AU1639492A – Processes for the diastereoselective synthesis of nucleosides
– Google Patents
AU1639492A – Processes for the diastereoselective synthesis of nucleosides
– Google Patents
Processes for the diastereoselective synthesis of nucleosides
Info
Publication number
AU1639492A
AU1639492A
AU16394/92A
AU1639492A
AU1639492A
AU 1639492 A
AU1639492 A
AU 1639492A
AU 16394/92 A
AU16394/92 A
AU 16394/92A
AU 1639492 A
AU1639492 A
AU 1639492A
AU 1639492 A
AU1639492 A
AU 1639492A
Authority
AU
Australia
Prior art keywords
processes
nucleosides
diastereoselective synthesis
diastereoselective
synthesis
Prior art date
1991-05-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU16394/92A
Other versions
AU655973B2
(en
Inventor
Haolun Jin
Tarek Mansour
M. Arshad Siddiqui
Allan H.L. Tse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
Shire Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1991-05-21
Filing date
1992-05-20
Publication date
1992-11-26
Family has litigation
First worldwide family litigation filed
litigation
Critical
https://patents.darts-ip.com/?family=24825144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU1639492(A)
«Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
1992-05-20
Application filed by Shire Canada Inc
filed
Critical
Shire Canada Inc
1992-11-26
Publication of AU1639492A
publication
Critical
patent/AU1639492A/en
1995-01-19
Application granted
granted
Critical
1995-01-19
Publication of AU655973B2
publication
Critical
patent/AU655973B2/en
2008-04-10
Assigned to SHIRE CANADA INC.
reassignment
SHIRE CANADA INC.
Request to Amend Deed and Register
Assignors: BIOCHEM PHARMA INC.
2012-05-20
Anticipated expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P31/12—Antivirals
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D317/34—Oxygen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
C07D327/04—Five-membered rings
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
C07D339/02—Five-membered rings
C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
C07H19/06—Pyrimidine radicals
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
C07H19/16—Purine radicals
Abstract
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
AU16394/92A
1991-05-21
1992-05-20
Processes for the diastereoselective synthesis of nucleosides
Expired
AU655973B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US70337991A
1991-05-21
1991-05-21
US703379
1991-05-21
Publications (2)
Publication Number
Publication Date
AU1639492A
true
AU1639492A
(en)
1992-11-26
AU655973B2
AU655973B2
(en)
1995-01-19
Family
ID=24825144
Family Applications (4)
Application Number
Title
Priority Date
Filing Date
AU16395/92A
Ceased
AU668086B2
(en)
1991-05-21
1992-05-20
Processes for the diastereoselective synthesis of nucleosides
AU16913/92A
Abandoned
AU1691392A
(en)
1991-05-21
1992-05-20
Processes for the diastereoselective synthesis of nucleosides
AU16908/92A
Abandoned
AU1690892A
(en)
1991-05-21
1992-05-20
Processes for the diastereoselective synthesis of nucleosides
AU16394/92A
Expired
AU655973B2
(en)
1991-05-21
1992-05-20
Processes for the diastereoselective synthesis of nucleosides
Family Applications Before (3)
Application Number
Title
Priority Date
Filing Date
AU16395/92A
Ceased
AU668086B2
(en)
1991-05-21
1992-05-20
Processes for the diastereoselective synthesis of nucleosides
AU16913/92A
Abandoned
AU1691392A
(en)
1991-05-21
1992-05-20
Processes for the diastereoselective synthesis of nucleosides
AU16908/92A
Abandoned
AU1690892A
(en)
1991-05-21
1992-05-20
Processes for the diastereoselective synthesis of nucleosides
Country Status (34)
Country
Link
US
(5)
US5756706A
(en)
EP
(2)
EP0515157B1
(en)
JP
(3)
JP3229013B2
(en)
KR
(3)
KR0160144B1
(en)
CN
(6)
CN1035555C
(en)
AT
(2)
ATE157662T1
(en)
AU
(4)
AU668086B2
(en)
BG
(2)
BG61695B1
(en)
CA
(2)
CA2069024C
(en)
CZ
(3)
CZ284975B6
(en)
DE
(2)
DE69208144T2
(en)
DK
(2)
DK0515157T3
(en)
EE
(1)
EE03044B1
(en)
ES
(2)
ES2084937T3
(en)
FI
(3)
FI106377B
(en)
GR
(2)
GR3018941T3
(en)
GT
(1)
GT199800047A
(en)
HK
(2)
HK132196A
(en)
HU
(2)
HU223838B1
(en)
IE
(2)
IE921618A1
(en)
IL
(6)
IL101931A
(en)
MD
(1)
MD1155C2
(en)
MX
(2)
MX9202404A
(en)
NO
(2)
NO300593B1
(en)
NZ
(2)
NZ242818A
(en)
OA
(1)
OA10212A
(en)
PL
(3)
PL176026B1
(en)
RO
(1)
RO116812B1
(en)
RU
(4)
RU2163909C2
(en)
SG
(1)
SG43863A1
(en)
SK
(2)
SK279438B6
(en)
TW
(4)
TW467907B
(en)
WO
(2)
WO1992020669A1
(en)
ZA
(2)
ZA923641B
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU668086B2
(en)
*
1991-05-21
1996-04-26
Shire Canada Inc.
Processes for the diastereoselective synthesis of nucleosides
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* Cited by examiner, † Cited by third party
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Publication Date
Title
AU1639592A
(en)
1992-11-26
Processes for the diastereoselective synthesis of nucleosides
None