GB2001985A – Penam and cephem production
– Google Patents
GB2001985A – Penam and cephem production
– Google Patents
Penam and cephem production
Info
Publication number
GB2001985A
GB2001985A
GB7832264A
GB7832264A
GB2001985A
GB 2001985 A
GB2001985 A
GB 2001985A
GB 7832264 A
GB7832264 A
GB 7832264A
GB 7832264 A
GB7832264 A
GB 7832264A
GB 2001985 A
GB2001985 A
GB 2001985A
Authority
GB
United Kingdom
Prior art keywords
silylating agent
derivatives
carrying
carried out
tertiary base
Prior art date
1977-08-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7832264A
Other versions
GB2001985B
(en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lark SpA
Original Assignee
Lark SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1977-08-05
Filing date
1978-08-04
Publication date
1979-02-14
1978-08-04
Application filed by Lark SpA
filed
Critical
Lark SpA
1978-08-04
Priority to GB7832264A
priority
Critical
patent/GB2001985B/en
1979-02-14
Publication of GB2001985A
publication
Critical
patent/GB2001985A/en
1982-07-07
Application granted
granted
Critical
1982-07-07
Publication of GB2001985B
publication
Critical
patent/GB2001985B/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Abstract
A process for the preparation of derivatives of certain penicillanic and cephalosporanic acids is disclosed. Such derivatives have previously been prepared by reacting the relevant acid with a silylating agent, which product is then reacted with a suitably substituted alpha -amino- phenylacetic acid or a reactive derivative thereof. Any silyl groups are thereafter removed by hydrolysis. Such known reaction was carried out at elevated temperature in the presence of a tertiary base as a proton acceptor. The present invention improves such process, which is carried out at room temperature and in the absence of a tertiary base by either utilising an amide carrying one or more alkylsilyl substituents, e.g. N,O-bis(trimethylsilyl) acetamide, as silylating agent, or carrying out the silylation reaction, using a known silylating agent, in the presence of a substituted amide, e.g. dimethylacetamide.
GB7832264A
1977-08-05
1978-08-04
Process for the preparation of penicillanic and cephalosporanic acid derivatives
Expired
GB2001985B
(en)
Priority Applications (1)
Application Number
Priority Date
Filing Date
Title
GB7832264A
GB2001985B
(en)
1977-08-05
1978-08-04
Process for the preparation of penicillanic and cephalosporanic acid derivatives
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
GB3287277
1977-08-05
GB7832264A
GB2001985B
(en)
1977-08-05
1978-08-04
Process for the preparation of penicillanic and cephalosporanic acid derivatives
Publications (2)
Publication Number
Publication Date
GB2001985A
true
GB2001985A
(en)
1979-02-14
GB2001985B
GB2001985B
(en)
1982-07-07
Family
ID=26261606
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB7832264A
Expired
GB2001985B
(en)
1977-08-05
1978-08-04
Process for the preparation of penicillanic and cephalosporanic acid derivatives
Country Status (1)
Country
Link
GB
(1)
GB2001985B
(en)
Cited By (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4278600A
(en)
1979-03-19
1981-07-14
Bristol-Myers Company
Production of penicillins
GB2240102A
(en)
*
1990-01-22
1991-07-24
Biochemie Gmbh
Beta-lactam production
US5998610A
(en)
*
1994-11-21
1999-12-07
Biochemie Gesellschaft M.B.H.
Silylation process
1978
1978-08-04
GB
GB7832264A
patent/GB2001985B/en
not_active
Expired
Cited By (6)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4278600A
(en)
1979-03-19
1981-07-14
Bristol-Myers Company
Production of penicillins
GB2240102A
(en)
*
1990-01-22
1991-07-24
Biochemie Gmbh
Beta-lactam production
EP0439096A2
(en)
*
1990-01-22
1991-07-31
Biochemie Gesellschaft M.B.H.
Improvements in or relating to beta lactam production
EP0439096A3
(en)
*
1990-01-22
1992-06-10
Biochemie Gesellschaft M.B.H.
Improvements in or relating to beta lactam production
GB2240102B
(en)
*
1990-01-22
1993-10-20
Biochemie Gmbh
Improvements in or relating to beta lactam production
US5998610A
(en)
*
1994-11-21
1999-12-07
Biochemie Gesellschaft M.B.H.
Silylation process
Also Published As
Publication number
Publication date
GB2001985B
(en)
1982-07-07
Similar Documents
Publication
Publication Date
Title
SE8403896D0
(en)
1984-07-27
ANTIBIOTICS
IE36353B1
(en)
1976-10-13
Rearrangement of 6-acylamidopenicillanic acid sulfoxides and production fo cephalexin or hetacephalexin
GB2001985A
(en)
1979-02-14
Penam and cephem production
ES401263A1
(en)
1975-02-16
Penicillin synthesis
JPS6425767A
(en)
1989-01-27
Production of quinazoline derivative or salt thereof
ES356543A1
(en)
1970-01-16
Process for the preparation of 7-aminocephalosporanic acid and its derivatives
ES8102578A1
(en)
1981-02-16
Process for the preparation of 7-(D(-)-alpha-amino-p-hydroxyphenylacetamido)desacetoxycephalosporanic acid
NO160004B
(en)
1988-11-21
PROCEDURE FOR PREPARING 7-ACYLAMINO-3- (THIOS-SUBSTITUTED) METHYL-3-CEFEM-4-CARBOXYLIC ACID-1-OXYDE DERIVATIVES.
ES403290A1
(en)
1975-04-16
Procedure for the preparation of penicillin derivatives. (Machine-translation by Google Translate, not legally binding)
ATE14121T1
(en)
1985-07-15
PROCESS FOR PRODUCTION OF 1H-INDAZOLE-3-YLESSIGS|URE DERIVATIVES.
GB882101A
(en)
1961-11-15
Organosilicon compounds and processes for producing the same
GB964449A
(en)
1964-07-22
Derivatives of 6-amino penicillanic acid
KR940009191A
(en)
1994-05-20
7- [α- (Z) -methoxyimino-α- (2-aminothiazol-4-yl) acetamido] -3-[(5-carboxymethyl-4-methylthiazol-2-yl ) How to prepare thiomethyl] -3-cepem-4-carboxylic acid
ES448787A1
(en)
1978-01-01
Chemical compounds process for preparing said compounds and process for preparing 6-(p-hydroxyphenyl-glycylamido)-penam or 7-(p-hydroxyphenyl-glycylamido)-cephem compounds
ES414178A1
(en)
1976-02-16
Procedure for the preparation of acid 3,3-dimethyl-7- -oxo-4-tia-1-azobiciclo (3,2,0) heptano-2-carboxilico. (Machine-translation by Google Translate, not legally binding)
KR940009190A
(en)
1994-05-20
7β- [2- (2-aminothiazol-4-yl)-(Z) -2-methoxyiminoacetamido] -3-[(1,2,3-thiadiazol-5-yl) Method for preparing thiomethyl] -3-cepem-4-carboxylic acid
GB1542049A
(en)
1979-03-14
Method for preparing 7-amino-delta3-desacetoxycephalosporanic acid derivatives
ES411401A1
(en)
1976-01-01
A procedure for the obtaining of p-acetamol derivatives. (Machine-translation by Google Translate, not legally binding)
JPS57131792A
(en)
1982-08-14
Novel 2-oxabicyclo(2.2.2)octan-3-one derivative
DE3261924D1
(en)
1985-02-28
Process for the preparation of 3,3-dimethylglutaric acid or its esters
ES460514A1
(en)
1978-05-16
Process for the production of penam and cephem derivatives
ES437503A2
(en)
1977-02-01
Process for the production of succinylosuccinic diester
JPS6479190A
(en)
1989-03-24
Production of gamma-substituted-alpha-siloxy-butenolide derivative
SE7900889L
(en)
1979-09-04
WAY TO PRODUCE XANTONE DERIVATIVES
KR850000031A
(en)
1985-02-25
Process for preparing imidazole compound
Legal Events
Date
Code
Title
Description
1987-03-18
PCNP
Patent ceased through non-payment of renewal fee
