GB1381464A

GB1381464A – Pyrimidine derivatives
– Google Patents

GB1381464A – Pyrimidine derivatives
– Google Patents
Pyrimidine derivatives

Info

Publication number
GB1381464A

GB1381464A
GB565373A
GB565373A
GB1381464A
GB 1381464 A
GB1381464 A
GB 1381464A
GB 565373 A
GB565373 A
GB 565373A
GB 565373 A
GB565373 A
GB 565373A
GB 1381464 A
GB1381464 A
GB 1381464A
Authority
GB
United Kingdom
Prior art keywords
difluoroethyl
pentafluoroethyl
trifluoroethyl
feb
amino
Prior art date
1972-02-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB565373A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1972-02-08
Filing date
1973-02-05
Publication date
1975-01-22

1973-02-05
Application filed by Merck and Co Inc
filed
Critical
Merck and Co Inc

1975-01-22
Publication of GB1381464A
publication
Critical
patent/GB1381464A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings

C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members

C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

C07D239/32—One oxygen, sulfur or nitrogen atom

C07D239/42—One nitrogen atom

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P33/00—Antiparasitic agents

A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00

C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00 in which the condensed system contains two hetero rings

C07D471/04—Ortho-condensed systems

Abstract

1381464 Pyrimidine derivatives MERCK & CO Inc 5 Feb 1973 [8 Feb 1972] 5653/73 Heading C2C [Also in Division A5] Novel coccidiostatic compounds (I) where R1 is C 1 to C 3 alkyl, methoxymethyl, cyclopropylmethyl, C 1 to C 3 perfluoroalkyl, 1,1- difluoroethyl or 2,2,2-trifluoroethyl and -#N) signifies a radical (II) to (VIII) or a derivative thereof having a single additional Me group in a position not occupied by R, R, R* or R11 (R and R11 are H or Me and one of R and R* is H and the other is Me), are made, e.g. by quaternization. The following compounds are prepared: 2- pentafluoroethyl-, -heptafluoropropyl-, -trifluoromethyl-, -(2,2,2 – trifluoroethyl)- and -(1,1 – difluoroethyl) – 4 – amino – 5 – hydroxymethyl – pyrimidines, 2 – pentafluoroethyl – 4- amino – 5 – bromomethyl pyrimidine hydrobromide pentafluoropropionamidine, 3,3,3-trifluoro – propionamidine and its hydrochloride, 3,3,3 – trifluoropropionimido ethyl ester hydrochloride, ethyl 2,2-difluoropropionate, 2,2-difluoropropionamide, 2,2 – difluoropropionitrile and 2,2-difluoropropionamidine.

GB565373A
1972-02-08
1973-02-05
Pyrimidine derivatives

Expired

GB1381464A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US22462072A

1972-02-08
1972-02-08

Publications (1)

Publication Number
Publication Date

GB1381464A
true

GB1381464A
(en)

1975-01-22

Family
ID=22841447
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB565373A
Expired

GB1381464A
(en)

1972-02-08
1973-02-05
Pyrimidine derivatives

Country Status (18)

Country
Link

JP
(1)

JPS5829059B2
(en)

AR
(1)

AR205081A1
(en)

AT
(1)

AT327913B
(en)

AU
(1)

AU472130B2
(en)

BE
(1)

BE795071A
(en)

BG
(1)

BG20796A3
(en)

CA
(1)

CA985684A
(en)

DD
(1)

DD104301A5
(en)

ES
(1)

ES411392A1
(en)

FR
(1)

FR2181712B1
(en)

GB
(1)

GB1381464A
(en)

HU
(1)

HU165410B
(en)

IE
(1)

IE37178B1
(en)

IL
(1)

IL41447A0
(en)

LU
(1)

LU66983A1
(en)

NL
(1)

NL7301317A
(en)

RO
(1)

RO71884A
(en)

ZA
(1)

ZA73874B
(en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

NL257970A
(en)

*

1959-11-20

NL109464C
(en)

*

1960-02-02

IL26554A
(en)

*

1965-10-05
1971-04-28
Ciba Geigy Ag
Compositions containing pyrimidine derivatives for treatment of coccidiosis

0

BE
BE795071D
patent/BE795071A/en
unknown

1973

1973-01-01
AR
AR246419A
patent/AR205081A1/en
active

1973-01-30
NL
NL7301317A
patent/NL7301317A/xx
not_active
Application Discontinuation

1973-01-31
CA
CA162,520A
patent/CA985684A/en
not_active
Expired

1973-02-01
RO
RO7373694A
patent/RO71884A/en
unknown

1973-02-02
AU
AU51759/73A
patent/AU472130B2/en
not_active
Expired

1973-02-02
IL
IL41447A
patent/IL41447A0/en
unknown

1973-02-02
IE
IE169/73A
patent/IE37178B1/en
unknown

1973-02-05
GB
GB565373A
patent/GB1381464A/en
not_active
Expired

1973-02-05
BG
BG22620A
patent/BG20796A3/xx
unknown

1973-02-06
DD
DD168691A
patent/DD104301A5/xx
unknown

1973-02-07
AT
AT108473A
patent/AT327913B/en
not_active
IP Right Cessation

1973-02-07
LU
LU66983A
patent/LU66983A1/xx
unknown

1973-02-07
ES
ES411392A
patent/ES411392A1/en
not_active
Expired

1973-02-07
HU
HUME1602A
patent/HU165410B/hu
unknown

1973-02-07
ZA
ZA730874A
patent/ZA73874B/en
unknown

1973-02-08
FR
FR7304436A
patent/FR2181712B1/fr
not_active
Expired

1973-02-08
JP
JP48015257A
patent/JPS5829059B2/en
not_active
Expired

Also Published As

Publication number
Publication date

IE37178L
(en)

1973-08-08

NL7301317A
(en)

1973-08-10

HU165410B
(en)

1974-08-28

ES411392A1
(en)

1976-05-16

FR2181712A1
(en)

1973-12-07

BE795071A
(en)

1973-08-07

AT327913B
(en)

1976-02-25

IL41447A0
(en)

1973-04-30

CA985684A
(en)

1976-03-16

BG20796A3
(en)

1975-12-20

LU66983A1
(en)

1973-08-17

RO71884A
(en)

1982-05-10

ZA73874B
(en)

1974-09-25

DE2306001A1
(en)

1973-08-23

DD104301A5
(en)

1974-03-05

DE2306001B2
(en)

1977-03-17

AU5175973A
(en)

1974-08-08

AU472130B2
(en)

1976-05-20

IE37178B1
(en)

1977-05-25

ATA108473A
(en)

1975-05-15

FR2181712B1
(en)

1976-03-05

JPS5829059B2
(en)

1983-06-20

AR205081A1
(en)

1976-04-05

JPS4887010A
(en)

1973-11-16

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Legal Events

Date
Code
Title
Description

1975-06-04
PS
Patent sealed [section 19, patents act 1949]

1985-10-02
PCNP
Patent ceased through non-payment of renewal fee

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