/en
unknown
1971-07-15
DE
DE19712135458
patent/DE2135458A1/en
active
Pending
1971-07-19
ES
ES393429A
patent/ES393429A1/en
not_active
Expired
1971-07-19
AU
AU31381/71A
patent/AU459326B2/en
not_active
Expired
1971-07-20
FR
FR7126484A
patent/FR2100935B1/fr
not_active
Expired
1971-07-20
CH
CH1068271A
patent/CH527198A/en
not_active
IP Right Cessation
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0000758A1
(en)
*
1977-08-02
1979-02-21
Takeda Chemical Industries, Ltd.
Dihydronaphthalene derivatives, their preparation and pharmaceutical compositions
Also Published As
Publication number
Publication date
DE2135458A1
(en)
1972-01-27
FR2100935A1
(en)
1972-03-24
PH10173A
(en)
1976-09-15
IL37258A0
(en)
1971-10-20
FR2100935B1
(en)
1975-08-01
IL37258A
(en)
1975-12-31
CH527198A
(en)
1972-08-31
AU459326B2
(en)
1975-03-20
AU3138171A
(en)
1973-01-25
ZA714377B
(en)
1972-03-29
CA969955A
(en)
1975-06-24
ES393429A1
(en)
1973-08-16
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Legal Events
Date
Code
Title
Description
1974-05-15
PS
Patent sealed [section 19, patents act 1949]
1977-02-02
PLNP
Patent lapsed through nonpayment of renewal fees
