GB1374918A – Radiography opacifier
– Google Patents
GB1374918A – Radiography opacifier
– Google Patents
Radiography opacifier
Info
Publication number
GB1374918A
GB1374918A
GB1051572A
GB1051572A
GB1374918A
GB 1374918 A
GB1374918 A
GB 1374918A
GB 1051572 A
GB1051572 A
GB 1051572A
GB 1051572 A
GB1051572 A
GB 1051572A
GB 1374918 A
GB1374918 A
GB 1374918A
Authority
GB
United Kingdom
Prior art keywords
methylcarbamyl
compounds
triiodo
formula
acetylcarboxymethylamino
Prior art date
1971-04-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1051572A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Andre Guerbet
Original Assignee
Laboratoires Andre Guerbet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1971-04-07
Filing date
1972-03-07
Publication date
1974-11-20
1972-03-07
Application filed by Laboratoires Andre Guerbet
filed
Critical
Laboratoires Andre Guerbet
1974-11-20
Publication of GB1374918A
publication
Critical
patent/GB1374918A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K49/00—Preparations for testing in vivo
A61K49/04—X-ray contrast preparations
A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
Abstract
1374918 Triiodinated amide substituted benzenes LABORATORIES ANDRE GUERBET 7 March 1972 [7 April 1971] 10515/72 Heading C2C [Also in Division A5] The invention comprises compounds of the formula in which R 1 is an alkylene radical, R 2 and R 3 are alkyl radicals, X is OH or NH 2 , Y is OH or -NHR 4 , R 4 being an alkyl group, and ammonium, alkali metal, alkaline earth metal or organic base salts thereof. The compounds are prepared by reacting an amide of formula with a halogenated compound of formula wherein Z is halogen optionally in a solvent. It is preferred that alkyl and alkylene groups have 1-6 carbon atoms and the preferred salts of compounds of Formula I are the methylglucamine salts. Exemplified compounds are 3 – (N – acetylcarboxymethylamino) – 2,4, 6- triiodo – 5 – (N – methylcarbamyl) – benzoic acid, 3 – (N – acetylcarbamyl methylamino)- 2,4,6 – triiodo – 5 – (N – methylcarbamyl)- benzoic acid and 2,4,6-triiodo-1,5-di-(N- methylcarbamyl) – 3 – (N – acetylcarboxymethylamino)-benzene. 2,4,6 – Truodo – 3,5 – di – (N – methylcarbamyl)-acetanilide is prepared from the corresponding aniline by reaction with acetyl chloride and is subsequently reacted with bromoacetic acid to form the methyl ester of 2,4,6-triiodo-1,5- di – (N – methylcarbamyl) – 3 – (N – acetylcarboxymethylamino)benzene. The compounds of the invention are of value as radiation opacifiers in Urography, Angiography and Myelography. and may be applied as aqueous solutions, optionally together with preservatives, after adjustment to pH 7, by intravascular injection or by the oral or retrograde routes.
GB1051572A
1971-04-07
1972-03-07
Radiography opacifier
Expired
GB1374918A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
FR7112285A
FR2132530B1
(en)
1971-04-07
1971-04-07
Publications (1)
Publication Number
Publication Date
GB1374918A
true
GB1374918A
(en)
1974-11-20
Family
ID=9074907
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB1051572A
Expired
GB1374918A
(en)
1971-04-07
1972-03-07
Radiography opacifier
Country Status (3)
Country
Link
DE
(1)
DE2216627C3
(en)
FR
(1)
FR2132530B1
(en)
GB
(1)
GB1374918A
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US6610885B1
(en)
1996-08-29
2003-08-26
Amersham Health As
Process for the preparation of contrast agents
Families Citing this family (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR2541676A1
(en)
*
1983-02-25
1984-08-31
Guerbet Sa
NON-IONIC COMPOUNDS HAVING IOWED OR BROMINATED BENZENIC STRUCTURES AND OPACIFYING PRODUCTS CONTAINING SAME
GB9618055D0
(en)
*
1996-08-29
1996-10-09
Nycomed Imaging As
Process
Family Cites Families (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3346630A
(en)
*
1963-10-07
1967-10-10
Mallinckrodt Chemical Works
Triiodinated benzoic acids
GB1275745A
(en)
*
1968-06-10
1972-05-24
Nyegaard & Co As
2,4,6-triiodobenzoic acid derivatives and their use as x-ray contrast agents
1971
1971-04-07
FR
FR7112285A
patent/FR2132530B1/fr
not_active
Expired
1972
1972-03-07
GB
GB1051572A
patent/GB1374918A/en
not_active
Expired
1972-04-06
DE
DE19722216627
patent/DE2216627C3/en
not_active
Expired
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US6610885B1
(en)
1996-08-29
2003-08-26
Amersham Health As
Process for the preparation of contrast agents
Also Published As
Publication number
Publication date
DE2216627B2
(en)
1975-02-27
FR2132530A1
(en)
1972-11-24
DE2216627C3
(en)
1975-10-09
FR2132530B1
(en)
1974-08-02
DE2216627A1
(en)
1972-10-19
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Legal Events
Date
Code
Title
Description
1975-04-03
PS
Patent sealed
1983-10-26
PCNP
Patent ceased through non-payment of renewal fee
