GB1457238A – Cephalosporin derivatives
– Google Patents
GB1457238A – Cephalosporin derivatives
– Google Patents
Cephalosporin derivatives
Info
Publication number
GB1457238A
GB1457238A
GB2193875A
GB2193875A
GB1457238A
GB 1457238 A
GB1457238 A
GB 1457238A
GB 2193875 A
GB2193875 A
GB 2193875A
GB 2193875 A
GB2193875 A
GB 2193875A
GB 1457238 A
GB1457238 A
GB 1457238A
Authority
GB
United Kingdom
Prior art keywords
compounds
aco
reacting
formation
prepared
Prior art date
1974-05-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2193875A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SANGYO KAGAKU KENKYU KYOKAI
Original Assignee
SANGYO KAGAKU KENKYU KYOKAI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1974-05-28
Filing date
1975-05-21
Publication date
1976-12-01
1974-05-28
Priority claimed from JP6129674A
external-priority
patent/JPS6127398B2/ja
1974-07-03
Priority claimed from JP7677174A
external-priority
patent/JPS516982A/en
1975-05-21
Application filed by SANGYO KAGAKU KENKYU KYOKAI
filed
Critical
SANGYO KAGAKU KENKYU KYOKAI
1976-12-01
Publication of GB1457238A
publication
Critical
patent/GB1457238A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
C07D501/14—Compounds having a nitrogen atom directly attached in position 7
C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
C07D501/02—Preparation
C07D501/12—Separation; Purification
Abstract
1457238 Cephalosporins SANGYOKAGAKUKENKYUKYOKAI 21 May 1975 [28 May 1974 3 July 1974] 21938/75 Heading C2C The invention comprises compounds of formula and their salts and adducts, wherein R 1 is C 1-5 alkyl, aryl or aralkyl, R 2 is C 1-3 alkylene, Y is S or SO, and X is H, AcO, N 3 or SR 3 where R 3 is (optionally Me-substituted)heterocyclyl. These compounds are prepared (where X is H or AcO : Ia) by reacting an aqueous solution containing cephalosporin C or deacetoxycephalosporin C with a reactive derivative of R 1 -Y-R 2 -COOH and isolating the desired compound in the form of its quinoline or isoquinoline adduct; the starting materials may be present in e.g. an industrial fermentation broth. The remaining compounds are prepared by reacting Ia with an alkali metal azide or with R 3 SH. The above compounds (I) are converted to the corresponding 7-aminocephen acids by the steps of CO 2 H-group protection, iminochloride formation, iminoether formation and hydrolysis.
GB2193875A
1974-05-28
1975-05-21
Cephalosporin derivatives
Expired
GB1457238A
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
JP6129674A
JPS6127398B2
(en)
1974-05-28
1974-05-28
JP7677174A
JPS516982A
(en)
1974-07-03
1974-07-03
33 chikan 77 aminosefuarosuhoransanruinoseizoho
Publications (1)
Publication Number
Publication Date
GB1457238A
true
GB1457238A
(en)
1976-12-01
Family
ID=26402334
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB2193875A
Expired
GB1457238A
(en)
1974-05-28
1975-05-21
Cephalosporin derivatives
Country Status (6)
Country
Link
US
(1)
US4036833A
(en)
CH
(1)
CH617201A5
(en)
DE
(1)
DE2523280A1
(en)
GB
(1)
GB1457238A
(en)
IE
(1)
IE41150B1
(en)
NL
(1)
NL7506232A
(en)
Families Citing this family (7)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4178445A
(en)
*
1974-03-28
1979-12-11
Fujisawa Pharmaceutical Co., Ltd.
7-(α-Substituted glycinamido)-3-substituted methyl-3-cephem-4-carboxylic acids and their derivatives
US4154831A
(en)
*
1974-05-13
1979-05-15
Ciba-Geigy Corporation
Cephalosporins having an α-acylaminoacetic acid side chain
US3996355A
(en)
*
1975-01-02
1976-12-07
American Home Products Corporation
Permanent suspension pharmaceutical dosage form
GR70261B
(en)
*
1977-12-12
1982-09-02
Takeda Chemical Industries Ltd
JP2004538265A
(en)
*
2001-04-19
2004-12-24
ビオフェルマ ムルシア，エス．アー．
Method for producing 3-cephalosporanic acid derivative using α-keto acid derivative
GB2461290B
(en)
*
2008-06-26
2012-12-05
One80 Ltd
Rear wheel steering system
US9120861B2
(en)
*
2008-10-17
2015-09-01
Mississippi State University
Functional enhancement of antimicrobials
Family Cites Families (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
BE793191A
(en)
*
1971-12-28
1973-06-22
Toyama Chemical Co Ltd
PROCESS FOR PRODUCING 7-ACYLAMIDO-3-CEPHEM-4- CARBOXYLIC ACIDS
US3865819A
(en)
*
1972-05-03
1975-02-11
Smithkline Corp
Substituted sulfonylacetamido cephalosporins
US3923795A
(en)
*
1972-06-19
1975-12-02
Lilly Co Eli
2-Alkoxycephalosporins
US3910900A
(en)
*
1974-05-24
1975-10-07
Bristol Myers Co
7-(D-a-hydroxy-2-arylacetamido)-3-(3-hydroxypyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acids
1975
1975-05-21
GB
GB2193875A
patent/GB1457238A/en
not_active
Expired
1975-05-26
DE
DE19752523280
patent/DE2523280A1/en
not_active
Withdrawn
1975-05-27
NL
NL7506232A
patent/NL7506232A/en
not_active
Application Discontinuation
1975-05-27
CH
CH677275A
patent/CH617201A5/de
not_active
IP Right Cessation
1975-05-27
US
US05/580,965
patent/US4036833A/en
not_active
Expired – Lifetime
1975-05-28
IE
IE1185/75A
patent/IE41150B1/en
unknown
Also Published As
Publication number
Publication date
US4036833A
(en)
1977-07-19
CH617201A5
(en)
1980-05-14
IE41150L
(en)
1975-11-28
IE41150B1
(en)
1979-10-24
DE2523280A1
(en)
1975-12-18
NL7506232A
(en)
1975-12-02
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Legal Events
Date
Code
Title
Description
1977-04-21
PS
Patent sealed [section 19, patents act 1949]
1981-01-28
PCNP
Patent ceased through non-payment of renewal fee
