AU2778089A – New 3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as pharmaceuticals, pharmaceutical products and intermediates
– Google Patents
AU2778089A – New 3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as pharmaceuticals, pharmaceutical products and intermediates
– Google Patents
New 3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as pharmaceuticals, pharmaceutical products and intermediates
Info
Publication number
AU2778089A
AU2778089A
AU27780/89A
AU2778089A
AU2778089A
AU 2778089 A
AU2778089 A
AU 2778089A
AU 27780/89 A
AU27780/89 A
AU 27780/89A
AU 2778089 A
AU2778089 A
AU 2778089A
AU 2778089 A
AU2778089 A
AU 2778089A
Authority
AU
Australia
Prior art keywords
pharmaceuticals
intermediates
derivatives
preparation
new
Prior art date
1988-01-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU27780/89A
Other versions
AU612449B2
(en
Inventor
Ekkehard Baader
Gerhard Beck
Heiner Jendralla
Bela Kerekjarto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1988-01-09
Filing date
1989-01-06
Publication date
1989-07-13
1989-01-06
Application filed by Hoechst AG
filed
Critical
Hoechst AG
1989-07-13
Publication of AU2778089A
publication
Critical
patent/AU2778089A/en
1991-07-11
Application granted
granted
Critical
1991-07-11
Publication of AU612449B2
publication
Critical
patent/AU612449B2/en
2009-01-06
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P3/00—Drugs for disorders of the metabolism
A61P3/06—Antihyperlipidemics
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C43/00—Ethers; Compounds having groups, groups or groups
C07C43/02—Ethers
C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
C07C49/217—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings
C07C49/223—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings polycyclic
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
C07C49/567—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing halogen
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
AU27780/89A
1988-01-09
1989-01-06
New 3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as pharmaceuticals, pharmaceutical products and intermediates
Ceased
AU612449B2
(en)
Applications Claiming Priority (4)
Application Number
Priority Date
Filing Date
Title
DE3800439
1988-01-09
DE3800439
1988-01-09
DE3800785
1988-01-14
DE3800785A
DE3800785A1
(en)
1988-01-09
1988-01-14
SUBSTITUTED 7- (PYRIDAZIN-5-YL) -3,5-DIHYDROXYHEPTANE (EN) – ACID, YOUR CORRESPONDING (DELTA) -LACTONE OR. DERIVATIVES, PROCESS FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS, PHARMACEUTICAL PREPARATIONS AND INTERMEDIATE PRODUCTS
Publications (2)
Publication Number
Publication Date
AU2778089A
true
AU2778089A
(en)
1989-07-13
AU612449B2
AU612449B2
(en)
1991-07-11
Family
ID=25863830
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU27780/89A
Ceased
AU612449B2
(en)
1988-01-09
1989-01-06
New 3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as pharmaceuticals, pharmaceutical products and intermediates
Country Status (15)
Country
Link
US
(1)
US4946841A
(en)
EP
(1)
EP0324347A3
(en)
JP
(1)
JPH01213270A
(en)
KR
(1)
KR890011859A
(en)
AU
(1)
AU612449B2
(en)
DE
(1)
DE3800785A1
(en)
DK
(1)
DK5289A
(en)
FI
(1)
FI890050A
(en)
HU
(1)
HU202502B
(en)
IL
(1)
IL88908A0
(en)
NO
(1)
NO890062L
(en)
NZ
(1)
NZ227551A
(en)
PH
(1)
PH26148A
(en)
PT
(1)
PT89409B
(en)
ZA
(1)
ZA89121B
(en)
Families Citing this family (16)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE3826814A1
(en)
*
1988-08-06
1990-02-08
Hoechst Ag
NEW 6-FLUORO-3,5-DIHYDROXYCARBONSAEURES AND THEIR DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL PREPARATES AND INTERMEDIATE PRODUCTS
DE3832570A1
(en)
*
1988-09-24
1990-03-29
Hoechst Ag
7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-ACID, METHODS FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND INTERMEDIATE PRODUCTS
SE8903226L
(en)
*
1988-10-03
1990-04-04
Glaxo Group Ltd
CHEMICAL SOCIETIES
AU637408B2
(en)
*
1989-10-10
1993-05-27
Glaxo Group Limited
Substituted N-vinyl imidazole derivatives.
IT1237792B
(en)
*
1989-12-21
1993-06-17
Zambon Spa
ACTIVE COMPOUNDS AS INHIBITORS OF THE HMG-COA REDUCTASE ENZYME
JPH054943A
(en)
*
1990-08-30
1993-01-14
Sagami Chem Res Center
Optically active beta,delta-diketo-acid ester and reduced material thereof
DE4208052A1
(en)
*
1992-03-13
1993-09-16
Bayer Ag
IMIDAZOLYL SUBSTITUTED PHENYL ACIDANCE AMIDE
DE4208051A1
(en)
*
1992-03-13
1993-09-16
Bayer Ag
SUBSTITUTED PHENYL ACIDIC ACID AMIDE
DE4212796A1
(en)
*
1992-04-16
1993-10-21
Bayer Ag
Propenoyl-imidazole derivatives
DE4215587A1
(en)
*
1992-05-12
1993-11-18
Bayer Ag
Sulfonylbenzyl-substituted benzo- and pyridopyridones
DE4215588A1
(en)
*
1992-05-12
1993-11-18
Bayer Ag
Biphenylmethyl-substituted pyridones
DE4220983A1
(en)
*
1992-06-26
1994-01-05
Bayer Ag
Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives
DE4319041A1
(en)
*
1992-10-23
1994-04-28
Bayer Ag
Trisubstituted biphenyls
WO2004094379A2
(en)
*
2003-04-16
2004-11-04
Amgen Inc.
3-phenyl-4- (pyrimidin-2-yl) -6- (piperidin-4-yl) derivatives and related compounds as tnf-alpha and il-1 inhibitors for the treatment of inflammations
US8372877B2
(en)
2010-04-16
2013-02-12
Cumberland Pharmaceuticals
Stabilized statin formulations
WO2012046772A1
(en)
2010-10-06
2012-04-12
国立大学法人東京大学
Prophylactic and/or therapeutic agent against lymphedema
Family Cites Families (10)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE2752820A1
(en)
*
1977-11-26
1979-05-31
Bayer Ag
NEW NITRO-SUBSTITUTED 1,4-DIHYDROPYRIDINE, THE METHOD FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
US4375475A
(en)
*
1979-08-17
1983-03-01
Merck & Co., Inc.
Substituted pyranone inhibitors of cholesterol synthesis
US4540796A
(en)
*
1982-05-03
1985-09-10
Merck & Co., Inc.
Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase via a chiral synthon
US4613610A
(en)
*
1984-06-22
1986-09-23
Sandoz Pharmaceuticals Corp.
Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
AU573368B2
(en)
*
1984-06-22
1988-06-02
Sandoz Ag
Pyrazole analogs of mevalonolactone and derivatives thereof, process for their production and their use
US4647576A
(en)
*
1984-09-24
1987-03-03
Warner-Lambert Company
Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4681893A
(en)
*
1986-05-30
1987-07-21
Warner-Lambert Company
Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4735958A
(en)
*
1986-12-22
1988-04-05
Warner-Lambert Company
Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis
US4761419A
(en)
*
1987-12-07
1988-08-02
Warner-Lambert Company
6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
DE3826814A1
(en)
*
1988-08-06
1990-02-08
Hoechst Ag
NEW 6-FLUORO-3,5-DIHYDROXYCARBONSAEURES AND THEIR DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL PREPARATES AND INTERMEDIATE PRODUCTS
1988
1988-01-14
DE
DE3800785A
patent/DE3800785A1/en
not_active
Withdrawn
1989
1989-01-03
EP
EP19890100031
patent/EP0324347A3/en
not_active
Withdrawn
1989-01-05
FI
FI890050A
patent/FI890050A/en
not_active
IP Right Cessation
1989-01-06
HU
HU8945A
patent/HU202502B/en
unknown
1989-01-06
NO
NO89890062A
patent/NO890062L/en
unknown
1989-01-06
PT
PT89409A
patent/PT89409B/en
not_active
IP Right Cessation
1989-01-06
NZ
NZ227551A
patent/NZ227551A/en
unknown
1989-01-06
PH
PH38012A
patent/PH26148A/en
unknown
1989-01-06
JP
JP64000586A
patent/JPH01213270A/en
active
Pending
1989-01-06
US
US07/294,096
patent/US4946841A/en
not_active
Expired – Fee Related
1989-01-06
ZA
ZA89121A
patent/ZA89121B/en
unknown
1989-01-06
DK
DK005289A
patent/DK5289A/en
not_active
Application Discontinuation
1989-01-06
AU
AU27780/89A
patent/AU612449B2/en
not_active
Ceased
1989-01-07
KR
KR1019890000100A
patent/KR890011859A/en
unknown
1989-01-09
IL
IL88908A
patent/IL88908A0/en
unknown
Also Published As
Publication number
Publication date
EP0324347A3
(en)
1990-12-05
PH26148A
(en)
1992-03-18
HU202502B
(en)
1991-03-28
FI890050A0
(en)
1989-01-05
NO890062L
(en)
1989-07-10
FI890050A
(en)
1989-07-10
DE3800785A1
(en)
1989-07-20
HUT50790A
(en)
1990-03-28
PT89409B
(en)
1993-12-31
DK5289D0
(en)
1989-01-06
ZA89121B
(en)
1989-09-27
AU612449B2
(en)
1991-07-11
EP0324347A2
(en)
1989-07-19
PT89409A
(en)
1990-02-08
JPH01213270A
(en)
1989-08-28
DK5289A
(en)
1989-07-10
NZ227551A
(en)
1990-11-27
NO890062D0
(en)
1989-01-06
US4946841A
(en)
1990-08-07
KR890011859A
(en)
1989-08-23
IL88908A0
(en)
1989-08-15
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None