GB1371056A

GB1371056A – 1,3-aminoalcohol benzoates
– Google Patents

GB1371056A – 1,3-aminoalcohol benzoates
– Google Patents
1,3-aminoalcohol benzoates

Info

Publication number
GB1371056A

GB1371056A
GB4859371A
GB4859371A
GB1371056A
GB 1371056 A
GB1371056 A
GB 1371056A
GB 4859371 A
GB4859371 A
GB 4859371A
GB 4859371 A
GB4859371 A
GB 4859371A
GB 1371056 A
GB1371056 A
GB 1371056A
Authority
GB
United Kingdom
Prior art keywords
compound
alkenyl
phenyl
cycloalkyl
reaction
Prior art date
1970-10-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB4859371A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Richter Gedeon Vegyeszeti Gyar Nyrt

Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1970-10-19
Filing date
1971-10-19
Publication date
1974-10-23

1971-10-19
Application filed by Richter Gedeon Vegyeszeti Gyar RT
filed
Critical
Richter Gedeon Vegyeszeti Gyar RT

1974-10-23
Publication of GB1371056A
publication
Critical
patent/GB1371056A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Abstract

1371056 1,3 – Aminoalcohol benzoates RICHTER GEDEON VEGYESZETI GYAR RT 19 Oct 1971 [19 Oct 1970] 48593/71 Heading C2C Novel compounds of Formula I and their salts of Formula II and acid addition salts in which R 1 , R 2 and R 3 are H, alkyl, alkenyl, cycloalkyl or phenyl; R 4 is H, 1-6 C alkyl, alkenyl or benzyl; Z is -O- or -CH 2 -; Y is a mineral or organic acid residue; X 1 , X 2 and X 3 are H, halo, alkoxy, phenoxy, or 1-6 C alkyl or two of them may form -OCH 2 O-; with the provisos: (i) if the benzoyl group is monosubstituted and X 2 is H in the para position, R 1 and R2 are CH 3 or R 1 is CH 3 or isopropyl while R 2 is H and Z is CH 2 ; then R 3 may only represent alkyl, alkenyl, cycloalkyl or phenyl; (ii) if the benzoyl group is monosubstituted (i.e. X 1 and X 3 are H), X 2 is p-ethoxy, p-nbutoxy or p-isobutoxy, and R 1 and R 2 are CH 3 ; then R 3 may only represent alkyl, alkenyl, cycloalkyl or phenyl; (iii) if the benzoyl group is monosubstituted (i.e. X 1 and X 3 are H) X 2 is primary n-butoxy, R 1 and R 2 are H and Z is CH 2 ; then R 3 may only represent alkyl, alkenyl, cycloalkyl or phenyl; (iv) if X 1 is H; then X 2 and X 3 do not both represent halogen atoms; (v) if the benzoyl group is trisubstituted by OCH 3 in the 31, 41 and 51-positions, R 1 and R 2 are H or R 1 is ethyl while R 2 is ethyl or phenyl; then R 3 may only represent alkyl, alkenyl, cycloalkyl or phenyl; are described. They may be prepared by the following methods: (i) by reaction of a compound III with a reactive derivative of a compound IV (ii) by reaction of a compound IV with a compound V (iii) by reaction of morpholine or piperidine with a compound VI (iv) by reaction of a compound VII with morpholine or piperidine followed where necessary in any of (i)-(iv) by salt formation. Intermediates isolated are 3-hydroxypropyl 31 – trifluoromethylbenzoate, prepared from trimethylene glycol and the appropriate acid halide and 3-chloropropyl 31-trifluoromethylbenzoate, prepared by reaction of the first intermediate with SOCl 2 . Pharmaceutical compositions useful as local anaesthetics comprise a compound I or II together with a suitable carrier or diluent.

GB4859371A
1970-10-19
1971-10-19
1,3-aminoalcohol benzoates

Expired

GB1371056A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

HURI411A

HU162470B
(en)

1970-10-19
1970-10-19

Publications (1)

Publication Number
Publication Date

GB1371056A
true

GB1371056A
(en)

1974-10-23

Family
ID=11000852
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB4859371A
Expired

GB1371056A
(en)

1970-10-19
1971-10-19
1,3-aminoalcohol benzoates

Country Status (17)

Country
Link

AT
(2)

AT313291B
(en)

AU
(1)

AU461481B2
(en)

BE
(1)

BE774153A
(en)

CA
(1)

CA983928A
(en)

CH
(1)

CH564547A5
(en)

CS
(4)

CS152975B2
(en)

DE
(1)

DE2152001C3
(en)

FI
(1)

FI54708C
(en)

FR
(1)

FR2111704B1
(en)

GB
(1)

GB1371056A
(en)

HU
(1)

HU162470B
(en)

IL
(1)

IL37919A
(en)

NL
(1)

NL7114373A
(en)

NO
(1)

NO140187C
(en)

PL
(1)

PL81419B1
(en)

SU
(2)

SU509217A3
(en)

YU
(1)

YU34690B
(en)

1970

1970-10-19
HU
HURI411A
patent/HU162470B/hu
unknown

1971

1971-10-13
IL
IL37919A
patent/IL37919A/en
unknown

1971-10-14
AU
AU34589/71A
patent/AU461481B2/en
not_active
Expired

1971-10-18
SU
SU1959281A
patent/SU509217A3/en
active

1971-10-18
NO
NO3851/71A
patent/NO140187C/en
unknown

1971-10-18
CH
CH1519971A
patent/CH564547A5/xx
not_active
IP Right Cessation

1971-10-18
SU
SU1707572A
patent/SU482043A3/en
active

1971-10-18
CA
CA125,357A
patent/CA983928A/en
not_active
Expired

1971-10-18
YU
YU2657/71A
patent/YU34690B/en
unknown

1971-10-18
PL
PL1971151097A
patent/PL81419B1/en
unknown

1971-10-19
FI
FI2927/71A
patent/FI54708C/en
active

1971-10-19
CS
CS732571A
patent/CS152975B2/cs
unknown

1971-10-19
AT
AT902271A
patent/AT313291B/en
not_active
IP Right Cessation

1971-10-19
BE
BE774153A
patent/BE774153A/en
unknown

1971-10-19
CS
CS364271*[A
patent/CS152977B2/cs
unknown

1971-10-19
DE
DE2152001A
patent/DE2152001C3/en
not_active
Expired

1971-10-19
FR
FR7137480A
patent/FR2111704B1/fr
not_active
Expired

1971-10-19
NL
NL7114373A
patent/NL7114373A/xx
not_active
Application Discontinuation

1971-10-19
GB
GB4859371A
patent/GB1371056A/en
not_active
Expired

1971-10-19
AT
AT259673A
patent/AT316571B/en
not_active
IP Right Cessation

1971-10-19
CS
CS364371*[A
patent/CS152978B2/cs
unknown

1971-10-19
CS
CS364171*[A
patent/CS152976B2/cs
unknown

Also Published As

Publication number
Publication date

CA983928A
(en)

1976-02-17

SU509217A3
(en)

1976-03-30

IL37919A
(en)

1975-08-31

FR2111704B1
(en)

1975-08-01

NO140187C
(en)

1979-07-18

FR2111704A1
(en)

1972-06-09

FI54708B
(en)

1978-10-31

CS152975B2
(en)

1974-02-22

AT316571B
(en)

1974-07-25

AU461481B2
(en)

1975-05-29

BE774153A
(en)

1972-02-14

HU162470B
(en)

1973-02-28

DE2152001B2
(en)

1979-07-26

NO140187B
(en)

1979-04-09

NL7114373A
(en)

1972-04-21

PL81419B1
(en)

1975-08-30

SU482043A3
(en)

1975-08-25

YU34690B
(en)

1979-12-31

FI54708C
(en)

1979-02-12

DE2152001C3
(en)

1980-06-26

CS152977B2
(en)

1974-02-22

CH564547A5
(en)

1975-07-31

AU3458971A
(en)

1973-04-19

CS152976B2
(en)

1974-02-22

AT313291B
(en)

1974-02-11

CS152978B2
(en)

1974-02-22

DE2152001A1
(en)

1972-04-20

YU265771A
(en)

1979-07-10

IL37919A0
(en)

1971-12-29

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Legal Events

Date
Code
Title
Description

1975-03-05
PS
Patent sealed [section 19, patents act 1949]

1981-06-03
PCNP
Patent ceased through non-payment of renewal fee

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