AU3934795A

AU3934795A – Bicyclic nonane and decane compounds having dopamine receptor affinity
– Google Patents

AU3934795A – Bicyclic nonane and decane compounds having dopamine receptor affinity
– Google Patents
Bicyclic nonane and decane compounds having dopamine receptor affinity

Info

Publication number
AU3934795A

AU3934795A
AU39347/95A
AU3934795A
AU3934795A
AU 3934795 A
AU3934795 A
AU 3934795A
AU 39347/95 A
AU39347/95 A
AU 39347/95A
AU 3934795 A
AU3934795 A
AU 3934795A
AU 3934795 A
AU3934795 A
AU 3934795A
Authority
AU
Australia
Prior art keywords
4alkyl
dopamine receptor
receptor
receptor affinity
benzyloxy
Prior art date
1994-12-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Application number
AU39347/95A
Inventor
Patricia L Power
Sumanas Rakhit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Allelix Biopharmaceuticals Inc

Original Assignee
Allelix Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1994-12-12
Filing date
1995-12-08
Publication date
1996-07-03

1995-12-08
Application filed by Allelix Biopharmaceuticals Inc
filed
Critical
Allelix Biopharmaceuticals Inc

1996-07-03
Publication of AU3934795A
publication
Critical
patent/AU3934795A/en

Status
Abandoned
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00

C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00 in which the condensed system contains two hetero rings

C07D471/04—Ortho-condensed systems

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00

C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00 in which the condensed system contains two hetero rings

C07D487/04—Ortho-condensed systems

Abstract

Described herein are D4 receptor-selective compounds of the general formula: wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from CH2, O, NH, S, C=O, CH-OH, CH-N(C1-4alkyl)2, C=CHCl, C=CHCN, N-C1-4alkyl, N-acetyl, SO2and SO; X2 – – – is selected from N=, CH2-, CH=, C(O)-, O-, and S-; n is 1 or 2; R1 is selected from H and an amino acid side chain; R2 is selected from H, OH, C1-9alkyl, C1-9alkoxy, and benzyloxy; and R3 is selected from H, OH, halo, cyano, C1-4alkyl, C1-4alkoxy, phenoxy, benzyloxy, =O, =S, C1-4alkylsulfonyl, C1-4alkylsulfonyl, C1-4alkylthio, amino, and aminocarbonyl; and acid addition salts, solvates and hydrates thereof. Their use as ligands for dopamine receptor identification and in a drug screening program, and as pharmaceuticals to treat indications in which the D4 receptor is implicated, such as schizophrenia, is also described.

AU39347/95A
1994-12-12
1995-12-08
Bicyclic nonane and decane compounds having dopamine receptor affinity

Abandoned

AU3934795A
(en)

Applications Claiming Priority (3)

Application Number
Priority Date
Filing Date
Title

US354906

1994-12-12

US08/354,906

US5576314A
(en)

1994-12-12
1994-12-12
Bicyclic nonane and decane compounds having dopamine receptor affinity

PCT/IB1995/001110

WO1996018630A1
(en)

1994-12-12
1995-12-08
Bicyclic nonane and decane compounds having dopamine receptor affinity

Publications (1)

Publication Number
Publication Date

AU3934795A
true

AU3934795A
(en)

1996-07-03

Family
ID=23395404
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU39347/95A
Abandoned

AU3934795A
(en)

1994-12-12
1995-12-08
Bicyclic nonane and decane compounds having dopamine receptor affinity

Country Status (7)

Country
Link

US
(2)

US5576314A
(en)

EP
(1)

EP0797577B1
(en)

AT
(1)

ATE194988T1
(en)

AU
(1)

AU3934795A
(en)

CA
(1)

CA2207546A1
(en)

DE
(1)

DE69518165T2
(en)

WO
(1)

WO1996018630A1
(en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US5576314A
(en)

*

1994-12-12
1996-11-19
Allelix Biopharmaceuticals Inc.
Bicyclic nonane and decane compounds having dopamine receptor affinity

WO1999011647A1
(en)

1997-09-02
1999-03-11
Yoshitomi Pharmaceutical Industries, Ltd.
Fused thiophene compounds and medicinal use thereof

US6251893B1
(en)

*

1998-06-15
2001-06-26
Nps Allelix Corp.
Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity

US6107313A
(en)

*

1998-10-02
2000-08-22
Combichem, Inc.
Dopamine receptor antagonists

GB9926303D0
(en)

*

1999-11-05
2000-01-12
Smithkline Beecham Plc
Novel compounds

US6890919B2
(en)

*

2001-06-26
2005-05-10
Shitij Kapur
Atypical antipsychotic agents having low affinity for the D2 receptor

FR2928150A1
(en)

*

2008-02-29
2009-09-04
Vetoquinol Sa Sa

NOVEL 7-SUBSTITUTED 3-CARBOXY-OXADIAZINO-QUINOLONES DERIVATIVES, THEIR PREPARATION AND APPLICATION AS ANTI-BACTERIANS

EP2145891A1
(en)

*

2008-07-09
2010-01-20
Vetoquinol S.A.
9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials

Family Cites Families (14)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

CA772160A
(en)

*

1967-11-21
Schmutz Jean
Diazepine and thiazepine derivatives

NL140242B
(en)

*

1963-03-01
1973-11-15
Wander Ag Dr A

METHOD FOR PREPARING THE 11-PLACE SUBSTITUTED DIBENZ (B.F.) (1.4) OXAZEPINES BY A BASIC GROUP.

US3908010A
(en)

*

1967-03-22
1975-09-23
Wander Ag Dr A
Basically substituted heterocycles as anti-emetics

US3539573A
(en)

*

1967-03-22
1970-11-10
Jean Schmutz
11-basic substituted dibenzodiazepines and dibenzothiazepines

US3751415A
(en)

*

1967-03-22
1973-08-07
Sandoz Ag
2-nitro-11-(1-piperazinyl)-dibenz(b,f)(1,4)oxazepines

US3758479A
(en)

*

1967-03-22
1973-09-11
Sandoz Ag
Nitro and sulphamoyl substituted dibenzodiazepines

US3983234A
(en)

*

1974-07-04
1976-09-28
Sandoz Ltd.
Treatment of dyskinesias

US4096261A
(en)

*

1977-02-23
1978-06-20
Abbott Laboratories
Dibenzodiazepines

DD151166A1
(en)

*

1979-11-05
1981-10-08
Carla Rueger

PROCESS FOR PRODUCTION OF 5H-DIBENZO SUBSTITUTED IN 11-POSITION SINGLE BRACKET ON B, E SQUARE BRACKET TO CORNER BRACKET ON 1.4 SQUARE BRACKET TO DIAZEPINE

SU1015618A1
(en)

*

1980-01-28
1986-12-15
Научно-исследовательский институт фармакологии АМН СССР
11/n-(diazabicyclo(4.m.o)alkanyl)/-5h-dibenzo-(b,e)(1,4)diazepines possessing neuroleptic action

CS224988B1
(en)

*

1982-08-17
1984-02-13
Jilek Jiri
The derivate of octanehydropyrrole (1,2- a)pyrazine and its methansulphonate

US5393752A
(en)

*

1992-05-26
1995-02-28
Therabel Research S.A./N.V.
Methylpiperazinoazepine compounds, preparation and use thereof

US5354747A
(en)

*

1993-06-16
1994-10-11
G. D. Searle & Co.
2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use

US5576314A
(en)

*

1994-12-12
1996-11-19
Allelix Biopharmaceuticals Inc.
Bicyclic nonane and decane compounds having dopamine receptor affinity

1994

1994-12-12
US
US08/354,906
patent/US5576314A/en
not_active
Expired – Lifetime

1995

1995-12-08
DE
DE69518165T
patent/DE69518165T2/en
not_active
Expired – Fee Related

1995-12-08
AU
AU39347/95A
patent/AU3934795A/en
not_active
Abandoned

1995-12-08
WO
PCT/IB1995/001110
patent/WO1996018630A1/en
active
IP Right Grant

1995-12-08
AT
AT95937148T
patent/ATE194988T1/en
active

1995-12-08
EP
EP95937148A
patent/EP0797577B1/en
not_active
Expired – Lifetime

1995-12-08
CA
CA002207546A
patent/CA2207546A1/en
not_active
Abandoned

1996

1996-04-01
US
US08/625,358
patent/US5703072A/en
not_active
Expired – Lifetime

Also Published As

Publication number
Publication date

US5703072A
(en)

1997-12-30

WO1996018630A1
(en)

1996-06-20

US5576314A
(en)

1996-11-19

DE69518165T2
(en)

2001-06-07

CA2207546A1
(en)

1996-06-20

EP0797577B1
(en)

2000-07-26

DE69518165D1
(en)

2000-08-31

EP0797577A1
(en)

1997-10-01

ATE194988T1
(en)

2000-08-15

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