AU1904388A

AU1904388A – Mitotic inhibitor and method for preventing posterior lens capsule opacification after extracapsular extraction
– Google Patents

AU1904388A – Mitotic inhibitor and method for preventing posterior lens capsule opacification after extracapsular extraction
– Google Patents
Mitotic inhibitor and method for preventing posterior lens capsule opacification after extracapsular extraction

Info

Publication number
AU1904388A

AU1904388A
AU19043/88A
AU1904388A
AU1904388A
AU 1904388 A
AU1904388 A
AU 1904388A
AU 19043/88 A
AU19043/88 A
AU 19043/88A
AU 1904388 A
AU1904388 A
AU 1904388A
AU 1904388 A
AU1904388 A
AU 1904388A
Authority
AU
Australia
Prior art keywords
lens capsule
posterior lens
mitotic inhibitor
capsule opacification
extracapsular extraction
Prior art date
1987-07-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU19043/88A
Other versions

AU602993B2
(en

Inventor
Ihab Hamel
Thomsen J. Hansen
David B. Soll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ophthalmic Research Corp

Drexel University

Original Assignee
Ophthalmic Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1987-07-16
Filing date
1988-07-14
Publication date
1989-01-19

1988-07-14
Application filed by Ophthalmic Research Corp
filed
Critical
Ophthalmic Research Corp

1989-01-19
Publication of AU1904388A
publication
Critical
patent/AU1904388A/en

1990-11-01
Application granted
granted
Critical

1990-11-01
Publication of AU602993B2
publication
Critical
patent/AU602993B2/en

2008-07-14
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS

A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/02—Prostheses implantable into the body

A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes

A61F2/16—Intraocular lenses

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS

A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS

A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/02—Prostheses implantable into the body

A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes

A61F2/16—Intraocular lenses

A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient

A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates

A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent

A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent

A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES

A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses

A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

A61L27/54—Biologically active materials, e.g. therapeutic substances

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P27/00—Drugs for disorders of the senses

A61P27/02—Ophthalmic agents

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P27/00—Drugs for disorders of the senses

A61P27/02—Ophthalmic agents

A61P27/12—Ophthalmic agents for cataracts

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P35/00—Antineoplastic agents

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS

A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/02—Prostheses implantable into the body

A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes

A61F2/16—Intraocular lenses

A61F2/1602—Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes

A61F2/1605—Anterior chamber lenses for use in addition to the natural lenses of the eyes, e.g. iris fixated, iris floating

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS

A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/02—Prostheses implantable into the body

A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes

A61F2/16—Intraocular lenses

A61F2/1602—Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes

A61F2/161—Posterior chamber lenses for use in addition to the natural lenses of the eyes

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS

A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth

A61F2002/009—Special surfaces of prostheses, e.g. for improving ingrowth for hindering or preventing attachment of biological tissue

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES

A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials

A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines

A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES

A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action

A61L2300/432—Inhibitors, antagonists

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES

A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action

A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

AU19043/88A
1987-07-16
1988-07-14
Mitotic inhibitor and method for preventing posterior lens capsule opacification after extracapsular extraction

Ceased

AU602993B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

US074444

1987-07-16

US07/074,444

US4918165A
(en)

1987-07-16
1987-07-16
Mitotic inhibitor and method for preventing posterior lens capsule opacification after extracapsular extraction

Publications (2)

Publication Number
Publication Date

AU1904388A
true

AU1904388A
(en)

1989-01-19

AU602993B2

AU602993B2
(en)

1990-11-01

Family
ID=22119581
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU19043/88A
Ceased

AU602993B2
(en)

1987-07-16
1988-07-14
Mitotic inhibitor and method for preventing posterior lens capsule opacification after extracapsular extraction

Country Status (5)

Country
Link

US
(1)

US4918165A
(en)

EP
(1)

EP0299467A1
(en)

JP
(1)

JP2767428B2
(en)

AU
(1)

AU602993B2
(en)

CA
(1)

CA1339770C
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU619328B2
(en)

*

1988-08-08
1992-01-23
Eli Lilly And Company
Cytotoxic drug conjugates

Families Citing this family (31)

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Publication number
Priority date
Publication date
Assignee
Title

US5080647A
(en)

*

1988-03-25
1992-01-14
Seymour Dubroff
Composition for preventing clouding of posterior capsule after extracapsular cataract eye surgery and method of performing cataract surgery

WO1995003783A1
(en)

*

1990-03-06
1995-02-09
Houston Biotechnology Incorporated
Polymeric device for the delivery of immunotoxins for the prevention of secondary cataract

EP0446399A1
(en)

*

1990-03-16
1991-09-18
Chiron Adatomed Pharmazeutische und Medizintechnische Gesellschaft mbH
Solution inhibiting cell growth

EP0567627A4
(en)

*

1991-11-14
1994-06-22
Stanley Poler
Secondary eye growth impeding device and method

US5354269A
(en)

*

1991-12-20
1994-10-11
Fibrogenex, Inc.
Method for treating cancer resections

US5375611A
(en)

*

1993-01-26
1994-12-27
Pharmacia Ab
Method for preventing secondary cataract

US5382582A
(en)

*

1993-03-26
1995-01-17
Chan; Carcy L.
Methotrexate analogs and methods of using same

US5876438A
(en)

*

1993-08-02
1999-03-02
Houston Biotechnology Incorporated
Polymeric device for the delivery of immunotoxins for the prevention of secondary cataract

US5834215A
(en)

*

1994-10-05
1998-11-10
The Administrators Of The Tulane Educational Fund
Method for detecting antipolymer antibodies and diagnosing silicone related disease (SRD) fibromyalgia and chronic fatigue syndrome (CFS)

US5620013A
(en)

*

1994-10-21
1997-04-15
American Cyanamid Company
Method for destroying residual lens epithelial cells

US6063116A
(en)

*

1994-10-26
2000-05-16
Medarex, Inc.
Modulation of cell proliferation and wound healing

US5698556A
(en)

*

1995-06-07
1997-12-16
Chan; Carcy L.
Methotrexate analogs and methods of using same

US5554187A
(en)

*

1995-08-18
1996-09-10
Rizzo, Iii; Joseph
Medication dispensing intra-ocular lens system

US5843186A
(en)

*

1996-12-20
1998-12-01
Implemed, Inc.
Intraocular lens with antimicrobial activity

BR9908779A
(en)

1998-04-15
2000-12-05
Alcon Lab Inc

Compositions for intraocular lens coating

US6491721B2
(en)

1998-04-15
2002-12-10
Alcon Manufacturing, Ltd.
Toric intraocular lens material

US6482230B1
(en)

1998-04-15
2002-11-19
Alcon Manufacturing, Ltd.
Lens epithelial cell growth assay for intraocular lens materials

US6455318B1
(en)

1998-04-15
2002-09-24
Alcon Manufacturing, Ltd.
Collagen IV adhesion assay for intraocular lens materials

WO1999052571A1
(en)

1998-04-15
1999-10-21
Alcon Laboratories, Inc.
Bicomposite intraocular lens and method for its preparation

US6106554A
(en)

*

1999-02-25
2000-08-22
Bausch & Lomb Surgical, Inc.
Intraocular lens implants for the prevention of secondary cataracts

US6454802B1
(en)

2000-08-21
2002-09-24
Bausch & Lomb Incorporated
Intraocular lens implant for the prevention of secondary cataracts

DE60131773T2
(en)

2000-09-06
2008-04-10
Alcon Inc.

COATING AGENT WITH CHANGED ADHESIVITY FOR EYE IMPLANTS

JP2004518649A
(en)

*

2000-12-11
2004-06-24
ムーアフィールズ アイ ホスピタル エヌエイチエス トラスト

Treatment of late cataract

US6703466B1
(en)

2001-06-18
2004-03-09
Alcon, Inc.
Foldable intraocular lens optics having a glassy surface

DE60219189T2
(en)

*

2001-07-20
2008-01-03
Iomed, Inc., Salt Lake City

IOPOPHORETIC OKULAR DEVICE FOR DISTRIBUTING METHOTATEX-BASED MEDICAMENTS AND USE THEREOF FOR THE TREATMENT OF NEOPLASTIC, ANGIOGENIC, FIBROPLASTIC AND / OR IMMUNOSUPPRESSIVE EYE-BREAKING MEASURES

AU2004222653C1
(en)

2003-03-17
2010-10-07
Amo Groningen B.V.
New method

WO2006031614A2
(en)

*

2004-09-10
2006-03-23
Tosk, Inc.
Reduced toxicity methotrexate formulations and methods for using the same

KR20080082659A
(en)

2005-11-28
2008-09-11
버논 디. 로웨
Compositions useful for reducing nephrotoxicity and methods of use thereof

CN102014919B
(en)

2008-03-03
2015-02-25
托斯克公司
Methotrexate adjuvants to reduce toxicity and methods for using the same

US20110082543A1
(en)

*

2009-10-06
2011-04-07
Cleo Cosmetic And Pharmaceutical Company, Llc
Methods and Devices for Preventing or Delaying Posterior Capsule Opacification

US20120191185A1
(en)

*

2011-01-26
2012-07-26
Micheal Colvin
Ophthalmic intraocular lens for promoting healing

Family Cites Families (6)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB2020180B
(en)

*

1978-05-08
1982-08-25
Nelson Res & Dev
Ophthalmic compositions containingcolchicine or vinblastinr

US4515794A
(en)

*

1981-10-09
1985-05-07
Baylor College Of Medicine
Mitotic inhibitors preventing posterior lens capsule opacification

DE3271414D1
(en)

*

1981-10-09
1986-07-03
Baylor College Medicine
Use of methotrexate and/or retinoic acid for the manufacture of compositions for use in preventing proliferation of remnant lens epithelial cells after extracapsular extraction

US4399460A
(en)

*

1981-10-09
1983-08-16
Rca Corporation
Video signal peaking control system with provision for automatic and manual control

US4432751A
(en)

*

1982-03-05
1984-02-21
Baylor College Of Medicine
Monoclonal antibodies against lens epithelial cells and preventing proliferation of remnant lens epithelial cells after extracapsular extraction

US4699784A
(en)

*

1986-02-25
1987-10-13
Center For Molecular Medicine & Immunology
Tumoricidal methotrexate-antibody conjugate

1987

1987-07-16
US
US07/074,444
patent/US4918165A/en
not_active
Expired – Lifetime

1988

1988-07-14
EP
EP88111290A
patent/EP0299467A1/en
not_active
Withdrawn

1988-07-14
AU
AU19043/88A
patent/AU602993B2/en
not_active
Ceased

1988-07-15
JP
JP63175259A
patent/JP2767428B2/en
not_active
Expired – Fee Related

1988-07-15
CA
CA000572099A
patent/CA1339770C/en
not_active
Expired – Fee Related

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU619328B2
(en)

*

1988-08-08
1992-01-23
Eli Lilly And Company
Cytotoxic drug conjugates

Also Published As

Publication number
Publication date

US4918165A
(en)

1990-04-17

JP2767428B2
(en)

1998-06-18

AU602993B2
(en)

1990-11-01

EP0299467A1
(en)

1989-01-18

CA1339770C
(en)

1998-03-24

JPH01100133A
(en)

1989-04-18

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