AU1685883A – Platinum-anti-tumor immunoglobulin complexes
– Google Patents
AU1685883A – Platinum-anti-tumor immunoglobulin complexes
– Google Patents
Platinum-anti-tumor immunoglobulin complexes
Info
Publication number
AU1685883A
AU1685883A
AU16858/83A
AU1685883A
AU1685883A
AU 1685883 A
AU1685883 A
AU 1685883A
AU 16858/83 A
AU16858/83 A
AU 16858/83A
AU 1685883 A
AU1685883 A
AU 1685883A
AU 1685883 A
AU1685883 A
AU 1685883A
Authority
AU
Australia
Prior art keywords
platinum
tumor
immunoglobulin
dextranamine
moieties
Prior art date
1982-07-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU16858/83A
Other versions
AU555324B2
(en
Inventor
Ruth Arnon
Ester Hurwitz
Rena Kashi
Bilha Schechter
Michael Sela
Meir Wilchek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1982-07-15
Filing date
1983-07-14
Publication date
1984-01-19
1983-07-14
Application filed by Yeda Research and Development Co Ltd
filed
Critical
Yeda Research and Development Co Ltd
1984-01-19
Publication of AU1685883A
publication
Critical
patent/AU1685883A/en
1986-09-18
Application granted
granted
Critical
1986-09-18
Publication of AU555324B2
publication
Critical
patent/AU555324B2/en
2003-07-14
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
Abstract
There are provided anti-tumor agents comprising as active ingredient platinum complexed directly or via dextranamine moieties to an anti-tumor immunoglobulin. These are prepared by reacting an anti-tumor immunoglobulin or such immunoglobulin coupled to a dextran-amine with a platinum salt. Immunoglobulins having a specific binding activity towards certain types of cancer cells can be used. Immunoglobulins specific for ovarian or testicular carcinoma or for renal adenocarcinoma complexed directly or via dextranamine moieties with platinum are effective agents for the treatment of these malignancies.
AU16858/83A
1982-07-15
1983-07-14
Platinum-anti-tumor immunoglobulin complexes
Ceased
AU555324B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
IL66338A
IL66338A
(en)
1982-07-15
1982-07-15
Anti-cancer drugs comprising platinum complexed antitumor immunoglobulins
IL66338
1982-07-15
Publications (2)
Publication Number
Publication Date
AU1685883A
true
AU1685883A
(en)
1984-01-19
AU555324B2
AU555324B2
(en)
1986-09-18
Family
ID=11053640
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU16858/83A
Ceased
AU555324B2
(en)
1982-07-15
1983-07-14
Platinum-anti-tumor immunoglobulin complexes
Country Status (7)
Country
Link
EP
(1)
EP0099133B1
(en)
JP
(1)
JPS59130222A
(en)
AT
(1)
ATE38775T1
(en)
AU
(1)
AU555324B2
(en)
CA
(1)
CA1224718A
(en)
DE
(1)
DE3378524D1
(en)
IL
(1)
IL66338A
(en)
Families Citing this family (9)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4956454A
(en)
*
1984-06-27
1990-09-11
Johnson Matthey Plc
Monoclonal antibody – platinum co-ordination compound complex
US4952676A
(en)
*
1984-06-27
1990-08-28
Johnson Matthey Plc
Monoclonal antibody-platinum co-ordination compound complex
DE3582961D1
(en)
*
1984-06-27
1991-07-04
Johnson Matthey Plc
PLATINO COORDINATION CONNECTIONS.
EP0169645A1
(en)
*
1984-06-27
1986-01-29
Johnson Matthey Public Limited Company
Platinum co-ordination compounds
US4948784A
(en)
*
1986-05-21
1990-08-14
Kuraray Company, Ltd.
Platinum containing pullulan derivatives and compositions containing the same
US5100877A
(en)
*
1986-05-21
1992-03-31
Kuraray Co., Ltd.
Platinum containing pullulan derivatives and pharmaceutical compositions comprising the same
US4793986A
(en)
*
1987-02-25
1988-12-27
Johnson Matthey, Inc.
Macromolecular platinum antitumor compounds
JP2520262B2
(en)
*
1987-08-21
1996-07-31
春幸 川原
Patch test material
CN104934660B
(en)
*
2015-07-14
2017-03-01
北京航空航天大学
A kind of ultra-thin oxygen metal battery of convenient rolling
1982
1982-07-15
IL
IL66338A
patent/IL66338A/en
unknown
1983
1983-07-12
CA
CA000432233A
patent/CA1224718A/en
not_active
Expired
1983-07-14
AU
AU16858/83A
patent/AU555324B2/en
not_active
Ceased
1983-07-15
AT
AT83106965T
patent/ATE38775T1/en
active
1983-07-15
EP
EP83106965A
patent/EP0099133B1/en
not_active
Expired
1983-07-15
DE
DE8383106965T
patent/DE3378524D1/en
not_active
Expired
1983-07-15
JP
JP58128057A
patent/JPS59130222A/en
active
Pending
Also Published As
Publication number
Publication date
EP0099133B1
(en)
1988-11-23
EP0099133A2
(en)
1984-01-25
CA1224718A
(en)
1987-07-28
AU555324B2
(en)
1986-09-18
ATE38775T1
(en)
1988-12-15
EP0099133A3
(en)
1984-09-05
JPS59130222A
(en)
1984-07-26
IL66338A
(en)
1986-03-31
DE3378524D1
(en)
1988-12-29
IL66338A0
(en)
1982-11-30
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None