GB1383625A

GB1383625A – 1,4-dihydropyridine carboxylic acid compounds their production and their medicinal use
– Google Patents

GB1383625A – 1,4-dihydropyridine carboxylic acid compounds their production and their medicinal use
– Google Patents
1,4-dihydropyridine carboxylic acid compounds their production and their medicinal use

Info

Publication number
GB1383625A

GB1383625A
GB1872573A
GB1872573A
GB1383625A
GB 1383625 A
GB1383625 A
GB 1383625A
GB 1872573 A
GB1872573 A
GB 1872573A
GB 1872573 A
GB1872573 A
GB 1872573A
GB 1383625 A
GB1383625 A
GB 1383625A
Authority
GB
United Kingdom
Prior art keywords
compound
reacting
enamine
alkyl
salt
Prior art date
1972-04-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB1872573A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1972-04-18
Filing date
1973-04-18
Publication date
1974-02-12

1973-04-18
Application filed by Bayer AG
filed
Critical
Bayer AG

1974-02-12
Publication of GB1383625A
publication
Critical
patent/GB1383625A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P11/00—Drugs for disorders of the respiratory system

A61P11/08—Bronchodilators

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P13/00—Drugs for disorders of the urinary system

A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P15/00—Drugs for genital or sexual disorders; Contraceptives

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P3/00—Drugs for disorders of the metabolism

A61P3/06—Antihyperlipidemics

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/06—Antiarrhythmics

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/08—Vasodilators for multiple indications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/12—Antihypertensives

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members

C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms

C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms

C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

1383625 1,4-Dihydropyridine carboxylic acid esters BAYER AG 18 April 1973 [18 April 1972] 18725/73 Heading C2C Novel compounds of Formula I in which R is H or aliphatic hydrocarbyl; R1 and R4 are H or alkyl; X is alkylene, Y is pyridyl or -NR1R11, R1 and R11 being H or alkyl or together with the N atom forming a 5 to 7- membered heterocyclic ring, R2 is phenyl optionally carrying 1 to 3 substituents selected from NO 2 , CN, N 3 , alkyl, alkoxy, acyloxy, carbalkoxy, NH 2 , acylamino, alkylamino, dialkylamino, SO n -alkyl (n being 0, 1 or 2), phenyl, CF 3 and halogen, or is benzyl, styryl, cycloalkyl or cycloalkenyl, or is naphthyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, thienyl, furyl or pyrryl optionally carrying one or more substituents selected from alkyl, alkoxy, NO 2 and halogen; and R3 is a hydrocarbon radical optionally carrying 1 or 2 OH substituents and optionally having the hydrocarbon chain interrupted by 1 or 2 O atoms, or R3 is OQ (Q being a hydrocarbon radical optionally carrying 1 or 2 OH substituents and optionally having the hydrocarbon chain interrupted by 1 or 2 O atoms) or R 3 is -O-X1-Y1 (X1 and Y1 being as defined above for X and Y respectively), and salts thereof, are prepared by (a) reacting a compound R1-CO-CH 2 -COO-X-Y with a compound H 2 N-R or a salt thereof, to produce an enamine and reacting this enamine with a compound R2-CH=C(COR3)-COR4, or (b) reacting a compound R4-CO-CH 2 -CO-R3 with a compound H 2 N-R or a salt thereof, to produce an enamine and. reacting this enamine with a compound or (c) reacting a compound and an enamine with an aldehyde R2-CHO, or (d) reacting a compound R1-CO-CH 2 -COO-X-Y and an enamine R-NH-C(R4)=CH-CO-R3 with an aldehyde R2-CHO, or (e) reacting 2 moles of a compound R1-CO-CH 2 -COO-X-Y and one mole of a compound H 2 R or a salt thereof, with an aldehyde R2-CHO, or (f) reacting a compound of Formula II in which Z is H, an alkali metal or an equivalent of an alkaline earth metal, with a compound. halogen -X-Y. Starting materials.-The #-pyridylmethyl, α- pyridylmethyl, #-morpholinonisopropyl, #- morpholinoethyl and γ-(N-methylpiperazino) propyl esters of acetoacetic acid, 3-nitro-6- methylthiobenzaldehyde, and the 5-methyl and 5-ethyl esters of 1,2,6-trimethyl-4-(31– nitrophenyl) – 1,4 – dihydropyridine – 3,5- dicarboxylic acid are prepared by standard methods. Pharmaceutical compositions having coronary activity, for oral, parenteral, perlingual, topical or rectal administration, comprise a compound I, or a salt thereof, together with a pharmaceutical carrier.

GB1872573A
1972-04-18
1973-04-18
1,4-dihydropyridine carboxylic acid compounds their production and their medicinal use

Expired

GB1383625A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

DE2218644A

DE2218644C3
(en)

1972-04-18
1972-04-18

Basic esters of 1,4-dihydropyridines, processes for their preparation and their use as pharmaceuticals

Publications (1)

Publication Number
Publication Date

GB1383625A
true

GB1383625A
(en)

1974-02-12

Family
ID=5842285
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB1872573A
Expired

GB1383625A
(en)

1972-04-18
1973-04-18
1,4-dihydropyridine carboxylic acid compounds their production and their medicinal use

Country Status (22)

Country
Link

US
(1)

US3905970A
(en)

JP
(2)

JPS5637225B2
(en)

AT
(7)

ATA45775A
(en)

AU
(1)

AU467406B2
(en)

BE
(1)

BE798403A
(en)

CA
(1)

CA1006515A
(en)

CH
(6)

CH590842A5
(en)

CS
(6)

CS174250B2
(en)

DD
(1)

DD107275A5
(en)

DE
(1)

DE2218644C3
(en)

DK
(1)

DK137753C
(en)

ES
(1)

ES413809A1
(en)

FI
(1)

FI55997C
(en)

FR
(1)

FR2182983B1
(en)

GB
(1)

GB1383625A
(en)

HU
(1)

HU167989B
(en)

IE
(1)

IE37538B1
(en)

IL
(1)

IL42044A
(en)

NL
(1)

NL176942C
(en)

SE
(1)

SE398876B
(en)

SU
(6)

SU518127A3
(en)

ZA
(1)

ZA732633B
(en)

Cited By (8)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0063365A1
(en)

*

1981-04-17
1982-10-27
Kyowa Hakko Kogyo Co., Ltd.
1,4-Dihydropyridine derivative and pharmaceutical composition containing same

EP0088903A2
(en)

*

1982-03-17
1983-09-21
Yoshitomi Pharmaceutical Industries, Ltd.
1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives

EP0094159A1
(en)

*

1982-05-10
1983-11-16
Takeda Chemical Industries, Ltd.
Dihydropyridine derivatives, their production and use

EP0097821A2
(en)

*

1982-06-03
1984-01-11
Pierrel S.p.A.
Dihydropyridines with an antagonistic activity to calcium, process for their preparation, and pharmaceutical compositions containing them

EP0106276A2
(en)

*

1982-10-15
1984-04-25
Kyowa Hakko Kogyo Co., Ltd.
1,4-Dihydropyridine derivatives

EP0106275A3
(en)

*

1982-10-15
1984-05-23
Kyowa Hakko Kogyo Co., Ltd.
1,4-dihydropyridine derivatives

GB2156809A
(en)

*

1984-03-27
1985-10-16
Invest Y Desarrolo Quimico Bio
1,4-dihydropyridine derivatives, their preparations and their use

US4578395A
(en)

*

1983-06-02
1986-03-25
Teijin Limited
Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as antihypertensive

Families Citing this family (55)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4038399A
(en)

*

1972-04-18
1977-07-26
Bayer Aktiengesellschaft
1,4-dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives

US3985758A
(en)

*

1973-02-20
1976-10-12
Yamanouchi Pharmaceutical Co., Ltd.
1,4-Dihydropyridine derivatives

FR2218107A1
(en)

*

1973-02-20
1974-09-13
Yamanouchi Pharma Co Ltd
Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates – useful as cerebral vasodilators and musculotropic spasmolytic agents

DE2508181A1
(en)

*

1975-02-26
1976-09-09
Bayer Ag

1,4-DIHYDROPYRIDINCARBONIC ACID ARAL KYLESTER, METHOD FOR MANUFACTURING AND USING THEY AS A MEDICINAL PRODUCT

FR2320750A1
(en)

*

1975-08-12
1977-03-11
Hexachimie

1,4-DIHYDRO PYRIDINES AND THEIR THERAPEUTIC APPLICATION

DE2738153A1
(en)

*

1977-08-24
1979-03-08
Bayer Ag

2-PYRIDYL-1,4-DIHYDROPYRIDINE, THE METHOD FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT

JPS55301A
(en)

*

1978-02-14
1980-01-05
Yamanouchi Pharmaceut Co Ltd
1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation

US4285955A
(en)

*

1978-10-31
1981-08-25
Bayer Aktiengesellschaft
1,4-Dihydropyridinecarboxylic acids

DE2847237A1
(en)

*

1978-10-31
1980-05-14
Bayer Ag
Cardiovascular 1,4-di:hydro-pyridine-3-carboxylic acids prodn. – by alkaline hydrolysis of ester(s) with electron withdrawing substit.

DE2949464A1
(en)

*

1978-12-18
1980-06-26
Sandoz Ag

BENZOXADIAZOLES AND BENZOTHIADIAZOLES, THEIR PRODUCTION AND USE

JPS57200386A
(en)

*

1981-06-04
1982-12-08
Yoshitomi Pharmaceut Ind Ltd
Novel 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salts

NZ201395A
(en)

*

1981-07-30
1987-02-20
Bayer Ag
Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines

JPS58131982A
(en)

*

1982-02-01
1983-08-06
Tokyo Tanabe Co Ltd
Novel 1,4-dihydropyridine derivative

FR2511370B1
(en)

*

1981-08-12
1986-10-24
Tokyo Tanabe Co

1,4-DIHYDROPYRIDINE DERIVATIVES WITH VASODILATOR AND HYPOTENSION ACTIVITY

JPS58159490A
(en)

*

1982-02-23
1983-09-21
Nikken Kagaku Kk
1,4-dihydropyridne compound

JPS58201765A
(en)

*

1982-05-10
1983-11-24
Takeda Chem Ind Ltd
Dihydropyridine derivative, its preparation and use

US4419518A
(en)

*

1982-07-26
1983-12-06
Tokyo Tanabe Co. L.T.D.
1,4-Dihydropyridine derivatives

PH19166A
(en)

*

1982-09-04
1986-01-16
Pfizer
Dihydropyridined,pharmaceutical compositions and method of use

JPS5951281A
(en)

*

1982-09-17
1984-03-24
Yoshitomi Pharmaceut Ind Ltd
1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative

DE3234684A1
(en)

*

1982-09-18
1984-03-22
Bayer Ag, 5090 Leverkusen

NEW DIHYDROPYRIMIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS

JPS59225162A
(en)

*

1983-06-03
1984-12-18
Kyowa Hakko Kogyo Co Ltd
1,4-dihydropyridine derivative

JPS5970667A
(en)

*

1982-10-15
1984-04-21
Kyowa Hakko Kogyo Co Ltd
1,4-dihydropyridine derivative

US4656181A
(en)

*

1982-11-24
1987-04-07
Cermol S.A.
Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same

US4491582A
(en)

*

1983-03-03
1985-01-01
Usv Pharmaceutical Corporation
N-(substituted piperazino)-1,4-dihydropyridine-3,5-carboxylic acid

US4603135A
(en)

*

1983-10-17
1986-07-29
Takeda Chemical Industries, Ltd.
Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates

JPS6092266A
(en)

*

1983-10-27
1985-05-23
Teijin Ltd
1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative, its preparation and pharmaceutical containing said derivative as active component

JPS60120861A
(en)

*

1983-12-02
1985-06-28
Otsuka Pharmaceut Co Ltd
Dihydropyridine derivative

DE4342196A1
(en)

*

1993-12-10
1995-06-14
Bayer Ag

New 4-phenyl-substituted 1,4-dihydropyridines

JPS60156671A
(en)

*

1984-01-25
1985-08-16
Yamanouchi Pharmaceut Co Ltd
Dihydropyridine derivative and its preparation

US4755512A
(en)

*

1984-04-11
1988-07-05
Bristol-Myers Company
Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities

US4895846A
(en)

*

1984-04-11
1990-01-23
Bristol-Myers Company
Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties

KR890004904B1
(en)

*

1984-08-03
1989-11-30
미쓰이 붓상 가부시기 가이샤
Method of and apparatus for freezing food

JPS6147477A
(en)

*

1984-08-14
1986-03-07
Kowa Co
Novel 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative

US4757071A
(en)

*

1984-12-14
1988-07-12
Nisshin Flour Milling Co., Ltd.
1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases

JPH0676405B2
(en)

*

1986-06-13
1994-09-28
日清製粉株式会社

1,4-Dihydropyridine derivative and pharmaceutical composition containing the same

US4652573A
(en)

*

1985-03-14
1987-03-24
Nelson Research & Development Co.
Calcium antagonist N-hetero ester 1,4-dihydropyridines

US4833150A
(en)

*

1985-03-14
1989-05-23
Nelson Research & Development Co.
1,4-dihydropyridines

US4593033A
(en)

*

1985-04-24
1986-06-03
Merck & Co., Inc.
Substituted indeno[2,1-c] pyridines useful as calcium channel blockers

DK8602336A
(en)

*

1985-05-21
1986-11-22

US4605660A
(en)

*

1985-06-03
1986-08-12
Merck & Co., Inc.
Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers

US4670443A
(en)

*

1985-07-02
1987-06-02
Merck & Co., Inc.
Benzo(f)isoquinoline compounds useful as calcium entry blockers

US4735956A
(en)

*

1985-09-13
1988-04-05
Merck & Co., Inc.
Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers

DE3682857D1
(en)

*

1985-09-13
1992-01-23
Green Cross Corp
Dihydropyridinderivate.

IT1201476B
(en)

*

1985-10-04
1989-02-02
Yason Srl

DIHYDROPYRIDINE DERIVATIVE, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT

US4721708A
(en)

*

1985-11-26
1988-01-26
Merck & Co., Inc.
Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use

US4788203A
(en)

*

1985-11-26
1988-11-29
Merck & Co., Inc.
Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders

US4771057A
(en)

*

1986-02-03
1988-09-13
University Of Alberta
Reduced pyridyl derivatives with cardiovascular regulating properties

US4849436A
(en)

*

1986-03-11
1989-07-18
Nelson Research & Development Co.
1,4-dihydropyridines

HU196755B
(en)

*

1986-09-16
1989-01-30
Gyogyszerkutato Intezet
Process for production of new substituated amilid derivatives and medical compositions containing them

EP0394243A1
(en)

*

1987-05-22
1990-10-31
Byk Gulden Lomberg Chemische Fabrik GmbH
Process for manufacturing carboxylic acids

DE3732380A1
(en)

*

1987-09-25
1989-04-06
Bayer Ag

DIHYDROPYRIDINETHER, METHOD FOR THEIR PRODUCTION AND THEIR USE

US5216172A
(en)

*

1988-02-24
1993-06-01
Ajinomoto Co., Inc.
1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells

EP0330470A3
(en)

*

1988-02-24
1992-01-02
Ajinomoto Co., Inc.
1,4-dihydropyridine derivatives useful against tumour cells

CA1331613C
(en)

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1988-07-28
1994-08-23
Nikken Chemicals Co., Ltd.
1,4-dihydropyridine derivative

DE4342195A1
(en)

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1993-12-10
1995-06-14
Bayer Ag

Dihydropyridines with heterocyclically substituted esters

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Assignee
Title

DE1545873A1
(en)

*

1965-11-10
1970-02-26
Bayer Ag

Process for the preparation of dihydrodipyridyl derivatives

DE1670827C3
(en)

*

1967-03-20
1974-10-24
Bayer Ag, 5090 Leverkusen

4- (2′-nitrophenyl) -2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridine

DE1923990C3
(en)

*

1969-05-10
1978-11-23
Bayer Ag

Process for the preparation of N-substituted M-dihydropyridine-S.S-dicarboxylic acid esters

DE1963185A1
(en)

*

1969-12-17
1971-06-24
Bayer Ag
4-(nitrophenyl)-1,4-dihydropyridine derivs

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1971-04-10
1979-10-11
Bayer Ag, 5090 Leverkusen

Asymmetrical 1,4-dihydropyridine-33-dicarboxylic acid esters, process for their preparation and their use as pharmaceuticals

1972

1972-04-18
DE
DE2218644A
patent/DE2218644C3/en
not_active
Expired

1973

1973-04-12
US
US350381A
patent/US3905970A/en
not_active
Expired – Lifetime

1973-04-13
AU
AU54491/73A
patent/AU467406B2/en
not_active
Expired

1973-04-16
JP
JP4225373A
patent/JPS5637225B2/ja
not_active
Expired

1973-04-16
AT
AT45775*A
patent/ATA45775A/en
not_active
IP Right Cessation

1973-04-16
AT
AT337373A
patent/AT327191B/en
not_active
IP Right Cessation

1973-04-16
SU
SU1911372A
patent/SU518127A3/en
active

1973-04-16
CA
CA168,760A
patent/CA1006515A/en
not_active
Expired

1973-04-16
IL
IL42044A
patent/IL42044A/en
unknown

1973-04-16
AT
AT45775*7A
patent/AT327905B/en
not_active
IP Right Cessation

1973-04-16
DD
DD170202A
patent/DD107275A5/xx
unknown

1973-04-16
AT
AT45875*A
patent/ATA45875A/en
not_active
IP Right Cessation

1973-04-16
AT
AT45875*7A
patent/AT329559B/en
not_active
IP Right Cessation

1973-04-16
FI
FI1193/73A
patent/FI55997C/en
active

1973-04-16
AT
AT45975*7A
patent/AT329560B/en
not_active
IP Right Cessation

1973-04-16
JP
JP48042254A
patent/JPS4914614A/ja
active
Pending

1973-04-16
AT
AT45975*A
patent/ATA45975A/en
not_active
IP Right Cessation

1973-04-17
DK
DK208973A
patent/DK137753C/en
not_active
IP Right Cessation

1973-04-17
CH
CH319176A
patent/CH590842A5/xx
not_active
IP Right Cessation

1973-04-17
ES
ES413809A
patent/ES413809A1/en
not_active
Expired

1973-04-17
CS
CS6249A
patent/CS174250B2/cs
unknown

1973-04-17
CH
CH319076A
patent/CH590841A5/xx
not_active
IP Right Cessation

1973-04-17
CH
CH319276A
patent/CH591445A5/xx
not_active
IP Right Cessation

1973-04-17
IE
IE604/73A
patent/IE37538B1/en
unknown

1973-04-17
CS
CS6246A
patent/CS174247B2/cs
unknown

1973-04-17
CS
CS6247A
patent/CS174248B2/cs
unknown

1973-04-17
CS
CS6245A
patent/CS174246B2/cs
unknown

1973-04-17
ZA
ZA732633A
patent/ZA732633B/en
unknown

1973-04-17
SE
SE7305462A
patent/SE398876B/en
unknown

1973-04-17
CH
CH319476A
patent/CH591446A5/xx
not_active
IP Right Cessation

1973-04-17
CH
CH319376A
patent/CH588464A5/xx
not_active
IP Right Cessation

1973-04-17
CH
CH554373A
patent/CH589627A5/xx
not_active
IP Right Cessation

1973-04-17
CS
CS6248A
patent/CS174249B2/cs
unknown

1973-04-17
CS
CS2764A
patent/CS174201B2/cs
unknown

1973-04-18
BE
BE130166A
patent/BE798403A/en
not_active
IP Right Cessation

1973-04-18
NL
NLAANVRAGE7305479,A
patent/NL176942C/en
not_active
IP Right Cessation

1973-04-18
HU
HUBA2916A
patent/HU167989B/hu
unknown

1973-04-18
FR
FR7314175A
patent/FR2182983B1/fr
not_active
Expired

1973-04-18
GB
GB1872573A
patent/GB1383625A/en
not_active
Expired

1974

1974-06-13
SU
SU2032539A
patent/SU516351A3/en
active

1974-06-13
SU
SU2032540A
patent/SU513620A3/en
active

1974-06-13
SU
SU2032538A
patent/SU515452A3/en
active

1974-06-13
SU
SU2032541A
patent/SU516352A3/en
active

1974-06-13
SU
SU2032542A
patent/SU513621A3/en
active

Cited By (12)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0063365A1
(en)

*

1981-04-17
1982-10-27
Kyowa Hakko Kogyo Co., Ltd.
1,4-Dihydropyridine derivative and pharmaceutical composition containing same

EP0088903A2
(en)

*

1982-03-17
1983-09-21
Yoshitomi Pharmaceutical Industries, Ltd.
1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives

US4618607A
(en)

*

1982-03-17
1986-10-21
Yoshitomi Pharmaceutical Industries, Ltd.
1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives and pharmaceutical compositions

EP0088903B1
(en)

*

1982-03-17
1988-11-23
Yoshitomi Pharmaceutical Industries, Ltd.
1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives

EP0094159A1
(en)

*

1982-05-10
1983-11-16
Takeda Chemical Industries, Ltd.
Dihydropyridine derivatives, their production and use

EP0097821A2
(en)

*

1982-06-03
1984-01-11
Pierrel S.p.A.
Dihydropyridines with an antagonistic activity to calcium, process for their preparation, and pharmaceutical compositions containing them

EP0097821A3
(en)

*

1982-06-03
1984-09-12
Pierrel S.P.A.
Dihydropyridines with an antagonistic activity to calcium, process for their preparation, and pharmaceutical compositions containing them

EP0106276A2
(en)

*

1982-10-15
1984-04-25
Kyowa Hakko Kogyo Co., Ltd.
1,4-Dihydropyridine derivatives

EP0106275A3
(en)

*

1982-10-15
1984-05-23
Kyowa Hakko Kogyo Co., Ltd.
1,4-dihydropyridine derivatives

EP0106276A3
(en)

*

1982-10-15
1984-05-23
Kyowa Hakko Kogyo Co., Ltd.
1,4-dihydropyridine derivatives

US4578395A
(en)

*

1983-06-02
1986-03-25
Teijin Limited
Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as antihypertensive

GB2156809A
(en)

*

1984-03-27
1985-10-16
Invest Y Desarrolo Quimico Bio
1,4-dihydropyridine derivatives, their preparations and their use

Also Published As

Publication number
Publication date

IL42044A
(en)

1976-09-30

CH590841A5
(en)

1977-08-31

SU513620A3
(en)

1976-05-05

FR2182983A1
(en)

1973-12-14

CS174250B2
(en)

1977-03-31

NL176942B
(en)

1985-02-01

DE2218644A1
(en)

1973-10-25

AU467406B2
(en)

1975-11-27

FI55997B
(en)

1979-07-31

CS174248B2
(en)

1977-03-31

ATA45975A
(en)

1975-08-15

NL7305479A
(en)

1973-10-22

AT329559B
(en)

1976-05-25

IE37538B1
(en)

1977-08-17

JPS4914614A
(en)

1974-02-08

AT327905B
(en)

1976-02-25

NL176942C
(en)

1985-07-01

DD107275A5
(en)

1974-07-20

SU518127A3
(en)

1976-06-15

DK137753B
(en)

1978-05-01

US3905970A
(en)

1975-09-16

ZA732633B
(en)

1974-03-27

DE2218644B2
(en)

1980-04-30

JPS5637225B2
(en)

1981-08-29

SU516351A3
(en)

1976-05-30

CS174247B2
(en)

1977-03-31

CS174201B2
(en)

1977-03-31

CH588464A5
(en)

1977-06-15

CH591445A5
(en)

1977-09-15

SU516352A3
(en)

1976-05-30

SU513621A3
(en)

1976-05-05

DK137753C
(en)

1978-10-09

FI55997C
(en)

1979-11-12

AU5449173A
(en)

1974-10-17

FR2182983B1
(en)

1976-12-03

ATA337373A
(en)

1975-04-15

IE37538L
(en)

1973-10-18

CS174249B2
(en)

1977-03-31

ES413809A1
(en)

1976-01-16

AT329560B
(en)

1976-05-25

CH591446A5
(en)

1977-09-15

SE398876B
(en)

1978-01-23

IL42044A0
(en)

1973-06-29

CS174246B2
(en)

1977-03-31

DE2218644C3
(en)

1982-08-19

AT327191B
(en)

1976-01-26

HU167989B
(en)

1976-02-28

ATA45775A
(en)

1975-05-15

CH589627A5
(en)

1977-07-15

SU515452A3
(en)

1976-05-25

JPS5024277A
(en)

1975-03-15

CA1006515A
(en)

1977-03-08

BE798403A
(en)

1973-10-18

ATA45875A
(en)

1975-08-15

CH590842A5
(en)

1977-08-31

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Legal Events

Date
Code
Title
Description

1975-05-29
PS
Patent sealed [section 19, patents act 1949]

1993-05-19
PE20
Patent expired after termination of 20 years

Effective date:
19930417

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