AU1229088A – Novel cc-1065 analogs
– Google Patents
AU1229088A – Novel cc-1065 analogs
– Google Patents
Novel cc-1065 analogs
Info
Publication number
AU1229088A
AU1229088A
AU12290/88A
AU1229088A
AU1229088A
AU 1229088 A
AU1229088 A
AU 1229088A
AU 12290/88 A
AU12290/88 A
AU 12290/88A
AU 1229088 A
AU1229088 A
AU 1229088A
AU 1229088 A
AU1229088 A
AU 1229088A
Authority
AU
Australia
Prior art keywords
formula
analogs
compounds
novel
useful
Prior art date
1986-12-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU12290/88A
Other versions
AU617304B2
(en
Inventor
Paul A. Aristoff
Robert C. Kelly
David G. Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1986-12-19
Filing date
1987-12-11
Publication date
1988-07-15
1987-12-11
Application filed by Pharmacia and Upjohn Co, Upjohn Co
filed
Critical
Pharmacia and Upjohn Co
1988-07-15
Publication of AU1229088A
publication
Critical
patent/AU1229088A/en
1991-11-28
Application granted
granted
Critical
1991-11-28
Publication of AU617304B2
publication
Critical
patent/AU617304B2/en
1997-04-24
Assigned to PHARMACIA & UPJOHN COMPANY
reassignment
PHARMACIA & UPJOHN COMPANY
Request to Amend Deed and Register
Assignors: UPJOHN COMPANY, THE
2007-12-11
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00
C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00 in which the condensed system contains two hetero rings
C07D487/04—Ortho-condensed systems
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P35/00—Antineoplastic agents
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
C07F9/02—Phosphorus compounds
C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
2-Acyl-4,5,8,8a-tetrahydro-4-oxycyclopropan[c]pyrrol(3,2-e) indole derivatives of Formula (I’). The compounds of Formula (I’) are useful as uv light absorber substances, as chemical intermediates and as prodrugs of known spirocyclopropylpyrroloindole CC-1065 analogs. Representative Formula (I’) compounds have been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.
AU12290/88A
1986-12-19
1987-12-11
Novel cc-1065 analogs
Ceased
AU617304B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US94463386A
1986-12-19
1986-12-19
US944633
1986-12-19
Publications (2)
Publication Number
Publication Date
AU1229088A
true
AU1229088A
(en)
1988-07-15
AU617304B2
AU617304B2
(en)
1991-11-28
Family
ID=25481770
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU12290/88A
Ceased
AU617304B2
(en)
1986-12-19
1987-12-11
Novel cc-1065 analogs
Country Status (9)
Country
Link
EP
(1)
EP0340243B1
(en)
JP
(1)
JP2598819B2
(en)
KR
(1)
KR960009264B1
(en)
AT
(1)
ATE112279T1
(en)
AU
(1)
AU617304B2
(en)
DE
(1)
DE3750612T2
(en)
HK
(1)
HK1000510A1
(en)
MX
(1)
MX9203200A
(en)
WO
(1)
WO1988004659A2
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU632288B2
(en)
*
1988-09-12
1992-12-24
Pharmacia & Upjohn Company
Novel cc-1065 analogs having two cpi subunits
Families Citing this family (31)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
JPH0684377B1
(en)
*
1986-04-17
1994-10-26
Kyowa Hakko Kogyo Kk
US4994578A
(en)
*
1987-11-27
1991-02-19
Meiji Seika Kaisha, Ltd.
Certain anti-tumor duocarmycin antibiotics from streptomyces
JP2562935B2
(en)
*
1988-04-28
1996-12-11
明治製菓株式会社
Antitumor substance SF2582 derivative
JP2642165B2
(en)
*
1988-07-22
1997-08-20
協和醗酵工業株式会社
Novel DC-89 compound and method for producing the same
US5084468A
(en)
*
1988-08-11
1992-01-28
Kyowa Hakko Kogyo Co., Ltd.
Dc-88a derivatives
US5008271A
(en)
*
1988-10-21
1991-04-16
Kyowa Hakko Kogyo Co., Ltd.
DC-88A derivatives
JP2510335B2
(en)
*
1989-07-03
1996-06-26
協和醗酵工業株式会社
DC-88A derivative
US5187186A
(en)
*
1989-07-03
1993-02-16
Kyowa Hakko Kogyo Co., Ltd.
Pyrroloindole derivatives
CA2078118C
(en)
*
1990-04-25
1999-11-16
Paul A. Aristoff
Cc-1065 analogs
US5214065A
(en)
*
1990-06-11
1993-05-25
Kyowa Hakko Kogyo Co., Ltd.
Dc-89 derivatives
US5248692A
(en)
*
1990-06-11
1993-09-28
Kyowa Hakko Kogyo Co., Ltd.
DC-89 derivatives as anti-tumor agents
US5258383A
(en)
*
1991-06-28
1993-11-02
Kyowa Hakko Kogyo Co., Ltd.
DC-89 derivatives
ES2149768T3
(en)
*
1992-03-25
2000-11-16
Immunogen Inc
CONJUGATES OF BINDING AGENTS OF CELLS DERIVED FROM CC-1065.
US5248691A
(en)
*
1992-09-03
1993-09-28
Eli Lilly And Company
Furanoindolines
US5670492A
(en)
*
1994-04-01
1997-09-23
Kyowa Hakko Kogyo Co., Ltd.
DC-89 derivatives
ATE271557T1
(en)
*
1994-04-22
2004-08-15
Kyowa Hakko Kogyo Kk
DC-89 DERIVATIVE
CN1051552C
(en)
*
1994-11-29
2000-04-19
杏林制药株式会社
Acrylamide derivatives and process for producing the same
GB9516943D0
(en)
*
1995-08-18
1995-10-18
Cancer Soc Auckland Div Nz Inc
Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
ATE310725T1
(en)
*
1996-09-12
2005-12-15
Auckland Uniservices Ltd
CONDENSED N-ACYLINDOLS AS ANTI-TUMOR AGENTS
US6130237A
(en)
*
1996-09-12
2000-10-10
Cancer Research Campaign Technology Limited
Condensed N-aclyindoles as antitumor agents
GB9818730D0
(en)
1998-08-27
1998-10-21
Univ Portsmouth
Collections of compounds
WO2000012508A2
(en)
1998-08-27
2000-03-09
Spirogen Limited
Pyrrolbenzodiazepines
US6909006B1
(en)
1999-08-27
2005-06-21
Spirogen Limited
Cyclopropylindole derivatives
WO2002096910A1
(en)
*
2001-05-31
2002-12-05
Medarex, Inc.
Cytotoxins, prodrugs, linkers and stabilizers useful therefor
GB0226593D0
(en)
2002-11-14
2002-12-24
Consultants Ltd
Compounds
GB0321295D0
(en)
2003-09-11
2003-10-15
Spirogen Ltd
Synthesis of protected pyrrolobenzodiazepines
EP2121667B1
(en)
2007-02-21
2016-06-08
E. R. Squibb & Sons, L.L.C.
Chemical linkers with single amino acids and conjugates thereof
US9901567B2
(en)
2007-08-01
2018-02-27
Syntarga B.V.
Substituted CC-1065 analogs and their conjugates
EP2344478B1
(en)
2008-11-03
2017-09-27
Syntarga B.V.
Cc-1065 analogs and their conjugates
RU2578719C9
(en)
2010-04-21
2016-10-10
Синтарга Б.В.
Novel conjugates of cc-1065 analogues and bifunctional linkers
EP3092010B1
(en)
2014-01-10
2018-07-11
Synthon Biopharmaceuticals B.V.
Method for purifying cys-linked antibody-drug conjugates
Family Cites Families (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
CA1238907A
(en)
*
1984-02-21
1988-07-05
Robert C. Kelly
1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
1987
1987-12-11
DE
DE3750612T
patent/DE3750612T2/en
not_active
Expired – Fee Related
1987-12-11
EP
EP88901185A
patent/EP0340243B1/en
not_active
Expired – Lifetime
1987-12-11
MX
MX9203200A
patent/MX9203200A/en
unknown
1987-12-11
WO
PCT/US1987/003227
patent/WO1988004659A2/en
active
IP Right Grant
1987-12-11
AT
AT88901185T
patent/ATE112279T1/en
not_active
IP Right Cessation
1987-12-11
JP
JP63501400A
patent/JP2598819B2/en
not_active
Expired – Lifetime
1987-12-11
AU
AU12290/88A
patent/AU617304B2/en
not_active
Ceased
1988
1988-08-19
KR
KR88701019A
patent/KR960009264B1/en
not_active
IP Right Cessation
1997
1997-11-06
HK
HK97102115A
patent/HK1000510A1/en
not_active
IP Right Cessation
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU632288B2
(en)
*
1988-09-12
1992-12-24
Pharmacia & Upjohn Company
Novel cc-1065 analogs having two cpi subunits
Also Published As
Publication number
Publication date
AU617304B2
(en)
1991-11-28
DE3750612D1
(en)
1994-11-03
KR890700127A
(en)
1989-03-02
ATE112279T1
(en)
1994-10-15
EP0340243A1
(en)
1989-11-08
WO1988004659A2
(en)
1988-06-30
JPH02502005A
(en)
1990-07-05
WO1988004659A3
(en)
1988-08-11
DE3750612T2
(en)
1995-03-02
MX9203200A
(en)
1992-09-01
JP2598819B2
(en)
1997-04-09
HK1000510A1
(en)
1998-04-03
KR960009264B1
(en)
1996-07-16
EP0340243B1
(en)
1994-09-28
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Legal Events
Date
Code
Title
Description
2001-07-12
MK14
Patent ceased section 143(a) (annual fees not paid) or expired
