GB1363658A

GB1363658A – Benzobicycloalkane compounds
– Google Patents

GB1363658A – Benzobicycloalkane compounds
– Google Patents
Benzobicycloalkane compounds

Info

Publication number
GB1363658A

GB1363658A
GB5571771A
GB5571771A
GB1363658A
GB 1363658 A
GB1363658 A
GB 1363658A
GB 5571771 A
GB5571771 A
GB 5571771A
GB 5571771 A
GB5571771 A
GB 5571771A
GB 1363658 A
GB1363658 A
GB 1363658A
Authority
GB
United Kingdom
Prior art keywords
alkyl
alkoxy
phenyl
substituted
phenyl group
Prior art date
1970-12-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB5571771A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth LLC

Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1970-12-03
Filing date
1971-12-01
Publication date
1974-08-14

1971-12-01
Application filed by American Home Products Corp
filed
Critical
American Home Products Corp

1972-11-06
Priority to IN1824/1972A
priority
Critical
patent/IN138507B/en

1974-08-14
Publication of GB1363658A
publication
Critical
patent/GB1363658A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups

C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton

C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Abstract

1363658 Benzobicycloalkanes AMERICAN HOME PRODUCTS CORP- 1 Dec 1971 [3 Dec 1970] 55717/71 Heading C2C Compounds of the general formula (X=NR2R3, N(-#O)R4R5; R=H, C 1-4 alkyl or alkoxy, OH, acyloxy, phenyl-(C 1-4 alkoxy) in which the phenyl group may be substituted by C 1-4 alkyl or alkoxy, halogen, CF 3 ; R1 = C 1-4 alkyl, phenyl-(C 1-4 alkyl) in which the phenyl group may be substituted as above or, when X = NR2R3, CH 2 OH, C 3-5 alkenyl; R2=H, C 1-4 alkyl, phenyl-(C 1-4 alkyl) in which the phenyl group may be substituted as above; R3=R2, C 3-5 alkenyl, C 3-6 alkynyl; R4,5=C 1-4 alkyl; m = 0, 1; n =2-6) and their acid addition salts are prepared by reducing a compound of the formula (R6 = R2 (except when R7=alkoxycarbonyl), OH, alkoxy; R7=R1, alkoxycarbonyl) or (A = CH = CH, CH(OTosyl)CH 2 ; B=CHNR2R3, C = NR6), optionally followed by introduction of R2 and/or R3, conversion of R to a different value, oxidation, salt formation and/or isomer separation. The above compounds possess analgesic and anti-inflammatory activity, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.

GB5571771A
1970-12-03
1971-12-01
Benzobicycloalkane compounds

Expired

GB1363658A
(en)

Priority Applications (1)

Application Number
Priority Date
Filing Date
Title

IN1824/1972A

IN138507B
(en)

1971-11-29
1972-11-06

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US9498370A

1970-12-03
1970-12-03

Publications (1)

Publication Number
Publication Date

GB1363658A
true

GB1363658A
(en)

1974-08-14

Family
ID=22248330
Family Applications (3)

Application Number
Title
Priority Date
Filing Date

GB3538973A
Expired

GB1363659A
(en)

1970-12-03
1971-12-01
Tetralones and indanones

GB3539073A
Expired

GB1363660A
(en)

1970-12-03
1971-12-01
Benzobicycloalkane compounds

GB5571771A
Expired

GB1363658A
(en)

1970-12-03
1971-12-01
Benzobicycloalkane compounds

Family Applications Before (2)

Application Number
Title
Priority Date
Filing Date

GB3538973A
Expired

GB1363659A
(en)

1970-12-03
1971-12-01
Tetralones and indanones

GB3539073A
Expired

GB1363660A
(en)

1970-12-03
1971-12-01
Benzobicycloalkane compounds

Country Status (21)

Country
Link

JP
(1)

JPS5747176B1
(en)

AR
(5)

AR193714A1
(en)

AT
(2)

AT321265B
(en)

AU
(1)

AU475974B2
(en)

BE
(1)

BE776173A
(en)

CA
(1)

CA1005822A
(en)

CH
(1)

CH569689A5
(en)

CY
(1)

CY922A
(en)

DE
(1)

DE2159324C2
(en)

DK
(1)

DK142984C
(en)

ES
(1)

ES397603A1
(en)

FI
(1)

FI53967C
(en)

FR
(1)

FR2116509B1
(en)

GB
(3)

GB1363659A
(en)

HK
(1)

HK12678A
(en)

KE
(1)

KE2770A
(en)

NL
(1)

NL175292C
(en)

PH
(1)

PH13159A
(en)

SE
(1)

SE385471B
(en)

YU
(1)

YU35866B
(en)

ZA
(1)

ZA717697B
(en)

Cited By (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US20190010114A1
(en)

*

2016-01-04
2019-01-10
Shandong Danhong Pharmaceutical Co., Ltd.
Dezocine analogue

CN110283085A
(en)

*

2019-06-04
2019-09-27
华润双鹤利民药业（济南）有限公司
A kind of dezocine fabrication processing

EP3919472A4
(en)

*

2019-02-02
2022-11-09
Yangtze River Pharmaceutical Group Co., Ltd.
Dezocine derivative and medical use thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB1504694A
(en)

*

1974-04-08
1978-03-22
Akzo Nv
Benzo-bicyclononene derivatives

GB1549172A
(en)

*

1975-04-29
1979-08-01
Akzonv
Benzobicyclononene derivatives

US5098916A
(en)

*

1990-03-29
1992-03-24
G. D. Searle & Co.
Propanobicyclic amine derivatives for cns disorders

CN113979875B
(en)

*

2020-07-27
2022-11-08
扬子江药业集团有限公司
Dezocine derivative crystal form A and preparation method and application thereof

1971

1971-11-16
ZA
ZA717697A
patent/ZA717697B/en
unknown

1971-11-29
PH
PH13059A
patent/PH13159A/en
unknown

1971-11-29
AU
AU36248/71A
patent/AU475974B2/en
not_active
Expired

1971-11-29
AT
AT1024771A
patent/AT321265B/en
not_active
IP Right Cessation

1971-11-29
AT
AT10874A
patent/AT325597B/en
not_active
IP Right Cessation

1971-11-30
DE
DE2159324A
patent/DE2159324C2/en
not_active
Expired

1971-12-01
GB
GB3538973A
patent/GB1363659A/en
not_active
Expired

1971-12-01
GB
GB3539073A
patent/GB1363660A/en
not_active
Expired

1971-12-01
YU
YU3022/71A
patent/YU35866B/en
unknown

1971-12-01
CY
CY922A
patent/CY922A/en
unknown

1971-12-01
FI
FI3437/71A
patent/FI53967C/en
active

1971-12-01
GB
GB5571771A
patent/GB1363658A/en
not_active
Expired

1971-12-02
BE
BE776173A
patent/BE776173A/en
not_active
IP Right Cessation

1971-12-02
JP
JP46097546A
patent/JPS5747176B1/ja
active
Pending

1971-12-02
DK
DK592071A
patent/DK142984C/en
active

1971-12-02
NL
NLAANVRAGE7116567,A
patent/NL175292C/en
not_active
IP Right Cessation

1971-12-02
FR
FR7143351A
patent/FR2116509B1/fr
not_active
Expired

1971-12-02
SE
SE7115498A
patent/SE385471B/en
unknown

1971-12-02
AR
AR239391A
patent/AR193714A1/en
active

1971-12-02
ES
ES397603A
patent/ES397603A1/en
not_active
Expired

1971-12-03
CH
CH1763671A
patent/CH569689A5/xx
not_active
IP Right Cessation

1971-12-03
CA
CA129,373A
patent/CA1005822A/en
not_active
Expired

1972

1972-10-26
AR
AR224829A
patent/AR197202A1/en
active

1972-10-26
AR
AR244832A
patent/AR193903A1/en
active

1972-10-26
AR
AR244830A
patent/AR194020A1/en
active

1972-10-26
AR
AR244831A
patent/AR198637A1/en
active

1977

1977-09-06
KE
KE2770A
patent/KE2770A/en
unknown

1978

1978-03-09
HK
HK126/78A
patent/HK12678A/en
unknown

Cited By (5)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US20190010114A1
(en)

*

2016-01-04
2019-01-10
Shandong Danhong Pharmaceutical Co., Ltd.
Dezocine analogue

CN110054568A
(en)

*

2016-01-04
2019-07-26
山东丹红制药有限公司
Dezocine analog

US10414718B2
(en)

*

2016-01-04
2019-09-17
Shandong Danhong Pharmaceutical Co., Ltd.
Dezocine analogue

EP3919472A4
(en)

*

2019-02-02
2022-11-09
Yangtze River Pharmaceutical Group Co., Ltd.
Dezocine derivative and medical use thereof

CN110283085A
(en)

*

2019-06-04
2019-09-27
华润双鹤利民药业（济南）有限公司
A kind of dezocine fabrication processing

Also Published As

Publication number
Publication date

CH569689A5
(en)

1975-11-28

FI53967C
(en)

1978-09-11

YU35866B
(en)

1981-08-31

DK142984C
(en)

1981-09-28

FR2116509A1
(en)

1972-07-13

SE385471B
(en)

1976-07-05

AU475974B2
(en)

1976-09-09

AT321265B
(en)

1975-03-25

DE2159324A1
(en)

1972-06-15

CA1005822A
(en)

1977-02-22

AR197202A1
(en)

1974-03-22

GB1363659A
(en)

1974-08-14

HK12678A
(en)

1978-03-17

CY922A
(en)

1977-12-23

NL7116567A
(en)

1972-06-06

AR194020A1
(en)

1973-06-12

AR198637A1
(en)

1974-07-15

ES397603A1
(en)

1975-03-16

DE2159324C2
(en)

1984-06-14

NL175292B
(en)

1984-05-16

JPS5747176B1
(en)

1982-10-07

AR193903A1
(en)

1973-05-31

ZA717697B
(en)

1973-06-27

DK142984B
(en)

1981-03-09

AU3624871A
(en)

1973-06-07

AR193714A1
(en)

1973-05-22

NL175292C
(en)

1984-10-16

GB1363660A
(en)

1974-08-14

YU302271A
(en)

1981-02-28

FI53967B
(en)

1978-05-31

FR2116509B1
(en)

1975-08-01

ATA10874A
(en)

1975-01-15

KE2770A
(en)

1977-10-21

BE776173A
(en)

1972-06-02

PH13159A
(en)

1980-01-08

AT325597B
(en)

1975-10-27

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Legal Events

Date
Code
Title
Description

1974-12-27
PS
Patent sealed

1992-01-02
PE20
Patent expired after termination of 20 years

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