AU1681288A – Improved process for recovering microbially produced IL-2
– Google Patents
AU1681288A – Improved process for recovering microbially produced IL-2
– Google Patents
Improved process for recovering microbially produced IL-2
Info
Publication number
AU1681288A
AU1681288A
AU16812/88A
AU1681288A
AU1681288A
AU 1681288 A
AU1681288 A
AU 1681288A
AU 16812/88 A
AU16812/88 A
AU 16812/88A
AU 1681288 A
AU1681288 A
AU 1681288A
AU 1681288 A
AU1681288 A
AU 1681288A
Authority
AU
Australia
Prior art keywords
ril
oxidized
solution
purified
improved process
Prior art date
1987-05-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU16812/88A
Other versions
AU619185B2
(en
Inventor
Robert F. Halenbeck
Michael Kunitani
Flint Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOVARTIS VACCINES AND DIAGNOSTICS Inc
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1987-05-11
Filing date
1988-03-31
Publication date
1988-12-06
1988-03-31
Application filed by Cetus Corp
filed
Critical
Cetus Corp
1988-12-06
Publication of AU1681288A
publication
Critical
patent/AU1681288A/en
1992-01-23
Application granted
granted
Critical
1992-01-23
Publication of AU619185B2
publication
Critical
patent/AU619185B2/en
1992-09-10
Assigned to CETUS ONCOLOGY CORPORATION
reassignment
CETUS ONCOLOGY CORPORATION
Request to Amend Deed and Register
Assignors: CETUS CORPORATION
1996-12-05
Assigned to CHIRON CORPORATION
reassignment
CHIRON CORPORATION
Alteration of Name(s) in Register under S187
Assignors: CETUS ONCOLOGY CORPORATION
2008-01-31
Assigned to NOVARTIS VACCINES AND DIAGNOSTICS, INC.
reassignment
NOVARTIS VACCINES AND DIAGNOSTICS, INC.
Request to Amend Deed and Register
Assignors: CHIRON CORPORATION
2008-03-31
Anticipated expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
C07K14/52—Cytokines; Lymphokines; Interferons
C07K14/54—Interleukins [IL]
C07K14/55—IL-2
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
Y10S530/82—Proteins from microorganisms
Y10S530/825—Bacteria
Abstract
A process for recovering substantially pure rIL-2 from transformed microorganisms in which the cells are disrupted, impure insoluble rIL-2 is separated from the bulk of the cellular components, the separated impure rIL-2 is solubilized and partially purified in a reduced form, the solubilized rIL-2 is oxidized, the oxidized rIL-2 is purified to clinically acceptable levels, and the oxidized, purified IL-2 is denatured by placing it into a solution of a chaotropic agent, solids are removed from the solution and rIL-2 is renatured from the solution.
AU16812/88A
1987-05-11
1988-03-31
Improved process for recovering microbially produced il-2
Expired
AU619185B2
(en)
Applications Claiming Priority (4)
Application Number
Priority Date
Filing Date
Title
US4840587A
1987-05-11
1987-05-11
US048405
1987-05-11
US07/167,145
US4931543A
(en)
1987-05-11
1988-03-25
Process for recovering microbially produced interleukin-2
US167145
1998-10-06
Publications (2)
Publication Number
Publication Date
AU1681288A
true
AU1681288A
(en)
1988-12-06
AU619185B2
AU619185B2
(en)
1992-01-23
Family
ID=26726086
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU16812/88A
Expired
AU619185B2
(en)
1987-05-11
1988-03-31
Improved process for recovering microbially produced il-2
Country Status (9)
Country
Link
US
(1)
US4931543A
(en)
EP
(1)
EP0357645B1
(en)
AT
(1)
ATE152730T1
(en)
AU
(1)
AU619185B2
(en)
CA
(1)
CA1335925C
(en)
DE
(1)
DE3855899T2
(en)
IE
(1)
IE80433B1
(en)
IL
(1)
IL86327A
(en)
WO
(1)
WO1988008850A1
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU622860B2
(en)
*
1987-05-11
1992-04-30
Novartis Vaccines And Diagnostics, Inc.
Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
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Chiron Corporation
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Cetus Oncology Corporation
Process for recovering refractile bodies containing heterologous proteins from microbial hosts
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1987-04-16
1998-03-17
Robert F. Halenbeck
Production of purified biologically active, bacterially produced recombinant human csf-1
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1987-04-16
1990-05-29
Cetus Corporation
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Amgen, Inc.
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1987-05-11
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Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
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1989-11-20
1989-11-20
Novo Nordisk As
PROCEDURE FOR PURIFICATION OF POLYPEPTIDES
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1990-03-21
1994-11-15
Board Of Trustees Of The Leland Stanford Junior University
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Scios Nova Inc.
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Roussel Uclaf
STABILIZED PHARMACEUTICAL COMPOSITION OF RECOMBINANT, NON-GLYCOSYLATED HUMAN IL2 IN REDUCED FORM AND PROCESS FOR PREPARING THE SAME.
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1992-07-02
1998-07-29
皮特曼-穆尔有限公司
A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein
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1998-08-12
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Antigen Gmbh
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Cancer treatments by using a combination of an antibody against her2 and interleukin-2
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2003-11-04
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Novartis Vaccines & Diagnostic
Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection
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Methods for treating lymphomas using a combination of a chemotherapeutic agent and il-2 and optionally an anti-cd20 antibody
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2010-12-22
2012-06-28
Board Of Trustees Of The Leland Stanford Junior University
Superagonists and antagonists of interleukin-2
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2013-09-24
2023-08-29
Medicenna Therapeutics, Inc.
Interleukin-2 fusion proteins and uses thereof
CA2946398A1
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2014-04-24
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The Board Of Trustees Of The Leland Stanford Junior University
Superagonists, partial agonists and antagonists of interleukin-2
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2017-06-19
2018-12-27
Medicenna Therapeutics Inc.
Uses and methods for il-2 superagonists, agonists, and fusions thereof
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2020-01-14
2023-07-04
シンセカイン インコーポレイテッド
Biased IL2 muteins, methods, and compositions
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1984-12-25
Hoffmann-La Roche Inc.
Homogeneous human interleukin 2
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Purification and activity assurance of precipitated heterologous proteins
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1986-02-11
Cetus Corporation
Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
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Cetus Corporation
Controlled oxidation of microbially produced cysteine-containing proteins
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Cetus Corporation
Pharmaceutical compositions of microbially produced interleukin-2
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Takeda Chemical Industries, Ltd.
Stable composition of interleukin-2
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Biogen Nv
Purifying protein
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CONTINUOUS CRYSTALLIZATION PROCESS AND DEVICE, ESPECIALLY SUCROSE
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Cetus Corporation
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*
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1987-04-21
American Cyanamid Company
Process for solubilization, purification and characterization of protein from insoluble protein aggregates or complexes and compositions of matter therefrom
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Creighton T E
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1985-04-25
1989-10-10
Amgen
Method for purifying interferon and composition of matter produced thereby
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Cetus Corporation
Process for recovering refractile bodies containing heterologous proteins from microbial hosts
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1985-07-11
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Repligen Corporation
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Repligen Corporation
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Natinco Nv
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Ze’ev Shaked
Pharmaceutical compositions of recombinant interleukin-2 and formulation process
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Cetus Oncology Corp
Production of purified, biologically active, bacterially produced recombinant human csf-1
DE3855986T2
(en)
*
1987-05-11
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Chiron Corp
PROCESS FOR OBTAINING CLEANED, OXIDIZED, RENATURED, RECOMBINANT INTERLEUKIN-2 FROM MICROORGANISMS
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Method for removing sodium dodecyl sulfate from sodium dodecyl sulfate solubilized protein solutions
1988
1988-03-25
US
US07/167,145
patent/US4931543A/en
not_active
Expired – Lifetime
1988-03-31
AT
AT88903687T
patent/ATE152730T1/en
not_active
IP Right Cessation
1988-03-31
WO
PCT/US1988/001064
patent/WO1988008850A1/en
active
IP Right Grant
1988-03-31
DE
DE3855899T
patent/DE3855899T2/en
not_active
Expired – Lifetime
1988-03-31
AU
AU16812/88A
patent/AU619185B2/en
not_active
Expired
1988-03-31
EP
EP88903687A
patent/EP0357645B1/en
not_active
Expired – Lifetime
1988-04-11
CA
CA000563759A
patent/CA1335925C/en
not_active
Expired – Lifetime
1988-05-10
IL
IL86327A
patent/IL86327A/en
not_active
IP Right Cessation
1988-05-10
IE
IE140988A
patent/IE80433B1/en
not_active
IP Right Cessation
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU622860B2
(en)
*
1987-05-11
1992-04-30
Novartis Vaccines And Diagnostics, Inc.
Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
Also Published As
Publication number
Publication date
EP0357645A1
(en)
1990-03-14
IE80433B1
(en)
1998-07-15
IL86327A
(en)
1992-12-01
IE881409L
(en)
1988-11-11
US4931543A
(en)
1990-06-05
AU619185B2
(en)
1992-01-23
ATE152730T1
(en)
1997-05-15
WO1988008850A1
(en)
1988-11-17
CA1335925C
(en)
1995-06-13
EP0357645B1
(en)
1997-05-07
DE3855899T2
(en)
1997-09-18
IL86327A0
(en)
1988-11-15
DE3855899D1
(en)
1997-06-12
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