GB2014581A – Polypeptides and Methods for the Preparation Thereof
– Google Patents
GB2014581A – Polypeptides and Methods for the Preparation Thereof
– Google Patents
Polypeptides and Methods for the Preparation Thereof
Info
Publication number
GB2014581A
GB2014581A
GB7847642A
GB7847642A
GB2014581A
GB 2014581 A
GB2014581 A
GB 2014581A
GB 7847642 A
GB7847642 A
GB 7847642A
GB 7847642 A
GB7847642 A
GB 7847642A
GB 2014581 A
GB2014581 A
GB 2014581A
Authority
GB
United Kingdom
Prior art keywords
polypeptides
seryl
methods
alamyl
asparagyl
Prior art date
1977-12-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7847642A
Other versions
GB2014581B
(en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1977-12-08
Filing date
1978-12-07
Publication date
1979-08-30
1978-11-17
Priority claimed from US05/960,550
external-priority
patent/US4232008A/en
1978-12-07
Application filed by Ortho Pharmaceutical Corp
filed
Critical
Ortho Pharmaceutical Corp
1979-08-30
Publication of GB2014581A
publication
Critical
patent/GB2014581A/en
1982-05-19
Application granted
granted
Critical
1982-05-19
Publication of GB2014581B
publication
Critical
patent/GB2014581B/en
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
C07K7/04—Linear peptides containing only normal peptide links
C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P37/00—Drugs for immunological or allergic disorders
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
C07K5/10—Tetrapeptides
C07K5/1002—Tetrapeptides with the first amino acid being neutral
C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
C07K5/10—Tetrapeptides
C07K5/1021—Tetrapeptides with the first amino acid being acidic
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
C07K7/04—Linear peptides containing only normal peptide links
C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K7/062—Serum thymic factor
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K38/00—Medicinal preparations containing peptides
Abstract
Biologically active polypeptides containing the following polypeptide segment: -ALA-LYS-SER-GLN- are disclosed. Biological activity is generally retained upon substitution of an amino acid radical selected from L- asparagyl, L-glutamyl, L-threonyl, glycyl, L-valyl, L-leucyl, L-alamyl, L- seryl, sarcosyl, 2-methylalonyl, D- asparagyl, D-glutamyl, D-threonyl, D- valyl, D-leucyl, D-alamyl and D-seryl for either or both of L-alanyl in the first position and L-seryl in the third position, which polypeptides are capable of induction of the differentiation of T-lymphocytes, as measured by the acquisition of the thymic differentiation antigen Th-1, as well as B-lymphocytes as measured by the acquisition of the differentiation antigen Bu-1. The polypeptides are thus useful in thymic function and immunity areas such as in treatment for congential absence of thymus. Also provided are methods of manufacture of the polypeptides, therapeutic compositions, and methods of use of the polypeptides.
GB7847642A
1977-12-08
1978-12-07
Tetrapeptides and methods for the preparation thereof
Expired
GB2014581B
(en)
Applications Claiming Priority (3)
Application Number
Priority Date
Filing Date
Title
US85849677A
1977-12-08
1977-12-08
US94053178A
1978-09-08
1978-09-08
US05/960,550
US4232008A
(en)
1978-11-17
1978-11-17
Tetrapeptides and methods
Publications (2)
Publication Number
Publication Date
GB2014581A
true
GB2014581A
(en)
1979-08-30
GB2014581B
GB2014581B
(en)
1982-05-19
Family
ID=27420392
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
GB7847642A
Expired
GB2014581B
(en)
1977-12-08
1978-12-07
Tetrapeptides and methods for the preparation thereof
Country Status (19)
Country
Link
JP
(1)
JPS5498719A
(en)
CA
(1)
CA1120031A
(en)
CH
(1)
CH642058A5
(en)
DE
(1)
DE2853002A1
(en)
DK
(1)
DK149595C
(en)
ES
(1)
ES475857A1
(en)
FI
(1)
FI67368C
(en)
FR
(1)
FR2411174A1
(en)
GB
(1)
GB2014581B
(en)
GR
(1)
GR65013B
(en)
IE
(1)
IE47611B1
(en)
IL
(1)
IL56150A
(en)
IT
(1)
IT1110889B
(en)
NL
(1)
NL7812004A
(en)
NO
(1)
NO149631C
(en)
NZ
(1)
NZ189101A
(en)
PT
(1)
PT68883A
(en)
SE
(1)
SE444687B
(en)
YU
(1)
YU41322B
(en)
Cited By (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0016611A2
(en)
*
1979-03-14
1980-10-01
Ortho Pharmaceutical Corporation
Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use
EP0018793A2
(en)
*
1979-04-26
1980-11-12
Ortho Pharmaceutical Corporation
Peptides and process for their preparation
WO2004004753A1
(en)
*
2002-07-09
2004-01-15
Terentiev Alexandr Alexandrovi
Peptide having an immunoregulatory property and the composition of said peptide
Families Citing this family (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4215111A
(en)
*
1979-03-14
1980-07-29
Ortho Pharmaceutical Corporation
Peptides having ubiquitin-like activity
US4426324A
(en)
*
1979-09-28
1984-01-17
Hoffmann-La Roche Inc.
Immunopotentiating peptides
JPS5711950A
(en)
1980-06-25
1982-01-21
Kureha Chem Ind Co Ltd
Peptide and its synthesis
FR2546164B1
(en)
*
1983-05-16
1987-07-17
Centre Nat Rech Scient
NOVEL PEPTIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS ELASTASE INHIBITORS
FR2741076B1
(en)
*
1995-11-15
1998-01-30
Rech De Pathologie Appliquee S
PEPTIDE CONJUGATES DERIVED FROM THERMAL HORMONES, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM
Family Cites Families (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE2544348C3
(en)
*
1975-10-03
1979-12-13
Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen
L-leucine-13-motiline, process for its preparation and agent containing the same
FR2391994A1
(en)
*
1977-05-25
1978-12-22
Anvar
Polypeptide analogues of serum thymus factor – with thymus hormonal or antagonistic activity
FR2423481A2
(en)
*
1978-04-21
1979-11-16
Anvar
Polypeptide analogues of serum thymus factor – with thymus hormonal or antagonistic activity
IT1156766B
(en)
*
1977-05-25
1987-02-04
Anvar
POLYPEPTIDES EQUIPPED WITH THYME OR ANTAGONIST ACTIVITY AND PROCEDURE FOR THEIR SYNTHESIS
1978
1978-12-06
NZ
NZ189101A
patent/NZ189101A/en
unknown
1978-12-07
GB
GB7847642A
patent/GB2014581B/en
not_active
Expired
1978-12-07
CA
CA000317547A
patent/CA1120031A/en
not_active
Expired
1978-12-07
PT
PT68883A
patent/PT68883A/en
unknown
1978-12-07
IE
IE2423/78A
patent/IE47611B1/en
unknown
1978-12-07
ES
ES475857A
patent/ES475857A1/en
not_active
Expired
1978-12-07
IT
IT52239/78A
patent/IT1110889B/en
active
1978-12-07
GR
GR57816A
patent/GR65013B/en
unknown
1978-12-07
NO
NO784128A
patent/NO149631C/en
unknown
1978-12-07
IL
IL56150A
patent/IL56150A/en
unknown
1978-12-07
SE
SE7812614A
patent/SE444687B/en
not_active
IP Right Cessation
1978-12-07
FR
FR7834508A
patent/FR2411174A1/en
active
Granted
1978-12-07
DE
DE19782853002
patent/DE2853002A1/en
not_active
Withdrawn
1978-12-07
FI
FI783769A
patent/FI67368C/en
not_active
IP Right Cessation
1978-12-07
DK
DK554078A
patent/DK149595C/en
not_active
IP Right Cessation
1978-12-08
YU
YU2880/78A
patent/YU41322B/en
unknown
1978-12-08
NL
NL7812004A
patent/NL7812004A/en
not_active
Application Discontinuation
1978-12-08
CH
CH1256678A
patent/CH642058A5/en
not_active
IP Right Cessation
1978-12-08
JP
JP15116378A
patent/JPS5498719A/en
active
Granted
Cited By (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
EP0016611A2
(en)
*
1979-03-14
1980-10-01
Ortho Pharmaceutical Corporation
Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use
EP0016611A3
(en)
*
1979-03-14
1981-01-07
Ortho Pharmaceutical Corporation
Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use
EP0018793A2
(en)
*
1979-04-26
1980-11-12
Ortho Pharmaceutical Corporation
Peptides and process for their preparation
EP0018793A3
(en)
*
1979-04-26
1981-01-07
Ortho Pharmaceutical Corporation
Peptides and process for their preparation
WO2004004753A1
(en)
*
2002-07-09
2004-01-15
Terentiev Alexandr Alexandrovi
Peptide having an immunoregulatory property and the composition of said peptide
Also Published As
Publication number
Publication date
YU288078A
(en)
1983-02-28
NO784128L
(en)
1979-06-11
SE7812614L
(en)
1979-06-09
FR2411174A1
(en)
1979-07-06
DK149595B
(en)
1986-08-04
JPS6327360B2
(en)
1988-06-02
YU41322B
(en)
1987-02-28
ES475857A1
(en)
1980-01-16
NO149631C
(en)
1984-05-23
IT7852239D0
(en)
1978-12-07
FI67368B
(en)
1984-11-30
NL7812004A
(en)
1979-06-12
IT1110889B
(en)
1986-01-06
NO149631B
(en)
1984-02-13
CA1120031A
(en)
1982-03-16
JPS5498719A
(en)
1979-08-03
SE444687B
(en)
1986-04-28
DE2853002A1
(en)
1979-06-13
GR65013B
(en)
1980-06-12
DK149595C
(en)
1987-03-23
IL56150A0
(en)
1979-03-12
IE47611B1
(en)
1984-05-02
PT68883A
(en)
1979-01-01
NZ189101A
(en)
1984-07-06
IE782423L
(en)
1979-06-08
IL56150A
(en)
1982-02-28
CH642058A5
(en)
1984-03-30
DK554078A
(en)
1979-06-09
FI783769A
(en)
1979-06-09
GB2014581B
(en)
1982-05-19
FR2411174B1
(en)
1984-05-25
FI67368C
(en)
1985-03-11
Similar Documents
Publication
Publication Date
Title
Günther et al.
1982
Suppression of T cell responses through competition for T cell growth factor (interleukin 2)
EP0458878A4
(en)
1992-04-08
Novel monoclonal antibody to novel antigen associated with human tumors
ZA943464B
(en)
1995-11-20
Vascular endothelial growth factor 2
AU531556B2
(en)
1983-08-25
Tripeptides
MY102918A
(en)
1993-03-31
Purified antineoplaston fractions and methods of treating neoplastic disease.
GB2014581A
(en)
1979-08-30
Polypeptides and Methods for the Preparation Thereof
JPH04227000A
(en)
1992-08-17
Serum reactive epitope in protein of human papilloma virus 18
EP1323824A3
(en)
2004-01-21
Use of human keratinocyte growth factor-2 for the preparation of pharmaceutical compositions
WO1993019178A3
(en)
1993-11-25
Peptides useful for inducing tolerance
DK0523330T3
(en)
1996-04-15
Implantable compositions containing a biologically active protein, peptide or polypeptide
Blumenthal
1982
Structure and action of heteronemertine polypeptide toxins. Membrane penetration by Cerebratulus lacteus toxin A-III
Chiarenza et al.
1994
Modulating effects of the synthetic thymic dipeptide pidotimod on the immune system in the aging rat
IL129855A
(en)
2013-06-27
Isolated polypeptide of bovine lactation associated immunotropic protein (cd14), use thereof, in vitro method for inducing growth and differentiation of b cells and kit for the preparation of a vaccination
FR2408581A1
(en)
1979-06-08
COMPOSITION OF PENTAPEPTIDE, ITS PROCESS FOR OBTAINING AND THERAPEUTIC COMPOSITION INCLUDING
RU2136308C1
(en)
1999-09-10
Growth stimulating agent for human bone marrow cells
Gruner et al.
1990
Stimulation of the recruitment of epidermal Langerhans cells by splenopentin
Okada et al.
1974
A new pyroglutamylpeptide (Pyr-Lys-Ser) isolated from the venom of Agkistrodon halys blomhoffii
Abiko et al.
1995
Synthesis of [Phe (4F) 3] thymopoietin II and examination of its immunological effect on the impaired blastogenic response of T-lymphocytes of uremic patients
Sztein et al.
1986
Recent Advances in Thymic Hormone Research
Elouaer-Blanc et al.
1987
Bombesin (BBS) stimulation of gastrin release from gastrinoma cells in long term culture
Crabtree et al.
1990
Small intestinal glycoprotein synthesis and secretion: effects of T lymphocyte activation
ATE96035T1
(en)
1993-11-15
USE OF A POLYPEPTIDE HAVING GAMMA INTERFERON ACTIVITY FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PRIMITIVE PLEURAL CANCER.
Legal Events
Date
Code
Title
Description
1989-08-02
PCNP
Patent ceased through non-payment of renewal fee
