AU3275684A – Preparation of phosphorus-containing nucleoside derivatives
– Google Patents
AU3275684A – Preparation of phosphorus-containing nucleoside derivatives
– Google Patents
Preparation of phosphorus-containing nucleoside derivatives
Info
Publication number
AU3275684A
AU3275684A
AU32756/84A
AU3275684A
AU3275684A
AU 3275684 A
AU3275684 A
AU 3275684A
AU 32756/84 A
AU32756/84 A
AU 32756/84A
AU 3275684 A
AU3275684 A
AU 3275684A
AU 3275684 A
AU3275684 A
AU 3275684A
Authority
AU
Australia
Prior art keywords
denotes
general formula
see diagramm
given above
meanings given
Prior art date
1983-09-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU32756/84A
Other versions
AU570266B2
(en
Inventor
Joachim Engels
Alfred Jager
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1983-09-06
Filing date
1984-09-05
Publication date
1985-03-14
1984-09-05
Application filed by Hoechst AG
filed
Critical
Hoechst AG
1985-03-14
Publication of AU3275684A
publication
Critical
patent/AU3275684A/en
1988-03-10
Application granted
granted
Critical
1988-03-10
Publication of AU570266B2
publication
Critical
patent/AU570266B2/en
2004-09-05
Anticipated expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
C07F9/02—Phosphorus compounds
C07F9/28—Phosphorus compounds with one or more P—C bonds
C07F9/48—Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof
C07F9/4883—Amides or esteramides thereof, e.g. RP(NR’2)2 or RP(XR’)(NR»2) (X = O, S)
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
Y02P20/00—Technologies relating to chemical industry
Y02P20/50—Improvements relating to the production of bulk chemicals
Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
1. Claims for the contracting states : BE, CH, LI, DE, FR, GB, IT, LU, NL, SE A process for the preparation of deoxyribonucleoside phosphonates of the general formula I see diagramm : EP0136543,P14,F1 in which T denotes a protecting group for a primary hydroxyl group, B denotes a nucleoside base radical in which any exoamino group present is protected, G denotes a protecting group for a secondary hydroxyl group, Z denotes oxygen, sulfur or selenium and R denotes alkyl having up to 8 C atoms, cyclohexyl, benzyl, or phenyl which is optionally substituted by fluorine, chlorine, bromine, lower alkyl, lower alkoxy or trifluoromethyl, characterized in that a difunctional phosphonylating reagent of the general formula II see diagramm : EP0136543,P14,F2 in which X denotes chlorine or Y and Y denotes a group of the formula see diagramm : EP0136543,P14,F3 R**1 and R**2 representing identical or different alkyl or cycloalkyl radicals having up to 8 C atoms, or phenyl radicals, or R**1 and R**2 , together with the nitrogen, representing a saturated or unsaturated heterocyclic ring which can contain further hetero atoms, being reacted with a nucleoside of the general formula III see diagramm : EP0136543,P14,F4 in which T and B have the meanings given above, the resulting compound of the general formula IV see diagramm : EP0136543,P14,F5 being reacted with a compound of the general formula V see diagramm : EP0136543,P15,F1 in which B and G have the meanings given above, and the resulting compounds of the general formula VI see diagramm : EP0136543,P15,F2 in which T, R, B and G have the meanings given above, being oxidatively converted to compound of the general formula I. 1. Claims for the contracting state AT A process for the preparation of deoxyribonucleoside phosphonates of the general formula I see diagramm : EP0136543,P15,F3 in which T denotes a protecting group for a primary hydroxyl group, B denotes a nucleoside base radical in which any exoamino group present is protected, G denotes a protecting group for a secondary hydroxyl group, Z denotes oxygen, sulfur or selenium and R denotes alkyl having up to 8 C atoms, cyclohexyl, benzyl, or phenyl which is optionally substituted by fluorine, chlorine, bromine, lower alkyl, lower alkoxy or trifluoromethyl, characterized in that a difunctional phosphonylating reagent of the general formula II see diagramm : EP0136543,P16,F1 in which X denotes chlorine or Y and Y denotes a group of the formula see diagramm : EP0136543,P16,F2 R**1 and R**2 representing identical or different alkyl or cycloalkyl radicals having up to 8 C atoms, or phenyl radicals, or R**1 and R**2 , together with the nitrogen, representing a saturated or unsaturated heterocyclic ring which can contain further hetero atoms, being reacted with a nucleoside of the general formula III see diagramm : EP0136543,P16,F3 in which T and B have the meanings given above, the resulting compound of the general formula IV see diagramm : EP0136543,P16,F4 being reacted with a compound of the general formula V see diagramm : EP0136543,P16,F5 in which B and G have the meanings given above, and the resulting compounds of the general formula VI see diagramm : EP0136543,P17,F1 in which T, R, B and G have the meanings given above, being oxidatively converted to compound of the general formula I.
AU32756/84A
1983-09-06
1984-09-05
Preparation of phosphorus-containing nucleoside derivatives
Expired
AU570266B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
DE3332068
1983-09-06
DE19833332068
DE3332068A1
(en)
1983-09-06
1983-09-06
METHOD FOR PRODUCING NUCLEOSIDALKYL, ARALKYL AND ARYLPHOSPHONITES AND PHOSPHONATES
Related Child Applications (1)
Application Number
Title
Priority Date
Filing Date
AU11384/88A
Division
AU601257B2
(en)
1983-09-06
1988-02-08
5′-protected nucleoside phosphonites and process for their preparation
Publications (2)
Publication Number
Publication Date
AU3275684A
true
AU3275684A
(en)
1985-03-14
AU570266B2
AU570266B2
(en)
1988-03-10
Family
ID=6208339
Family Applications (2)
Application Number
Title
Priority Date
Filing Date
AU32756/84A
Expired
AU570266B2
(en)
1983-09-06
1984-09-05
Preparation of phosphorus-containing nucleoside derivatives
AU11384/88A
Expired
AU601257B2
(en)
1983-09-06
1988-02-08
5′-protected nucleoside phosphonites and process for their preparation
Family Applications After (1)
Application Number
Title
Priority Date
Filing Date
AU11384/88A
Expired
AU601257B2
(en)
1983-09-06
1988-02-08
5′-protected nucleoside phosphonites and process for their preparation
Country Status (11)
Country
Link
EP
(1)
EP0136543B1
(en)
JP
(2)
JPS6072899A
(en)
AT
(1)
ATE38839T1
(en)
AU
(2)
AU570266B2
(en)
CA
(1)
CA1235079A
(en)
DE
(2)
DE3332068A1
(en)
DK
(3)
DK162895C
(en)
ES
(1)
ES8505384A1
(en)
GR
(1)
GR80287B
(en)
IE
(1)
IE57904B1
(en)
PT
(1)
PT79172B
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4959463A
(en)
*
1985-10-15
1990-09-25
Genentech, Inc.
Intermediates
Families Citing this family (12)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE3916871A1
(en)
*
1989-05-24
1990-11-29
Boehringer Mannheim Gmbh
MODIFIED PHOSPHORAMIDITE PROCESS FOR THE PREPARATION OF MODIFIED NUCLEIC ACIDS
DE59108644D1
(en)
*
1990-07-02
1997-05-07
Hoechst Ag
Oligonucleotide analogs with terminal 3′-3 ‘or. 5’-5 ‘internucleotide linkages
US5512668A
(en)
*
1991-03-06
1996-04-30
Polish Academy Of Sciences
Solid phase oligonucleotide synthesis using phospholane intermediates
WO1994002499A1
(en)
*
1992-07-27
1994-02-03
Hybridon, Inc.
Oligonucleotide alkylphosphonothioates
US6087491A
(en)
*
1993-01-08
2000-07-11
Hybridon, Inc.
Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
ES2100051T3
(en)
*
1993-01-08
1997-06-01
Hybridon Inc
SYNTHESIS OF DIMER BLOCKS AND THEIR USE IN THE ASSEMBLY OF OLIGONUCLEOTIDES.
AU6165494A
(en)
*
1993-01-25
1994-08-15
Hybridon, Inc.
Oligonucleotide alkylphosphonates and alkylphosphonothioates
DE69527266T2
(en)
*
1994-07-26
2003-03-06
Sony Corp
IMAGE TRANSFER METHOD
PT828749E
(en)
*
1995-05-26
2003-11-28
Genta Inc
COMPOSITIONS AND METHODS FOR SYNTHESIS OF ORGANOPHOSPHORUS DERIVATIVES
CA2226111C
(en)
*
1996-05-03
2005-09-20
Hybridon, Inc.
In situ preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides
DE102004049339A1
(en)
2004-10-08
2006-04-13
Basf Ag
Process for the purification of phosphorus-containing chelate ligands
DE102007038930B4
(en)
*
2007-08-13
2013-12-05
Universität Leipzig
New chemical compound and its use in medicine, in particular for use in tumor therapy
Family Cites Families (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
IL62834A0
(en)
*
1980-05-14
1981-07-31
Ens Bio Logicals Inc
Polynucleotide synthesis
US4415732A
(en)
*
1981-03-27
1983-11-15
University Patents, Inc.
Phosphoramidite compounds and processes
EP0090789A1
(en)
*
1982-03-26
1983-10-05
Monsanto Company
Chemical DNA synthesis
DE3239888A1
(en)
*
1982-10-28
1984-05-03
Hubert Prof. Dr. 2000 Hamburg Köster
METHOD FOR PRODUCING OLIGONUCLEOSIDE PHOSPHONATES
1983
1983-09-06
DE
DE19833332068
patent/DE3332068A1/en
not_active
Withdrawn
1984
1984-08-30
AT
AT84110314T
patent/ATE38839T1/en
not_active
IP Right Cessation
1984-08-30
DE
DE8484110314T
patent/DE3475307D1/en
not_active
Expired
1984-08-30
EP
EP84110314A
patent/EP0136543B1/en
not_active
Expired
1984-09-04
GR
GR80287A
patent/GR80287B/en
unknown
1984-09-04
PT
PT79172A
patent/PT79172B/en
active
IP Right Revival
1984-09-04
ES
ES535627A
patent/ES8505384A1/en
not_active
Expired
1984-09-05
AU
AU32756/84A
patent/AU570266B2/en
not_active
Expired
1984-09-05
JP
JP59184717A
patent/JPS6072899A/en
active
Granted
1984-09-05
IE
IE2268/84A
patent/IE57904B1/en
not_active
IP Right Cessation
1984-09-05
DK
DK424784A
patent/DK162895C/en
active
1984-09-05
CA
CA000462469A
patent/CA1235079A/en
not_active
Expired
1988
1988-02-08
AU
AU11384/88A
patent/AU601257B2/en
not_active
Expired
1991
1991-07-05
DK
DK131691A
patent/DK167359B1/en
active
IP Right Grant
1991-07-05
DK
DK131591A
patent/DK166585C/en
active
1992
1992-11-18
JP
JP4307481A
patent/JPH0662662B2/en
not_active
Expired – Fee Related
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4959463A
(en)
*
1985-10-15
1990-09-25
Genentech, Inc.
Intermediates
Also Published As
Publication number
Publication date
DK166585B
(en)
1993-06-14
AU570266B2
(en)
1988-03-10
GR80287B
(en)
1985-01-07
IE842268L
(en)
1985-03-06
PT79172A
(en)
1984-10-01
DK131591D0
(en)
1991-07-05
CA1235079A
(en)
1988-04-12
DK162895B
(en)
1991-12-23
DK424784A
(en)
1985-03-07
JPH0531560B2
(en)
1993-05-12
DK166585C
(en)
1993-10-25
JPH0662662B2
(en)
1994-08-17
PT79172B
(en)
1986-09-10
EP0136543A2
(en)
1985-04-10
JPH05262787A
(en)
1993-10-12
DE3332068A1
(en)
1985-03-21
EP0136543A3
(en)
1986-07-16
AU601257B2
(en)
1990-09-06
DK131691A
(en)
1991-07-05
ES535627A0
(en)
1985-05-16
AU1138488A
(en)
1988-07-14
JPS6072899A
(en)
1985-04-24
DK131591A
(en)
1991-07-05
DK131691D0
(en)
1991-07-05
ATE38839T1
(en)
1988-12-15
DK424784D0
(en)
1984-09-05
IE57904B1
(en)
1993-05-05
DK162895C
(en)
1992-05-11
DK167359B1
(en)
1993-10-18
DE3475307D1
(en)
1988-12-29
ES8505384A1
(en)
1985-05-16
EP0136543B1
(en)
1988-11-23
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