GB1365770A

GB1365770A – Basically substituted 1/2h/-phtalazinone derivatives and proce sses for the production thereof
– Google Patents

GB1365770A – Basically substituted 1/2h/-phtalazinone derivatives and proce sses for the production thereof
– Google Patents
Basically substituted 1/2h/-phtalazinone derivatives and proce sses for the production thereof

Info

Publication number
GB1365770A

GB1365770A
GB1388072A
GB1388072A
GB1365770A
GB 1365770 A
GB1365770 A
GB 1365770A
GB 1388072 A
GB1388072 A
GB 1388072A
GB 1388072 A
GB1388072 A
GB 1388072A
GB 1365770 A
GB1365770 A
GB 1365770A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
amine
group
reacted
Prior art date
1971-03-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB1388072A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cassella Farbwerke Mainkur AG

Original Assignee
Cassella Farbwerke Mainkur AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1971-03-27
Filing date
1972-03-24
Publication date
1974-09-04

1972-03-24
Application filed by Cassella Farbwerke Mainkur AG
filed
Critical
Cassella Farbwerke Mainkur AG

1974-09-04
Publication of GB1365770A
publication
Critical
patent/GB1365770A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings

C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems

C07D237/30—Phthalazines

C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/08—Vasodilators for multiple indications

Abstract

1365770 Phthalazinones CASSELLA FARBWERKE MAINKUR AG 24 March 1972 [27 March 1971] 13880/72 Heading C2C Novel compounds of Formula I and their pharmaceutically acceptable acid salts, wherein R1 stands for an N-linked and otherwise fully N-substituted aliphatic, cycloaliphatic, araliphatic or saturated 5, 6 or 7 ring membered heterocyclic amine or diamine radical, having 2-10 carbon atoms in the case of an aliphatic, cycloaliphatic or araliphatic amine, and optionally containing an O or S heteroatom in the case of a heterocyclic monoamine, in which amine radical the N-substituents may themselves additionally be substituted by alkoxy or a group of formula R 1 represent hydrogen or an alkoxy group having 1 to 4 carbon atoms, R 2 represents an alkoxy group having 1 to 4 carbon atoms, m is 1, 2, or 3 and n is 2 or 3, the groups R 1 being attached if present to the phthalazine nucleus in the 6 and 7, 7 and 8 or 5, 6 and 7 positions are prepared by the following method: acylation of the compound of Formula II wherein R is as R1 above or is the hydroxy substituted group which would acylate to an R1 group. Intermediates of Formula II are prepared by one of the following methods: (a) a compound of formula is reacted with a compound of formula Halogen-CH 2 -CH(OH)CH 2 -R; (b) a compound of formula is reacted with the compound of formula and (c) a compound of formula is reacted with the amine RH. Pharmaceutical compositions in conventional forms and having coronary dilating activity comprise an above novel compound and a carrier or diluent.

GB1388072A
1971-03-27
1972-03-24
Basically substituted 1/2h/-phtalazinone derivatives and proce sses for the production thereof

Expired

GB1365770A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

DE19712114884

DE2114884A1
(en)

1971-03-27
1971-03-27

Basically substituted derivatives of 1 (2H) -phthalazinone

Publications (1)

Publication Number
Publication Date

GB1365770A
true

GB1365770A
(en)

1974-09-04

Family
ID=5802944
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB1388072A
Expired

GB1365770A
(en)

1971-03-27
1972-03-24
Basically substituted 1/2h/-phtalazinone derivatives and proce sses for the production thereof

Country Status (12)

Country
Link

US
(1)

US3845052A
(en)

AT
(1)

AT313290B
(en)

BE
(1)

BE781299A
(en)

CH
(1)

CH574938A5
(en)

DD
(1)

DD98676A5
(en)

DE
(1)

DE2114884A1
(en)

FR
(1)

FR2132079B1
(en)

GB
(1)

GB1365770A
(en)

HU
(2)

HU164008B
(en)

NL
(1)

NL7204029A
(en)

PL
(1)

PL88953B1
(en)

SU
(1)

SU428602A3
(en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4665181A
(en)

*

1984-05-17
1987-05-12
Pennwalt Corporation
Anti-inflammatory phthalazinones

ATE49205T1
(en)

*

1984-09-14
1990-01-15
Asta Pharma Ag

SUBSTITUTE BENZYLPHTHALAZINONE DERIVATIVES.

ATE60598T1
(en)

*

1985-11-11
1991-02-15
Asta Pharma Ag

4-BENZYL-1-(2H)-PHTHALAZINONE DERIVATIVES.

US4868301A
(en)

*

1987-06-09
1989-09-19
Pfizer Inc.
Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains

LT2377557T
(en)

2004-11-24
2017-02-10
Meda Pharmaceuticals Inc.
Compositions comprising azelastine and methods of use thereof

US8758816B2
(en)

2004-11-24
2014-06-24
Meda Pharmaceuticals Inc.
Compositions comprising azelastine and methods of use thereof

US20070020330A1
(en)

2004-11-24
2007-01-25
Medpointe Healthcare Inc.
Compositions comprising azelastine and methods of use thereof

1971

1971-03-27
DE
DE19712114884
patent/DE2114884A1/en
active
Pending

1972

1972-03-22
HU
HUCA324A
patent/HU164008B/hu
unknown

1972-03-22
HU
HUCA344A
patent/HU164874B/hu
unknown

1972-03-22
DD
DD161717A
patent/DD98676A5/xx
unknown

1972-03-24
GB
GB1388072A
patent/GB1365770A/en
not_active
Expired

1972-03-24
NL
NL7204029A
patent/NL7204029A/xx
unknown

1972-03-24
SU
SU1765687A
patent/SU428602A3/en
active

1972-03-24
US
US00237957A
patent/US3845052A/en
not_active
Expired – Lifetime

1972-03-24
AT
AT258072A
patent/AT313290B/en
not_active
IP Right Cessation

1972-03-25
PL
PL1972154331A
patent/PL88953B1/pl
unknown

1972-03-27
FR
FR7210628A
patent/FR2132079B1/fr
not_active
Expired

1972-03-27
CH
CH451972A
patent/CH574938A5/xx
not_active
IP Right Cessation

1972-03-27
BE
BE781299A
patent/BE781299A/en
unknown

Also Published As

Publication number
Publication date

AT313290B
(en)

1974-02-11

PL88953B1
(en)

1976-10-30

FR2132079B1
(en)

1975-04-25

DE2114884A1
(en)

1972-10-12

FR2132079A1
(en)

1972-11-17

SU428602A3
(en)

1974-05-15

DD98676A5
(en)

1973-07-05

BE781299A
(en)

1972-09-27

NL7204029A
(en)

1972-09-29

US3845052A
(en)

1974-10-29

HU164008B
(en)

1973-12-28

HU164874B
(en)

1974-05-28

CH574938A5
(en)

1976-04-30

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Legal Events

Date
Code
Title
Description

1975-01-15
PS
Patent sealed [section 19, patents act 1949]

1977-10-19
PLNP
Patent lapsed through nonpayment of renewal fees

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