GB1501438A

GB1501438A – Fused pyrimidine-4-(3h)-ones and preparation thereof
– Google Patents

GB1501438A – Fused pyrimidine-4-(3h)-ones and preparation thereof
– Google Patents
Fused pyrimidine-4-(3h)-ones and preparation thereof

Info

Publication number
GB1501438A

GB1501438A
GB18583/75A
GB1858375A
GB1501438A
GB 1501438 A
GB1501438 A
GB 1501438A
GB 18583/75 A
GB18583/75 A
GB 18583/75A
GB 1858375 A
GB1858375 A
GB 1858375A
GB 1501438 A
GB1501438 A
GB 1501438A
Authority
GB
United Kingdom
Prior art keywords
compounds
prepared
alkoxy
alkyl
ones
Prior art date
1974-07-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB18583/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Inc

Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1974-07-05
Filing date
1975-05-02
Publication date
1978-02-15

1974-07-05
Priority claimed from US05/485,945
external-priority
patent/US3974161A/en

1975-05-02
Application filed by Pfizer Inc
filed
Critical
Pfizer Inc

1978-02-15
Publication of GB1501438A
publication
Critical
patent/GB1501438A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms

C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines

C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems

C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring

C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4

C07D265/26—Two oxygen atoms, e.g. isatoic anhydride

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C255/00—Carboxylic acid nitriles

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems

C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom

C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00

C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00 in which the condensed system contains two hetero rings

C07D471/04—Ortho-condensed systems

Abstract

1501438 Fused – pyrimidine – 4(3H) – ones PFIZER Inc 2 May 1975 [5 July 1974] 18583/75 Addition to 1458205 Heading C2C Novel compounds I, II and III and salts thereof in which R is Me, Et, MeCO or COR0 (where R is OH, alkoxy, hydroxyalkoxy, NH 2 or NHOH); Y is H, alkyl, carbalkoxyalkyl, carboxyalkyl, -(CH 2 ) m -OCOPh or -(CH 2 ) m -OCOalkyl (where m is 2 to 4) with the proviso that when R0 is NH 2 or NHOH then Y is H; R1 is H, alkyl or Ph and R2, R3, R4 and R5 are selected from (a), H, alkyl, alkoxy, halo, benzyloxy, MeS and MeSO or (b) OH, SH, alkanoyloxy, benzoyloxy, benzylthio and benzylsulphinyl providing that at least one is selected from (b); are prepared by methods analogous to those described in the parent Specification for compounds where R is COR; compounds I (Y= H; R=Me, Et) are prepared oyclizing the appropriate 2 – amino – quinoline – 3 – carboxamide or 2-aminonicotinamide either with Ac 2 O or (EtCO) 2 O or with (EtO) 3 Me or (EtO) 3 Et in the presence of H 2 SO 4 ; compounds I (R= MeCO) are prepared by oxidation of the corresponding compound (R=Et) using SeO 2 ; compounds I where Y Is other than H are prepared by alkylation of such compounds where Y=H using an appropriate alkylating agent. Compounds where R is hydroxyalkyl are prepared by transesterification of compounds where R is alkoxy. Compounds where any one of R 2 , R 3 , R 4 or R 5 is MeSO or B 3 SO are prepared by oxidation of corresponding MeS or B 3 S compound. Compounds where R 2 , R 3 , R 4 or R 5 are B 3 O or B 3 S are debenzylated to give the corresponding OH or SH compounds and these compounds may in turn be acylated to give compounds containing an alkanoyloxy or benzyloxy substituent. Compounds I, II and III have anti-allergy activity and form with a carrier a pharmaceutical composition which may be administered orally, parenterally or by inhalation.

GB18583/75A
1974-07-05
1975-05-02
Fused pyrimidine-4-(3h)-ones and preparation thereof

Expired

GB1501438A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US05/485,945

US3974161A
(en)

1974-02-20
1974-07-05
Fused pyrimidin-4(3H)-ones as antiallergy agents

Publications (1)

Publication Number
Publication Date

GB1501438A
true

GB1501438A
(en)

1978-02-15

Family
ID=23930024
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB18583/75A
Expired

GB1501438A
(en)

1974-07-05
1975-05-02
Fused pyrimidine-4-(3h)-ones and preparation thereof

Country Status (20)

Country
Link

JP
(1)

JPS518280A
(en)

AR
(1)

AR214389A1
(en)

AT
(1)

AT351546B
(en)

BE
(1)

BE829987R
(en)

BG
(1)

BG25226A3
(en)

CA
(1)

CA1053674A
(en)

CH
(1)

CH619951A5
(en)

DD
(1)

DD118093A6
(en)

DE
(1)

DE2525050A1
(en)

DK
(1)

DK250275A
(en)

ES
(1)

ES437966A2
(en)

FI
(1)

FI59097C
(en)

GB
(1)

GB1501438A
(en)

IE
(1)

IE42746B1
(en)

LU
(1)

LU72672A1
(en)

NO
(1)

NO751594L
(en)

RO
(1)

RO69550A
(en)

SE
(1)

SE420610B
(en)

YU
(1)

YU145675A
(en)

ZA
(1)

ZA752908B
(en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

JPS5510891U
(en)

*

1979-08-03
1980-01-24

JPS5510896U
(en)

*

1979-08-03
1980-01-24

JPS5510892U
(en)

*

1979-08-03
1980-01-24

JPS5510894U
(en)

*

1979-08-03
1980-01-24

JPS59210071A
(en)

*

1982-12-30
1984-11-28
バイオメジヤ−・インコ−ポレ−テツド
Antiviral compound

US7482455B2
(en)

*

2002-10-16
2009-01-27
Smithkline Beecham Corporation
Chemical compounds

1975

1975-04-30
CA
CA225,936A
patent/CA1053674A/en
not_active
Expired

1975-05-01
IE
IE980/75A
patent/IE42746B1/en
unknown

1975-05-02
GB
GB18583/75A
patent/GB1501438A/en
not_active
Expired

1975-05-05
NO
NO751594A
patent/NO751594L/no
unknown

1975-05-06
ZA
ZA00752908A
patent/ZA752908B/en
unknown

1975-05-27
ES
ES437966A
patent/ES437966A2/en
not_active
Expired

1975-06-03
FI
FI751628A
patent/FI59097C/en
not_active
IP Right Cessation

1975-06-03
DE
DE19752525050
patent/DE2525050A1/en
not_active
Ceased

1975-06-04
BG
BG7500030186A
patent/BG25226A3/en
unknown

1975-06-04
DK
DK250275A
patent/DK250275A/en
unknown

1975-06-04
RO
RO7582428A
patent/RO69550A/en
unknown

1975-06-05
YU
YU01456/75A
patent/YU145675A/en
unknown

1975-06-06
CH
CH730075A
patent/CH619951A5/en
not_active
IP Right Cessation

1975-06-06
AR
AR259117A
patent/AR214389A1/en
active

1975-06-06
BE
BE1006719A
patent/BE829987R/en
active

1975-06-06
LU
LU72672A
patent/LU72672A1/xx
unknown

1975-06-06
JP
JP50068456A
patent/JPS518280A/ja
active
Pending

1975-06-06
AT
AT432675A
patent/AT351546B/en
not_active
IP Right Cessation

1975-06-06
DD
DD186490A
patent/DD118093A6/xx
unknown

1975-06-21
SE
SE7504599A
patent/SE420610B/en
unknown

Also Published As

Publication number
Publication date

RO69550A
(en)

1981-08-30

CA1053674A
(en)

1979-05-01

ZA752908B
(en)

1976-04-28

NO751594L
(en)

1976-01-06

SE420610B
(en)

1981-10-19

CH619951A5
(en)

1980-10-31

DK250275A
(en)

1976-01-06

ES437966A2
(en)

1977-02-16

BE829987R
(en)

1975-12-08

FI751628A
(en)

1976-01-06

YU145675A
(en)

1982-08-31

AR214389A1
(en)

1979-06-15

AT351546B
(en)

1979-07-25

DD118093A6
(en)

1976-02-12

FI59097B
(en)

1981-02-27

JPS518280A
(en)

1976-01-23

IE42746B1
(en)

1980-10-08

ATA432675A
(en)

1979-01-15

AU8095575A
(en)

1976-11-11

IE42746L
(en)

1976-01-05

SE7504599L
(en)

1976-01-07

LU72672A1
(en)

1976-03-17

BG25226A3
(en)

1978-08-10

DE2525050A1
(en)

1976-01-22

FI59097C
(en)

1981-06-10

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Legal Events

Date
Code
Title
Description

1978-06-28
PS
Patent sealed [section 19, patents act 1949]

1979-07-04
PCNP
Patent ceased through non-payment of renewal fee

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