GB1479380A – D and l-cyanocyproheptadine compositions containing it and methods of using it
– Google Patents
GB1479380A – D and l-cyanocyproheptadine compositions containing it and methods of using it
– Google Patents
D and l-cyanocyproheptadine compositions containing it and methods of using it
Info
Publication number
GB1479380A
GB1479380A
GB28109/75A
GB2810975A
GB1479380A
GB 1479380 A
GB1479380 A
GB 1479380A
GB 28109/75 A
GB28109/75 A
GB 28109/75A
GB 2810975 A
GB2810975 A
GB 2810975A
GB 1479380 A
GB1479380 A
GB 1479380A
Authority
GB
United Kingdom
Prior art keywords
base
cyanocyproheptadine
methods
cyclohepten
ylidene
Prior art date
1974-07-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28109/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1974-07-10
Filing date
1975-07-03
Publication date
1977-07-13
1975-07-03
Application filed by Merck and Co Inc
filed
Critical
Merck and Co Inc
1977-07-13
Publication of GB1479380A
publication
Critical
patent/GB1479380A/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Abstract
(-)-1-Methyl-4-(3-cyano-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperi dine and (+)-1-methyl-4-(3-cyano-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidin e are prepared in virtually pure form. These compounds are obtained by preparing the diastereomeric salts of the corresponding (+/-)-racemate in suitable solvents using optically active acids. The (-)-form, which is virtually free of the (+)-form, is then removed by crystallisation. The salt obtained is then converted into the free base, and the (+)-form is isolated from the residue as the free base. The (+)-form of the base and also the corresponding acid addition salts can be used as peripheral and central anticholinergics. The (-)-form of the base including corresponding acid addition salts can be used as sedatives.
GB28109/75A
1974-07-10
1975-07-03
D and l-cyanocyproheptadine compositions containing it and methods of using it
Expired
GB1479380A
(en)
Applications Claiming Priority (1)
Application Number
Priority Date
Filing Date
Title
US48697874A
1974-07-10
1974-07-10
Publications (1)
Publication Number
Publication Date
GB1479380A
true
GB1479380A
(en)
1977-07-13
Family
ID=23933896
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB28109/75A
Expired
GB1479380A
(en)
1974-07-10
1975-07-03
D and l-cyanocyproheptadine compositions containing it and methods of using it
Country Status (22)
Country
Link
JP
(1)
JPS5134166A
(en)
AR
(1)
AR210995A1
(en)
AT
(1)
AT343661B
(en)
BE
(1)
BE831170A
(en)
CA
(1)
CA1050887A
(en)
CH
(1)
CH612182A5
(en)
DE
(1)
DE2530686A1
(en)
DK
(1)
DK288575A
(en)
ES
(1)
ES439125A1
(en)
FI
(1)
FI58914C
(en)
FR
(1)
FR2277583A1
(en)
GB
(1)
GB1479380A
(en)
HU
(1)
HU171309B
(en)
IE
(1)
IE41488B1
(en)
IL
(1)
IL47616A
(en)
LU
(1)
LU72928A1
(en)
NL
(1)
NL7507568A
(en)
NO
(1)
NO752346L
(en)
PH
(1)
PH12160A
(en)
PL
(1)
PL101286B1
(en)
SE
(1)
SE424989B
(en)
ZA
(1)
ZA754405B
(en)
1975
1975-06-24
SE
SE7507241A
patent/SE424989B/en
unknown
1975-06-24
FI
FI751865A
patent/FI58914C/en
not_active
IP Right Cessation
1975-06-25
NL
NL7507568A
patent/NL7507568A/en
not_active
Application Discontinuation
1975-06-25
DK
DK288575A
patent/DK288575A/en
not_active
Application Discontinuation
1975-06-27
NO
NO752346A
patent/NO752346L/no
unknown
1975-07-01
IL
IL47616A
patent/IL47616A/en
unknown
1975-07-02
PH
PH17341A
patent/PH12160A/en
unknown
1975-07-03
GB
GB28109/75A
patent/GB1479380A/en
not_active
Expired
1975-07-03
FR
FR7520899A
patent/FR2277583A1/en
active
Granted
1975-07-03
HU
HU75ME00001875A
patent/HU171309B/en
unknown
1975-07-03
ES
ES439125A
patent/ES439125A1/en
not_active
Expired
1975-07-08
PL
PL1975181930A
patent/PL101286B1/en
unknown
1975-07-08
LU
LU72928A
patent/LU72928A1/xx
unknown
1975-07-08
AT
AT526075A
patent/AT343661B/en
not_active
IP Right Cessation
1975-07-08
IE
IE1516/75A
patent/IE41488B1/en
unknown
1975-07-09
CH
CH896575A
patent/CH612182A5/en
not_active
IP Right Cessation
1975-07-09
DE
DE19752530686
patent/DE2530686A1/en
active
Pending
1975-07-09
CA
CA231,114A
patent/CA1050887A/en
not_active
Expired
1975-07-09
ZA
ZA754405A
patent/ZA754405B/en
unknown
1975-07-09
BE
BE158128A
patent/BE831170A/en
not_active
IP Right Cessation
1975-07-10
AR
AR259505A
patent/AR210995A1/en
active
1975-07-10
JP
JP50084050A
patent/JPS5134166A/en
active
Granted
Also Published As
Publication number
Publication date
FR2277583B1
(en)
1980-05-16
NL7507568A
(en)
1976-01-13
SE424989B
(en)
1982-08-23
FR2277583A1
(en)
1976-02-06
JPS5134166A
(en)
1976-03-23
IL47616A0
(en)
1975-10-15
AR210995A1
(en)
1977-10-14
HU171309B
(en)
1977-12-28
IE41488B1
(en)
1980-01-16
PH12160A
(en)
1978-11-10
AU8268575A
(en)
1977-01-06
DE2530686A1
(en)
1976-01-22
AT343661B
(en)
1978-06-12
LU72928A1
(en)
1976-05-31
FI751865A
(en)
1976-01-11
SE7507241L
(en)
1976-01-12
ATA526075A
(en)
1977-10-15
FI58914C
(en)
1981-05-11
CH612182A5
(en)
1979-07-13
BE831170A
(en)
1976-01-09
NO752346L
(en)
1976-01-13
IL47616A
(en)
1978-07-31
ES439125A1
(en)
1977-06-01
JPS5622864B2
(en)
1981-05-27
DK288575A
(en)
1976-01-11
FI58914B
(en)
1981-01-30
PL101286B1
(en)
1978-12-30
ZA754405B
(en)
1977-02-23
CA1050887A
(en)
1979-03-20
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Legal Events
Date
Code
Title
Description
1977-11-30
PS
Patent sealed [section 19, patents act 1949]
1986-03-05
PCNP
Patent ceased through non-payment of renewal fee
