GB1525762A

GB1525762A – Quaternary ammonium polymers
– Google Patents

GB1525762A – Quaternary ammonium polymers
– Google Patents
Quaternary ammonium polymers

Info

Publication number
GB1525762A

GB1525762A
GB15642/76A
GB1564276A
GB1525762A
GB 1525762 A
GB1525762 A
GB 1525762A
GB 15642/76 A
GB15642/76 A
GB 15642/76A
GB 1564276 A
GB1564276 A
GB 1564276A
GB 1525762 A
GB1525762 A
GB 1525762A
Authority
GB
United Kingdom
Prior art keywords
polymers
reacted
end groups
aqueous solution
chloropropyl
Prior art date
1975-04-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB15642/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1975-04-23
Filing date
1976-04-15
Publication date
1978-09-20

1976-04-15
Application filed by Merck and Co Inc
filed
Critical
Merck and Co Inc

1978-09-20
Publication of GB1525762A
publication
Critical
patent/GB1525762A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON

C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS

C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 – C08G71/00

C08G73/02—Polyamines

C08G73/0206—Polyalkylene(poly)amines

C08G73/0213—Preparatory process

C08G73/0226—Quaternisation of polyalkylene(poly)amines

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton

C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton

C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton

C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation

Abstract

1525762 Quaternary ammonium polymers MERCK & CO Inc 15 April 1976 [23 April 1975] 15642/76 Heading C3R The invention comprises polymers of formula and their acid addition salts, where W is propyl, 3-halopropyl, 3-hydroxypropyl, allyl, trialkylammoniopropyl (associated with an anion Y) or RSCH 2 CH 2 CH 2 -, R being alkyl, phenyl or naphthyl, Y is pharmaceutically acceptable anion, a is the anionic charge on Y, m is such that the product of m and a is 1, n is such that the polymer has a molecular weight above 2000. The polymers where W is -CH 2 CH 2 CH 2 X (X being chlorine, bromine or iodine) are obtained by heating an aqueous solution of a compound of formula These polymers then may be reacted with appropriate materials to replace the halogen atom and obtain the polymers where W has the other meanings listed above. In examples 3-[N1– (3 – chloropropyl – N1 – methylamino] – N,N,N- trimethyl – 1 – propanaminium chloride hydrochloride and the corresponding bromine compound, are reacted with sodium hydroxide in aqueous solution to obtain the free bases which are polymerized by heating in aqueous solution to obtain polymeric[methyl – (3 – trimethylammoniopropyl) – imino] trimethylene dichloride and dibromide; the chloropropyl end groups of the first polymer are hydrogenated to propyl groups, reacted with 2-naphthylmercaptan to form 2-naphthylthiopropyl end groups, reacted with benzenethiol to form benzenethiopropyl end groups and reacted with trimethylamine to form 3-trimethylaminopropyl end groups. The polymers may be formed into tablets, capsules, powder or aqueous solutions or suspensions with pharmaceutically acceptable carriers for use in treating hypercholesterolemia.

GB15642/76A
1975-04-23
1976-04-15
Quaternary ammonium polymers

Expired

GB1525762A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US05/570,910

US4016209A
(en)

1975-04-23
1975-04-23
3-[N’-(3-Halopropyl)-N-‘-methylamino]-N,N,N-trimethyl-1-propanaminium halide and acid addition salts thereof

Publications (1)

Publication Number
Publication Date

GB1525762A
true

GB1525762A
(en)

1978-09-20

Family
ID=24281556
Family Applications (2)

Application Number
Title
Priority Date
Filing Date

GB43741/77A
Expired

GB1539006A
(en)

1975-04-23
1976-04-15
Aminoalkylammonium compound

GB15642/76A
Expired

GB1525762A
(en)

1975-04-23
1976-04-15
Quaternary ammonium polymers

Family Applications Before (1)

Application Number
Title
Priority Date
Filing Date

GB43741/77A
Expired

GB1539006A
(en)

1975-04-23
1976-04-15
Aminoalkylammonium compound

Country Status (29)

Country
Link

US
(3)

US4016209A
(en)

JP
(1)

JPS51136605A
(en)

AR
(1)

AR223301A1
(en)

AT
(1)

AT354099B
(en)

AU
(1)

AU506771B2
(en)

BE
(1)

BE841005A
(en)

CA
(1)

CA1082228A
(en)

CS
(1)

CS190529B2
(en)

DD
(2)

DD131564A5
(en)

DE
(1)

DE2617524A1
(en)

DK
(1)

DK164576A
(en)

EG
(1)

EG12656A
(en)

ES
(1)

ES447059A1
(en)

FI
(1)

FI760939A
(en)

FR
(2)

FR2308375A1
(en)

GB
(2)

GB1539006A
(en)

GR
(1)

GR59848B
(en)

HU
(1)

HU175963B
(en)

IE
(1)

IE44097B1
(en)

IL
(1)

IL49392A
(en)

LU
(1)

LU74759A1
(en)

NL
(1)

NL7603653A
(en)

NO
(1)

NO761208L
(en)

NZ
(1)

NZ180581A
(en)

PH
(1)

PH14726A
(en)

PL
(1)

PL113974B1
(en)

PT
(1)

PT65031B
(en)

SE
(1)

SE7604094L
(en)

ZA
(1)

ZA762407B
(en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4093657A
(en)

*

1976-04-09
1978-06-06
Merck & Co., Inc.
Process for preparing monomer of bile acid sequestrant polymer

FR2356425A1
(en)

*

1976-07-01
1978-01-27
Roussel Uclaf

APPLICATION AS MEDICINAL PRODUCTS FROM ORGANIC DERIVATIVES OF MONTMORILLONITE

US4185088A
(en)

*

1977-02-17
1980-01-22
Merck & Co., Inc.
Non-adhesive ionene quaternary polymer compositions useful as bile acid sequestrants

NZ191762A
(en)

*

1978-10-19
1982-09-14
Merck & Co Inc
Hypocholesteremic composition containing cholesterol synthesis inhibitor and anion exchange resin

IT1185484B
(en)

*

1985-10-31
1987-11-12
Pirelli Cavi Spa

ELECTRIC CABLE AND MATERIAL FOR COATING ELECTRICAL CONDUCTORS WITH THE FUNCTION OF INSULATOR AND / OR SHEATH

US4824602A
(en)

*

1986-10-27
1989-04-25
The Procter & Gamble Company
Processes for purification of quaternary cationic surfactant materials and cosmetic compositions containing same

US5349089A
(en)

*

1989-07-07
1994-09-20
National Starch And Chemical Investment Holding Corporation
Reagent for preparing polycationic polysaccharides

US6129910A
(en)

*

1993-06-02
2000-10-10
Geltex Pharmaceuticals, Inc.
Water-insoluble noncrosslinked bile acid sequestrants

US5618530A
(en)

*

1994-06-10
1997-04-08
Geltex Pharmaceuticals, Inc.
Hydrophobic amine polymer sequestrant and method of cholesterol depletion

US5929184A
(en)

*

1993-06-02
1999-07-27
Geltex Pharmaceuticals, Inc.
Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants

US5624963A
(en)

*

1993-06-02
1997-04-29
Geltex Pharmaceuticals, Inc.
Process for removing bile salts from a patient and compositions therefor

US5900475A
(en)

*

1994-06-10
1999-05-04
Geltex Pharmaceuticals, Inc.
Hydrophobic sequestrant for cholesterol depletion

US5607669A
(en)

*

1994-06-10
1997-03-04
Geltex Pharmaceuticals, Inc.
Amine polymer sequestrant and method of cholesterol depletion

US5703188A
(en)

*

1993-06-02
1997-12-30
Geltex Pharmaceuticals, Inc.
Process for removing bile salts from a patient and compositions therefor

US5667775A
(en)

1993-08-11
1997-09-16
Geltex Pharmaceuticals, Inc.
Phosphate-binding polymers for oral administration

US5496545A
(en)

*

1993-08-11
1996-03-05
Geltex Pharmaceuticals, Inc.
Phosphate-binding polymers for oral administration

TW474813B
(en)

*

1994-06-10
2002-02-01
Geltex Pharma Inc
Alkylated composition for removing bile salts from a patient

WO1996021454A1
(en)

*

1995-01-12
1996-07-18
Geltex Pharmaceuticals, Inc.
Phosphate-binding polymers for oral administration

CN1108801C
(en)

*

1995-01-12
2003-05-21
吉尔特药品公司
Phosphate-binding polymers for oral administration

US20040053208A1
(en)

*

1995-08-29
2004-03-18
V. I. TECHNOLOGIES, Inc.
Methods to selectively inactivate parasites in biological compositions

US6203785B1
(en)

1996-12-30
2001-03-20
Geltex Pharmaceuticals, Inc.
Poly(diallylamine)-based bile acid sequestrants

GB2321900A
(en)

*

1997-02-11
1998-08-12
Procter & Gamble
Cationic surfactants

US6423754B1
(en)

1997-06-18
2002-07-23
Geltex Pharmaceuticals, Inc.
Method for treating hypercholesterolemia with polyallylamine polymers

US6093564A
(en)

*

1997-10-03
2000-07-25
V.I. Technologies, Inc.
Methods and compositions for the selective modification of nucleic acids

US6352695B1
(en)

1997-10-03
2002-03-05
V.I. Technologies, Inc.
Methods and compositions for the selective modification of nucleic acids

US6726905B1
(en)

1997-11-05
2004-04-27
Genzyme Corporation
Poly (diallylamines)-based phosphate binders

US6403359B1
(en)

1998-09-25
2002-06-11
V. I. TECHNOLOGIES, Inc.
Solid phase quenching systems

US6617100B2
(en)

1998-09-25
2003-09-09
V.I. Technologies, Inc.
Solid phase quenching systems

US6733780B1
(en)

1999-10-19
2004-05-11
Genzyme Corporation
Direct compression polymer tablet core

US7985418B2
(en)

2004-11-01
2011-07-26
Genzyme Corporation
Aliphatic amine polymer salts for tableting

EP1951266A2
(en)

2005-09-02
2008-08-06
Genzyme Corporation
Method for removing phosphate and polymer used therefore

EP3000460A1
(en)

2005-09-15
2016-03-30
Genzyme Corporation
Sachet formulation for amine polymers

MA41202A
(en)

2014-12-18
2017-10-24
Genzyme Corp

CROSS-LINKED POLYDIALLYMINE COPOLYMERS FOR THE TREATMENT OF TYPE 2 DIABETES

Family Cites Families (14)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US2163181A
(en)

*

1935-03-01
1939-06-20
Ig Farbenindustrie Ag
Process of producing halogen-alkyl amines or their salts

US2884057A
(en)

*

1954-02-25
1959-04-28
American Cyanamid Co
Paper of improved dry strength and method of making same

US3147065A
(en)

*

1960-05-02
1964-09-01
Minnesota Mining & Mfg
Quaternized halomethylamides

US3234150A
(en)

*

1960-06-16
1966-02-08
Nalco Chemical Co
Strong base anion exchange resins from polymeric tertiary amines

AT252890B
(en)

*

1961-02-07
1967-03-10
American Cyanamid Co

Process for the production of new hydroxydiamines

NL282900A
(en)

*

1961-09-22
1900-01-01

US3372129A
(en)

*

1964-10-06
1968-03-05
Nalco Chemical Co
Method of preparing polyamines

US3370048A
(en)

*

1965-03-15
1968-02-20
Eastman Kodak Co
Process for the preparation of new linear condensation polymers

CH508583A
(en)

*

1968-01-31
1971-06-15
Bayer Ag

Process for the preparation of 3-aminopropanols

US3493615A
(en)

*

1968-10-28
1970-02-03
Colgate Palmolive Co
Surfactant anti-microbial compounds

NL7103340A
(en)

*

1970-03-19
1971-09-21

US3632507A
(en)

*

1970-06-30
1972-01-04
Standard Brands Chem Ind Inc
Flocculation of particles dispersed in aqueous media and flocculants used therein

CH553284A
(en)

*

1971-03-15
1974-08-30

CH568958A5
(en)

*

1972-04-28
1975-11-14
Sandoz Ag

1975

1975-04-23
US
US05/570,910
patent/US4016209A/en
not_active
Expired – Lifetime

1976

1976-04-07
SE
SE7604094A
patent/SE7604094L/en
not_active
Application Discontinuation

1976-04-07
FI
FI760939A
patent/FI760939A/fi
not_active
Application Discontinuation

1976-04-07
NL
NL7603653A
patent/NL7603653A/en
not_active
Application Discontinuation

1976-04-07
DK
DK164576A
patent/DK164576A/en
unknown

1976-04-08
NO
NO761208A
patent/NO761208L/no
unknown

1976-04-12
NZ
NZ180581A
patent/NZ180581A/en
unknown

1976-04-12
IL
IL49392A
patent/IL49392A/en
unknown

1976-04-13
GR
GR50537A
patent/GR59848B/en
unknown

1976-04-14
AU
AU12991/76A
patent/AU506771B2/en
not_active
Expired

1976-04-14
CA
CA250,746A
patent/CA1082228A/en
not_active
Expired

1976-04-14
ES
ES447059A
patent/ES447059A1/en
not_active
Expired

1976-04-14
LU
LU74759A
patent/LU74759A1/xx
unknown

1976-04-15
GB
GB43741/77A
patent/GB1539006A/en
not_active
Expired

1976-04-15
GB
GB15642/76A
patent/GB1525762A/en
not_active
Expired

1976-04-16
FR
FR7611409A
patent/FR2308375A1/en
active
Granted

1976-04-16
CS
CS762547A
patent/CS190529B2/en
unknown

1976-04-20
AR
AR262931A
patent/AR223301A1/en
active

1976-04-20
EG
EG233/76A
patent/EG12656A/en
active

1976-04-21
IE
IE832/76A
patent/IE44097B1/en
unknown

1976-04-21
DD
DD7600192453A
patent/DD131564A5/en
unknown

1976-04-21
PL
PL1976188926A
patent/PL113974B1/en
unknown

1976-04-21
DD
DD7600199971A
patent/DD131645A5/en
unknown

1976-04-21
AT
AT290976A
patent/AT354099B/en
not_active
IP Right Cessation

1976-04-22
ZA
ZA762407A
patent/ZA762407B/en
unknown

1976-04-22
DE
DE19762617524
patent/DE2617524A1/en
not_active
Withdrawn

1976-04-22
PT
PT65031A
patent/PT65031B/en
unknown

1976-04-22
HU
HU76ME1968A
patent/HU175963B/en
unknown

1976-04-22
BE
BE166369A
patent/BE841005A/en
unknown

1976-04-23
JP
JP51045650A
patent/JPS51136605A/en
active
Pending

1976-12-10
FR
FR7637266A
patent/FR2357528A1/en
active
Granted

1977

1977-04-01
US
US05/783,886
patent/US4098726A/en
not_active
Expired – Lifetime

1977-04-01
US
US05/783,885
patent/US4156693A/en
not_active
Expired – Lifetime

1978

1978-08-18
PH
PH21512A
patent/PH14726A/en
unknown

Also Published As

Publication number
Publication date

FR2357528A1
(en)

1978-02-03

DD131645A5
(en)

1978-07-12

US4016209A
(en)

1977-04-05

HU175963B
(en)

1980-11-28

IE44097B1
(en)

1981-08-12

AR223301A1
(en)

1981-08-14

PH14726A
(en)

1981-11-13

ATA290976A
(en)

1979-05-15

DE2617524A1
(en)

1976-11-04

FR2308375A1
(en)

1976-11-19

FR2308375B1
(en)

1981-07-31

DD131564A5
(en)

1978-07-05

PT65031A
(en)

1976-05-01

FI760939A
(en)

1976-10-24

GB1539006A
(en)

1979-01-24

IL49392A0
(en)

1976-06-30

CA1082228A
(en)

1980-07-22

AU506771B2
(en)

1980-01-24

US4098726A
(en)

1978-07-04

AT354099B
(en)

1979-12-27

JPS51136605A
(en)

1976-11-26

LU74759A1
(en)

1977-02-04

NL7603653A
(en)

1976-10-26

CS190529B2
(en)

1979-05-31

ZA762407B
(en)

1977-11-30

DK164576A
(en)

1976-10-24

AU1299176A
(en)

1977-10-20

NZ180581A
(en)

1978-11-13

PT65031B
(en)

1978-04-03

ES447059A1
(en)

1977-11-16

SE7604094L
(en)

1976-10-24

FR2357528B1
(en)

1980-09-26

US4156693A
(en)

1979-05-29

IL49392A
(en)

1980-07-31

GR59848B
(en)

1978-03-07

IE44097L
(en)

1976-10-23

NO761208L
(en)

1976-10-26

PL113974B1
(en)

1981-01-31

EG12656A
(en)

1979-06-30

BE841005A
(en)

1976-10-22

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Legal Events

Date
Code
Title
Description

1979-02-07
PS
Patent sealed [section 19, patents act 1949]

1982-11-10
PCNP
Patent ceased through non-payment of renewal fee

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