GB2007218A

GB2007218A – Prostaglandin I2 analogues
– Google Patents

GB2007218A – Prostaglandin I2 analogues
– Google Patents
Prostaglandin I2 analogues

Info

Publication number
GB2007218A

GB2007218A
GB7838358A
GB7838358A
GB2007218A
GB 2007218 A
GB2007218 A
GB 2007218A
GB 7838358 A
GB7838358 A
GB 7838358A
GB 7838358 A
GB7838358 A
GB 7838358A
GB 2007218 A
GB2007218 A
GB 2007218A
Authority
GB
United Kingdom
Prior art keywords
alkyl
prostaglandin
hydrogen
optionally substituted
represents hydrogen
Prior art date
1977-09-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
GB7838358A
Other versions

GB2007218B
(en

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ono Pharmaceutical Co Ltd

Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1977-09-29
Filing date
1978-09-27
Publication date
1979-05-16

1978-09-27
Application filed by Ono Pharmaceutical Co Ltd
filed
Critical
Ono Pharmaceutical Co Ltd

1979-05-16
Publication of GB2007218A
publication
Critical
patent/GB2007218A/en

1982-08-04
Application granted
granted
Critical

1982-08-04
Publication of GB2007218B
publication
Critical
patent/GB2007218B/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom

C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins Analogues or derivatives thereof

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins Analogues or derivatives thereof

C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups

C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur

Abstract

Prostaglandin analogues of the general formula:- [wherein Y represents ethylene or trans-vinylene, R<1> represents hydrogen or alkyl, R<2> represents hydrogen, methyl or ethyl, R<3> represents a single bond or C1-4 alkylene, R<4> represents hydrogen, alkyl, cycloalkyl optionally substituted by at least one alkyl, or represents a phenyl or phenoxy group optionally substituted by at least one chlorine atom, trifluoromethyl or alkyl, and the double bond between C5-C6 is Z] and cyclodextrin clathrates of such acids and esters and, when R<1> represents a hydrogen atom, non-toxic salts thereof, with the exclusion of thiaprostacyclin and its methyl ester, are new compounds possessing characteristic prostaglandin-like activity.

GB7838358A
1977-09-29
1978-09-27
Prostaglandin 1 anologues

Expired

GB2007218B
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

JP11613877A

JPS5452069A
(en)

1977-09-29
1977-09-29
Prostaglandin i2 analog compound and its preparation

Publications (2)

Publication Number
Publication Date

GB2007218A
true

GB2007218A
(en)

1979-05-16

GB2007218B

GB2007218B
(en)

1982-08-04

Family
ID=14679665
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB7838358A
Expired

GB2007218B
(en)

1977-09-29
1978-09-27
Prostaglandin 1 anologues

Country Status (5)

Country
Link

JP
(1)

JPS5452069A
(en)

DE
(1)

DE2841360A1
(en)

FR
(1)

FR2404637A1
(en)

GB
(1)

GB2007218B
(en)

IT
(1)

IT1099217B
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE3310556A1
(en)

*

1982-03-25
1983-11-24
Ono Pharmaceutical Co. Ltd., Osaka

USE OF PROSTAGLANDINE ANALOGS

Families Citing this family (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4291166A
(en)

*

1978-03-13
1981-09-22
Research Corporation
Pharmaceutically active 6,9-thiaprostacyclin analogs and derivatives thereof

1977

1977-09-29
JP
JP11613877A
patent/JPS5452069A/en
active
Pending

1978

1978-09-22
DE
DE19782841360
patent/DE2841360A1/en
not_active
Withdrawn

1978-09-27
GB
GB7838358A
patent/GB2007218B/en
not_active
Expired

1978-09-27
IT
IT28156/78A
patent/IT1099217B/en
active

1978-09-28
FR
FR7827768A
patent/FR2404637A1/en
active
Granted

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE3310556A1
(en)

*

1982-03-25
1983-11-24
Ono Pharmaceutical Co. Ltd., Osaka

USE OF PROSTAGLANDINE ANALOGS

Also Published As

Publication number
Publication date

IT1099217B
(en)

1985-09-18

FR2404637B1
(en)

1982-02-05

GB2007218B
(en)

1982-08-04

DE2841360A1
(en)

1979-04-05

FR2404637A1
(en)

1979-04-27

IT7828156D0
(en)

1978-09-27

JPS5452069A
(en)

1979-04-24

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Legal Events

Date
Code
Title
Description

1983-06-08
PCNP
Patent ceased through non-payment of renewal fee

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