GB1353534A

GB1353534A – Pyrimidotriazines and a process for the manufacture thereof
– Google Patents

GB1353534A – Pyrimidotriazines and a process for the manufacture thereof
– Google Patents
Pyrimidotriazines and a process for the manufacture thereof

Info

Publication number
GB1353534A

GB1353534A
GB1311672A
GB3280171A
GB1353534A
GB 1353534 A
GB1353534 A
GB 1353534A
GB 1311672 A
GB1311672 A
GB 1311672A
GB 3280171 A
GB3280171 A
GB 3280171A
GB 1353534 A
GB1353534 A
GB 1353534A
Authority
GB
United Kingdom
Prior art keywords
alkyl
formula
compounds
pyrimido
july
Prior art date
1971-07-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB1311672A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Roche Products Ltd

Original Assignee
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1971-07-13
Filing date
1971-07-13
Publication date
1974-05-22

Priority to BE786129D
priority
Critical
patent/BE786129A/en

1971-07-13
Application filed by Roche Products Ltd
filed
Critical
Roche Products Ltd

1971-07-13
Priority to GB1311672A
priority
patent/GB1353534A/en

1972-06-13
Priority to ZA724061A
priority
patent/ZA724061B/en

1972-06-16
Priority to AU43532/72A
priority
patent/AU4353272A/en

1972-06-19
Priority to IL39714A
priority
patent/IL39714A0/en

1972-06-23
Priority to US00265879A
priority
patent/US3813393A/en

1972-06-26
Priority to NL7208756A
priority
patent/NL7208756A/xx

1972-07-03
Priority to IE928/72A
priority
patent/IE36520B1/en

1972-07-06
Priority to DE2233242A
priority
patent/DE2233242A1/en

1972-07-11
Priority to FR7225081A
priority
patent/FR2145591B1/fr

1972-07-12
Priority to AT933973A
priority
patent/AT321313B/en

1972-07-12
Priority to AT596572A
priority
patent/AT317903B/en

1973-02-20
Priority to AR246680A
priority
patent/AR193576A1/en

1974-05-22
Publication of GB1353534A
publication
Critical
patent/GB1353534A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00

C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00 in which the condensed system contains two hetero rings

C07D487/04—Ortho-condensed systems

Abstract

1353534 Pyrimido-[5,4-e]-1 ,2,4-triazines ROCHE PRODUCTS Ltd 12 July 1972 [13 July 1971 6 Aug 1971 21 March 1972] 32801/71 37049/71 and 13116/72 Heading C2C The invention comprises compounds of formula wherein R is CF 3 , C 1-6 alkyl, Ar or Ar-C 1-6 – alkyl, R1 is H, C 1-6 alkyl, Ar or Ar-C 1-6 -alkyl, R2 is H and R3 is H, C 1-6 alkyl, C 2-6 alkenyl or alkynyl, C 3-6 cycloalkyl, Ar, Ar-C 1-6 -alkyl, HO, HO-C 1-6 alky or acyl, or R2, R3 are each C 1-6 alkyl which may be joined directly, or through N, O or S to form (with the N shown) a 5- or 6-membered heteromonocyclic ring; and Ar is Ph, possibly substituted by halogen, C 1-6 alkyl and/or C 1-6 alkoxy. These compounds are prepared by reacting (1)a 5-amino-4-chloro-6- hydrazino-2-R-pyrimidine with R1C(OR4) 3 where R4 is C 1-6 alkyl, and reacting the thus-formed 5- chloro – 1,2 – dihydro – 7 – R – 3 – R1 – pyrimido- [5,4-e]-1,2,4-triazine with the appropriate amine under oxidizing conditions or with NH 3 and/or alkali metal azide; (2) a compound of Formula I (R2 = R3 = H) with a primary amine or with an acylating agent; or (3) a compound of Formula I (R2 = R3 = Me) with NH 3 , NH 2 OH or a primary amine. Therapeutic compositions having anti-inflammatory, and in some cases diuretic activity comprise compounds of the above formula, which may be administered enterally, parenterally or rectally.

GB1311672A
1971-07-13
1971-07-13
Pyrimidotriazines and a process for the manufacture thereof

Expired

GB1353534A
(en)

Priority Applications (13)

Application Number
Priority Date
Filing Date
Title

BE786129D

BE786129A
(en)

1971-07-13

BICYCLIC COMPOUNDS

GB1311672A

GB1353534A
(en)

1971-07-13
1971-07-13
Pyrimidotriazines and a process for the manufacture thereof

ZA724061A

ZA724061B
(en)

1971-07-13
1972-06-13
Bicyclic compounds

AU43532/72A

AU4353272A
(en)

1971-07-13
1972-06-16
Bicyclic compounds

IL39714A

IL39714A0
(en)

1971-07-13
1972-06-19
Pyrimidotriazines and their preparation

US00265879A

US3813393A
(en)

1971-07-13
1972-06-23
Pyrimidotriazines

NL7208756A

NL7208756A
(en)

1971-07-13
1972-06-26

IE928/72A

IE36520B1
(en)

1971-07-13
1972-07-03
Pyrimidotriazines and a process for the manufacture thereof

DE2233242A

DE2233242A1
(en)

1971-07-13
1972-07-06

BICYCLIC CONNECTIONS

FR7225081A

FR2145591B1
(en)

1971-07-13
1972-07-11

AT933973A

AT321313B
(en)

1971-07-13
1972-07-12

Process for the preparation of new pyrimidotriazines

AT596572A

AT317903B
(en)

1971-07-13
1972-07-12

Process for the preparation of new pyrimidotriazines

AR246680A

AR193576A1
(en)

1971-07-13
1973-02-20

PROCEDURE FOR THE PREPARATION OF PYRIMIDOTRIACINES

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

GB1311672A

GB1353534A
(en)

1971-07-13
1971-07-13
Pyrimidotriazines and a process for the manufacture thereof

Publications (1)

Publication Number
Publication Date

GB1353534A
true

GB1353534A
(en)

1974-05-22

Family
ID=10344196
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB1311672A
Expired

GB1353534A
(en)

1971-07-13
1971-07-13
Pyrimidotriazines and a process for the manufacture thereof

Country Status (3)

Country
Link

AU
(1)

AU4353272A
(en)

GB
(1)

GB1353534A
(en)

ZA
(1)

ZA724061B
(en)

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US6943158B2
(en)

2002-11-18
2005-09-13
Roche Palo Alto Llc
Diazinopyrimidines

WO2022081912A3
(en)

*

2020-10-15
2022-06-02
Kumquat Biosciences Inc.
Heterocycles and uses thereof

1971

1971-07-13
GB
GB1311672A
patent/GB1353534A/en
not_active
Expired

1972

1972-06-13
ZA
ZA724061A
patent/ZA724061B/en
unknown

1972-06-16
AU
AU43532/72A
patent/AU4353272A/en
not_active
Expired

Cited By (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US6943158B2
(en)

2002-11-18
2005-09-13
Roche Palo Alto Llc
Diazinopyrimidines

WO2022081912A3
(en)

*

2020-10-15
2022-06-02
Kumquat Biosciences Inc.
Heterocycles and uses thereof

Also Published As

Publication number
Publication date

ZA724061B
(en)

1973-03-28

AU4353272A
(en)

1973-12-20

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2-amidino-4-hydroxy-1,2,3,4-tetrahydroisoquinoline and salts thereof

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Legal Events

Date
Code
Title
Description

1974-10-02
PS
Patent sealed

1977-02-09
PLNP
Patent lapsed through nonpayment of renewal fees

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