GB1374344A

GB1374344A – Pharmaceutically active nitrosourea derivatives
– Google Patents

GB1374344A – Pharmaceutically active nitrosourea derivatives
– Google Patents
Pharmaceutically active nitrosourea derivatives

Info

Publication number
GB1374344A

GB1374344A
GB5357872A
GB5357872A
GB1374344A
GB 1374344 A
GB1374344 A
GB 1374344A
GB 5357872 A
GB5357872 A
GB 5357872A
GB 5357872 A
GB5357872 A
GB 5357872A
GB 1374344 A
GB1374344 A
GB 1374344A
Authority
GB
United Kingdom
Prior art keywords
group
alkyl
formula
substituted
atom
Prior art date
1971-11-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB5357872A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sankyo Co Ltd

Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1971-11-20
Filing date
1972-11-20
Publication date
1974-11-20

1971-11-20
Priority claimed from JP9348571A
external-priority
patent/JPS5033072B2/ja

1971-12-04
Priority claimed from JP9803471A
external-priority
patent/JPS5125030B2/ja

1972-07-26
Priority claimed from JP7478272A
external-priority
patent/JPS5425027B2/ja

1972-11-20
Application filed by Sankyo Co Ltd
filed
Critical
Sankyo Co Ltd

1974-11-20
Publication of GB1374344A
publication
Critical
patent/GB1374344A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members

C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

C07D213/36—Radicals substituted by singly-bound nitrogen atoms

C07D213/40—Acylated substituent nitrogen atom

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members

C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D211/56—Nitrogen atoms

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members

C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D211/56—Nitrogen atoms

C07D211/58—Nitrogen atoms attached in position 4

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings

C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings

C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles

C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2

C07D235/08—Radicals containing only hydrogen and carbon atoms

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings

C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members

C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

C07D239/32—One oxygen, sulfur or nitrogen atom

C07D239/42—One nitrogen atom

Abstract

1374344 Nitrosoureas and ureas SANKYO CO Ltd 20 Nov 1972 [20 Nov 1971 4 Dec 1971 26 July 1972] 53578/72 Heading C2C Novel compounds (I) of formula (including salts and hydrates thereof) wherein: A represents a group of the formula in which B is an unsaturated 5- or 6-membered heterocyclyl group containing at least one nitrogen hetero-atom, or an unsaturated 9- or 10-membered bicyclic fused-ring heterocyclyl group containing at least one nitrogen heteroatom, said heterocyclyl group optionally being ring-substituted with one or more alkyl, alkoxy, hydroxy, amino or hydroxyalkyl groups or halogen atoms; and Y is a methylene or ethylene group which may optionally be alkyl-substituted; or a group of the formula in which R1, R2, R3, R4, R5, R6, R7, R8 and R9 may be the same or different, and each represents a hydrogen atom or an alkyl group; or a group of the formula in which Z is an unsubstituted or alkyl-substituted ethylene group; n = 0, 1, 2 or 3; and R is a halogen atom or an alkyl group, the substituents R being the same or different when n= 2 or 3; and X represents a halogen atom; are made by nitrosating the corresponding ureas (prepared by interacting appropriate amines and isocyanates). Pharmaceutical preparations especially useful as antileukemic agents contain (I) as active ingredient; administration may be orally or parenterally.

GB5357872A
1971-11-20
1972-11-20
Pharmaceutically active nitrosourea derivatives

Expired

GB1374344A
(en)

Applications Claiming Priority (3)

Application Number
Priority Date
Filing Date
Title

JP9348571A

JPS5033072B2
(en)

1971-11-20
1971-11-20

JP9803471A

JPS5125030B2
(en)

1971-12-04
1971-12-04

JP7478272A

JPS5425027B2
(en)

1972-07-26
1972-07-26

Publications (1)

Publication Number
Publication Date

GB1374344A
true

GB1374344A
(en)

1974-11-20

Family
ID=27301617
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB5357872A
Expired

GB1374344A
(en)

1971-11-20
1972-11-20
Pharmaceutically active nitrosourea derivatives

Country Status (7)

Country
Link

BE
(1)

BE791647A
(en)

CH
(1)

CH576443A5
(en)

DE
(1)

DE2257360C2
(en)

DK
(1)

DK134909B
(en)

FR
(1)

FR2160594B1
(en)

GB
(1)

GB1374344A
(en)

NL
(1)

NL163119C
(en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB8526154D0
(en)

*

1985-02-06
1985-11-27
Kotobuki Seiyaku Co Ltd
2-substituted cyclo-heptoimidazoles

0

BE
BE791647D
patent/BE791647A/en
not_active
IP Right Cessation

1972

1972-11-17
DK
DK574472A
patent/DK134909B/en
not_active
IP Right Cessation

1972-11-17
FR
FR7240888A
patent/FR2160594B1/fr
not_active
Expired

1972-11-20
NL
NL7215698A
patent/NL163119C/en
not_active
IP Right Cessation

1972-11-20
GB
GB5357872A
patent/GB1374344A/en
not_active
Expired

1972-11-20
DE
DE19722257360
patent/DE2257360C2/en
not_active
Expired

1972-11-20
CH
CH1686072A
patent/CH576443A5/xx
not_active
IP Right Cessation

Also Published As

Publication number
Publication date

BE791647A
(en)

1973-05-21

DE2257360A1
(en)

1973-05-24

NL7215698A
(en)

1973-05-22

FR2160594B1
(en)

1976-05-21

NL163119B
(en)

1980-03-17

DK134909C
(en)

1977-07-04

FR2160594A1
(en)

1973-06-29

NL163119C
(en)

1980-08-15

DK134909B
(en)

1977-02-07

DE2257360C2
(en)

1982-03-11

CH576443A5
(en)

1976-06-15

Similar Documents

Publication
Publication Date
Title

GB1147379A
(en)

1969-04-02

4-alkyl-dialkoxy-ª‡-methylphenethylamines and pharmacologically acceptable salts

ES345981A1
(en)

1968-12-01

Pyridines and poultry feedstuffs and additives thereof containing pyridines

GB1433701A
(en)

1976-04-28

5-6-benzene ring substituted benzimidazole-2-carbamate derivative having anthelmintic activity apparatus

GB1456627A
(en)

1976-11-24

Pyridobenzodiazepinones

GB1154547A
(en)

1969-06-11

Substituted Benzylamines

GB1475314A
(en)

1977-06-01

Phenyl-propylamine derivatives

GB1374344A
(en)

1974-11-20

Pharmaceutically active nitrosourea derivatives

GB1296414A
(en)

1972-11-15

GB1398058A
(en)

1975-06-18

1,1-hexamethylene-bisguanidino compounds

GB1246117A
(en)

1971-09-15

Pharmaceutical preparations containing glucose compounds, glucose derivatives and process for their manufacture

GB1469430A
(en)

1977-04-06

Daunomycin derivatives

GB1273399A
(en)

1972-05-10

Novel formamido-cycloalkane derivatives

GB1297401A
(en)

1972-11-22

GB1423761A
(en)

1976-02-04

Xylidides

GB1169990A
(en)

1969-11-12

Phenoxy Propan-2-Olamines

GB1305725A
(en)

1973-02-07

GB1181268A
(en)

1970-02-11

6-Amino-Uracil-5-Carbonamido-N-sulphonamides and Process for Their Preparation

GB1390650A
(en)

1975-04-16

Oxazines and thiazines

GB1504707A
(en)

1978-03-22

1-aryl-2-oxo-2,4,5,6,7,7a-hexahydroindoles

GB1371757A
(en)

1974-10-23

Substituted aminoquinolizinium bromides their preparation and compositions thereof

GB1327042A
(en)

1973-08-15

Oxazole derivatives their preparation and pharmaceutical compositions containing the same

GB1073521A
(en)

1967-06-28

Indole derivatives

GB1067544A
(en)

1967-05-03

Iminocycloheptatriene derivatives and a process for preparing the same

GB1067695A
(en)

1967-05-03

2-alkyl-4-alkylamino-6-alkoxy-s-triazines

GB1222947A
(en)

1971-02-17

Thiophene derivatives

Legal Events

Date
Code
Title
Description

1975-04-03
PS
Patent sealed

1992-12-23
PE20
Patent expired after termination of 20 years

Download PDF in English